Rajani Ravi

Assistant Professor

19962018

Research output per year

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Research Output

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2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

2017

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

Makarev, E., Schubert, A. D., Kanherkar, R. R., London, N., Teka, M., Ozerov, I., Lezhnina, K., Bedi, A., Ravi, R., Mehra, R., Hoque, M. O., Sloma, I., Gaykalova, D. A., Csoka, A. B., Sidransky, D., Zhavoronkov, A. & Izumchenko, E., Dec 4 2017, In : Cell Death Discovery. 3, 1, 17022.

Research output: Contribution to journalArticle

Open Access

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L. H., Hoque, M. O., Rodriguez-Galindo, C., Pass, H., Peled, N. & 4 others, Davies, A., Morris, R., Hidalgo, M. & Sidransky, D., Jan 1 2017, In : Annals of Oncology. 28, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

SMAD4 loss is associated with cetuximab resistance and induction of MAPK/JNK activation in head and neck cancer cells

Ozawa, H., Ranaweera, R. S., Izumchenko, E., Makarev, E., Zhavoronkov, A., Fertig, E., Howard, J. D., Markovic, A., Bedi, A., Ravi, R., Perez, J., Le, Q. T., Kong, C. S., Jordan, R. C., Wang, H., Kang, H., Quon, H., Sidransky, D. & Chung, C. H., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5162-5175 14 p.

Research output: Contribution to journalArticle

2015

A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma

Gilbert, J., Schell, M. J., Zhao, X., Murphy, B., Tanvetyanon, T., Leon, M. E., Hayes, D. N., Haigentz, M., Saba, N., Nieva, J., Bishop, J., Sidransky, D., Ravi, R., Bedi, A. & Chung, C. H., Jan 1 2015, In : Oral Oncology. 51, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

Milk derived colloid as a novel drug delivery carrier for breast cancer

Hayashi, M., Silanikove, N., Chang, X., Ravi, R., Pham, V., Baia, G., Paz, K., Brait Rodrigues De Oliveira, M., Sidransky, D. & Koch, W. M., 2015, In : Cancer Biology and Therapy. 16, 8, p. 1184-1193 10 p.

Research output: Contribution to journalArticle

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA

Izumchenko, E., Chang, X., Brait, M., Fertig, E., Kagohara, L. T., Bedi, A., Marchionni, L., Agrawal, N., Ravi, R., Jones, S., Hoque, M. O., Westra, W. H. & Sidransky, D., Sep 16 2015, In : Nature communications. 6, 8258.

Research output: Contribution to journalArticle

2014

Cold atmospheric plasma treatment selectively targets head and neck squamous cell carcinoma cells

Guerrero-Preston, R., Ogawa, T., Uemura, M., Shumulinsky, G., Valle, B. L., Pirini, F., Ravi, R., Sidransky, D., Keidar, M. & Trink, B., Oct 2014, In : International journal of molecular medicine. 34, 4, p. 941-946 6 p.

Research output: Contribution to journalArticle

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors

Izumchenko, E., Chang, X., Michailidi, C., Kagohara, L., Ravi, R., Paz, K., Brait, M., Hoque, M., Ling, S., Bedi, A. & Sidransky, D., Jul 15 2014, In : Cancer Research. 74, 14, p. 3995-4005 11 p.

Research output: Contribution to journalArticle

2012

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

Bedi, A., Chang, X., Noonan, K., Pham, V., Bedi, R., Fertig, E. J., Considine, M., Califano, J. A., Borrello, I., Chung, C. H., Sidransky, D. & Ravi, R., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2429-2439 11 p.

Research output: Contribution to journalArticle

OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB Function

Sen, T., Sen, N., Noordhuis, M. G., Ravi, R., Wu, T. C., Ha, P. K., Sidransky, D. & Hoque, M. O., Nov 12 2012, In : PloS one. 7, 11, e48770.

Research output: Contribution to journalArticle

2011

Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance

Chang, X., Ravi, R., Pham, V., Bedi, A., Chatterjee, A. & Sidransky, D., Jun 20 2011, In : PloS one. 6, 6, e20806.

Research output: Contribution to journalArticle

Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy

Keidar, M., Walk, R., Shashurin, A., Srinivasan, P., Sandler, A., Dasgupta, S., Ravi, R., Guerrero-Preston, R. & Trink, B., Oct 25 2011, In : British journal of cancer. 105, 9, p. 1295-1301 7 p.

Research output: Contribution to journalArticle

2010

Regulation of p53 family member isoform ΔNp63α by the nuclear factor-κB targeting kinase IκB kinase β

Chatterjee, A., Chang, X., Sen, T., Ravi, R., Bedi, A. & Sidransky, D., Feb 15 2010, In : Cancer Research. 70, 4, p. 1419-1429 11 p.

Research output: Contribution to journalArticle

Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer

Bisht, S., Mizuma, M., Feldmann, G., Ottenhof, N. A., Hong, S. M., Pramanik, D., Chenna, V., Karikari, C., Sharma, R., Goggins, M. G., Rudek, M. A., Ravi, R., Maitra, A. & Maitra, A., Aug 1 2010, In : Molecular cancer therapeutics. 9, 8, p. 2255-2264 10 p.

Research output: Contribution to journalArticle

2007

A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury

Ma, X., Hua, J., Mohamood, A. R., Hamad, A. R. A., Ravi, R. & Li, Z., Nov 1 2007, In : Hepatology. 46, 5, p. 1519-1529 11 p.

Research output: Contribution to journalArticle

Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy

Bisht, S., Feldmann, G., Soni, S., Ravi, R., Karikar, C., Maitra, A. & Maitra, A., Apr 17 2007, In : Journal of Nanobiotechnology. 5, 3.

Research output: Contribution to journalArticle

2006

Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling

Ravi, R., Fuchs, E. J., Jain, A., Pham, V., Yoshimura, K., Prouser, T., Jalla, S., Zhou, X., Garrett-Mayer, E., Kaufmann, S. H., Schulick, R. D., Pardoll, D. M. & Bedi, A., Feb 1 2006, In : Cancer Research. 66, 3, p. 1730-1739 10 p.

Research output: Contribution to journalArticle

2005

Effects of acetaldehyde and TNFα on the inhibitory kappa B- α protein and nuclear factor kappa B activation in hepatic stellate cells

Novitskiy, G., Ravi, R., Potter, J. J., Rennie-Tankersley, L., Wang, L. & Mezey, E., Mar 1 2005, In : Alcohol and Alcoholism. 40, 2, p. 96-101 6 p.

Research output: Contribution to journalArticle

2004

Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL

Ravi, R., Jain, A. J., Schulick, R. D., Pham, V., Prouser, T. S., Allen, H., Mayer, E. G., Yu, H., Pardoll, D. M., Ashkenazi, A. & Bedi, A., Dec 15 2004, In : Cancer Research. 64, 24, p. 9105-9114 10 p.

Research output: Contribution to journalArticle

NF-κB in cancer - A friend turned foe

Ravi, R. & Bedi, A., Feb 2004, In : Drug Resistance Updates. 7, 1, p. 53-67 15 p.

Research output: Contribution to journalArticle

Magnetic resonance molecular imaging of the HER-2/neu receptor

Artemov, D., Mori, N., Ravi, R. & Bhujwalla, Z. M., Jun 1 2003, In : Cancer Research. 63, 11, p. 2723-2727 5 p.

Research output: Contribution to journalArticle

2002

Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II

Ravi, R. & Bedi, A., Aug 1 2002, In : Cancer Research. 62, 15, p. 4180-4185 6 p.

Research output: Contribution to journalArticle

2001

Notch signaling induces cell cycle arrest in small cell lung cancer cells

Sriuranpong, V., Borges, M. W., Ravi, R. K., Arnold, D. R., Nelkin, B. D., Baylin, S. B. & Ball, D. W., Apr 1 2001, In : Cancer Research. 61, 7, p. 3200-3205 6 p.

Research output: Contribution to journalArticle

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest

Niu, G., Shain, K. H., Huang, M., Ravi, R., Bedi, A., Dalton, W. S., Jove, R. & Yu, H., Apr 15 2001, In : Cancer Research. 61, 8, p. 3276-3280 5 p.

Research output: Contribution to journalArticle

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

Ravi, R., Bedi, G. C., Engstrom, L. W., Zeng, Q., Mookerjee, B., Gélinas, C., Fuchs, E. J. & Bedi, A., Apr 23 2001, In : Nature cell biology. 3, 4, p. 409-416 8 p.

Research output: Contribution to journalArticle

'The metabolism of tumours': 70 years later

Semenza, G. L., Artemov, D., Bedi, A., Bhujwalla, Z., Chiles, K., Feldser, D., Laughner, E., Ravi, R., Simons, J., Taghavi, P. & Zhong, H., Dec 1 2001, In : Novartis Foundation Symposium. 240, p. 251-260 10 p.

Research output: Contribution to journalArticle

2000

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L. & Bedi, A., Jan 1 2000, In : Genes and Development. 14, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

1999

Depsipeptide (FR901228): A novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells

Byrd, J. C., Shinn, C., Ravi, R., Willis, C. R., Waselenko, J. K., Flinn, I. W., Dawson, N. A. & Grever, M. R., Aug 15 1999, In : Blood. 94, 4, p. 1401-1408 8 p.

Research output: Contribution to journalArticle

Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells

Ravi, R. K., Thiagalingam, A., Weber, E., McMahon, M., Nelkin, B. D. & Mabry, M., Jan 1 1999, In : American journal of respiratory cell and molecular biology. 20, 4, p. 543-549 7 p.

Research output: Contribution to journalArticle

Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells

Ravi, R. K., McMahon, M., Yangang, Z., Williams, J. R., Dillehay, L. E., Nelkin, B. D. & Mabry, M., Mar 15 1999, In : Journal of cellular biochemistry. 72, 4, p. 458-469 12 p.

Research output: Contribution to journalArticle

Retinoic acid-mediated growth inhibition of small cell lung cancer cells is associated with reduced myc and increased p27(Kip1) expression

Weber, E., Ravi, R. K., Knudsen, E. S., Williams, J. R., Dillehay, L. E., Nelkin, B. D., Kalemkerian, G. P., Feramisco, J. R. & Mabry, M., Mar 15 1999, In : International Journal of Cancer. 80, 6, p. 935-943 9 p.

Research output: Contribution to journalArticle

1998

Activated Raf-1 causes growth arrest in human small cell lung cancer cells

Ravi, R. K., Weber, E., McMahon, M., Williams, J. R., Baylin, S., Mal, A., Harter, M. L., Dillehay, L. E., Claudio, P. P., Giordano, A., Nelkin, B. D. & Mabry, M., Jan 1 1998, In : Journal of Clinical Investigation. 101, 1, p. 153-159 7 p.

Research output: Contribution to journalArticle

Open Access

CD95 (Fas)-induced caspase-mediated proteolysis of NF-κB

Ravi, R., Bedi, A., Fuchs, E. J. & Bedi, A., Mar 1 1998, In : Cancer Research. 58, 5, p. 882-886 5 p.

Research output: Contribution to journalArticle

Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells

Ravi, R. K., Scott, F. M., Cuttitta, F., Weber, E., Kalemkerian, G. P., Nelkin, B. D. & Mabry, M., Mar 18 1998, In : Oncology reports. 5, 2, p. 497-501 5 p.

Research output: Contribution to journalArticle

p53-mediated repression of nuclear factor-κB RelA via the transcriptional integrator p300

Ravi, R., Mookerjee, B., Van Hensbergen, Y., Bedi, G. C., Giordano, A., El-Deiry, W. S., Fuchs, E. J. & Bedi, A., Oct 15 1998, In : Cancer Research. 58, 20, p. 4531-4536 6 p.

Research output: Contribution to journalArticle

1997

Conversion of Bcl-2 to a bax-like death effector by caspases

Cheng, E. H. Y., Kirsch, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K. & Hardwick, J. M., Dec 12 1997, In : Science. 278, 5345, p. 1966-1968 3 p.

Research output: Contribution to journalArticle

1996

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34(cdc2) kinase

Yao, S. L., Akhtar, A. J., Mckenna, K. A., Bedi, G. C., Sidransky, D., Mabry, M., Ravi, R., Collector, M. I., Jones, R. J., Sharkis, S. J., Fuchs, E. J. & Bedi, A., Oct 1 1996, In : Nature medicine. 2, 10, p. 1140-1143 4 p.

Research output: Contribution to journalArticle