Ralph H Hruban

Professor

1984 …2019
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Research Output 1984 2019

2019

Added value of apparent diffusion coefficient in distinguishing between serous and mucin-producing pancreatic cystic neoplasms

Pandey, P., Pandey, A., Shao, N., Varzaneh, F. N., Ghasabeh, M. A., Zharghampour, M., Khoshpouri, P., Fouladi, D., Eng, J., O'Broin-Lennon, A. M., Canto, M., Hruban, R. H. & Kamel, I. R., Jan 1 2019, In : European Radiology.

Research output: Contribution to journalArticle

Mucins
Pancreatic Neoplasms
Reading
Logistic Models
Odds Ratio

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care
Abdomen
Cone-Beam Computed Tomography
Tomography
Learning
Pancreatic Diseases

Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience

Chu, L. C. H., Park, S., Kawamoto, S., Wang, Y., Zhou, Y., Shen, W., Zhu, Z., Xia, Y., Xie, L., Liu, F., Yu, Q., Fouladi, D. F., Shayesteh, S., Zinreich, E. S., Graves, J. S., Horton, K. M., Yuille, A. L., Hruban, R. H., Kinzler, K. W., Vogelstein, B. & 1 others, Fishman, E. K., Jan 1 2019, In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Learning

Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture

Matsushita, Y., Smith, B., Delannoy, M., Trujillo, M. A., Chianchiano, P., McMillan, R., Kamiyama, H., Liang, H., Thompson, E. D., Hruban, R. H., Matsui, W., Wood, L. D., Roberts, N. J. & Eshleman, J. R., Oct 1 2019, In : Pancreas. 48, 9, p. 1225-1231 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Organoids
Pancreatic Ducts
Microvilli

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N., London, N., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access
Deceleration
Cell Division
Incidence
Neoplasms
Stem Cells

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA
Neoplasms
Adenocarcinoma
Recurrence

Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance

Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., O'Broin-Lennon, A. M., Shin, E., Klein, A., Hruban, R. H., Canto, M. & Goggins, M. S., May 1 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 13, p. 1070-1080 11 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Pancreatic Neoplasms
Neoplasm Genes
Mutation
Incidence

Follow-up of incidentally detected pancreatic cystic neoplasms: Do baseline MRI and CT features predict cyst growth?

Pandey, P., Pandey, A., Luo, Y., Ghasabeh, M. A., Khoshpouri, P., Ameli, S., O'Broin-Lennon, A. M., Canto, M., Hruban, R. H., Goggins, M. S., Wolfgang, C. & Kamel, I. R., Jan 1 2019, In : Radiology. 292, 3, p. 647-654 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Cysts
Growth
Radiology

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Hutchings, D., Jiang, Z., Skaro, M., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Zheng, L., Klimstra, D. S., Brand, R. E., Singhi, A. D., Goggins, M. S., Klein, A., Roberts, N. & Hruban, R. H., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Pancreatic Neoplasms
Colloids
Adenocarcinoma
Carcinoma

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., Springer, S., Dal Molin, M., Masica, D., Scharpf, R. B., Thompson, E. D., He, J., Wolfgang, C. L., Hruban, R. H., Roberts, N. J., Lennon, A. M. & 3 others, Jiao, Y., Karchin, R. & Wood, L. D., Oct 1 2019, In : Gastroenterology. 157, 4, p. 1123-1137.e22

Research output: Contribution to journalArticle

Clone Cells
Mutation
Neoplasms
Carcinogenesis
Pancreatic Neoplasms

Is the Early Detection of Pancreatic Cancer Possible? It Is Good News, Bad News

Hruban, R. H., May 1 2019, In : Pancreas. 48, 5, p. 591-593 3 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer

Management of patients with increased risk for familial pancreatic cancer: Updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E., Fockens, P., Gress, T. M., Van Hooft, J. E., Hruban, R. H., Kastrinos, F., Klein, A., Lennon, A. M., Lucas, A., Park, W., Rustgi, A. & 6 others, Simeone, D., Stoffel, E., Vasen, H. F. A., Cahen, D. L., Canto, M. I. & Bruno, M., Jan 1 2019, (Accepted/In press) In : Gut. 319352.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Consensus
Germ-Line Mutation
Cost-Benefit Analysis

Multiple KRAS mutations in the non-mucinous epithelial lining in the majority of mucinous cystic neoplasms of the pancreas

An, S., Kim, M. J., Kim, S. J., Sung, Y. N., Kim, Y. W., Song, K. B., Hwang, D. W., Kim, S. C., Hruban, R. H. & Hong, S. M., Oct 1 2019, In : Histopathology. 75, 4, p. 559-567 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epithelium
Mutation
Neoplasms
Laser Capture Microdissection

Pancreatic Nerve Sheath Tumors: a Single Institutional Series and Systematic Review of the Literature

Javed, A. A., Wright, M. J., Hasanain, A., Chang, K., Burkhart, R., Hruban, R. H., Thompson, E., Fishman, E. K., Cameron, J. L., He, J., Wolfgang, C. & Weiss, M. J., Jan 1 2019, In : Journal of Gastrointestinal Surgery.

Research output: Contribution to journalArticle

Nerve Sheath Neoplasms
Diagnostic Errors
Neoplasms
Lost to Follow-Up
Databases

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasms
Pancreatic Neoplasms
Mutation
Confidence Intervals

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Eissa, M. A. L., Lerner, L., Abdelfatah, E., Shankar, N., Canner, J. K., Hasan, N. M., Yaghoobi, V., Huang, B., Kerner, Z., Takaesu, F., Wolfgang, C., Kwak, R., Ruiz, M., Tam, M., Pisanic, T. R., Iacobuzio-Donahue, C. A., Hruban, R. H., He, J., Wang, T. H., Wood, L. D. & 2 others, Sharma, A. & Ahuja, N., Apr 5 2019, In : Clinical Epigenetics. 11, 1, 59.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Early Detection of Cancer
Methylation
Biomarkers
Area Under Curve

Screening for Pancreatic Cancer Gets a D, but the Student Is Improving

Hruban, R. H. & Lillemoe, K. D., Jan 1 2019, In : JAMA surgery.

Research output: Contribution to journalEditorial

Pancreatic Neoplasms
Students

Screening for Pancreatic Cancer - Is There Hope?

O'Broin-Lennon, A. M., Hruban, R. H. & Klein, A., Oct 1 2019, In : JAMA internal medicine. 179, 10, p. 1313-1315 3 p.

Research output: Contribution to journalEditorial

Pancreatic Neoplasms

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E. D., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Roberts, N. J., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Neoplasms
Mutation
Genes
Pancreatic Neoplasms
Pancreatectomy
Length of Stay
Adenocarcinoma
Mortality

Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection

Gemenetzis, G., Groot, V. P., Blair, A. B., Laheru, D. A., Zheng, L., Narang, A. K., Fishman, E. K., Hruban, R. H., Yu, J., Burkhart, R. A., Cameron, J. L., Weiss, M. J., Wolfgang, C. L. & He, J., Aug 1 2019, In : Annals of surgery. 270, 2, p. 340-347 8 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Pancreatic Neoplasms
Survival
gemcitabine
Neoplasms
Open Access
Pathology
Medicine
Students
Medical Students
North American Indians

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

Hong, S. M., Jung, D. J., Kiemen, A., Gaida, M. M., Yoshizawa, T., Braxton, A. M., Noë, M., Lionheart, G., Oshima, K., Thompson, E. D., Burkhart, R., Wu, P. H., Wirtz, D., Hruban, R. H. & Wood, L. D., Jan 1 2019, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
Cadherins
Veins
Keratin-19
Adenocarcinoma
Pancreas
Tissue Donors
Kidney
Pancreatic Diseases

Well-differentiated Pancreatic Neuroendocrine Tumor in a Patient with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)

Noë, M., Hackeng, W. M., De Leng, W. W. J., Vergeer, M., Vleggaar, F. P., Morsink, F. H. M., Wood, L. D., Hruban, R. H., Offerhaus, G. J. A. & Brosens, L. A. A., Jan 1 2019, In : American Journal of Surgical Pathology.

Research output: Contribution to journalArticle

Dysplastic Nevus Syndrome
Neuroendocrine Tumors
Germ-Line Mutation
Neurofibromatosis 2
p16 Genes

Why is pancreatic cancer so deadly? The pathologist's view

Hruban, R. H., Gaida, M. M., Thompson, E., Hong, S. M., Noë, M., Brosens, L. A. A., Jongepier, M., Offerhaus, G. J. A. & Wood, L. D., Jan 1 2019, In : Journal of Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Pathologists
2018

A "clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques

Hong, S. M., Noë, M., Hruban, C. A., Thompson, E., Wood, L. D. & Hruban, R. H., Jan 1 2018, (Accepted/In press) In : Advances in Anatomic Pathology.

Research output: Contribution to journalArticle

Microscopy
Pathology
Anatomy
Light
Exocrine Pancreas

Are pancreatic IPMN volumes measured on MRI images more reproducible than diameters? An assessment in a large single-institution cohort

Pandey, P., Pandey, A., Varzaneh, F. N., Ghasabeh, M. A., Fouladi, D., Khoshpouri, P., Shao, N., Zarghampour, M., Hruban, R. H., Canto, M., O'Broin-Lennon, A. M. & Kamel, I. R., Feb 5 2018, (Accepted/In press) In : European Radiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Observer Variation
Neoplasms
Radiologists

Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome

Robinson, C., Estrada, A., Zaheer, A., Singh, V., Wolfgang, C., Goggins, M. S., Hruban, R. H., Wood, L. D., Noë, M., Montgomery, E. A., Guthrie, L. C., O'Broin-Lennon, A. M., Boyce, A. M. & Collins, M. T., Nov 1 2018, In : The Journal of clinical endocrinology and metabolism. 103, 11, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Pathology
Magnetic resonance
Medical problems
Magnetic Resonance Cholangiopancreatography

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas
Long Interspersed Nucleotide Elements
Aneuploidy
Neoplasms
Biopsy
Chromosomes

Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas

Attiyeh, M. A., Fernández-Del Castillo, C., Al Efishat, M., Eaton, A. A., Gönen, M., Batts, R., Pergolini, I., Rezaee, N., Lillemoe, K. D., Ferrone, C. R., Mino-Kenudson, M., Weiss, M. J., Cameron, J. L., Hruban, R. H., D'Angelica, M. I., Dematteo, R. P., Kingham, T. P., Jarnagin, W. R., Wolfgang, C. & Allen, P. J., Jan 1 2018, In : Annals of Surgery. 267, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

Nomograms
Pancreatic Neoplasms
Neoplasms
Carcinoma
Unnecessary Procedures

Erratum: Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy (eLife (2018) 7 PII: e43237)

Springer, S. U., Chen, C. H., Rodriguez Pena, M. D. C., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Nov 12 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

Aneuploidy
Chromosomes
Gene expression
Genes
Gene Expression

Evaluation of liquid from the papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Aug 1 2018, In : Obstetrical and Gynecological Survey. 73, 8, p. 463-464 2 p.

Research output: Contribution to journalComment/debate

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Mar 21 2018, In : Science Translational Medicine. 10, 433, 8793.

Research output: Contribution to journalArticle

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy
Confidence Intervals

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

Hata, T., Suenaga, M., Marchionni, L., Macgregor-Das, A., Yu, J., Shindo, K., Tamura, K., Hruban, R. H. & Goggins, M. S., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1723-1733 11 p.

Research output: Contribution to journalArticle

Genome
Mutation
Neoplasms
Adenocarcinoma
Single Nucleotide Polymorphism

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
deletion
Dystrophin
Genes
genes

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë, M., Rezaee, N., Asrani, K., Skaro, M., Groot, V. P., Wu, P. H., Olson, M. T., Hong, S. M., Kim, S. J., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Wirtz, D., Roberts, N., Offerhaus, G. J. A., Brosens, L. A. A., Wood, L. D. & Hruban, R. H., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1530-1535 6 p.

Research output: Contribution to journalArticle

Pancreas
Anatomy
Pathology
Pancreatic Neoplasms
Paraffin

Implications of the Pattern of Disease Recurrence on Survival Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma

Groot, V. P., Gemenetzis, G., Blair, A. B., Ding, D., Javed, A. A., Burkhart, R., Yu, J., Borel Rinkes, I. H., Molenaar, I. Q., Cameron, J. L., Fishman, E. K., Hruban, R. H., Weiss, M. J., Wolfgang, C. & He, J., Jun 14 2018, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Pancreatectomy
Adenocarcinoma
Recurrence
Survival
Neoadjuvant Therapy

Incidentally detected pancreatic neuroendocrine microadenoma with lymph node metastasis

Kwon, J. H., Kim, H. J., Park, D. H., Lee, Y. J., Heaphy, C. M., Klöppel, G., Hruban, R. H. & Hong, S. M., Jul 12 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Lymph Nodes
Neoplasm Metastasis
Bile Ducts
Chromogranins

IPMNs with co-occurring invasive cancers: Neighbours but not always relatives

Felsenstein, M., Noë, M., Masica, D. L., Hosoda, W., Chianchiano, P., Fischer, C. G., Lionheart, G., Brosens, L. A. A., Pea, A., Yu, J., Gemenetzis, G., Groot, V. P., Makary, M. A., He, J., Weiss, M. J., Cameron, J. L., Wolfgang, C., Hruban, R. H., Roberts, N., Karchin, R. & 2 others, Goggins, M. S. & Wood, L. D., Mar 2 2018, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Neoplasms
Adenocarcinoma
Mucinous Adenocarcinoma
Carcinoma
Carcinoma, Intraductal, Noninfiltrating

Is a Pathological Complete Response Following Neoadjuvant Chemoradiation Associated with Prolonged Survival in Patients with Pancreatic Cancer?

He, J., Blair, A. B., Groot, V. P., Javed, A. A., Burkhart, R., Gemenetzis, G., Hruban, R. H., Waters, K. M., Poling, J., Zheng, L., Laheru, D., Herman, J. M., Makary, M. A., Weiss, M. J., Cameron, J. L. & Wolfgang, C., Jul 1 2018, In : Annals of Surgery. 268, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Adenocarcinoma
Disease-Free Survival
Lymph Nodes

Lessons learned from 29 lymphoepithelial cysts of the pancreas: Institutional experience and review of the literature

Groot, V. P., Thakker, S. S., Gemenetzis, G., Noë, M., Javed, A. A., Burkhart, R., Noveiry, B. B., Cameron, J. L., Weiss, M. J., VandenBussche, C., Fishman, E. K., Hruban, R. H., Wolfgang, C., O'Broin-Lennon, A. M. & He, J., Jan 1 2018, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

Cysts
Pancreas
Fine Needle Biopsy
Pancreatic Cyst
Unnecessary Procedures

Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers

Schunke, K. J., Rosati, L. M., Zahurak, M., Herman, J. M., Narang, A., Usach, I., Klein, A., Yeo, C. J., Korman, L. T., Hruban, R. H., Cameron, J. L., Laheru, D. & Abrams, R. A., Jan 1 2018, (Accepted/In press) In : Advances in Radiation Oncology.

Research output: Contribution to journalArticle

Mitomycin
Pancreatic Neoplasms
Fluorouracil
Prospective Studies
Survival

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., MacGregor-Das, A., Borges, M., Wolfgang, C., Weiss, M. J., He, J., Canto, M., Petersen, G. M., Gallinger, S., Syngal, S., Brand, R. E., Rustgi, A., Olson, S. H., Stoffel, E., Cote, M. L. & 13 others, Zogopoulos, G., Potash, J. B., Goes, F. S., McCombie, R. W., Zandi, P. P., Pirooznia, M., Kramer, M., Parla, J., Eshleman, J., Roberts, N., Hruban, R. H., Klein, A. & Goggins, M. S., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4767-4772 6 p.

Research output: Contribution to journalArticle

Carboxypeptidases A
Pancreatic Neoplasms
Endoplasmic Reticulum Stress
Mutation
Enzymes

New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis

Felsenstein, M., Hruban, R. H. & Wood, L. D., Jan 1 2018, In : Advances in Anatomic Pathology. 25, 2, p. 131-142 12 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Carcinogenesis
Clonal Evolution
Explosions
Patient Care

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L. V., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Cytology
Aneuploidy
Urinary Bladder Neoplasms
Genes
Cell Biology

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., Lacomb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. C., Johnson, M., Arora, K. & 50 others, Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., Dimaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O’kane, G. M., Notta, F., Kim, E., Crawford, J. M., Devoe, C., Ocean, A., Wolfgang, C., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S. & Tuveson, D. A., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1112-1129 18 p.

Research output: Contribution to journalArticle

Organoids
Pancreatic Neoplasms
Drug Therapy
Therapeutics
Precision Medicine