Ralph Hruban

Research output

Research output per year 1984 1993 1994 1998 1999 2000 2001 2002 2003 2004 2005 2006 2009 2011 2012 2013 2014 2015 2016 2017 2018 2020 2021 2022 2023 2024

• 944 Article
• 82 Review article
• 34 Comment/debate
• 22 Letter
• 42 More
  • 21 Chapter
  • 9 Short survey
  • 6 Editorial
  • 2 Book
  • 2 Conference contribution
  • 1 Foreword/postscript
  • 1 Conference article

Research output per year

Research output per year

Search results

• 2024

  Accurate non-invasive grading of nonfunctional pancreatic neuroendocrine tumors with a CT derived radiomics signature

  Javed, A. A., Zhu, Z., Kinny-Köster, B., Habib, J. R., Kawamoto, S., Hruban, R. H., Fishman, E. K., Wolfgang, C. L., He, J. & Chu, L. C., Jan 2024, In: Diagnostic and Interventional Imaging. 105, 1, p. 33-39 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroendocrine Tumors 100%
  • Tomography 60%
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration 41%
  • Primitive Neuroectodermal Tumors 26%
  • Area Under Curve 23%

• Deep neural network-based segmentation of normal and abnormal pancreas on abdominal CT: evaluation of global and local accuracies

  Kawamoto, S., Zhu, Z., Chu, L. C., Javed, A. A., Kinny-Köster, B., Wolfgang, C. L., Hruban, R. H., Kinzler, K. W., Fouladi, D. F., Blanco, A., Shayesteh, S. & Fishman, E. K., Feb 2024, In: Abdominal Radiology. 49, 2, p. 501-511 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreas 100%
  • Radiologists 29%
  • Adenocarcinoma 24%
  • Artificial Intelligence 14%
  • Neoplasms 10%

• Detection of Pancreatic Ductal Adenocarcinoma-Associated Proteins in Serum

  Mamie Lih, T., Cao, L., Minoo, P., Omenn, G. S., Hruban, R., Chan, D. W., Bathe, O. F. & Zhang, H., Jan 2024, In: Molecular and Cellular Proteomics. 23, 1, 100687.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Machine learning to detect the SINEs of cancer

  Douville, C., Lahouel, K., Kuo, A., Grant, H., Avigdor, B. E., Curtis, S. D., Summers, M., Cohen, J. D., Wang, Y., Mattox, A., Dudley, J., Dobbyn, L., Popoli, M., Ptak, J., Nehme, N., Silliman, N., Blair, C., Romans, K., Thoburn, C., Gizzi, J., & 18 othersSchoen, R. E., Tie, J., Gibbs, P., Ho-Pham, L. T., Tran, B. N. H., Tran, T. S., Nguyen, T. V., Goggins, M., Wolfgang, C., Wang, T-L., Shih, I. M., O'Broin-Lennon, A. M. L., Hruban, R., Bettegowda, C., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Tomasetti, C., Jan 24 2024, In: Science translational medicine. 16, 731, eadi3883.

  Research output: Contribution to journal › Article › peer-review

• Magnetic Resonance Imaging–Based Assessment of Pancreatic Fat Strongly Correlates With Histology-Based Assessment of Pancreas Composition

  Kiemen, A. L., Dbouk, M., Diwan, E. A., Forjaz, A., Dequiedt, L., Baghdadi, A., Madani, S. P., Grahn, M. P., Jones, C., Vedula, S., Wu, P. H., Wirtz, D., Kern, S., Goggins, M., Hruban, R., Kamel, I. R. & Canto, M. I., Feb 1 2024, In: Pancreas. 53, 2, p. E180-E186

  Research output: Contribution to journal › Article › peer-review

  • Pancreas 100%
  • Magnetic Resonance Spectroscopy 98%
  • Histology 92%
  • Fats 87%
  • Magnetic Resonance Imaging 57%
• 2023

  A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising From Pancreatic Cysts

  Nikiforova, M. N., Wald, A. I., Spagnolo, D. M., Melan, M. A., Grupillo, M., Lai, Y. T., Brand, R. E., O'Broin-Lennon, A. M., McGrath, K., Park, W. G., Pfau, P. R., Polanco, P. M., Kubiliun, N., Dewitt, J., Easler, J. J., Dam, A., Mok, S. R., Wallace, M. B., Kumbhari, V., Boone, B. A., & 34 othersMarsh, W., Thakkar, S., Fairley, K. J., Afghani, E., Bhat, Y., Ramrakhiani, S., Nasr, J., Skef, W., Thiruvengadam, N. R., Khalid, A., Fasanella, K., Chennat, J., Das, R., Singh, H., Sarkaria, S., Slivka, A., Gabbert, C., Sawas, T., Tielleman, T., Vanderveldt, H. D., Tavakkoli, A., Smith, L. M., Smith, K., Bell, P. D., Hruban, R. H., Paniccia, A., Zureikat, A., Lee, K. K., Ongchin, M., Zeh, H., Minter, R., He, J., Nikiforov, Y. E. & Singhi, A. D., Oct 1 2023, In: Annals of surgery. 278, 4, p. E789-E797

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Cyst 100%
  • High-Throughput Nucleotide Sequencing 66%
  • Early Detection of Cancer 65%
  • Pancreatic Neoplasms 65%
  • RNA 47%

• A deep learning model to triage and predict adenocarcinoma on pancreas cytology whole slide imaging

  Sohn, A., Miller, D., Ribeiro, E., Shankar, N., Ali, S., Hruban, R. & Baras, A., Dec 2023, In: Scientific reports. 13, 1, 16517.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • Triage 80%
  • Cell Biology 63%
  • Pancreas 62%
  • Datasets 57%

• A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

  Chitty, J. L., Yam, M., Perryman, L., Parker, A. L., Skhinas, J. N., Setargew, Y. F. I., Mok, E. T. Y., Tran, E., Grant, R. D., Latham, S. L., Pereira, B. A., Ritchie, S. C., Murphy, K. J., Trpceski, M., Findlay, A. D., Melenec, P., Filipe, E. C., Nadalini, A., Velayuthar, S., Major, G., & 110 othersWyllie, K., Papanicolaou, M., Ratnaseelan, S., Phillips, P. A., Sharbeen, G., Youkhana, J., Russo, A., Blackwell, A., Hastings, J. F., Lucas, M. C., Chambers, C. R., Reed, D. A., Stoehr, J., Vennin, C., Pidsley, R., Zaratzian, A., Da Silva, A. M., Tayao, M., Charlton, B., Herrmann, D., Nobis, M., Clark, S. J., Biankin, A. V., Johns, A. L., Croucher, D. R., Nagrial, A., Gill, A. J., Grimmond, S. M., Chantrill, L. A., Chou, A., Dwarte, T., Metcalf, X. L., Jeong, G., Kenyon, L., Waddell, N., Pearson, J. V., Patch, A. M., Nones, K., Newell, F., Mukhopadhyay, P., Addala, V., Kazakoff, S., Holmes, O., Leonard, C., Wood, S., Hofmann, O., Samra, J. S., Pavlakis, N., Arena, J., High, H. A., Asghari, R., Merrett, N. D., Das, A., Cosman, P. H., Ismail, K., Stoita, A., Williams, D., Spigellman, A., McLeo, D., Kirk, J., Kench, J. G., Grimison, P., Sandroussi, C., Goodwin, A., Mead, R. S., Tucker, K., Andrews, L., Texler, M., Forrest, C., Ballal, M., Fletcher, D., Beilin, M., Feeney, K., Epari, K., Mukhedkar, S., Zeps, N., Nguyen, N. Q., Ruszkiewicz, A. R., Worthley, C., Chen, J., Brooke-Smith, M. E., Papangelis, V., Clouston, A. D., Barbour, A. P., O’Rourke, T. J., Fawcett, J. W., Slater, K., Hatzifotis, M., Hodgkinson, P., Nikfarjam, M., Eshleman, J. R., Hruban, R. H., Wolfgang, C. L., Scarpa, A., Lawlor, R. T., Corbo, V., Bassi, C., Jamieson, N. B., Chang, D. K., Dreyer, S. B., Abdulkhalek, L., Schmitz, T., Lee, V., Stewart, K. P., Arshi, M., Steinmann, A. M., Pajic, M., Timpson, P., Jarolimek, W. & Cox, T. R., Sep 2023, In: Nature Cancer. 4, 9, p. 1326-1344 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein-Lysine 6-Oxidase 100%
  • gemcitabine 77%
  • Pancreatic Neoplasms 65%
  • Survival 38%
  • Drug Therapy 24%

• A primer on artificial intelligence in pancreatic imaging

  Ahmed, T. M., Kawamoto, S., Hruban, R. H., Fishman, E. K., Soyer, P. & Chu, L. C., Sep 2023, In: Diagnostic and Interventional Imaging. 104, 9, p. 435-447 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Artificial Intelligence 100%
  • Deep Learning 69%
  • Diagnostic Imaging 25%
  • Radiology 25%
  • Theoretical Models 20%

• Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers (Nature Genetics, (2020), 52, 3, (342-352), 10.1038/s41588-019-0557-x)

  PCAWG Consortium, May 2023, In: Nature genetics. 55, 5, p. 892 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Seoul 100%
  • Mitochondrial Genome 98%
  • Korea 80%
  • Genome 52%
  • Neoplasms 25%

• Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (Nature Genetics, (2020), 52, 3, (306-319), 10.1038/s41588-019-0562-0)

  PCAWG Structural Variation Working Group & PCAWG Consortium, Jun 2023, In: Nature genetics. 55, 6, p. 1080 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Genome 100%
  • Medicine 53%
  • Neoplasms 47%
  • Baltimore 47%
  • Quebec 44%

• Author Correction: Pan-cancer analysis of whole genomes (Nature, (2020), 578, 7793, (82-93), 10.1038/s41586-020-1969-6)

  The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 16 2023, In: Nature. 614, 7948, p. E39

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Genome 100%
  • Neoplasms 47%

• Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing (Nature Genetics, (2020), 52, 3, (331-341), 10.1038/s41588-019-0576-7)

  PCAWG Structural Variation Working Group & PCAWG Consortium, Jun 2023, In: Nature genetics. 55, 6, p. 1076 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Chromothripsis 100%
  • Whole Genome Sequencing 67%
  • Genome 39%
  • Neoplasms 18%

• Author Correction: The landscape of viral associations in human cancers (Nature Genetics, (2020), 52, 3, (320-330), 10.1038/s41588-019-0558-9)

  PCAWG Pathogens & PCAWG Consortium, Jun 2023, In: Nature genetics. 55, 6, p. 1077 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Genome 100%
  • Neoplasms 47%
  • Germany 32%
  • Infections 17%

• Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers (Nature Genetics, (2020), 52, 3, (342-352), 10.1038/s41588-019-0557-x)

  PCAWG Consortium, Jun 2023, In: Nature genetics. 55, 6, p. 1078 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Mitochondrial Genome 100%
  • Genome 53%
  • Neoplasms 25%

• Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (Nature Genetics, (2020), 52, 3, (294-305), 10.1038/s41588-019-0564-y)

  PCAWG Structural Variation Working Group & PCAWG Consortium, Jun 2023, In: Nature genetics. 55, 6, p. 1079 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Chromatin 100%
  • Genome 76%
  • Neoplasms 36%

• Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis

  Lo, E. K. W., Mears, B. M., Maurer, H. C., Idrizi, A., Hansen, K. D., Thompson, E. D., Hruban, R. H., Olive, K. P. & Feinberg, A. P., 2023, In: Cancer Research. 83, 11, p. 1905-1916 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Adenocarcinoma 79%
  • Carcinogenesis 77%
  • Methylation 39%
  • Neoplasms 32%

• Frequent Intraluminal Growth of Large Muscular Veins in Surgically Resected Colorectal Cancer Tissues: A 3-Dimensional Pathologic Reconstruction Study

  Jung, D., Shin, J., Park, J., Shin, J., Sung, Y. N., Kim, Y., Yoo, S., Lee, B. W., Jang, S. W., Park, I. J., Wood, L. D., Pack, C. G., Hruban, R. H. & Hong, S. M., Mar 1 2023, In: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 36, 3, p. 100082 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Veins 100%
  • Colorectal Neoplasms 95%
  • Cadherins 76%
  • Growth 60%
  • Neoplasms 21%

• Histopathological tumour response scoring in resected pancreatic cancer following neoadjuvant therapy: international interobserver study (ISGPP-1)

  The International Study Group of Pancreatic Pathologists (ISGPP), Jan 1 2023, In: British Journal of Surgery. 110, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoadjuvant Therapy 100%
  • Pancreatic Neoplasms 82%
  • Pathologists 32%
  • Neoplasms 27%
  • Hematoxylin 13%

• Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer

  Kiemen, A. L., Choi, Y. G., Braxton, A. M., Almagro Pérez, C., Graham, S., Grahn, M. P., Nanda, N., Roberts, N., Wood, L., Wu, P. H., Hruban, R. H. & Wirtz, D., Feb 2023, In: Histopathology. 82, 3, p. 504-506 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Molecular Genetics of Neuroendocrine Tumors

  Papadopoulos, N. & Hruban, R. H., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. 771-780 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Molecular Mechanisms of Cystic Neoplasia

  Papadopoulos, N. & Hruban, R. H., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. 630-637 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Molecular Understanding of the Development of Ductal Pancreatic Cancer

  Lee, J. W., Hruban, R. H. & Wood, L. D., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. 912-920 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

  Chen, J., Zheng, Q., Hicks, J. L., Trabzonlu, L., Ozbek, B., Jones, T., Vaghasia, A. M., Larman, T. C., Wang, R., Markowski, M. C., Denmeade, S. R., Pienta, K. J., Hruban, R. H., Antonarakis, E. S., Gupta, A., Dang, C. V., Yegnasubramanian, S. & De Marzo, A. M., 2023, In: JCI Insight. 8, 24, e169868.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial DNA 100%
  • Prostatic Neoplasms 75%
  • Prostate 15%
  • Adenocarcinoma 14%
  • Prostatic Intraepithelial Neoplasia 13%

• Oncologic resection of pancreatic cancer with isolated liver metastasis: Favorable outcomes in select patients

  Nagai, M., Wright, M. J., Ding, D., Thompson, E. D., Javed, A. A., Weiss, M. J., Hruban, R. H., Yu, J., Burkhart, R. A., He, J., Cameron, J. L., Wolfgang, C. L. & Burns, W. R., Aug 2023, In: Journal of Hepato-Biliary-Pancreatic Sciences. 30, 8, p. 1025-1035 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Neoplasm Metastasis 65%
  • Liver 54%
  • Survival 51%
  • Adenocarcinoma 41%

• Pancreatoblastoma in an elderly woman: A case report simulating a pancreatic neuroendocrine tumour with emphasis on cytomorphological features

  Saoud, C., Wu, A. A., Fishman, E. K., Hruban, R. H. & Ali, S. Z., May 2023, In: Cytopathology. 34, 3, p. 254-258 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatoblastoma 100%
  • Neuroendocrine Tumors 64%
  • Elderly 38%
  • Acinar Cells 28%
  • Fine Needle Biopsy 24%

• Pancreatoblastoma in Elderly Adults: Report of Two Patients

  Kulak, O., Osipov, A., Hendifar, A. E., Nissen, N. N., Cox, B. K., Hruban, R. H. & Hutchings, D., Aug 2023, In: International journal of surgical pathology. 31, 5, p. 772-777 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatoblastoma 100%
  • Elderly 38%
  • Pancreatic Diseases 18%
  • Acinar Cells 16%
  • Germ-Line Mutation 16%

• Pathology of Exocrine Pancreatic Tumors

  Pittman, M. E. & Hruban, R. H., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. 957-968 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Preface

  Beger, H. G., Buchler, M. W., Hruban, R. H., Mayerle, J., Neoptolemos, J. P., Shimosegawa, T., Warshaw, A. L., Whitcomb, D. C. & Zhao, Y., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. v

  Research output: Chapter in Book/Report/Conference proceeding › Foreword/postscript

• Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts

  Paniccia, A., Polanco, P. M., Boone, B. A., Wald, A. I., McGrath, K., Brand, R. E., Khalid, A., Kubiliun, N., O'Broin-Lennon, A. M., Park, W. G., Klapman, J., Tharian, B., Inamdar, S., Fasanella, K., Nasr, J., Chennat, J., Das, R., DeWitt, J., Easler, J. J., Bick, B., & 48 othersSingh, H., Fairley, K. J., Sarkaria, S., Sawas, T., Skef, W., Slivka, A., Tavakkoli, A., Thakkar, S., Kim, V., Vanderveldt, H. D., Richardson, A., Wallace, M. B., Brahmbhatt, B., Engels, M., Gabbert, C., Dugum, M., El-Dika, S., Bhat, Y., Ramrakhiani, S., Bakis, G., Rolshud, D., Millspaugh, G., Tielleman, T., Schmidt, C., Mansour, J., Marsh, W., Ongchin, M., Centeno, B., Monaco, S. E., Ohori, N. P., Lajara, S., Thompson, E. D., Hruban, R. H., Bell, P. D., Smith, K., Permuth, J. B., Vandenbussche, C., Ernst, W., Grupillo, M., Kaya, C., Hogg, M., He, J., Wolfgang, C. L., Lee, K. K., Zeh, H., Zureikat, A., Nikiforova, M. N. & Singhi, A. D., Jan 2023, In: Gastroenterology. 164, 1, p. 117-133.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Cyst 100%
  • Cyst Fluid 94%
  • High-Throughput Nucleotide Sequencing 66%
  • Cysts 22%
  • Loss of Heterozygosity 19%

• Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers (Nature Genetics, (2020), 52, 3, (342-352), 10.1038/s41588-019-0557-x)

  PCAWG Consortium, May 2023, In: Nature genetics. 55, 5, p. 893 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Mitochondrial Genome 100%
  • Licensure 86%
  • Neoplasms 25%

• Radiologists' Expectations of Artificial Intelligence in Pancreatic Cancer Imaging: How Good Is Good Enough?

  Chu, L. C., Ahmed, T., Blanco, A., Javed, A., Weisberg, E. M., Kawamoto, S., Hruban, R. H., Kinzler, K. W., Vogelstein, B. & Fishman, E. K., Nov 1 2023, In: Journal of computer assisted tomography. 47, 6, p. 845-849 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Artificial Intelligence 100%
  • Pancreatic Neoplasms 71%
  • Radiologists 69%
  • Motivation 60%
  • Radiology 6%

• Recurring Pancreatic Neuroendocrine Tumor: Timing and Pattern of Recurrence and Current Treatment

  Pulvirenti, A., Javed, A. A., Michelakos, T., Sekigami, Y., Zheng, J., Kalvin, H. L., McIntyre, C. A., Nebbia, M., Chou, J. F., Gonen, M., Raj, N., Reidy-Lagunes, D. L., Zureikat, A. H., Ferrone, C. R., He, J., Wei, A. C., Singhi, A. D., Pulvirenti, A., Paniccia, A., Wei, A., & 36 othersZureikat, A. H., Javed, A. A., McIntyre, C. A., Del Castillo, C. F., Wolfgang, C., Ferrone, C. R., Klimstra, D. S., Reidy-Lagunes, D. L., Thompson, E., Fishman, E. K., Kalvin, H. L., Zheng, J., He, J., Chou, J. F., Cameron, J. L., Lillemoe, K. D., Lee, K. K., Soares, K. C., Tang, L. H., Nebbia, M., Makary, M. A., Weiss, M. J., D'Angelica, M. I., Gonen, M., Qadan, M., Raj, N., Hruban, R. H., Bukhart, R. A., Razi, S., Kingham, T. P., Michelakos, T., Deshpande, V., Balachandran, V. P., Burn, W. R., Jarnagin, W. R. & Sekigami, Y., Nov 1 2023, In: Annals of surgery. 278, 5, p. E1063-E1067

  Research output: Contribution to journal › Article › peer-review

  • Neuroendocrine Tumors 100%
  • Recurrence 50%
  • Survival 21%
  • Therapeutics 14%
  • Peptide Receptors 12%

• RNA Sequencing Identifies Frequent Mitogen-activated Protein Kinase–associated Fusion Genes in Intraductal Tubulopapillary Neoplasms of the Pancreas

  Pancreatic Cyst Alliance, Jun 2023, In: Gastroenterology. 164, 7, p. 1310-1313.e6

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

• Screening for pancreatic cancer has the potential to save lives, but is it practical?

  Mazer, B. L., Lee, J. W., Roberts, N. J., Chu, L. C., Lennon, A. M., Klein, A. P., Eshleman, J. R., Fishman, E. K., Canto, M. I., Goggins, M. G. & Hruban, R. H., 2023, In: Expert Review of Gastroenterology and Hepatology. 17, 6, p. 555-574 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Pancreatic Neoplasms 100%
  • Circulating Tumor DNA 37%
  • Artificial Intelligence 34%
  • Pancreatic Diseases 34%
  • Exosomes 31%

• Somatic loss of ATM is a late event in pancreatic tumorigenesis

  Paranal, R. M., Jiang, Z., Hutchings, D., Kryklyva, V., Gauthier, C., Fujikura, K., Nanda, N., Huang, B., Skaro, M., Wolfgang, C. L., He, J., Klimstra, D. S., Brand, R. E., Singhi, A. D., DeMarzo, A., Zheng, L., Goggins, M., Brosens, L. A. A., Hruban, R. H., Klein, A. P., & 3 othersLotan, T., Wood, L. D. & Roberts, N. J., Aug 2023, In: Journal of Pathology. 260, 4, p. 455-464 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Carcinogenesis 100%
  • Adenocarcinoma 68%
  • Mucinous Adenocarcinoma 55%
  • Pancreatic Neoplasms 41%
  • Carcinoma in Situ 24%

• The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer

  Mattox, A. K., Douville, C., Wang, Y., Popoli, M., Ptak, J., Silliman, N., Dobbyn, L., Schaefer, J., Lu, S., Pearlman, A. H., Cohen, J. D., Tie, J., Gibbs, P., Lahouel, K., Bettegowda, C., Hruban, R. H., Tomasetti, C., Jiang, P., Chan, K. C. A., Lo, Y. M. D., & 3 othersPapadopoulos, N., Kinzler, K. W. & Vogelstein, B., 2023, In: Cancer discovery. 13, 10, p. 2166-2179 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell-Free Nucleic Acids 100%
  • Pancreatic Neoplasms 75%
  • Ovarian Neoplasms 72%
  • Colorectal Neoplasms 63%
  • Lung Neoplasms 62%

• The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition

  Beger, H. G., Buchler, M. W., Hruban, R. H., Mayerle, J., Neoptolemos, J. P., Shimosegawa, T., Warshaw, A. L., Whitcomb, D. C. & Zhao, Y., Jan 1 2023, wiley. 1343 p.

  Research output: Book/Report › Book

  • Textbooks 100%
  • Pancreas 71%
  • Medicine 60%
  • Autoimmune Pancreatitis 29%
  • Pancreatic Diseases 26%

• Three-dimensional analysis of ductular reactions and their correlation with liver regeneration and fibrosis

  Yoshizawa, T., Lee, J. W., Hong, S. M., Jung, D. J., Noë, M., Zbijewski, W., Kiemen, A., Wu, P. H., Wirtz, D., Hruban, R. H., Wood, L. D. & Oshima, K., 2023, (Accepted/In press) In: Virchows Archiv.

  Research output: Contribution to journal › Article › peer-review

  • Liver Regeneration 100%
  • Liver Cirrhosis 75%
  • Hepatocytes 68%
  • Glutamate-Ammonia Ligase 62%
  • Liver Diseases 58%

• Tissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancer

  Kiemen, A. L., Damanakis, A. I., Braxton, A. M., He, J., Laheru, D., Fishman, E. K., Chames, P., Pérez, C. A., Wu, P. H., Wirtz, D., Wood, L. D. & Hruban, R. H., Feb 10 2023, In: Med. 4, 2, p. 75-91 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Microscopy 43%
  • Hematoxylin 26%
  • Eosine Yellowish-(YS) 26%
  • Back 26%
• 2022

  Accurate Nodal Staging in Pancreatic Cancer in the Era of Neoadjuvant Therapy

  Javed, A. A., Ding, D., Baig, E., Wright, M. J., Teinor, J. A., Mansoor, D., Thompson, E., Hruban, R. H., Narang, A., Burns, W. R., Burkhart, R. A., Lafaro, K., Weiss, M. J., Cameron, J. L., Wolfgang, C. L. & He, J., Mar 2022, In: World journal of surgery. 46, 3, p. 667-677 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoadjuvant Therapy 100%
  • Pancreatic Neoplasms 82%
  • Lymph Nodes 49%
  • Recurrence 39%
  • Survival 38%

• Anatomic Criteria Determine Resectability in Locally Advanced Pancreatic Cancer

  Gemenetzis, G., Blair, A. B., Nagai, M., Groot, V. P., Ding, D., Javed, A. A., Burkhart, R. A., Fishman, E. K., Hruban, R. H., Weiss, M. J., Cameron, J. L., Narang, A., Laheru, D., Lafaro, K., Herman, J. M., Zheng, L., Burns, W. R., Wolfgang, C. L. & He, J., Jan 2022, In: Annals of surgical oncology. 29, 1, p. 401-414 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Survival 7%
  • Radiotherapy 4%
  • Drug Therapy 3%
  • Therapeutics 2%

• A novel tool to predict nodal metastasis in small pancreatic neuroendocrine tumors: A multicenter study

  Pancreatic Neuroendocrine Disease Alliance (PANDA), Dec 2022, In: Surgery (United States). 172, 6, p. 1800-1806 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroendocrine Tumors 100%
  • Multicenter Studies 76%
  • Neoplasm Metastasis 54%
  • Disease-Free Survival 15%
  • Confidence Intervals 14%

• Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations (Nature Communications, (2020), 11, 1, (736), 10.1038/s41467-019-13885-w)

  PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group & PCAWG Consortium, Dec 1 2022, In: Nature communications. 13, 1, 7572.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • genome 100%
  • Gene Rearrangement 89%
  • genes 89%
  • cancer 71%
  • Communication 69%

• Author Correction: Inferring structural variant cancer cell fraction (Nature Communications, (2020), 11, 1, (730), 10.1038/s41467-020-14351-8)

  PCAWG Evolution and Heterogeneity Working Group & PCAWG Consortium, Dec 1 2022, In: Nature communications. 13, 1, 7568.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • genome 100%
  • cancer 71%
  • Communication 69%
  • document markup languages 68%
  • communication 63%

• Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Nature Communications, (2020), 11, 1, (733), 10.1038/s41467-019-13824-9)

  PCAWG Structural Variation Working Group & PCAWG Consortium, Dec 1 2022, In: Nature communications. 13, 1, 7574.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • telomeres 100%
  • genome 76%
  • document markup languages 70%
  • footprints 66%
  • Telomere 64%

• Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns (Nature Communications, (2020), 11, 1, (728), 10.1038/s41467-019-13825-8)

  PCAWG Tumor Subtypes and Clinical Translation Working Group & PCAWG Consortium, Dec 2022, In: Nature communications. 13, 1, 7573.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Deep Learning 100%
  • genome 94%
  • passengers 93%
  • document markup languages 86%
  • mutations 84%

• Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes (Nature Communications, (2020), 11, 1, (729), 10.1038/s41467-020-14367-0)

  PCAWG Drivers and Functional Interpretation Working Group & PCAWG Consortium, Dec 1 2022, In: Nature communications. 13, 1, 7566.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours (Nature Communications, (2020), 11, 1, (737), 10.1038/s41467-019-14052-x)

  PCAWG Consortium, Dec 2022, In: Nature communications. 13, 1, 7569.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • genome 100%
  • document markup languages 91%
  • tumors 73%
  • cancer 71%
  • Communication 69%

• Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig (Nature Communications, (2020), 11, 1, (731), 10.1038/s41467-020-14352-7)

  PCAWG Evolution and Heterogeneity Working Group & PCAWG Consortium, Dec 1 2022, In: Nature communications. 13, 1, 7567.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • genome 100%
  • document markup languages 91%
  • mutations 89%
  • cancer 71%
  • Communication 69%