1988 …2019

Research output per year

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Research Output

Article

A Cysteine Protease Inhibitor of Plasmodium berghei Is Essential for Exo-erythrocytic Development

Lehmann, C., Heitmann, A., Mishra, S., Burda, P. C., Singer, M., Prado, M., Niklaus, L., Lacroix, C., Ménard, R., Frischknecht, F., Stanway, R., Sinnis, P. & Heussler, V., Aug 28 2014, In : PLoS pathogens. 10, 8, e1004336.

Research output: Contribution to journalArticle

A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites

Millholland, M. G., Mishra, S., Dupont, C. D., Love, M. S., Patel, B., Shilling, D., Kazanietz, M. G., Foskett, J. K., Hunter, C. A., Sinnis, P. & Greenbaum, D. C., Jan 16 2013, In : Cell Host and Microbe. 13, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E. I., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A. & 18 others, Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G. Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F. P., Pancera, M. & Seder, R. A., May 1 2018, In : Nature Medicine. 24, 4, p. 408-416 9 p.

Research output: Contribution to journalArticle

A key role for lipoic acid synthesis during Plasmodium liver stage development

Falkard, B., Kumar, T. R. S., Hecht, L. S., Matthews, K. A., Henrich, P. P., Gulati, S., Lewis, R. E., Manary, M. J., Winzeler, E. A., Sinnis, P., Prigge, S. T., Heussler, V., Deschermeier, C. & Fidock, D., Sep 1 2013, In : Cellular microbiology. 15, 9, p. 1585-1604 20 p.

Research output: Contribution to journalArticle

Alpha-v–containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP

Dundas, K., Shears, M. J., Sun, Y., Hopp, C. S., Crosnier, C., Metcalf, T., Girling, G., Sinnis, P., Billker, O. & Wright, G. J., Apr 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. 4477-4482 6 p.

Research output: Contribution to journalArticle

A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Schleicher, T. R., Yang, J., Freudzon, M., Rembisz, A., Craft, S., Hamilton, M., Graham, M., Mlambo, G., Tripathi, A., Li, Y., Cresswell, P., Sinnis, P., Dimopoulos, G. & Fikrig, E., Dec 1 2018, In : Nature Communications. 9, 1, 2908.

Research output: Contribution to journalArticle

An immunoradiometric assay for the quantification of Plasmodium sporozoite invasion of HepG2 cells

Sinnis, P., Dec 1 1998, In : Journal of Immunological Methods. 221, 1-2, p. 17-23 7 p.

Research output: Contribution to journalArticle

Anopheles stephensi salivary glands bear receptors for region I of the circumsporozoite protein of Plasmodium falciparum

Sidjanski, S. P., Vanderberg, J. P. & Sinnis, P., Dec 1 1997, In : Molecular and Biochemical Parasitology. 90, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site

Flores-Garcia, Y., Nasir, G., Hopp, C. S., Munoz, C., Balaban, A. E., Zavala, F. P. & Sinnis, P., Nov 20 2018, In : mBio. 9, 6

Research output: Contribution to journalArticle

Antimalarial activity of allicin, a biologically active compound from garlic cloves

Coppi, A., Cabinian, M., Mirelman, D. & Sinnis, P., May 1 2006, In : Antimicrobial agents and chemotherapy. 50, 5, p. 1731-1737 7 p.

Research output: Contribution to journalArticle

Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity

Kelly, B. A., Neil, S. J., McKnight, Á., Santos, J. M., Sinnis, P., Jack, E. R., Middleton, D. A. & Dobson, C. B., Sep 1 2007, In : FEBS Journal. 274, 17, p. 4511-4525 15 p.

Research output: Contribution to journalArticle

Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity

Ting, L. M., Gissot, M., Coppi, A., Sinnis, P. & Kim, K., Sep 1 2008, In : Nature medicine. 14, 9, p. 954-958 5 p.

Research output: Contribution to journalArticle

Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG

Gantt, S. M., Clavijo, P., Bai, X., Esko, J. D. & Sinnis, P., Aug 1 1997, In : Journal of Biological Chemistry. 272, 31, p. 19205-19213 9 p.

Research output: Contribution to journalArticle

Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro

Frevert, U., Sinnis, P., Esko, J. D. & Nussenzweig, V., Jan 1 1996, In : Molecular and Biochemical Parasitology. 76, 1-2, p. 257-266 10 p.

Research output: Contribution to journalArticle

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

Bunnik, E. M., Cook, K. B., Varoquaux, N., Batugedara, G., Prudhomme, J., Cort, A., Shi, L., Andolina, C., Ross, L. S., Brady, D., Fidock, D. A., Nosten, F., Tewari, R., Sinnis, P., Ay, F., Vert, J. P., Noble, W. S. & Le Roch, K. G., Dec 1 2018, In : Nature communications. 9, 1, 1910.

Research output: Contribution to journalArticle

Comparative 3D genome organization in apicomplexan parasites

Bunnik, E. M., Venkat, A., Shao, J., McGovern, K. E., Batugedara, G., Worth, D., Prudhomme, J., Lapp, S. A., Andolina, C., Ross, L. S., Lawres, L., Brady, D., Sinnis, P., Nosten, F., Fidock, D. A., Wilson, E. H., Tewari, R., Galinski, M. R., Mamoun, C. B., Ay, F. & 1 others, Le Roch, K. G., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3183-3192 10 p.

Research output: Contribution to journalArticle

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites

Hopp, C. S., Bennett, B. L., Mishra, S., Lehmann, C., Hanson, K. K., Lin, J. W., Rousseau, K., Carvalho, F. A., van der Linden, W. A., Santos, N. C., Bogyo, M., Khan, S. M., Heussler, V. & Sinnis, P., Sep 2017, In : PLoS pathogens. 13, 9, e1006586.

Research output: Contribution to journalArticle

Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo

Cockburn, I. A., Tse, S. W., Radtke, A. J., Srinivasan, P., Chen, Y. C., Sinnis, P. & Zavala, F., Mar 1 2011, In : PLoS pathogens. 7, 3, e1001318.

Research output: Contribution to journalArticle

Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes

Ecker, A., Lakshmanan, V., Sinnis, P., Coppens, I. & Fidock, D. A., Jan 15 2011, In : Journal of Infectious Diseases. 203, 2, p. 228-236 9 p.

Research output: Contribution to journalArticle

Furuncular myiasis caused by Dermatobia hominis in a returning traveler

Bhandari, R., Janos, D. P. & Sinnis, P., Mar 1 2007, In : American Journal of Tropical Medicine and Hygiene. 76, 3, p. 598-599 2 p.

Research output: Contribution to journalArticle

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

McLean, K. J., Straimer, J., Hopp, C. S., Vega-Rodriguez, J., Small-Saunders, J. L., Kanatani, S., Tripathi, A., Mlambo, G., Dumoulin, P. C., Harris, C. T., Tong, X., Shears, M. J., Ankarklev, J., Kafsack, B. F. C., Fidock, D. A. & Sinnis, P., Sep 11 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Heparan Sulfate Proteoglycans Provide a Signal to Plasmodium Sporozoites to Stop Migrating and Productively Invade Host Cells

Coppi, A., Tewari, R., Bishop, J. R., Bennett, B. L., Lawrence, R., Esko, J. D., Billker, O. & Sinnis, P., Nov 15 2007, In : Cell Host and Microbe. 2, 5, p. 316-327 12 p.

Research output: Contribution to journalArticle

High mobility group protein HMGB2 is a critical regulator of Plasmodium oocyst development

Gissot, M., Ting, L. M., Daly, T. M., Bergman, L. W., Sinnis, P. & Kim, K., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17030-17038 9 p.

Research output: Contribution to journalArticle

HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim- sulfamethoxazole inhibit plasmodium liver stages

Hobbs, C. V., Voza, T., De La Vega, P., Vanvliet, J., Conteh, S., Penzak, S. R., Fay, M. P., Anders, N., Ilmet, T., Li, Y., Borkowsky, W., Krzych, U., Duffy, P. E. & Sinnis, P., Dec 1 2012, In : Journal of Infectious Diseases. 206, 11, p. 1706-1714 9 p.

Research output: Contribution to journalArticle

HIV protease inhibitors inhibit the development of preerythrocytic-stage Plasmodium parasites

Hobbs, C. V., Voza, T., Coppi, A., Kirmse, B., Marsh, K., Borkowsky, W. & Sinnis, P., Jan 1 2009, In : Journal of Infectious Diseases. 199, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Host biotin is required for liver stage development in malaria parasites

Dellibovi-Ragheb, T. A., Jhun, H., Goodman, C. D., Walters, M. S., Ragheb, D. R. T., Matthews, K. A., Rajaram, K., Mishra, S., McFadden, G. I., Sinnis, P. & Prigge, S. T., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 11, p. E2604-E2613

Research output: Contribution to journalArticle

Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection

Dundas, K., Shears, M. J., Sinnis, P. & Wright, G. J., Jan 1 2018, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

Inhibition by stabilization: Targeting the Plasmodium falciparum aldolase-TRAP complex

Nemetski, S. M., Cardozo, T. J., Bosch, G., Weltzer, R., O'Malley, K., Ejigiri, I., Kumar, K. A., Buscaglia, C. A., Nussenzweig, V., Sinnis, P., Levitskaya, J. & Bosch, J., Aug 20 2015, In : Malaria journal. 14, 1, 324.

Research output: Contribution to journalArticle

Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes

Prasad, T. S. K., Mohanty, A. K., Kumar, M., Sreenivasamurthy, S. K., Dey, G., Nirujogi, R. S., Pinto, S. M., Madugundu, A. K., Patil, A. H., Advani, J., Manda, S. S., Gupta, M. K., Dwivedi, S. B., Kelkar, D. S., Hall, B., Jiang, X., Peery, A., Rajagopalan, P., Yelamanchi, S. D., Solanki, H. S. & 22 others, Raja, R., Sathe, G. J., Chavan, S., Verma, R., Patel, K. M., Jain, A. P., Syed, N., Datta, K. K., Khan, A. A., Dammalli, M., Jayaram, S., Radhakrishnan, A., Mitchell, C. J., Na, C. H., Kumar, N., Sinnis, P., Sharakhov, I. V., Wang, C., Gowda, H., Tu, Z., Kumar, A. & Pandey, A., Jan 2017, In : Genome research. 27, 1, p. 133-144 12 p.

Research output: Contribution to journalArticle

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Swearingen, K. E., Lindner, S. E., Shi, L., Shears, M. J., Harupa, A., Hopp, C. S., Vaughan, A. M., Springer, T. A., Moritz, R. L., Kappe, S. H. I. & Sinnis, P., Apr 1 2016, In : PLoS Pathogens. 12, 4, e1005606.

Research output: Contribution to journalArticle

Open Access

Longitudinal analysis of plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

Hopp, C. S., Chiou, K., Ragheb, D. R. T., Salman, A. M., Khan, S. M., Liu, A. J. & Sinnis, P., Aug 13 2015, In : eLife. 4, AUGUST2015, e07789.

Research output: Contribution to journalArticle

Long-range restriction maps of Plasmodium falciparum chromosomes: Crossingover and size variation among geographically distant isolates

Sinnis, P. & Wellems, T. E., Nov 1988, In : Genomics. 3, 4, p. 287-295 9 p.

Research output: Contribution to journalArticle

Lymph-Node Resident CD8α+ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8+ T Cell Responses

Radtke, A. J., Kastenmüller, W., Espinosa, D. A., Gerner, M. Y., Tse, S. W., Sinnis, P., Germain, R. N., Zavala, F. P. & Cockburn, I. A., Jan 1 2015, In : PLoS pathogens. 11, 2, e1004637.

Research output: Contribution to journalArticle

Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes

Frevert, U., Sinnis, P., Cerami, C., Shreffler, W., Takacs, B. & Nussenzweig, V., May 1 1993, In : Journal of Experimental Medicine. 177, 5, p. 1287-1298 12 p.

Research output: Contribution to journalArticle

Open Access

Malaria in India: The Center for the Study of Complex Malaria in India

Das, A., Anvikar, A. R., Cator, L. J., Dhiman, R. C., Eapen, A., Mishra, N., Nagpal, B. N., Nanda, N., Raghavendra, K., Read, A. F., Sharma, S. K., Singh, O. P., Singh, V., Sinnis, P., Srivastava, H. C., Sullivan, S. A., Sutton, P. L., Thomas, M. B., Carlton, J. M. & Valecha, N., Mar 1 2012, In : Acta Tropica. 121, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum

Sack, B. K., Miller, J. L., Vaughan, A. M., Douglass, A., Kaushansky, A., Mikolajczak, S., Coppi, A., Gonzalez-Aseguinolaza, G., Tsuji, M., Zavala, F., Sinnis, P. & Kappe, S. H. I., Feb 1 2014, In : Infection and immunity. 82, 2, p. 808-817 10 p.

Research output: Contribution to journalArticle

Mosquito heparan sulfate and its potential role in malaria infection and transmission

Sinnis, P., Coppi, A., Toida, T., Toyoda, H., Kinoshita-Toyoda, A., Xie, J., Kemp, M. M. & Linhardt, R. J., Aug 31 2007, In : Journal of Biological Chemistry. 282, 35, p. 25376-25384 9 p.

Research output: Contribution to journalArticle

Noninvasive real-time monitoring of liver-stage development of bioluminescent plasmodium parasites

Mwakingwe, A., Ting, L. M., Hochman, S., Chen, J., Sinnis, P. & Kim, K., Nov 1 2009, In : Journal of Infectious Diseases. 200, 9, p. 1470-1478 9 p.

Research output: Contribution to journalArticle

Overexpression of Plasmodium berghei ATG8 by liver forms leads to cumulative defects in organelle dynamics and to generation of noninfectious merozoites

Voss, C., Ehrenman, K., Mlambo, G., Mishra, S., Kumar, K. A., Sacci, J. B., Sinnis, P. & Coppens, I., 2016, In : mBio. 7, 3, e00682-16.

Research output: Contribution to journalArticle

Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium

Hopp, C. S., Balaban, A. E., Bushell, E. S. C., Billker, O., Rayner, J. C. & Sinnis, P., 2016, (Accepted/In press) In : Cellular Microbiology.

Research output: Contribution to journalArticle

Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice

Pal, P., Balaban, A. E., DIamond, M. S., Sinnis, P., Klein, R. S. & Goldberg, D. E., May 2017, In : PloS one. 12, 5, e0177142.

Research output: Contribution to journalArticle

Plasmodium protease rom1 is important for proper formation of the parasitophorous vacuole

Vera, I. M., Beatty, W. L., Sinnis, P. & Kim, K., Sep 1 2011, In : PLoS pathogens. 7, 9, e1002197.

Research output: Contribution to journalArticle

Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein

Marshall, P., Rohlmann, A., Nussenzweig, V., Herz, J. & Sinnis, P., Mar 5 2000, In : Molecular and Biochemical Parasitology. 106, 2, p. 293-298 6 p.

Research output: Contribution to journalArticle

Plasmodium sporozoites trickle out of the injection site

Yamauchi Lucy M., L. M., Coppi, A., Snounou, G. & Sinnis, P., May 1 2007, In : Cellular microbiology. 9, 5, p. 1215-1222 8 p.

Research output: Contribution to journalArticle

Plasmodium yoelii sporozoites infect CD36-deficient mice

Sinnis, P. & Febbraio, M., Jan 1 2002, In : Experimental Parasitology. 100, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

Platelet factor 4 activity against P. Falciparum and its translation to nonpeptidic mimics as antimalarials

Love, M. S., Millholland, M. G., Mishra, S., Kulkarni, S., Freeman, K. B., Pan, W., Kavash, R. W., Costanzo, M. J., Jo, H., Daly, T. M., Williams, D. R., Kowalska, M. A., Bergman, L. W., Poncz, M., Degrado, W. F., Sinnis, P., Scott, R. W. & Greenbaum, D. C., Dec 13 2012, In : Cell Host and Microbe. 12, 6, p. 815-823 9 p.

Research output: Contribution to journalArticle

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

Aguiar, A. C. C., Figueiredo, F. J. B., Neuenfeldt, P. D., Katsuragawa, T. H., Drawanz, B. B., Cunico, W., Sinnis, P., Zavala, F. P. & Krettli, A. U., Mar 9 2017, In : Malaria Journal. 16, 1, 110.

Research output: Contribution to journalArticle