Rajani Ravi

Assistant Professor

19962018
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Research Output 1996 2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

beta factor
CTLA-4 Antigen
antibodies
Transforming Growth Factor beta
Immunotherapy

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L. H., Hoque, M., Rodriguez-Galindo, C., Pass, H., Peled, N. & 4 othersDavies, A., Morris, R., Hidalgo, M. & Sidransky, D., 2017, In : Annals of Oncology. 28, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Therapeutics
Exome
Translational Medical Research

SMAD4 loss is associated with cetuximab resistance and induction of MAPK/JNK activation in head and neck cancer cells

Ozawa, H., Ranaweera, R. S., Izumchenko, E., Makarev, E., Zhavoronkov, A., Fertig, E., Howard, J. D., Markovic, A., Bedi, A., Ravi, R., Perez, J., Le, Q. T., Kong, C. S., Jordan, R. C., Wang, H., Kang, H., Quon, H., Sidransky, D. & Chung, C. H., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5162-5175 14 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Gene Knockdown Techniques
Phenotype
Cell Line
Cetuximab

A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma

Gilbert, J., Schell, M. J., Zhao, X., Murphy, B., Tanvetyanon, T., Leon, M. E., Hayes, D. N., Haigentz, M., Saba, N., Nieva, J., Bishop, J., Sidransky, D., Ravi, R., Bedi, A. & Chung, C. H., 2015, In : Oral Oncology. 51, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Neoplasms
Cytokines
Human papillomavirus 6
Cetuximab
Drug Carriers
Colloids
Milk
Breast Neoplasms
Neoplasms