Rachel D Green

Professor

1989 …2019
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Research Output 1989 2019

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2019

Assaying RNA structure with LASER-Seq

Zinshteyn, B., Chan, D., England, W., Feng, C., Green, R. & Spitale, R. C., Jan 10 2019, In : Nucleic acids research. 47, 1, p. 43-55 13 p.

Research output: Contribution to journalArticle

Open Access
RNA
High-Throughput Nucleotide Sequencing
Light
Binding Sites
RNA Probes

A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution

Mohammad, F., Green, R. & Buskirk, A. R., Feb 6 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Ribosomes
Codon
Bacteria
Physiology
Transfer RNA

High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress

Wu, C. C. C., Zinshteyn, B., Wehner, K. A. & Green, R., Mar 7 2019, In : Molecular cell. 73, 5, p. 959-970.e5

Research output: Contribution to journalArticle

Ribosomes
Messenger RNA
Phosphorylation
Transfer RNA
Eukaryota

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Kearse, M. G., Goldman, D. H., Choi, J., Nwaezeapu, C., Liang, D., Green, K. M., Goldstrohm, A. C., Todd, P. K., Green, R. & Wilusz, J. E., Jul 2019, In : Genes and Development. 33, 13-14, p. 871-885 15 p.

Research output: Contribution to journalArticle

Open Access
Protein Synthesis Inhibitors
Initiator Codon
Ribosomes
Cycloheximide
Messenger RNA

The endonuclease cue2 cleaves mRNAs at stalled ribosomes during no go decay

D’Orazio, K. N., Wu, C. C. C., Sinha, N., Loll-Krippleber, R., Brown, G. W. & Green, R., Jun 2019, In : eLife. 8, e49117.

Research output: Contribution to journalArticle

Open Access
Endonucleases
Ribosomes
Messenger RNA
Biochemistry
Yeast

The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

D'Orazio, K. N., Wu, C. C. C., Sinha, N., Loll-Krippleber, R., Brown, G. W. & Green, R., Jun 20 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Endonucleases
Ribosomes
Messenger RNA
Biochemistry
Yeast
2018

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Liakath-Ali, K., Mills, E. W., Sequeira, I., Lichtenberger, B. M., Pisco, A. O., Sipilä, K. H., Mishra, A., Yoshikawa, H., Wu, C. C. C., Ly, T., Lamond, A. I., Adham, I. M., Green, R. & Watt, F. M., Apr 19 2018, In : Nature. 556, 7701, p. 376-380 5 p.

Research output: Contribution to journalArticle

homeostasis
eukaryote
quality control
gene expression
phenotype

Directed hydroxyl radical probing reveals Upf1 binding to the 80S ribosomal e site rRNA at the L1 stalk

Schuller, A. P., Zinshteyn, B., Enam, S. U. & Green, R., Feb 28 2018, In : Nucleic acids research. 46, 4, p. 2060-2073 14 p.

Research output: Contribution to journalArticle

Open Access
Ribosomes
Hydroxyl Radical
Yeasts
RNA Helicases
Eukaryota

Translation elongation and recoding in eukaryotes

Dever, T. E., Dinman, J. D. & Green, R., Aug 1 2018, In : Cold Spring Harbor Perspectives in Biology. 10, 8, a032649.

Research output: Contribution to journalArticle

Ribosomal Frameshifting
Eukaryota
Elongation
Kinetics
2017

Corrigendum: Rapid generation of hypomorphic mutations

Arthur, L. L., Chung, J. J., Janakirama, P., Keefer, K. M., Kolotilin, I., Pavlovic-Djuranovic, S., Chalker, D. L., Grbic, V., Green, R., Menassa, R., True, H. L., Skeath, J. B. & Djuranovic, S., Feb 16 2017, In : Nature communications. 8, 1 p.

Research output: Contribution to journalArticle

Open Access
mutations
Mutation
corrigendum

eIF5A Functions Globally in Translation Elongation and Termination

Schuller, A. P., Wu, C. C. C., Dever, T. E., Buskirk, A. & Green, R., Apr 20 2017, In : Molecular Cell. 66, 2, p. 194-205.e5

Research output: Contribution to journalArticle

Ribosomes
Proline
Peptide Initiation Factors
Terminator Codon
3' Untranslated Regions

Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks

Paix, A., Folkmann, A., Goldman, D. H., Kulaga, H., Grzelak, M. J., Rasoloson, D., Paidemarry, S., Green, R., Reed, R. R. & Seydoux, G., Dec 12 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. E10745-E10754

Research output: Contribution to journalArticle

DNA Breaks
DNA
Nucleotides
Genome
Gene Conversion

Rapid generation of hypomorphic mutations

Arthur, L. L., Chung, J. J., Jankirama, P., Keefer, K. M., Kolotilin, I., Pavlovic-Djuranovic, S., Chalker, D. L., Grbic, V., Green, R., Menassa, R., True, H. L., Skeath, J. B. & Djuranovic, S., Jan 20 2017, In : Nature Communications. 8, 14112.

Research output: Contribution to journalArticle

mutations
Genes
organisms
genes
Mutation

Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. Pombe

Guydosh, N. R., Kimmig, P., Walter, P. & Green, R., Sep 25 2017, In : eLife. 6, e29216.

Research output: Contribution to journalArticle

Schizosaccharomyces
RNA Stability
Endoplasmic Reticulum
Homeostasis
Ribosomes

Slowed decay of mRNAs enhances platelet specific translation

Mills, E. W., Green, R. & Ingolia, N. T., Apr 27 2017, In : Blood. 129, 17, p. e38-e48

Research output: Contribution to journalArticle

Platelets
Blood Platelets
Messenger RNA
RNA Sequence Analysis
Ribosomes

Translation of poly(A) tails leads to precise mRNA cleavage

Guydosh, N. R. & Green, R., May 1 2017, In : RNA. 23, 5, p. 749-761 13 p.

Research output: Contribution to journalArticle

Ribosomes
Messenger RNA
Polyadenylation
RNA Stability
Nucleotides
2016

Clarifying the Translational Pausing Landscape in Bacteria by Ribosome Profiling

Mohammad, F., Woolstenhulme, C., Green, R. & Buskirk, A., Feb 2 2016, In : Cell Reports. 14, 4, p. 686-694 9 p.

Research output: Contribution to journalArticle

Ribosomes
Bacteria
Messenger RNA
Gene expression
Elongation

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

Mills, E. W., Wangen, J., Green, R. & Ingolia, N. T., Sep 27 2016, In : Cell Reports. 17, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Erythroid Cells
Platelets
Ribosomes
Blood
Blood Platelets

Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A

McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J. C. P., Lu, J., Guo, Z., Ayinde, S., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R. & Liu, J., Dec 18 2016, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Biological Products
Ribosomes
agelastatin A
Chemotherapy
Cell proliferation

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality

Radhakrishnan, A., Chen, Y. H., Martin, S., Alhusaini, N., Green, R. & Coller, J., Sep 22 2016, In : Cell. 167, 1, p. 122-132.e9

Research output: Contribution to journalArticle

RNA Stability
Protein Biosynthesis
Codon
Ribosomes
Messenger RNA

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

Di Santo, R., Aboulhouda, S., Weinberg, D. E. & Green, R., Oct 1 2016, In : eLife. 5, OCTOBER2016, e20069.

Research output: Contribution to journalArticle

Unfolded Protein Response
Introns
Messenger RNA
Proteins
Stored Messenger RNA
2015

High-Precision analysis of translational pausing by ribosome profiling in bacteria lacking EFP

Woolstenhulme, C., Guydosh, N. R., Green, R. & Buskirk, A., Apr 7 2015, In : Cell Reports. 11, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
Ribosomes
Proline
Escherichia coli
Elongation

Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens

Suwantarat, N., Dalton, J. B., Lee, R., Green, R., Memon, W., Carroll, K. C., Riedel, S. & Zhang, S. X., May 1 2015, In : Diagnostic Microbiology and Infectious Disease. 82, 1, p. 54-56 3 p.

Research output: Contribution to journalArticle

Immunoassay
Cerebrospinal Fluid
Antigens
Serum
Cryptococcosis

Ribosomes slide on lysine-encoding homopolymeric A stretches

Koutmou, K. S., Schuller, A. P., Brunelle, J. L., Radhakrishnan, A., Djuranovic, S. & Green, R., Feb 19 2015, In : eLife. 2015, 4

Research output: Contribution to journalArticle

Ribosomes
Codon
Lysine
Proteins
Messenger RNA

Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3′UTRs In Vivo

Young, D. J., Guydosh, N. R., Zhang, F., Hinnebusch, A. G. & Green, R., Aug 17 2015, In : Cell. 162, 4, p. 872-884 13 p., 8356.

Research output: Contribution to journalArticle

Ribosomes
Recycling
Biochemistry
Mass spectrometry
Messenger RNA

Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases

Kowalinski, E., Schuller, A., Green, R. & Conti, E., Feb 17 2015, In : Structure. 23, 7, p. 1336-1343 8 p., 3180.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Guanosine Triphosphate
Saccharomyces cerevisiae
Carrier Proteins
Exosomes

Synthesis at the Speed of Codons

Koutmou, K. S., Radhakrishnan, A. & Green, R., 2015, In : Trends in Biochemical Sciences. 40, 12, p. 717-718 2 p.

Research output: Contribution to journalArticle

Codon
Messenger RNA
Protein folding
Protein Folding
Peptides

Translational control by lysine-encoding A-rich sequences

Arthur, L. L., Pavlovic-Djuranovic, S., Koutmou, K. S., Green, R., Szczesny, P. & Djuranovic, S., Jan 1 2015, In : Science Advances. 1, 6, 1500154.

Research output: Contribution to journalArticle

Open Access
Lysine
Genes
Gene Pool
Proteins
Protein Stability
2014

Cryoelectron microscopic structures of eukaryotic translation termination complexes containing eRF1-eRF3 or eRF1-ABCE1

Preis, A., Heuer, A., Barrio-Garcia, C., Hauser, A., Eyler, D. E., Berninghausen, O., Green, R., Becker, T. & Beckmann, R., Jul 10 2014, In : Cell Reports. 8, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

Terminator Codon
Guanosine Triphosphate
Decoding
Peptidyl Transferases
Ribosomes

Distinct roles for release factor 1 and release factor 2 in translational quality control

Petropoulos, A. D., McDonald, M. E., Green, R. & Zaher, H. S., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17589-17596 8 p.

Research output: Contribution to journalArticle

Quality Control
Quality control
Ribosomes
Terminator Codon
Peptide Termination Factors

Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress

Van Den Elzen, A. M. G., Schuller, A., Green, R. & Séraphin, B., Feb 3 2014, In : The EMBO journal. 33, 3, p. 265-276 12 p.

Research output: Contribution to journalArticle

Ribosomes
Ribosome Subunits
Yeast
Yeasts
Starvation

Dom34 rescues ribosomes in 3′ untranslated regions

Guydosh, N. R. & Green, R., Feb 27 2014, In : Cell. 156, 5, p. 950-962 13 p.

Research output: Contribution to journalArticle

3' Untranslated Regions
Ribosomes
Messenger RNA
Decoding
Peptides

First report of Westerdykella dispersa as a cause of an Angioinvasive fungal infection in a neutropenic host

Sue, P. K., Gurda, G. T., Lee, R., Watkins, T., Green, R., Memon, W., Milstone, A., Zelazny, A. M., Fahle, G. A., Pham, T. A., Gibas, C. F., Sutton, D. A., Wickes, B. L., Wiederhold, N. P. & Zhang, S. X., Dec 1 2014, In : Journal of Clinical Microbiology. 52, 12, p. 4407-4411 5 p.

Research output: Contribution to journalArticle

Mycoses
Immunocompromised Host
Pediatrics
Morbidity
Mortality

RF3: GTP promotes rapid dissociation of the class 1 termination factor

Koutmou, K. S., McDonald, M. E., Brunelle, J. L. & Green, R., 2014, In : RNA. 20, 5, p. 609-620 12 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Ribosomes
GTP Phosphohydrolases
Thermodynamics
Nucleotides
2013

Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1

Eyler, D. E., Wehner, K. A. & Green, R., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29530-29538 9 p.

Research output: Contribution to journalArticle

Catalysis
Peptides
peptide-chain-release factor 3
Terminator Codon
GTP Phosphohydrolases

Getting past polyproline pauses

Buskirk, A. & Green, R., Jan 4 2013, In : Science. 339, 6115, p. 38-39 2 p.

Research output: Contribution to journalArticle

Ribosomes
Proline
Proteins
polyproline

Regulation of Argonaute slicer activity by guide RNA 3′ end interactions with the N-terminal lobe

Hur, J. K., Zinchenko, M. K., Djuranovic, S. & Green, R., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7829-7840 12 p.

Research output: Contribution to journalArticle

Guide RNA
RNA
Argonaute Proteins
Sequence Deletion
MicroRNAs
2012

Another burst of smoke: Atomic resolution structures of RF3 bound to the ribosome

Mcdonald, M. E. & Green, R., Apr 2012, In : RNA. 18, 4, p. 605-609 5 p.

Research output: Contribution to journalArticle

Ribosomes
Smoke
GTP Phosphohydrolases
Proteins

A role for the 2′ OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue

Shaw, J. J., Trobro, S., He, S. L., Qvist, J. & Green, R., Aug 24 2012, In : Chemistry and Biology. 19, 8, p. 983-993 11 p.

Research output: Contribution to journalArticle

Ribosomes
Catalysis
Peptides
Substrates
Nucleophiles

Further in vitro exploration fails to support the allosteric three-site model

Petropoulos, A. D. & Green, R., Apr 6 2012, In : Journal of Biological Chemistry. 287, 15, p. 11642-11648 7 p.

Research output: Contribution to journalArticle

Allosteric Site
Transfer RNA
Ribosomes
In Vitro Techniques
Codon

miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay

Djuranovic, S., Nahvi, A. & Green, R., Apr 13 2012, In : Science. 336, 6078, p. 237-240 4 p.

Research output: Contribution to journalArticle

RNA Stability
Gene Silencing
MicroRNAs
Messenger RNA
3' Untranslated Regions

Ribosomal biogenesis genes play an essential and p53- independent role in zebrafish pancreas development

Provost, E., Wehner, K. A., Zhong, X., Ashar, F., Nguyen, E., Green, R., Parsons, M. J. & Leach, S. D., Sep 1 2012, In : Development. 139, 17, p. 3232-3241 10 p.

Research output: Contribution to journalArticle

Essential Genes
p53 Genes
Zebrafish
Pancreas
Ribosomes

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

Becker, T., Franckenberg, S., Wickles, S., Shoemaker, C. J., Anger, A. M., Armache, J. P., Sieber, H., Ungewickell, C., Berninghausen, O., Daberkow, I., Karcher, A., Thomm, M., Hopfner, K. P., Green, R. & Beckmann, R., Feb 23 2012, In : Nature. 482, 7386, p. 501-506 6 p.

Research output: Contribution to journalArticle

Archaea
Recycling
Eukaryota
Ribosomes
Peptide Elongation Factor G

Structural characterization of mRNA-tRNA translocation intermediates

Agirrezabala, X., Liao, H. Y., Schreiner, E., Fu, J., Ortiz-Meoz, R. F., Schulten, K., Green, R. & Frank, J., Apr 17 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6094-6099 6 p.

Research output: Contribution to journalArticle

Transfer RNA
Ribosomes
Messenger RNA
Escherichia coli

The elongation, termination, and recycling phases of translation in eukaryotes.

Dever, T. E. & Green, R., Jul 2012, In : Cold Spring Harbor perspectives in biology. 4, 7

Research output: Contribution to journalArticle

Recycling
Eukaryota
Elongation
Ribosomes
Proteins

Translation drives mRNA quality control

Shoemaker, C. J. & Green, R., Jun 2012, In : Nature structural & molecular biology. 19, 6, p. 594-601 8 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Protein Biosynthesis
Ribosomes
Quality Control
Messenger RNA
2011

A parsimonious model for gene regulation by miRNAs

Djuranovic, S., Nahvi, A. & Green, R., Feb 4 2011, In : Science. 331, 6017, p. 550-553 4 p.

Research output: Contribution to journalArticle

MicroRNAs
Messenger RNA
Genes
Argonaute Proteins
Small Interfering RNA

A primary role for release factor 3 in quality control during translation elongation in Escherichia coli

Zaher, H. S. & Green, R., Oct 14 2011, In : Cell. 147, 2, p. 396-408 13 p.

Research output: Contribution to journalArticle

Quality Control
Escherichia coli
Quality control
Elongation
Proteins

Distinct response of yeast ribosomes to a miscoding event during translation

Eyler, D. E. & Green, R., May 2011, In : RNA. 17, 5, p. 925-932 8 p.

Research output: Contribution to journalArticle

Ribosomes
Yeasts
Quality Control
Saccharomyces cerevisiae
Anticodon

Helix 69 is key for uniformity during substrate selection on the ribosome

Ortiz-Meoz, R. F. & Green, R., Jul 22 2011, In : Journal of Biological Chemistry. 286, 29, p. 25604-25610 7 p.

Research output: Contribution to journalArticle

Transfer RNA
Ribosomes
Substrates
Terminator Codon
Molecular Biology