Research output per year
Research output per year
- 39 results
Search results
-
2023
Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito
Balta, V. A., Stiffler, D., Sayeed, A., Tripathi, A. K., Elahi, R., Mlambo, G., Bakshi, R. P., Dziedzic, A. G., Jedlicka, A. E., Nenortas, E., Romero-Rodriguez, K., Canonizado, M. A., Mann, A., Owen, A., Sullivan, D. J., Prigge, S. T., Sinnis, P. & Shapiro, T. A., Dec 2023, In: Nature communications. 14, 1, 6415.Research output: Contribution to journal › Article › peer-review
Open Access -
Interaction of Depot Medroxyprogesterone Acetate and Tenofovir Disoproxil Fumarate/Emtricitabine on Peripheral Blood Mononuclear Cells and Cervical Tissue Susceptibility to HIV Infection and Pharmacokinetics
Coleman, J. S., Diniz, C. P., Fuchs, E. J., Marzinke, M. A., Aung, W., Bakshi, R. P., Farzadegan, H., Bream, J. H., Nilles, T. L., Hudson, S., Bumpus, N. N., Schwartz, G. J., Rosenblum, M. A., Rooney, J. F. & Hendrix, C. W., Jan 1 2023, In: Journal of Acquired Immune Deficiency Syndromes. 92, 1, p. 89-96 8 p.Research output: Contribution to journal › Article › peer-review
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2022
Population pharmacokinetics of tenofovir, emtricitabine and intracellular metabolites in transgender women
Tanaudommongkon, A., Chaturvedula, A., Hendrix, C. W., Fuchs, E. J., Shieh, E., Bakshi, R. P. & Marzinke, M. A., Aug 2022, In: British Journal of Clinical Pharmacology. 88, 8, p. 3674-3682 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Examining the Safety, Pharmacokinetics, and Pharmacodynamics of a Rectally Administered IQP-0528 Gel for HIV Pre-Exposure Prophylaxis: A First-In-Human Study
Al-Khouja, A., Shieh, E., Fuchs, E. J., Marzinke, M. A., Bakshi, R. P., Hummert, P., Ham, A. S., Buckheit, K. W., Breakey, J., Weld, E. D., Chen, H., Caffo, B. S., Buckheit, R. W. & Hendrix, C. W., Jun 2021, In: AIDS research and human retroviruses. 37, 6, p. 444-452 9 p.Research output: Contribution to journal › Article › peer-review
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2019
Fecal Coliform Bacterial Detection to Assess Enema Adherence in HIV Prevention Clinical Studies
Aung, W., Bakshi, R. P., Breakey, J., Johnson, J. E., Hendrix, C. W., Weld, E., Fuchs, E. & Marzinke, M. A., Jan 15 2019, In: AIDS and behavior. 23, 1, p. 252-258 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Kinetic driver of antibacterial drugs against plasmodium falciparum and implications for clinical dosing
Caton, E., Nenortas, E., Bakshi, R. P. & Shapiro, T. A., 2019, In: Antimicrobial agents and chemotherapy. 63, 11, e00416-19.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men
Shieh, E., Marzinke, M. A., Fuchs, E. J., Hamlin, A., Bakshi, R., Aung, W., Breakey, J., Poteat, T., Brown, T., Bumpus, N. N. & Hendrix, C. W., Nov 1 2019, In: Journal of the International AIDS Society. 22, 11, e25405.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2018
Comparison of the Pharmacokinetics and Pharmacodynamics of Single-Dose Tenofovir Vaginal Film and Gel Formulation (FAME 05)
Robinson, J. A., Marzinke, M. A., Fuchs, E. J., Bakshi, R. P., Spiegel, H. M. L., Coleman, J. S., Rohan, L. C. & Hendrix, C. W., Feb 1 2018, In: Journal of Acquired Immune Deficiency Syndromes. 77, 2, p. 175-182 8 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Long-acting injectable atovaquone nanomedicines for malaria prophylaxis
Bakshi, R. P., Tatham, L. M., Savage, A. C., Tripathi, A. K., Mlambo, G., Ippolito, M. M., Nenortas, E., Rannard, S. P., Owen, A. & Shapiro, T. A., Dec 1 2018, In: Nature communications. 9, 1, 315.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Short Communication: Specimen Processing Impacts Tissue Tenofovir Pharmacokinetic Measurements
Bakshi, R. P., Breakey, J., Manohar, M., Jois, B., Fuchs, E. J. & Marzinke, M. A., Apr 2018, In: AIDS research and human retroviruses. 34, 4, p. 354-356 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Comparison of Dapivirine Vaginal Gel and Film Formulation Pharmacokinetics and Pharmacodynamics (FAME 02B)
Robinson, J. A., Marzinke, M. A., Bakshi, R. P., Fuchs, E. J., Radebaugh, C. L., Aung, W., Spiegel, H. M. L., Coleman, J. S., Rohan, L. C. & Hendrix, C. W., Apr 1 2017, In: AIDS research and human retroviruses. 33, 4, p. 339-346 8 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2016
Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)
Hendrix, C. W., Andrade, A., Bumpus, N. N., Kashuba, A. D., Marzinke, M. A., Moore, A., Anderson, P. L., Bushman, L. R., Fuchs, E. J., Wiggins, I., Radebaugh, C., Prince, H. A., Bakshi, R. P., Wang, R., Richardson, P., Shieh, E., McKinstry, L., Li, X., Donnell, D., Elharrar, V., & 2 others, Jan 1 2016, In: AIDS research and human retroviruses. 32, 1, p. 32-43 12 p.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
Feasibility of radiolabeled small molecule permeability as a quantitative measure of microbicide candidate toxicity
Coleman, J. S., Fuchs, E., Aung, W. S., Marzinke, M. A., Bakshi, R. P., Spiegel, H. M. L., Robinson, J. & Hendrix, C. W., Apr 1 2016, In: Contraception. 93, 4, p. 331-336 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds
Caton, E., Nenortas, E., Bakshi, R. P. & Shapiro, T. A., Mar 16 2016, In: Current protocols in chemical biology. 8, 1, p. 29-58 30 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Pharmacodynamics of Antimalarial Agents
Bakshi, R. P. & Shapiro, T. A., 2016, Methods in Pharmacology and Toxicology. Humana Press Inc., p. 415-439 25 p. (Methods in Pharmacology and Toxicology).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2015
A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02)
Hiruy, H., Fuchs, E. J., Marzinke, M. A., Bakshi, R. P., Breakey, J. C., Aung, W. S., Manohar, M., Yue, C., Caffo, B. S., Du, Y., Abebe, K. Z., Spiegel, H. M. L., Rohan, L. C., McGowan, I. & Hendrix, C. W., Nov 1 2015, In: AIDS research and human retroviruses. 31, 11, p. 1098-1108 11 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Simultaneous Evaluation of Safety, Acceptability, Pericoital Kinetics, and Ex Vivo Pharmacodynamics Comparing Four Rectal Microbicide Vehicle Candidates
Leyva, F., Fuchs, E. J., Bakshi, R., Carballo-Dieguez, A., Ventuneac, A., Yue, C., Caffo, B., Du, Y., Torbenson, M., Li, L., Mullin, G., Lee, L., Rohan, L., Anton, P. A. & Hendrix, C. W., Nov 1 2015, In: AIDS research and human retroviruses. 31, 11, p. 1089-1097 9 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2014
American ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assay
Bakshi, R. P., Brown, T. T., Simmons, A., Yuan, C. S., Bauer, B. A., Sloan, J. A. & Andrade, A., Oct 31 2014, In: BMC Complementary and Alternative Medicine. 14, 1, 427.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2013
Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect
Avery, L. B., Zarr, M. A., Bakshi, R. P., Siliciano, R. F. & Hendrix, C. W., 2013, In: AIDS research and human retroviruses. 29, 11, p. 1434-1442 9 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Isoosmolar Enemas Demonstrate Preferential Gastrointestinal Distribution, Safety, and Acceptability Compared with Hyperosmolar and Hypoosmolar Enemas as a Potential Delivery Vehicle for Rectal Microbicides
Leyva, F. J., Bakshi, R. P., Fuchs, E. J., Li, L., Caffo, B. S., Goldsmith, A. J., Ventuneac, A., Carballo-Diéguez, A., Du, Y., Leal, J. P., Lee, L. A., Torbenson, M. S. & Hendrix, C. W., 2013, In: AIDS research and human retroviruses. 29, 11, p. 1487-1495 9 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs
Grab, D. J., Nenortas, E., Bakshi, R. P., Nikolskaia, O. V., Friedman, J. E. & Shapiro, T. A., Oct 2013, In: Parasitology International. 62, 5, p. 461-463 3 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Model system to define pharmacokinetic requirements for antimalarial drug efficacy
Bakshi, R. P., Nenortas, E., Tripathi, A. K., Sullivan, D. J. & Shapiro, T. A., Oct 2 2013, In: Science translational medicine. 5, 205, 205ra135.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse
Fuchs, E. J., Grohskopf, L. A., Lee, L. A., Bakshi, R. P. & Hendrix, C. W., May 1 2013, In: Journal of Infectious Diseases. 207, 9, p. 1389-1396 8 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissue
Louissaint, N. A., Cao, Y. J., Skipper, P. L., Liberman, R. G., Tannenbaum, S. R., Nimmagadda, S., Anderson, J. R., Everts, S., Bakshi, R., Fuchs, E. J. & Hendrix, C. W., 2013, In: AIDS research and human retroviruses. 29, 11, p. 1443-1450 8 p.Research output: Contribution to journal › Article › peer-review
Open Access95 Scopus citations -
2012
Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men
Louissaint, N. A., Nimmagadda, S., Fuchs, E. J., Bakshi, R. P., Cao, Y. J., Lee, L. A., Goldsmith, J., Caffo, B. S., Du, Y., King, K. E., Menendez, F. A., Torbenson, M. S. & Hendrix, C. W., Jan 1 2012, In: Journal of Acquired Immune Deficiency Syndromes. 59, 1, p. 10-17 8 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Distribution of cell-free and cell-associated HIV surrogates in the female genital tract after simulated vaginal intercourse
Louissaint, N. A., Fuchs, E., Bakshi, R. P., Nimmagadda, S., Du, Y., MacUra, K. J., King, K. E., Wahl, R. L., Goldsmith, A. J., Caffo, B., Cao, Y. J., Anderson, J. & Hendrix, C. W., Mar 1 2012, In: Journal of Infectious Diseases. 205, 5, p. 725-732 8 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging
Cao, Y. J., Caffo, B. S., Fuchs, E. J., Lee, L. A., Du, Y., Li, L., Bakshi, R. P., Macura, K., Khan, W. A., Wahl, R. L., Grohskopf, L. A. & Hendrix, C. W., Dec 2012, In: British Journal of Clinical Pharmacology. 74, 6, p. 1013-1022 10 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2011
The male genital tract is not a pharmacological sanctuary from efavirenz
Avery, L. B., Bakshi, R. P., Cao, Y. J. & Hendrix, C. W., Jul 2011, In: Clinical pharmacology and therapeutics. 90, 1, p. 151-156 6 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
2010
The killing of African trypanosomes by ethidium bromide
Chowdhury, A. R., Bakshi, R., Wang, J., Yildirir, G., Liu, B., Pappas-Brown, V., Tolun, G., Griffith, J. D., Shapiro, T. A., Jensen, R. E. & Englund, P. T., 2010, In: PLoS pathogens. 6, 12, e1001226.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
2009
Activity of indenoisoquinolines against African trypanosomes
Bakshi, R. P., Sang, D., Morrell, A., Cushman, M. & Shapiro, T. A., Jan 2009, In: Antimicrobial agents and chemotherapy. 53, 1, p. 123-128 6 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites
Nyunt, M. M., Hendrix, C. W., Bakshi, R. P., Kumar, N. & Shapiro, T. A., Apr 2009, In: American Journal of Tropical Medicine and Hygiene. 80, 4, p. 528-535 8 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2008
Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates
Hendrix, C. W., Fuchs, E. J., MacUra, K. J., Lee, L. A., Parsons, T. L., Bakshi, R. P., Khan, W. A., Guidos, A., Leal, J. P. & Wahl, R., Jan 9 2008, In: Clinical pharmacology and therapeutics. 83, 1, p. 97-105 9 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
2007
Effect of hydroxyurea and dideoxyinosine on intracellular 3′-deoxyadenosine-5′-triphosphate concentrations in HIV-infected patients
Bakshi, R. P., Hamzeh, F., Frank, I., Eron, J. J., Bosch, R. J., Rosenkranz, S. L., Cramer, Y. S., Ussery, M. & Flexner, C., Nov 1 2007, In: AIDS research and human retroviruses. 23, 11, p. 1360-1365 6 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: Potential implication for HIV transmission
Fuchs, E. J., Lee, L. A., Torbenson, M. S., Parsons, T. L., Bakshi, R. P., Guidos, A. M., Wahl, R. L. & Hendrix, C. W., Mar 1 2007, In: Journal of Infectious Diseases. 195, 5, p. 703-710 8 p.Research output: Contribution to journal › Article › peer-review
117 Scopus citations -
2004
RNA interference of Trypanosoma brucei topoisomerase IB: Both subunits are essential
Bakshi, R. P. & Shapiro, T. A., Aug 2004, In: Molecular and Biochemical Parasitology. 136, 2, p. 249-255 7 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
2003
DNA topoisomerases as targets for antiprotozoal therapy.
Bakshi, R. P. & Shapiro, T. A., Sep 2003, In: Mini reviews in medicinal chemistry. 3, 6, p. 597-608 12 p.Research output: Contribution to journal › Review article › peer-review
26 Scopus citations -
2001
Developmental and hormonal regulation of type II DNA topoisomerase in rat testis
Bakshi, R. P., Galande, S., Bali, P., Dighe, R. & Muniyappa, K., 2001, In: Journal of Molecular Endocrinology. 26, 3, p. 193-206 14 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase
Bakshi, R. P., Galande, S. & Muniyappa, K., 2001, In: Critical reviews in biochemistry and molecular biology. 36, 1, p. 1-37 37 p.Research output: Contribution to journal › Review article › peer-review
46 Scopus citations -
Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIα
Bakshi, R., Galande, S. & Muniyappa, K., 2001, In: Journal of Biomolecular Structure and Dynamics. 18, 5, p. 749-760 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations