1988 …2019

Research output per year

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Research Output

1988

Long-range restriction maps of Plasmodium falciparum chromosomes: Crossingover and size variation among geographically distant isolates

Sinnis, P. & Wellems, T. E., Nov 1988, In : Genomics. 3, 4, p. 287-295 9 p.

Research output: Contribution to journalArticle

1992

The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of plasmodium falciparum sporozoites

Cerami, C., Frevert, U., Sinnis, P., Takacs, B., Clavijo, P., Santos, M. J. & Nussenzweig, V., Sep 18 1992, In : Cell. 70, 6, p. 1021-1033 13 p.

Research output: Contribution to journalArticle

1993

Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes

Frevert, U., Sinnis, P., Cerami, C., Shreffler, W., Takacs, B. & Nussenzweig, V., May 1 1993, In : Journal of Experimental Medicine. 177, 5, p. 1287-1298 12 p.

Research output: Contribution to journalArticle

Open Access
1994

Rapid clearance of malaria circumsporozoite protein (CS) by hepatocytes

Cerami, C., Frevert, U., Sinnis, P., Takacs, B. & Nussenzweig, V., Feb 1 1994, In : Journal of Experimental Medicine. 179, 2, p. 695-701 7 p.

Research output: Contribution to journalArticle

Open Access

Structural and functional properties of region II-plus of the malaria circumsporozoite protein

Sinnis, P., Clavijo, P., Fenyö, D., Chait, B. T., Cerami, C. & Nussenzweig, V., Jul 1 1994, In : Journal of Experimental Medicine. 180, 1, p. 297-306 10 p.

Research output: Contribution to journalArticle

1996

Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro

Frevert, U., Sinnis, P., Esko, J. D. & Nussenzweig, V., Jan 1 1996, In : Molecular and Biochemical Parasitology. 76, 1-2, p. 257-266 10 p.

Research output: Contribution to journalArticle

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes

Sinnis, P., Jan 1 1996, In : Journal of Investigative Medicine. 44, 3, p. 200a

Research output: Contribution to journalArticle

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes

Sinnis, P., Willnow, T. E., Briones, M. R. S., Herz, J. & Nussenzweig, V., Sep 1 1996, In : Journal of Experimental Medicine. 184, 3, p. 945-954 10 p.

Research output: Contribution to journalArticle

Open Access

The malaria sporozoite's journey into the liver

Sinnis, P., Jul 25 1996, In : Infectious Agents and Disease. 5, 3, p. 182-189 8 p.

Research output: Contribution to journalReview article

1997

Anopheles stephensi salivary glands bear receptors for region I of the circumsporozoite protein of Plasmodium falciparum

Sidjanski, S. P., Vanderberg, J. P. & Sinnis, P., Dec 1 1997, In : Molecular and Biochemical Parasitology. 90, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG

Gantt, S. M., Clavijo, P., Bai, X., Esko, J. D. & Sinnis, P., Aug 1 1997, In : Journal of Biological Chemistry. 272, 31, p. 19205-19213 9 p.

Research output: Contribution to journalArticle

Cell invasion by the vertebrate stages of Plasmodium

Sinnis, P. & Sim, B. K. L., Feb 1997, In : Trends in Microbiology. 5, 2, p. 52-58 7 p.

Research output: Contribution to journalReview article

1998

An immunoradiometric assay for the quantification of Plasmodium sporozoite invasion of HepG2 cells

Sinnis, P., Dec 1 1998, In : Journal of Immunological Methods. 221, 1-2, p. 17-23 7 p.

Research output: Contribution to journalArticle

Proteasome inhibitors block development of Plasmodium spp.

Gantt, S. M., Myung, J. M., Briones, M. R. S., Li, W. D., Corey, E. J., Omura, S., Nussenzweig, V. & Sinnis, P., Oct 1 1998, In : Antimicrobial agents and chemotherapy. 42, 10, p. 2731-2738 8 p.

Research output: Contribution to journalArticle

1999

The sorozoite, the merozoite, and the infected red cell: Parasite ligands and host receptors

Chitnis, C. E., Sinnis, P. & Miller, L. H., Jan 1 1999, Malaria: Molecular and Clinical Aspects. CRC Press, p. 249-285 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2000

Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein

Marshall, P., Rohlmann, A., Nussenzweig, V., Herz, J. & Sinnis, P., Mar 5 2000, In : Molecular and Biochemical Parasitology. 106, 2, p. 293-298 6 p.

Research output: Contribution to journalArticle

2001

The Binding of the Circumsporozoite Protein to Cell Surface Heparan Sulfate Proteoglycans is Required for Plasmodium Sporozoite Attachment to Target Cells

Pinzon-Ortiz, C., Friedman, J., Esko, J. & Sinnis, P., Jul 20 2001, In : Journal of Biological Chemistry. 276, 29, p. 26784-26791 8 p.

Research output: Contribution to journalArticle

2002

Plasmodium yoelii sporozoites infect CD36-deficient mice

Sinnis, P. & Febbraio, M., Jan 1 2002, In : Experimental Parasitology. 100, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

Sporozoite antigens: Biology and immunology of the circumsporozoite protein and thrombospondin-related anonymous protein

Sinnis, P. & Nardin, E., May 27 2002, In : Chemical Immunology. 80, p. 70-96 27 p.

Research output: Contribution to journalReview article

2004

The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites

Myung, J. M., Marshall, P. & Sinnis, P., Jan 2004, In : Molecular and Biochemical Parasitology. 133, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

2005

Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes

Medica, D. L. & Sinnis, P., Jul 1 2005, In : Infection and immunity. 73, 7, p. 4363-4369 7 p.

Research output: Contribution to journalArticle

The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion

Coppi, A., Pinzon-Ortiz, C., Hutter, C. & Sinnis, P., Jan 3 2005, In : Journal of Experimental Medicine. 201, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

2006

Antimalarial activity of allicin, a biologically active compound from garlic cloves

Coppi, A., Cabinian, M., Mirelman, D. & Sinnis, P., May 1 2006, In : Antimicrobial agents and chemotherapy. 50, 5, p. 1731-1737 7 p.

Research output: Contribution to journalArticle

Transgenic Plasmodium berghei sporozoites expressing β-galactosidase for quantification of sporozoite transmission

Engelmann, S., Sinnis, P. & Matuschewski, K., Mar 1 2006, In : Molecular and Biochemical Parasitology. 146, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

2007

A long and winding road: The Plasmodium sporozoite's journey in the mammalian host

Sinnis, P. & Coppi, A., Sep 1 2007, In : Parasitology International. 56, 3, p. 171-178 8 p.

Research output: Contribution to journalReview article

Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity

Kelly, B. A., Neil, S. J., McKnight, Á., Santos, J. M., Sinnis, P., Jack, E. R., Middleton, D. A. & Dobson, C. B., Sep 1 2007, In : FEBS Journal. 274, 17, p. 4511-4525 15 p.

Research output: Contribution to journalArticle

Erratum: Plasmodium sporozoites trickle out of the injection site (Cellular Microbiology)

Yamauchi, L. M., Coppi, A., Snounou, G. & Sinnis, P., Aug 1 2007, In : Cellular microbiology. 9, 8, 1 p.

Research output: Contribution to journalComment/debate

Furuncular myiasis caused by Dermatobia hominis in a returning traveler

Bhandari, R., Janos, D. P. & Sinnis, P., Mar 1 2007, In : American Journal of Tropical Medicine and Hygiene. 76, 3, p. 598-599 2 p.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans Provide a Signal to Plasmodium Sporozoites to Stop Migrating and Productively Invade Host Cells

Coppi, A., Tewari, R., Bishop, J. R., Bennett, B. L., Lawrence, R., Esko, J. D., Billker, O. & Sinnis, P., Nov 15 2007, In : Cell Host and Microbe. 2, 5, p. 316-327 12 p.

Research output: Contribution to journalArticle

Mosquito heparan sulfate and its potential role in malaria infection and transmission

Sinnis, P., Coppi, A., Toida, T., Toyoda, H., Kinoshita-Toyoda, A., Xie, J., Kemp, M. M. & Linhardt, R. J., Aug 31 2007, In : Journal of Biological Chemistry. 282, 35, p. 25376-25384 9 p.

Research output: Contribution to journalArticle

Plasmodium sporozoites trickle out of the injection site

Yamauchi Lucy M., L. M., Coppi, A., Snounou, G. & Sinnis, P., May 1 2007, In : Cellular microbiology. 9, 5, p. 1215-1222 8 p.

Research output: Contribution to journalArticle

Sterile protection against malaria is independent of immune responses to the circumsporozoite protein

Grüner, A. C., Mauduit, M., Tewari, R., Romero, J. F., Depinay, N., Kayibanda, M., Lallemand, E., Chavatte, J. M., Crisanti, A., Sinnis, P., Mazier, D., Corradin, G., Snounou, G. & Rénia, L., Dec 26 2007, In : PloS one. 2, 12, e1371.

Research output: Contribution to journalArticle

2008

Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity

Ting, L. M., Gissot, M., Coppi, A., Sinnis, P. & Kim, K., Sep 1 2008, In : Nature medicine. 14, 9, p. 954-958 5 p.

Research output: Contribution to journalArticle

CO-Opting the Host HO-1 Pathway in Tuberculosis and Malaria

Sinnis, P. & Ernst, J. D., May 15 2008, In : Cell Host and Microbe. 3, 5, p. 277-279 3 p.

Research output: Contribution to journalShort survey

High mobility group protein HMGB2 is a critical regulator of Plasmodium oocyst development

Gissot, M., Ting, L. M., Daly, T. M., Bergman, L. W., Sinnis, P. & Kim, K., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17030-17038 9 p.

Research output: Contribution to journalArticle

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

Yu, M., Kumar, T. R. S., Nkrumah, L. J., Coppi, A., Retzlaff, S., Li, C. D., Kelly, B. J., Moura, P. A., Lakshmanan, V., Freundlich, J. S., Valderramos, J. C., Vilcheze, C., Siedner, M., Tsai, J. H. C., Falkard, B., Sidhu, A. B. S., Purcell, L. A., Gratraud, P., Kremer, L., Waters, A. P. & 9 others, Schiehser, G., Jacobus, D. P., Janse, C. J., Ager, A., Jacobs, W. R., Sacchettini, J. C., Heussler, V., Sinnis, P. & Fidock, D. A., Dec 11 2008, In : Cell Host and Microbe. 4, 6, p. 567-578 12 p.

Research output: Contribution to journalArticle

The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites

Moreira, C. K., Templeton, T. J., Lavazec, C., Hayward, R. E., Hobbs, C. V., Kroeze, H., Janse, C. J., Waters, A. P., Sinnis, P. & Coppi, A., Jul 1 2008, In : Cellular microbiology. 10, 7, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

The skin stage of malaria infection: Biology and relevance to the malaria vaccine effort

Sinnis, P. & Zavala, F., Jun 1 2008, In : Future microbiology. 3, 3, p. 275-278 4 p.

Research output: Contribution to journalReview article

Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage

Belnoue, E., Voza, T., Costa, F. T. M., Grüner, A. C., Mauduit, M., Rosa, D. S., Depinay, N., Kayibanda, M., Vigário, A. M., Mazier, D., Snounou, G., Sinnis, P. & Rénia, L., Dec 15 2008, In : Journal of Immunology. 181, 12, p. 8552-8558 7 p.

Research output: Contribution to journalArticle

Open Access
2009

Giardiasis

Sinnis, P., Jan 1 2009, Medical Parasitology. CRC Press, p. 195-205 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

HIV protease inhibitors inhibit the development of preerythrocytic-stage Plasmodium parasites

Hobbs, C. V., Voza, T., Coppi, A., Kirmse, B., Marsh, K., Borkowsky, W. & Sinnis, P., Jan 1 2009, In : Journal of Infectious Diseases. 199, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Noninvasive real-time monitoring of liver-stage development of bioluminescent plasmodium parasites

Mwakingwe, A., Ting, L. M., Hochman, S., Chen, J., Sinnis, P. & Kim, K., Nov 1 2009, In : Journal of Infectious Diseases. 200, 9, p. 1470-1478 9 p.

Research output: Contribution to journalArticle

Plasmodium sporozoite-host interactions from the dermis to the hepatocyte

Ejigiri, I. & Sinnis, P., Aug 1 2009, In : Current Opinion in Microbiology. 12, 4, p. 401-407 7 p.

Research output: Contribution to journalReview article

2010

Structure-based design of novel small-molecule inhibitors of plasmodium falciparum

Kortagere, S., Welsh, W. J., Morrisey, J. M., Daly, T., Ejigiri, I., Sinnis, P., Vaidya, A. B. & Bergman, L. W., May 24 2010, In : Journal of Chemical Information and Modeling. 50, 5, p. 840-849 10 p.

Research output: Contribution to journalArticle

What can we learn from an unnatural immune response?

Bennett, B. L. & Sinnis, P., Jul 1 2010, In : Trends in parasitology. 26, 7, p. 319-321 3 p.

Research output: Contribution to journalShort survey

2011

Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo

Cockburn, I. A., Tse, S. W., Radtke, A. J., Srinivasan, P., Chen, Y. C., Sinnis, P. & Zavala, F., Mar 1 2011, In : PLoS pathogens. 7, 3, e1001318.

Research output: Contribution to journalArticle

Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes

Ecker, A., Lakshmanan, V., Sinnis, P., Coppens, I. & Fidock, D. A., Jan 15 2011, In : Journal of Infectious Diseases. 203, 2, p. 228-236 9 p.

Research output: Contribution to journalArticle

Plasmodium protease rom1 is important for proper formation of the parasitophorous vacuole

Vera, I. M., Beatty, W. L., Sinnis, P. & Kim, K., Sep 1 2011, In : PLoS pathogens. 7, 9, e1002197.

Research output: Contribution to journalArticle

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

Coppi, A., Natarajan, R., Pradel, G., Bennett, B. L., James, E. R., Roggero, M. A., Corradin, G., Persson, C., Tewari, R. & Sinnis, P., Feb 14 2011, In : Journal of Experimental Medicine. 208, 2, p. 341-356 16 p.

Research output: Contribution to journalArticle

2012