Quy Hoa Le Thi

Associate Professor

20062019

Research output per year

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Research Output

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Article

12486-12491 Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter

Le, A., Stine, Z. E., Nguyen, C., Afzal, J., Sun, P., Hamaker, M., Siegel, N. M., Gouw, A. M., Kang, B. H., Yu, S. H., Cochran, R. L., Sailor, K. A., Song, H. & Dang, C. V., Aug 26 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 34, p. 12486-12491 6 p.

Research output: Contribution to journalArticle

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold

Zimmermann, S. C., Wolf, E. F., Luu, A., Thomas, A. G., Stathis, M., Poore, B., Nguyen, C., Le Thi, Q. H., Rojas, C., Slusher, B. & Tsukamoto, T., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 520-524 5 p.

Research output: Contribution to journalArticle

Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury

Le, A., Damico, R., Damarla, M., Boueiz, A., Hyun, H. P., Skirball, J., Hasan, E., Peng, X., Chesley, A., Crow, M. T., Reddy, S. P., Tuder, R. M. & Hassoun, P. M., Oct 1 2008, In : Journal of applied physiology. 105, 4, p. 1282-1290 9 p.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J. S., Slusher, B. & Le Thi, Q. H., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Conceptual framework for cutting the pancreatic cancer fuel supply

Le, A., Rajeshkumar, N. V., Maitra, A. & Dang, C. V., Aug 15 2012, In : Clinical Cancer Research. 18, 16, p. 4285-4290 6 p.

Research output: Contribution to journalArticle

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le, A., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R., Ferraris, D., Powell, J., Majer, P. & Slusher, B. S., Sep 22 2016, In : Journal of medicinal chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Contribution to journalArticle

Open Access

Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors

Dutta, P., Le, A., Vander Jagt, D. L., Tsukamoto, T., Martinez, G. V., Dang, C. V. & Gillies, R. J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4190-4195 6 p.

Research output: Contribution to journalArticle

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in b cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., Zimmerman, L. J., Liebler, D. C., Slebos, R. J. C., Lorkiewicz, P. K., Higashi, R. M., Fan, T. W. M. & Dang, C. V., Jan 4 2012, In : Cell Metabolism. 15, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

Calvi, C., Podowski, M., Lopez-Mercado, A., Metzger, S., Misono, K., Malinina, A., Dikeman, D., Poonyagariyon, H., Ynalvez, L., Derakhshandeh, R., Le, A., Merchant, M., Schwall, R. & Neptune, E. R., Feb 1 2013, In : PLoS genetics. 9, 2, e1003228.

Research output: Contribution to journalArticle

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

Yustein, J. T., Liu, Y. C., Gao, P., Jie, C., Le, A., Vuica-Ross, M., Chng, W. J., Eberhart, C. G., Bergsagel, P. L. & Dang, C. V., Feb 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 8, p. 3534-3539 6 p.

Research output: Contribution to journalArticle

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Vander Jagt, D. L., Semenza, G. L. & Dang, C. V., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2037-2042 6 p.

Research output: Contribution to journalArticle

Lagtimes in diagnosis and treatment of colorectal cancer: Determinants and association with cancer stage and survival

Wattacheril, J., Kramer, J. R., Richardson, P., Havemann, B. D., Green, L. K., Le, A. & El-Serag, H. B., Nov 1 2008, In : Alimentary Pharmacology and Therapeutics. 28, 9, p. 1166-1174 9 p.

Research output: Contribution to journalArticle

Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cells

Emadi, A., Le, A., Harwood, C. J., Stagliano, K. W., Kamangar, F., Ross, A. E., Cooper, C. R., Dang, C. V., Karp, J. E. & Vuica-Ross, M., Dec 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 23, p. 7057-7062 6 p.

Research output: Contribution to journalArticle

Minimally invasive approaches for the management of difficult colonic polyps

Haas, E. M., Cruz, R. A., Ragupathi, M., Pedraza, R., Pickron, T. B. & Le, A. T., Sep 16 2011, In : Diagnostic and Therapeutic Endoscopy. 682793.

Research output: Contribution to journalArticle

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

Damarla, M., Hasan, E., Boueiz, A., Le, A., Pae, H. H., Montouchet, C., Kolb, T., Simms, T., Myers, A., Kayyali, U. S., Gaestel, M., Peng, X., Reddy, S. P., Damico, R. & Hassoun, P. M., Feb 25 2009, In : PloS one. 4, 2, e4600.

Research output: Contribution to journalArticle

MYC-induced cancer cell energy metabolism and therapeutic opportunities

Dang, C. V., Le, A. & Gao, P., Nov 1 2009, In : Clinical Cancer Research. 15, 21, p. 6479-6483 5 p.

Research output: Contribution to journalArticle

Noncardia gastric adenocarcinoma remains an important and deadly cancer in the United States: Secular trends in incidence and survival

Lau, M., Le, A. & El-Serag, H. B., Nov 1 2006, In : American Journal of Gastroenterology. 101, 11, p. 2485-2492 8 p.

Research output: Contribution to journalArticle

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation

Walker, A., Singh, A., Tully, E., Woo, J., Le Thi, Q. H., Nguyen, T., Biswal, S., Sharma, D. & Gabrielson, E., May 20 2018, In : Free Radical Biology and Medicine. 120, p. 407-413 7 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Shestov, A. A., Liu, X., Ser, Z., Cluntun, A. A., Hung, Y. P., Huang, L., Kim, D., Le, A., Yellen, G., Albeck, J. G. & Locasale, J. W., Jul 9 2014, In : eLife. 3, July2014, p. 1-18 18 p., e03342.

Research output: Contribution to journalArticle

Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension

Suresh, K., Servinsky, L., Jiang, H., Bigham, Z., Zaldumbide, J., Huetsch, J. C., Kliment, C., Acoba, M. G., Kirsch, B. J., Claypool, S. M., Le, A., Damarla, M. & Shimoda, L. A., Jan 1 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 5, p. L639-L652

Research output: Contribution to journalArticle

Open Access

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

Liu, W., Le, A., Hancock, C., Lane, A. N., Dang, C. V., Fan, T. W. M. & Phang, J. M., Jun 5 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 8983-8988 6 p.

Research output: Contribution to journalArticle

Secular trends in the use, quality, and outcomes of gastrectomy for noncardia gastric cancer in the United States

Le, A., Berger, D., Lau, M. & El-Serag, H. B., Sep 1 2007, In : Annals of Surgical Oncology. 14, 9, p. 2519-2527 9 p.

Research output: Contribution to journalArticle

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Xiang, Y., Stine, Z. E., Xia, J., Lu, Y., O'Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., Sun, L., Song, L., Yan, B., Slusher, B. S., Zhuo, J., Ooi, L. L., Lee, C. G. L., Mancuso, A., McCallion, A. S., Le, A. & 4 others, Milone, M. C., Rayport, S., Felsher, D. W. & Dang, C. V., Jun 1 2015, In : Journal of Clinical Investigation. 125, 6, p. 2293-2306 14 p.

Research output: Contribution to journalArticle

Targeting mitochondrial translation by inhibiting DDX3: A novel radiosensitization strategy for cancer treatment

Heerma Van Voss, M. R., Vesuna, F., Bol, G. M., Afzal, J., Tantravedi, S., Bergman, Y., Kammers, K., Lehar, M., Malek, R., Ballew, M., Ter Hoeve, N., Abou, D., Thorek, D., Berlinicke, C. A., Yazdankhah, M., Sinha, D., Le Thi, Q. H., Abrahams, R., Tran, P. T., Van Diest, P. J. & 1 others, Raman, V., Jan 4 2018, In : Oncogene. 37, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Therapeutic targeting of the warburg effect in pancreatic cancer relies on an absence of p53 function

Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., De Wilde, R. F., Martinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., Dang, C. V., Gillies, R. J. & Maitra, A., Aug 15 2015, In : Cancer Research. 75, 16, p. 3355-3364 10 p.

Research output: Contribution to journalArticle

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., Chaichana, K. L. & 7 others, Hartung, T., Betenbaugh, M. J., Marie, S. K., Jung, J. G., Wang, T-L., Gabrielson, E. & Le Thi, Q. H., Apr 9 2019, In : Cell Reports. 27, 2, p. 491-501.e6

Research output: Contribution to journalArticle

Open Access

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S., Nguyen, S., Hoang, G., Nguyen, T., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., Jung, J. G., Xu, Q., Fu, J., Thomas, A. G., Tsukamoto, T., Hanes, J. S., Slusher, B., Cooper, A. J. L. & Le Thi, Q. H., Jan 1 2019, In : Proteomics. 1800451.

Research output: Contribution to journalArticle

Open Access