Rahul Bakshi

Research Associate

20012019
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Research Output 2001 2019

2019

Kinetic driver of antibacterial drugs against plasmodium falciparum and implications for clinical dosing

Caton, E., Nenortas, E., Bakshi, R. P. & Shapiro, T. A., Jan 1 2019, In : Antimicrobial agents and chemotherapy. 63, 11, e00416-19.

Research output: Contribution to journalArticle

Plasmodium falciparum
Ciprofloxacin
Apicoplasts
Malaria
Parasites
Open Access
Tenofovir
Transgender Persons
Fumarates
Estrogens
HIV
2018
Tenofovir
Foams and Jellies Vaginal Creams
Pharmacokinetics
Gels
HIV

Fecal Coliform Bacterial Detection to Assess Enema Adherence in HIV Prevention Clinical Studies

Aung, W. S., Bakshi, R., Breakey, J., Johnson, J. E., Hendrix, C., Weld, E., Fuchs, E. & Marzinke, M. A., Jul 3 2018, (Accepted/In press) In : AIDS and Behavior. p. 1-7 7 p.

Research output: Contribution to journalArticle

Enema
HIV
Clinical Trials
Sensitivity and Specificity
Clinical Studies

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis

Bakshi, R., Tatham, L. M., Savage, A. C., Tripathi, A., Mlambo, G., Ippolito, M., Nenortas, E., Rannard, S. P., Owen, A. & Shapiro, T. A., Dec 1 2018, In : Nature Communications. 9, 1, 315.

Research output: Contribution to journalArticle

prophylaxis
Atovaquone
Nanomedicine
Medical nanotechnology
Malaria

Short Communication: Specimen Processing Impacts Tissue Tenofovir Pharmacokinetic Measurements

Bakshi, R., Breakey, J., Manohar, M., Jois, B., Fuchs, E. & Marzinke, M. A., Apr 1 2018, In : AIDS Research and Human Retroviruses. 34, 4, p. 354-356 3 p.

Research output: Contribution to journalArticle

Tenofovir
Pharmacokinetics
Biopsy
HIV
Pharmaceutical Preparations
2017

Comparison of Dapivirine Vaginal Gel and Film Formulation Pharmacokinetics and Pharmacodynamics (FAME 02B)

Robinson, J., Marzinke, M. A., Bakshi, R., Fuchs, E., Radebaugh, C. L., Aung, W., Spiegel, H. M. L., Coleman Fennell, J. S., Rohan, L. C. & Hendrix, C., Apr 1 2017, In : AIDS Research and Human Retroviruses. 33, 4, p. 339-346 8 p.

Research output: Contribution to journalArticle

Foams and Jellies Vaginal Creams
Pharmacokinetics
Gels
HIV
Tenofovir
2016

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Hendrix, C., Andrade, A., Bumpus, N. N., Kashuba, A. D., Marzinke, M. A., Moore, A., Anderson, P. L., Bushman, L. R., Fuchs, E., Wiggins, I., Radebaugh, C., Prince, H. A., Bakshi, R., Wang, R., Richardson, P., Shieh, E., McKinstry, L., Li, X., Donnell, D., Elharrar, V. & 2 others, Mayer, K. H. & Patterson, K. B., Jan 1 2016, In : AIDS Research and Human Retroviruses. 32, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle

Tenofovir
Benchmarking
Healthy Volunteers
Pharmacokinetics
Tablets
Anti-Infective Agents
Permeability
Gels
Pentetic Acid
Foams and Jellies Vaginal Creams

Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds

Caton, E., Nenortas, E., Bakshi, R. & Shapiro, T. A., Mar 16 2016, In : Current protocols in chemical biology. 8, 1, p. 29-58 30 p.

Research output: Contribution to journalArticle

Antimalarials
Pharmacokinetics
Plasmodium falciparum
Anti-Infective Agents
Animal Models
2015

A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02)

Hiruy, H., Fuchs, E., Marzinke, M. A., Bakshi, R., Breakey, J. C., Aung, W. S., Manohar, M., Yue, C., Caffo, B. S., Du, Y., Abebe, K. Z., Spiegel, H. M. L., Rohan, L. C., McGowan, I. & Hendrix, C., Nov 1 2015, In : AIDS Research and Human Retroviruses. 31, 11, p. 1098-1108 11 p.

Research output: Contribution to journalArticle

Tenofovir
Unsafe Sex
Anti-Infective Agents
Glycerol
Pharmacokinetics

Simultaneous Evaluation of Safety, Acceptability, Pericoital Kinetics, and Ex Vivo Pharmacodynamics Comparing Four Rectal Microbicide Vehicle Candidates

Leyva, F., Fuchs, E., Bakshi, R., Carballo-Dieguez, A., Ventuneac, A., Yue, C., Caffo, B. S., Du, Y., Torbenson, M., Li, L., Mullin, G., Lee, L. A., Rohan, L., Anton, P. A. & Hendrix, C., Nov 1 2015, In : AIDS Research and Human Retroviruses. 31, 11, p. 1089-1097 9 p.

Research output: Contribution to journalArticle

Anti-Infective Agents
Gels
HIV
Colon
Safety
2014

American ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assay

Bakshi, R., Brown, T. T., Simmons, A., Yuan, C. S., Bauer, B. A., Sloan, J. A. & Andrade, A., Oct 31 2014, (Accepted/In press) In : BMC Complementary and Alternative Medicine. p. 427 1 p.

Research output: Contribution to journalArticle

Panax
HIV-1
RNA
HIV Reverse Transcriptase
Volunteers
2013
efavirenz
etravirine
Antiviral Agents
Serum Albumin
Proteins
Enema
Anti-Infective Agents
Safety
Acids
Colon

Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs

Grab, D. J., Nenortas, E., Bakshi, R., Nikolskaia, O. V., Friedman, J. E. & Shapiro, T. A., Oct 2013, In : Parasitology International. 62, 5, p. 461-463 3 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Trypanosomiasis
Antimalarials
Chelating Agents
Membranes

Model system to define pharmacokinetic requirements for antimalarial drug efficacy

Bakshi, R., Nenortas, E., Tripathi, A., Sullivan, D. J. & Shapiro, T. A., Oct 2 2013, In : Science Translational Medicine. 5, 205, 205ra135.

Research output: Contribution to journalArticle

Antimalarials
Microbial Sensitivity Tests
Pharmacokinetics
Chloroquine
Plasmodium falciparum
Nonoxynol
Permeability
Anti-Infective Agents
Biopsy
Confidence Intervals

Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissue

Louissaint, N. A., Cao, Y. J., Skipper, P. L., Liberman, R. G., Tannenbaum, S. R., Nimmagadda, S., Anderson, J., Everts, S., Bakshi, R., Fuchs, E. & Hendrix, C., 2013, In : AIDS Research and Human Retroviruses. 29, 11, p. 1443-1450 8 p.

Research output: Contribution to journalArticle

Tenofovir
Blood Cells
Pharmacokinetics
Half-Life
Colon
2012

Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men

Louissaint, N. A., Nimmagadda, S., Fuchs, E., Bakshi, R., Cao, Y. J., Lee, L. A., Goldsmith, J., Caffo, B. S., Du, Y., King, K. E., Menendez, F. A., Torbenson, M. S. & Hendrix, C., Jan 1 2012, In : Journal of Acquired Immune Deficiency Syndromes. 59, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Colon
HIV
Semen
Single-Photon Emission-Computed Tomography
Leukocytes

Distribution of cell-free and cell-associated HIV surrogates in the female genital tract after simulated vaginal intercourse

Louissaint, N. A., Fuchs, E., Bakshi, R., Nimmagadda, S., Du, Y., Macura, K., King, K. E., Wahl, R., Goldsmith, A. J., Caffo, B. S., Cao, Y. J., Anderson, J. & Hendrix, C., Mar 1 2012, In : Journal of Infectious Diseases. 205, 5, p. 725-732 8 p.

Research output: Contribution to journalArticle

Satellite Viruses
HIV
Semen
Isotopes
Uterus
Anti-Infective Agents
Semen
Single-Photon Emission-Computed Tomography
Colon
Magnetic Resonance Imaging
2011

The male genital tract is not a pharmacological sanctuary from efavirenz

Avery, L. B., Bakshi, R., Cao, Y. J. & Hendrix, C., Jul 2011, In : Clinical Pharmacology and Therapeutics. 90, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

efavirenz
Pharmacology
Semen
Protein Binding
Pharmaceutical Preparations
2010

The killing of African trypanosomes by ethidium bromide

Chowdhury, A. R., Bakshi, R., Wang, J., Yildirir, G., Liu, B., Pappas-Brown, V., Tolun, G., Griffith, J. D., Shapiro, T. A., Jensen, R. E. & Englund, P. T., 2010, In : PLoS Pathogens. 6, 12, e1001226.

Research output: Contribution to journalArticle

Ethidium
Trypanosomiasis
Kinetoplast DNA
Z-Form DNA
Mitochondrial Genome
2009

Activity of indenoisoquinolines against African trypanosomes

Bakshi, R., Sang, D., Morrell, A., Cushman, M. & Shapiro, T. A., Jan 2009, In : Antimicrobial Agents and Chemotherapy. 53, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Poisons
African Trypanosomiasis
Trypanosoma brucei brucei
Leukemia L1210
Sporozoites
Antimalarials
Plasmodium falciparum
Healthy Volunteers
Placebos
2008

Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates

Hendrix, C., Fuchs, E., Macura, K., Lee, L. A., Parsons, T. L., Bakshi, R., Khan, W. A., Guidos, A., Leal, J. P. & Wahl, R., Jan 9 2008, In : Clinical Pharmacology and Therapeutics. 83, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Sigmoidoscopy
Anti-Infective Agents
Semen
Sulfur Acids
HIV
2007

Effect of hydroxyurea and dideoxyinosine on intracellular 3′-deoxyadenosine-5′-triphosphate concentrations in HIV-infected patients

Bakshi, R., Hamzeh, F., Frank, I., Eron, J. J., Bosch, R. J., Rosenkranz, S. L., Cramer, Y. S., Ussery, M. & Flexner, C. W., Nov 1 2007, In : AIDS Research and Human Retroviruses. 23, 11, p. 1360-1365 6 p.

Research output: Contribution to journalArticle

Didanosine
Hydroxyurea
HIV
Nonparametric Statistics
3'-deoxyadenosine 5'-triphosphate

Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: Potential implication for HIV transmission

Fuchs, E., Lee, L. A., Torbenson, M. S., Parsons, T. L., Bakshi, R., Guidos, A. M., Wahl, R. L. & Hendrix, C., Mar 1 2007, In : Journal of Infectious Diseases. 195, 5, p. 703-710 8 p.

Research output: Contribution to journalArticle

Lubricants
Colon
Gels
HIV
Enema
2004
Trypanosoma brucei brucei
RNA Interference
Nucleic Acids
Camptothecin
Messenger RNA
2003

DNA topoisomerases as targets for antiprotozoal therapy.

Bakshi, R. & Shapiro, T. A., Sep 2003, In : Mini reviews in medicinal chemistry. 3, 6, p. 597-608 12 p.

Research output: Contribution to journalArticle

DNA Topoisomerases
Topoisomerase Inhibitors
Protozoa
Parasitic Diseases
Medical problems
2001

Developmental and hormonal regulation of type II DNA topoisomerase in rat testis

Bakshi, R., Galande, S., Bali, P., Dighe, R. & Muniyappa, K., 2001, In : Journal of Molecular Endocrinology. 26, 3, p. 193-206 14 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Testis
Testosterone
Messenger RNA
Flutamide

Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase

Bakshi, R., Galande, S. & Muniyappa, K., 2001, In : Critical Reviews in Biochemistry and Molecular Biology. 36, 1, p. 1-37 37 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Chromosomes
DNA
DNA Topoisomerases
Chromosome Structures
Type II DNA Topoisomerase
Substrate Specificity
Testis
DNA
Chromatin