Quy Hoa Le Thi

Associate Professor

20062019

Research output per year

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Research Output

2019

Application of metabolomics technologies toward cancer prognosis and therapy

Hoang, G., Udupa, S. & Le Thi, Q. H., Jan 1 2019, International Review of Cell and Molecular Biology. Montrose, D. C. & Galluzzi, L. (eds.). Elsevier Inc., p. 191-223 33 p. (International Review of Cell and Molecular Biology; vol. 347).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension

Suresh, K., Servinsky, L., Jiang, H., Bigham, Z., Zaldumbide, J., Huetsch, J. C., Kliment, C., Acoba, M. G., Kirsch, B. J., Claypool, S. M., Le, A., Damarla, M. & Shimoda, L. A., Jan 1 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 5, p. L639-L652

Research output: Contribution to journalArticle

Open Access

The Metabolic Interplay between Cancer and Other Diseases

Le, A., Udupa, S. & Zhang, C., Dec 2019, In : Trends in Cancer. 5, 12, p. 809-821 13 p.

Research output: Contribution to journalReview article

Open Access

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., Chaichana, K. L. & 7 others, Hartung, T., Betenbaugh, M. J., Marie, S. K., Jung, J. G., Wang, T-L., Gabrielson, E. & Le Thi, Q. H., Apr 9 2019, In : Cell Reports. 27, 2, p. 491-501.e6

Research output: Contribution to journalArticle

Open Access

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S., Nguyen, S., Hoang, G., Nguyen, T., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., Jung, J. G., Xu, Q., Fu, J., Thomas, A. G., Tsukamoto, T., Hanes, J. S., Slusher, B., Cooper, A. J. L. & Le Thi, Q. H., Jan 1 2019, In : Proteomics. 1800451.

Research output: Contribution to journalArticle

Open Access
2018

Breast cancer metabolism

Tan, J. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 83-93 11 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Different tumor microenvironments lead to different metabolic phenotypes

Antonio, M. J. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 119-129 11 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glucose metabolism in cancer

Bose, S. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 3-12 10 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glutamine metabolism in cancer

Li, T. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 13-32 20 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolic relationship between cancer-associated fibroblasts and cancer cells

Sazeides, C. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 149-165 17 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Non-hodgkin lymphoma metabolism

Kirsch, B. J., Chang, S. J. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 95-106 12 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation

Walker, A., Singh, A., Tully, E., Woo, J., Le Thi, Q. H., Nguyen, T., Biswal, S., Sharma, D. & Gabrielson, E., May 20 2018, In : Free Radical Biology and Medicine. 120, p. 407-413 7 p.

Research output: Contribution to journalArticle

Preface

Le Thi, Q. H., Jan 1 2018, In : Advances in Experimental Medicine and Biology. 1063, p. vii

Research output: Contribution to journalEditorial

Targeting metabolic cross talk between cancer cells and cancer-associated fibroblasts

Jung, J. G. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 167-178 12 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

Targeting mitochondrial translation by inhibiting DDX3: A novel radiosensitization strategy for cancer treatment

Heerma Van Voss, M. R., Vesuna, F., Bol, G. M., Afzal, J., Tantravedi, S., Bergman, Y., Kammers, K., Lehar, M., Malek, R., Ballew, M., Ter Hoeve, N., Abou, D., Thorek, D., Berlinicke, C. A., Yazdankhah, M., Sinha, D., Le Thi, Q. H., Abrahams, R., Tran, P. T., Van Diest, P. J. & 1 others, Raman, V., Jan 4 2018, In : Oncogene. 37, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

The heterogeneity of lipid metabolism in cancer

Park, J. K., Coffey, N. J., Limoges, A. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 33-55 23 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

The intratumoral heterogeneity of cancer metabolism

Nabi, K. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 131-145 15 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

The intricate metabolism of pancreatic cancers

Camelo, F. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 73-81 9 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

The metabolism of renal cell carcinomas and liver cancer

Nguyen, T. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 107-118 12 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

The multifaceted metabolism of glioblastoma

Quinones, A. & Le Thi, Q. H., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 59-72 14 p. (Advances in Experimental Medicine and Biology; vol. 1063).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold

Zimmermann, S. C., Wolf, E. F., Luu, A., Thomas, A. G., Stathis, M., Poore, B., Nguyen, C., Le Thi, Q. H., Rojas, C., Slusher, B. & Tsukamoto, T., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 520-524 5 p.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J. S., Slusher, B. & Le Thi, Q. H., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le, A., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R., Ferraris, D., Powell, J., Majer, P. & Slusher, B. S., Sep 22 2016, In : Journal of medicinal chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Contribution to journalArticle

2015

Dysregulated metabolism contributes to oncogenesis

Target Validation Team, Dec 1 2015, In : Seminars in Cancer Biology. 35, p. S129-S150

Research output: Contribution to journalReview article

Glucose-independent glutamine-driven TCA cycle in cancer cells

Poore, B., Siegel, N., Park, J. K., Hwang, B. J., Afif, I. & Le, A., Jan 1 2015, Glutamine in Clinical Nutrition. Springer New York, p. 77-85 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Xiang, Y., Stine, Z. E., Xia, J., Lu, Y., O'Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., Sun, L., Song, L., Yan, B., Slusher, B. S., Zhuo, J., Ooi, L. L., Lee, C. G. L., Mancuso, A., McCallion, A. S., Le, A. & 4 others, Milone, M. C., Rayport, S., Felsher, D. W. & Dang, C. V., Jun 1 2015, In : Journal of Clinical Investigation. 125, 6, p. 2293-2306 14 p.

Research output: Contribution to journalArticle

Therapeutic targeting of the warburg effect in pancreatic cancer relies on an absence of p53 function

Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., De Wilde, R. F., Martinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., Dang, C. V., Gillies, R. J. & Maitra, A., Aug 15 2015, In : Cancer Research. 75, 16, p. 3355-3364 10 p.

Research output: Contribution to journalArticle

2014

12486-12491 Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter

Le, A., Stine, Z. E., Nguyen, C., Afzal, J., Sun, P., Hamaker, M., Siegel, N. M., Gouw, A. M., Kang, B. H., Yu, S. H., Cochran, R. L., Sailor, K. A., Song, H. & Dang, C. V., Aug 26 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 34, p. 12486-12491 6 p.

Research output: Contribution to journalArticle

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Shestov, A. A., Liu, X., Ser, Z., Cluntun, A. A., Hung, Y. P., Huang, L., Kim, D., Le, A., Yellen, G., Albeck, J. G. & Locasale, J. W., Jul 9 2014, In : eLife. 3, July2014, p. 1-18 18 p., e03342.

Research output: Contribution to journalArticle

2013

Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors

Dutta, P., Le, A., Vander Jagt, D. L., Tsukamoto, T., Martinez, G. V., Dang, C. V. & Gillies, R. J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4190-4195 6 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

Calvi, C., Podowski, M., Lopez-Mercado, A., Metzger, S., Misono, K., Malinina, A., Dikeman, D., Poonyagariyon, H., Ynalvez, L., Derakhshandeh, R., Le, A., Merchant, M., Schwall, R. & Neptune, E. R., Feb 1 2013, In : PLoS genetics. 9, 2, e1003228.

Research output: Contribution to journalArticle

Studying Myc's role in metabolism regulation

Le, A. & Dang, C. V., Jan 1 2013, The Myc Gene: Methods and Protocols. Humana Press Inc., p. 213-219 7 p. (Methods in Molecular Biology; vol. 1012).

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Conceptual framework for cutting the pancreatic cancer fuel supply

Le, A., Rajeshkumar, N. V., Maitra, A. & Dang, C. V., Aug 15 2012, In : Clinical Cancer Research. 18, 16, p. 4285-4290 6 p.

Research output: Contribution to journalArticle

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in b cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., Zimmerman, L. J., Liebler, D. C., Slebos, R. J. C., Lorkiewicz, P. K., Higashi, R. M., Fan, T. W. M. & Dang, C. V., Jan 4 2012, In : Cell Metabolism. 15, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

Liu, W., Le, A., Hancock, C., Lane, A. N., Dang, C. V., Fan, T. W. M. & Phang, J. M., Jun 5 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 8983-8988 6 p.

Research output: Contribution to journalArticle

2011

Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cells

Emadi, A., Le, A., Harwood, C. J., Stagliano, K. W., Kamangar, F., Ross, A. E., Cooper, C. R., Dang, C. V., Karp, J. E. & Vuica-Ross, M., Dec 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 23, p. 7057-7062 6 p.

Research output: Contribution to journalArticle

Minimally invasive approaches for the management of difficult colonic polyps

Haas, E. M., Cruz, R. A., Ragupathi, M., Pedraza, R., Pickron, T. B. & Le, A. T., Sep 16 2011, In : Diagnostic and Therapeutic Endoscopy. 682793.

Research output: Contribution to journalArticle

Therapeutic targeting of cancer cell metabolism

Dang, C. V., Hamaker, M., Sun, P., Le, A. & Gao, P., Mar 1 2011, In : Journal of Molecular Medicine. 89, 3, p. 205-212 8 p.

Research output: Contribution to journalReview article

2010

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

Yustein, J. T., Liu, Y. C., Gao, P., Jie, C., Le, A., Vuica-Ross, M., Chng, W. J., Eberhart, C. G., Bergsagel, P. L. & Dang, C. V., Feb 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 8, p. 3534-3539 6 p.

Research output: Contribution to journalArticle

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Vander Jagt, D. L., Semenza, G. L. & Dang, C. V., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2037-2042 6 p.

Research output: Contribution to journalArticle

2009

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

Damarla, M., Hasan, E., Boueiz, A., Le, A., Pae, H. H., Montouchet, C., Kolb, T., Simms, T., Myers, A., Kayyali, U. S., Gaestel, M., Peng, X., Reddy, S. P., Damico, R. & Hassoun, P. M., Feb 25 2009, In : PloS one. 4, 2, e4600.

Research output: Contribution to journalArticle

MYC-induced cancer cell energy metabolism and therapeutic opportunities

Dang, C. V., Le, A. & Gao, P., Nov 1 2009, In : Clinical Cancer Research. 15, 21, p. 6479-6483 5 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

2008

Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury

Le, A., Damico, R., Damarla, M., Boueiz, A., Hyun, H. P., Skirball, J., Hasan, E., Peng, X., Chesley, A., Crow, M. T., Reddy, S. P., Tuder, R. M. & Hassoun, P. M., Oct 1 2008, In : Journal of applied physiology. 105, 4, p. 1282-1290 9 p.

Research output: Contribution to journalArticle

Lagtimes in diagnosis and treatment of colorectal cancer: Determinants and association with cancer stage and survival

Wattacheril, J., Kramer, J. R., Richardson, P., Havemann, B. D., Green, L. K., Le, A. & El-Serag, H. B., Nov 1 2008, In : Alimentary Pharmacology and Therapeutics. 28, 9, p. 1166-1174 9 p.

Research output: Contribution to journalArticle

2007

Quality of Life in the Elderly with Rectal Cancer

Le, A. T., Albo, D. & Berger, D. H., Jul 1 2007, In : Journal of the American College of Surgeons. 205, 1, p. 124-131 8 p.

Research output: Contribution to journalReview article

Secular trends in the use, quality, and outcomes of gastrectomy for noncardia gastric cancer in the United States

Le, A., Berger, D., Lau, M. & El-Serag, H. B., Sep 1 2007, In : Annals of Surgical Oncology. 14, 9, p. 2519-2527 9 p.

Research output: Contribution to journalArticle

2006

Noncardia gastric adenocarcinoma remains an important and deadly cancer in the United States: Secular trends in incidence and survival

Lau, M., Le, A. & El-Serag, H. B., Nov 1 2006, In : American Journal of Gastroenterology. 101, 11, p. 2485-2492 8 p.

Research output: Contribution to journalArticle