Rachel L Damico

Associate Professor

1994 …2020

Research output per year

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2020

Cellular sources of IL-6 and associations with clinical phenotypes and outcomes in PAH

Simpson, C. E., Chen, J. Y., Damico, R. L., Hassoun, P. M., Martin, L. J., Yang, J., Nies, M., Griffiths, M., Dhananjay Vaidya, R., Brandal, S., Pauciulo, M. W., Lutz, K. A., Coleman, A. W., Austin, E. D., Ivy, D. D., Nichols, W. C. & Everett, A. D., Apr 1 2020, In : European Respiratory Journal. 55, 4

Research output: Contribution to journalArticle

Open Access

Functional impact of human genetic variants of COL18A1/endostatin on pulmonary endothelium

Goyanes, A. M., Moldobaeva, A., Marimoutou, M., Varela, L. C., Wang, L., Johnston, L. F., Aladdin, M. M., Peloquin, G. L., Kim, B. S., Damarla, M., Suresh, K., Sato, T., Kolb, T. M., Hassoun, P. M. & Damico, R. L., Jan 1 2020, In : American journal of respiratory cell and molecular biology. 62, 4, p. 524-534 11 p.

Research output: Contribution to journalArticle

Noninvasive Prognostic Biomarkers for Left-Sided Heart Failure as Predictors of Survival in Pulmonary Arterial Hypertension

Simpson, C. E., Damico, R. L., Hassoun, P. M., Martin, L. J., Yang, J., Nies, M. K., Vaidya, R. D., Brandal, S., Pauciulo, M. W., Austin, E. D., Ivy, D. D., Nichols, W. C. & Everett, A. D., Jan 1 2020, (Accepted/In press) In : CHEST.

Research output: Contribution to journalArticle

2019

Disconnect between fibrotic response and right ventricular dysfunction

Crnkovic, S., Egemnazarov, B., Damico, R., Marsh, L. M., Nagy, B. M., Douschan, P., Atsina, K., Kolb, T. M., Mathai, S. C., Hooper, J. E., Ghanim, B., Klepetko, W., Fruhwald, F., Lassner, D., Olschewski, A., Olschewski, H., Hassoun, P. M. & Kwapiszewska, G., Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1550-1560 11 p.

Research output: Contribution to journalArticle

Open Access

SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model

Peloquin, G. L., Johnston, L., Damarla, M., Damico, R. L., Hassoun, P. M. & Kolb, T. M., Jun 17 2019, In : Respiratory research. 20, 1, 123.

Research output: Contribution to journalArticle

Open Access

Validation of the REVEAL Prognostic Equation and Risk Score Calculator in Incident Systemic Sclerosis–Associated Pulmonary Arterial Hypertension

on behalf of the PHAROS Investigators, Jan 1 2019, (Accepted/In press) In : Arthritis and Rheumatology.

Research output: Contribution to journalArticle

2018

Imatinib Is Protective Against Ischemia-Reperfusion Injury in an Ex Vivo Rabbit Model of Lung Injury

Magruder, J. T., Grimm, J. C., Crawford, T. C., Johnston, L., Santhanam, L., Stephens, R., Berkowitz, D. E., Shah, A. S., Bush, E., Damarla, M., Damico, R. L., Hassoun, P. M. & Kim, B. S., Mar 1 2018, In : Annals of Thoracic Surgery. 105, 3, p. 950-956 7 p.

Research output: Contribution to journalArticle

Pulmonary arterial hypertension and atrial arrhythmias: incidence, risk factors, and clinical impact

Mercurio, V., Peloquin, G., Bourji, K. I., Diab, N., Sato, T., Enobun, B., Housten-Harris, T., Damico, R. L., Kolb, T. M., Mathai, S., Tedford, R. J., Tocchetti, C. G. & Hassoun, P. M., Apr 1 2018, In : Pulmonary Circulation. 8, 2

Research output: Contribution to journalArticle

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R., Mathai, S. C., Kasper, E. K., Hassoun, P. M., Kass, D. A. & Tedford, R. J., Apr 1 2018, In : Circulation: Heart Failure. 11, 4, e004436.

Research output: Contribution to journalArticle

Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S., Mukherjee, M., Shah, A., Wigley, F., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., Jan 1 2018, In : Circulation. 137, 22, p. 2360-2370 11 p.

Research output: Contribution to journalArticle

The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study

Sato, T., Ambale Venkatesh, B., Lima, J., Zimmerman, S., Tedford, R. J., Fujii, T., Hulme, O. L., Pullins, E. H., Corona Villalobos, C., Zamanian, R. T., Minai, O. A., Girgis, R. E., Chin, K., Khair, R., Damico, R. L., Kolb, T. M., Mathai, S. & Hassoun, P. M., Feb 1 2018, In : Pulmonary Circulation. 8, 1

Research output: Contribution to journalArticle

2017

Poor survival in patients with scleroderma and pulmonary hypertension due to heart failure with preserved ejection fraction

Bourji, K. I., Kelemen, B. W., Mathai, S., Damico, R. L., Kolb, T. M., Mercurio, V., Cozzi, F., Tedford, R. J. & Hassoun, P. M., 2017, In : Pulmonary Circulation. 7, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

2016

Health-related quality of life and survival in pulmonary arterial hypertension

Mathai, S., Suber, T., Khair, R. M., Kolb, T. M., Damico, R. L. & Hassoun, P. M., Jan 1 2016, In : Annals of the American Thoracic Society. 13, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Heart rate dependence of the pulmonary resistance x compliance (rc) time and impact on right ventricular load

Metkus, T., Mullin, C. J., Grandin, E. W., Rame, J. E., Tampakakis, E., Hsu, S., Kolb, T. M., Damico, R. L., Hassoun, P. M., Kass, D. A., Mathai, S. & Tedford, R. J., Nov 1 2016, In : PLoS One. 11, 11, e0166463.

Research output: Contribution to journalArticle

Identifying microRNAs targeting Wnt/β-catenin pathway in end-stage idiopathic pulmonary arterial hypertension

Wu, D., Talbot, C. C., Liu, Q., Jing, Z. C., Damico, R. L., Tuder, R., Barnes, K. C., Hassoun, P. M. & Gao, L., May 18 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-11 11 p.

Research output: Contribution to journalArticle

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension

Hsu, S., Houston, B. A., Tampakakis, E., Bacher, A. C., Rhodes, P. S., Mathai, S., Damico, R. L., Kolb, T. M., Hummers, L., Shah, A., McMahan, Z., Corona Villalobos, C., Zimmerman, S., Wigley, F., Hassoun, P. M., Kass, D. A. & Tedford, R. J., May 12 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

The minimal important difference in borg dyspnea score in pulmonary arterial hypertension

Khair, R. M., Nwaneri, C., Damico, R. L., Kolb, T. M., Hassoun, P. M. & Mathai, S., Jun 1 2016, In : Annals of the American Thoracic Society. 13, 6, p. 842-849 8 p.

Research output: Contribution to journalArticle

2015

Ambrisentan and tadalafil up-front combination therapy in scleroderma-associated pulmonary arterial hypertension

Hassoun, P. M., Zamanian, R. T., Damico, R., Lechtzin, N., Khair, R., Kolb, T. M., Tedford, R. J., Hulme, O. L., Housten, T., Pisanello, C., Sato, T., Pullins, E. H., Corona-Villalobos, C. P., Zimmerman, S. L., Gashouta, M. A., Minai, O. A., Torres, F., Girgis, R. E., Chin, K. & Mathai, S. C., Nov 1 2015, In : American journal of respiratory and critical care medicine. 192, 9, p. 1102-1110 9 p.

Research output: Contribution to journalArticle

Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia

Kim, B. S., Serebreni, L., Fallica, J., Hamdan, O., Wang, L., Johnston, L., Kolb, T., Damarla, M., Damico, R. & Hassoun, P. M., Apr 1 2015, In : PloS one. 10, 4, e0124189.

Research output: Contribution to journalArticle

Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension

Kolb, T. M., Peabody, J., Baddoura, P., Fallica, J., Mock, J. R., Singer, B. D., D'Alessio, F. R., Damarla, M., Damico, R. L. & Hassoun, P. M., Nov 1 2015, In : MICROCIRCULATION. 22, 8, p. 724-736 13 p.

Research output: Contribution to journalArticle

Right ventricular remodeling in idiopathic and scleroderma-associated pulmonary arterial hypertension: Two distinct phenotypes

Kelemen, B. W., Mathai, S., Tedford, R. J., Damico, R. L., Corona Villalobos, C., Kolb, T. M., Chaisson, N. F., Harris, T. H., Zimmerman, S., Kamel, I. R., Kass, D. A. & Hassoun, P. M., Jun 1 2015, In : Pulmonary Circulation. 5, 2, p. 327-334 8 p.

Research output: Contribution to journalArticle

Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension

Damico, R., Kolb, T. M., Valera, L., Wang, L., Housten, T., Tedford, R. J., Kass, D. A., Rafaels, N., Gao, L., Barnes, K. C., Benza, R. L., Rand, J. L., Hamid, R., Loyd, J. E., Robbins, I. M., Hemnes, A. R., Chung, W. K., Austin, E. D., Drummond, M. B., Mathai, S. C. & 1 others, Hassoun, P. M., Jan 15 2015, In : American journal of respiratory and critical care medicine. 191, 2, p. 208-218 11 p.

Research output: Contribution to journalArticle

2014

Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage

Fallica, J., Boyer, L., Kim, B., Serebreni, L., Varela, L., Hamdan, O., Wang, L., Simms, T., Damarla, M., Kolb, T. M., Bucala, R., Mitzner, W., Hassoun, P. M. & Damico, R., Jul 2014, In : American journal of respiratory cell and molecular biology. 51, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

Damarla, M., Parniani, A. R., Johnston, L., Maredia, H., Serebreni, L., Hamdan, O., Sidhaye, V. K., Shimoda, L. A., Myers, A. C., Crow, M. T., Schmidt, E. P., Machamer, C. E., Gaestel, M., Rane, M. J., Kolb, T. M., Kim, B. S., Damico, R. L. & Hassoun, P. M., May 2014, In : American journal of respiratory cell and molecular biology. 50, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Severity of systemic sclerosis-associated pulmonary arterial hypertension in African Americans

Blanco, I., Mathai, S., Shafiq, M., Boyce, D., Kolb, T. M., Chami, H., Hummers, L. K., Housten, T., Chaisson, N., Zaiman, A. L., Wigley, F. M., Tedford, R. J., Kass, D. A., Damico, R., Girgis, R. E. & Hassoun, P. M., Jul 1 2014, In : Medicine (United States). 93, 5, p. 177-185 9 p.

Research output: Contribution to journalArticle

2013

Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis

Kim, B. S., Serebreni, L., Hamdan, O., Wang, L., Parniani, A., Sussan, T., Scott Stephens, R., Boyer, L., Damarla, M., Hassoun, P. M. & Damico, R., Jul 2013, In : Free Radical Biology and Medicine. 60, p. 336-346 11 p.

Research output: Contribution to journalArticle

2011

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

Zaiman, A. L., Damico, R., Thoms-Chesley, A., Clark Files, D., Kesari, P., Johnston, L., Swaim, M., Mozammel, S., Myers, A. C., Halushka, M., El-Haddad, H., Shimoda, L. A., Peng, C. F., Hassoun, P. M., Champion, H. C., Kitsis, R. N. & Crow, M. T., Dec 6 2011, In : Circulation. 124, 23, p. 2533-2542 10 p.

Research output: Contribution to journalArticle

2010

Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung

Peng, X. Q., Damarla, M., Skirball, J., Nonas, S., Wang, X. Y., Han, E. J., Hasan, E. J., Cao, X., Boueiz, A., Damico, R., Tuder, R. M., Sciuto, A. M., Anderson, D. R., Garcia, J. G., Kass, D. A., Hassoun, P. M. & Zhang, J. T., Feb 1 2010, In : Acta Pharmacologica Sinica. 31, 2, p. 175-183 9 p.

Research output: Contribution to journalArticle

2009

Activated protein C protects against ventilator-induced pulmonary capillary leak

Finigan, J. H., Boueiz, A., Wilkinson, E., Damico, R., Skirball, J., Hyun, H. P., Damarla, M., Hasan, E., Pearse, D. B., Reddy, S. P., Grigoryev, D. N., Cheadle, C., Esmon, C. T., Garcia, J. G. N. & Hassoun, P. M., Jun 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6, p. L1002-L1011

Research output: Contribution to journalArticle

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

Damarla, M., Hasan, E., Boueiz, A., Le, A., Pae, H. H., Montouchet, C., Kolb, T., Simms, T., Myers, A., Kayyali, U. S., Gaestel, M., Peng, X., Reddy, S. P., Damico, R. & Hassoun, P. M., Feb 25 2009, In : PloS one. 4, 2, e4600.

Research output: Contribution to journalArticle

2008

Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury

Le, A., Damico, R., Damarla, M., Boueiz, A., Hyun, H. P., Skirball, J., Hasan, E., Peng, X., Chesley, A., Crow, M. T., Reddy, S. P., Tuder, R. M. & Hassoun, P. M., Oct 1 2008, In : Journal of applied physiology. 105, 4, p. 1282-1290 9 p.

Research output: Contribution to journalArticle

Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis

Damico, R. L., Chesley, A., Johnston, L., Bind, E. P., Amaro, E., Nijmeh, J., Karakas, B., Welsh, L., Pearse, D. B., Garcia, J. G. N. & Crow, M. T., Jul 1 2008, In : American journal of respiratory cell and molecular biology. 39, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

2004

Regulation of c-Jun N-terminal kinase and p38 kinase pathways in endothelial cells

Wadgaonkar, R., Pierce, J. W., Somnay, K., Damico, R. L., Crow, M. T., Collins, T. & Garcia, J. G. N., Oct 1 2004, In : American journal of respiratory cell and molecular biology. 31, 4, p. 423-431 9 p.

Research output: Contribution to journalArticle

2000

Soluble receptor-induced retroviral infection of receptor-deficient cells

Damico, R. & Bates, P., Jul 15 2000, In : Journal of virology. 74, 14, p. 6469-6475 7 p.

Research output: Contribution to journalArticle

1999
1998

Receptor-triggered membrane association of a model retroviral glycoprotein

Damico, R. L., Crane, J. & Bates, P., Mar 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 5, p. 2580-2585 6 p.

Research output: Contribution to journalArticle

1994

Human neonatal thymic organ culture: An ex vivo model of thymocyte ontogeny and HIV-1 infection

Rosenzweig, M., Bunting, E. M., Damico, R. L., Clark, D. P. & Gaulton, G. N., Jan 1 1994, In : Pathobiology. 62, 5-6, p. 245-251 7 p.

Research output: Contribution to journalArticle