1988 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Comparative 3D genome organization in apicomplexan parasites

Bunnik, E. M., Venkat, A., Shao, J., McGovern, K. E., Batugedara, G., Worth, D., Prudhomme, J., Lapp, S. A., Andolina, C., Ross, L. S., Lawres, L., Brady, D., Sinnis, P., Nosten, F., Fidock, D. A., Wilson, E. H., Tewari, R., Galinski, M. R., Mamoun, C. B., Ay, F. & 1 others, Le Roch, K. G., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3183-3192 10 p.

Research output: Contribution to journalArticle

Erratum to: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite (Nature Medicine, (2018), 24, 4, (408-416), 10.1038/nm.4512)

Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E. I., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A. & 18 others, Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G. Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F. P., Pancera, M. & Seder, R. A., Jan 1 2019, In : Nature Medicine. 25, 1, p. 188-189 2 p.

Research output: Contribution to journalComment/debate

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

McLean, K. J., Straimer, J., Hopp, C. S., Vega-Rodriguez, J., Small-Saunders, J. L., Kanatani, S., Tripathi, A., Mlambo, G., Dumoulin, P. C., Harris, C. T., Tong, X., Shears, M. J., Ankarklev, J., Kafsack, B. F. C., Fidock, D. A. & Sinnis, P., Sep 11 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria

Shears, M. J., Sekhar Nirujogi, R., Swearingen, K. E., Renuse, S., Mishra, S., Jaipal Reddy, P., Moritz, R. L., Pandey, A. & Sinnis, P., Sep 6 2019, In : Journal of proteome research. 18, 9, p. 3404-3418 15 p.

Research output: Contribution to journalArticle

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Lindner, S. E., Swearingen, K. E., Shears, M. J., Walker, M. P., Vrana, E. N., Hart, K. J., Minns, A. M., Sinnis, P., Moritz, R. L. & Kappe, S. H. I., Dec 1 2019, In : Nature communications. 10, 1, 4964.

Research output: Contribution to journalArticle

Open Access
2018

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E. I., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A. & 18 others, Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G. Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F. P., Pancera, M. & Seder, R. A., May 1 2018, In : Nature Medicine. 24, 4, p. 408-416 9 p.

Research output: Contribution to journalArticle

Alpha-v–containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP

Dundas, K., Shears, M. J., Sun, Y., Hopp, C. S., Crosnier, C., Metcalf, T., Girling, G., Sinnis, P., Billker, O. & Wright, G. J., Apr 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. 4477-4482 6 p.

Research output: Contribution to journalArticle

A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Schleicher, T. R., Yang, J., Freudzon, M., Rembisz, A., Craft, S., Hamilton, M., Graham, M., Mlambo, G., Tripathi, A., Li, Y., Cresswell, P., Sinnis, P., Dimopoulos, G. & Fikrig, E., Dec 1 2018, In : Nature Communications. 9, 1, 2908.

Research output: Contribution to journalArticle

Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site

Flores-Garcia, Y., Nasir, G., Hopp, C. S., Munoz, C., Balaban, A. E., Zavala, F. P. & Sinnis, P., Nov 20 2018, In : mBio. 9, 6

Research output: Contribution to journalArticle

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

Bunnik, E. M., Cook, K. B., Varoquaux, N., Batugedara, G., Prudhomme, J., Cort, A., Shi, L., Andolina, C., Ross, L. S., Brady, D., Fidock, D. A., Nosten, F., Tewari, R., Sinnis, P., Ay, F., Vert, J. P., Noble, W. S. & Le Roch, K. G., Dec 1 2018, In : Nature communications. 9, 1, 1910.

Research output: Contribution to journalArticle

Host biotin is required for liver stage development in malaria parasites

Dellibovi-Ragheb, T. A., Jhun, H., Goodman, C. D., Walters, M. S., Ragheb, D. R. T., Matthews, K. A., Rajaram, K., Mishra, S., McFadden, G. I., Sinnis, P. & Prigge, S. T., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 11, p. E2604-E2613

Research output: Contribution to journalArticle

Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection

Dundas, K., Shears, M. J., Sinnis, P. & Wright, G. J., Jan 1 2018, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

Robust fluorescent labelling of micropipettes for use in fluorescence microscopy: application to the observation of a mosquito borne parasite infection

Balaban, A. E., Neuman, K., Sinnis, P. & Balaban, R. S., Jan 1 2018, In : Journal of Microscopy. 269, 1, p. 78-84 7 p.

Research output: Contribution to journalArticle

2017

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites

Hopp, C. S., Bennett, B. L., Mishra, S., Lehmann, C., Hanson, K. K., Lin, J. W., Rousseau, K., Carvalho, F. A., van der Linden, W. A., Santos, N. C., Bogyo, M., Khan, S. M., Heussler, V. & Sinnis, P., Sep 2017, In : PLoS pathogens. 13, 9, e1006586.

Research output: Contribution to journalArticle

Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes

Prasad, T. S. K., Mohanty, A. K., Kumar, M., Sreenivasamurthy, S. K., Dey, G., Nirujogi, R. S., Pinto, S. M., Madugundu, A. K., Patil, A. H., Advani, J., Manda, S. S., Gupta, M. K., Dwivedi, S. B., Kelkar, D. S., Hall, B., Jiang, X., Peery, A., Rajagopalan, P., Yelamanchi, S. D., Solanki, H. S. & 22 others, Raja, R., Sathe, G. J., Chavan, S., Verma, R., Patel, K. M., Jain, A. P., Syed, N., Datta, K. K., Khan, A. A., Dammalli, M., Jayaram, S., Radhakrishnan, A., Mitchell, C. J., Na, C. H., Kumar, N., Sinnis, P., Sharakhov, I. V., Wang, C., Gowda, H., Tu, Z., Kumar, A. & Pandey, A., Jan 2017, In : Genome research. 27, 1, p. 133-144 12 p.

Research output: Contribution to journalArticle

Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice

Pal, P., Balaban, A. E., DIamond, M. S., Sinnis, P., Klein, R. S. & Goldberg, D. E., May 2017, In : PloS one. 12, 5, e0177142.

Research output: Contribution to journalArticle

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

Aguiar, A. C. C., Figueiredo, F. J. B., Neuenfeldt, P. D., Katsuragawa, T. H., Drawanz, B. B., Cunico, W., Sinnis, P., Zavala, F. P. & Krettli, A. U., Mar 9 2017, In : Malaria Journal. 16, 1, 110.

Research output: Contribution to journalArticle

2016

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Swearingen, K. E., Lindner, S. E., Shi, L., Shears, M. J., Harupa, A., Hopp, C. S., Vaughan, A. M., Springer, T. A., Moritz, R. L., Kappe, S. H. I. & Sinnis, P., Apr 1 2016, In : PLoS Pathogens. 12, 4, e1005606.

Research output: Contribution to journalArticle

Overexpression of Plasmodium berghei ATG8 by liver forms leads to cumulative defects in organelle dynamics and to generation of noninfectious merozoites

Voss, C., Ehrenman, K., Mlambo, G., Mishra, S., Kumar, K. A., Sacci, J. B., Sinnis, P. & Coppens, I., 2016, In : mBio. 7, 3, e00682-16.

Research output: Contribution to journalArticle

Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium

Hopp, C. S., Balaban, A. E., Bushell, E. S. C., Billker, O., Rayner, J. C. & Sinnis, P., 2016, (Accepted/In press) In : Cellular Microbiology.

Research output: Contribution to journalArticle

The plasmodium PHIST and RESA-like protein families of human and rodent malaria parasites

Moreira, C. K., Naissant, B., Coppi, A., Bennett, B. L., Aime, E., Franke-Fayard, B., Janse, C. J., Coppens, I., Sinnis, P. & Templeton, T. J., Mar 1 2016, In : PLoS One. 11, 3, e0152510.

Research output: Contribution to journalArticle

2015

Active migration and passive transport of malaria parasites

Douglas, R. G., Amino, R., Sinnis, P. & Frischknecht, F., Aug 1 2015, In : Trends in parasitology. 31, 8, p. 357-362 6 p.

Research output: Contribution to journalReview article

Inhibition by stabilization: Targeting the Plasmodium falciparum aldolase-TRAP complex

Nemetski, S. M., Cardozo, T. J., Bosch, G., Weltzer, R., O'Malley, K., Ejigiri, I., Kumar, K. A., Buscaglia, C. A., Nussenzweig, V., Sinnis, P., Levitskaya, J. & Bosch, J., Aug 20 2015, In : Malaria journal. 14, 1, 324.

Research output: Contribution to journalArticle

Longitudinal analysis of plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

Hopp, C. S., Chiou, K., Ragheb, D. R. T., Salman, A. M., Khan, S. M., Liu, A. J. & Sinnis, P., Aug 13 2015, In : eLife. 4, AUGUST2015, e07789.

Research output: Contribution to journalArticle

Lymph-Node Resident CD8α+ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8+ T Cell Responses

Radtke, A. J., Kastenmüller, W., Espinosa, D. A., Gerner, M. Y., Tse, S. W., Sinnis, P., Germain, R. N., Zavala, F. P. & Cockburn, I. A., Jan 1 2015, In : PLoS pathogens. 11, 2, e1004637.

Research output: Contribution to journalArticle

Proteolytic Cleavage of the Plasmodium falciparum Circumsporozoite Protein Is a Target of Protective Antibodies

Espinosa, D. A., Gutierrez, G. M., Rojas-Lopez, M., Noe, A. R., Shi, L., Tse, S. W., Sinnis, P. & Zavala, F., Oct 1 2015, In : Journal of Infectious Diseases. 212, 7, p. 1111-1119 9 p.

Research output: Contribution to journalArticle

Reversible conformational change in the plasmodium falciparum circumsporozoite protein masks Its adhesion domains

Herrera, R., Anderson, C., Kumar, K., Molina-Cruz, A., Nguyen, V., Burkhardt, M., Reiter, K., Shimp, R., Howard, R. F., Srinivasan, P., Nold, M. J., Ragheb, D., Shi, L., DeCotiis, M., Aebig, J., Lambert, L., Rausch, K. M., Muratova, O., Jin, A., Reed, S. G. & 5 others, Sinnis, P., Barillas-Mury, C., Duffy, P. E., MacDonald, N. J. & Naruma, D. L., Jan 1 2015, In : Infection and immunity. 83, 10, p. 3771-3780 10 p.

Research output: Contribution to journalArticle

The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin

Hopp, C. S. & Sinnis, P., Apr 1 2015, In : Annals of the New York Academy of Sciences. 1342, 1, p. 37-43 7 p.

Research output: Contribution to journalArticle

2014

A Cysteine Protease Inhibitor of Plasmodium berghei Is Essential for Exo-erythrocytic Development

Lehmann, C., Heitmann, A., Mishra, S., Burda, P. C., Singer, M., Prado, M., Niklaus, L., Lacroix, C., Ménard, R., Frischknecht, F., Stanway, R., Sinnis, P. & Heussler, V., Aug 28 2014, In : PLoS pathogens. 10, 8, e1004336.

Research output: Contribution to journalArticle

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum

Sack, B. K., Miller, J. L., Vaughan, A. M., Douglass, A., Kaushansky, A., Mikolajczak, S., Coppi, A., Gonzalez-Aseguinolaza, G., Tsuji, M., Zavala, F., Sinnis, P. & Kappe, S. H. I., Feb 1 2014, In : Infection and immunity. 82, 2, p. 808-817 10 p.

Research output: Contribution to journalArticle

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium

Ferguson, D. J. P., Balaban, A. E., Patzewitz, E. M., Wall, R. J., Hopp, C. S., Poulin, B., Mohmmed, A., Malhotra, P., Coppi, A., Sinnis, P. & Tewari, R., Dec 1 2014, In : PloS one. 9, 12, e113923.

Research output: Contribution to journalArticle

2013

A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites

Millholland, M. G., Mishra, S., Dupont, C. D., Love, M. S., Patel, B., Shilling, D., Kazanietz, M. G., Foskett, J. K., Hunter, C. A., Sinnis, P. & Greenbaum, D. C., Jan 16 2013, In : Cell Host and Microbe. 13, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

A key role for lipoic acid synthesis during Plasmodium liver stage development

Falkard, B., Kumar, T. R. S., Hecht, L. S., Matthews, K. A., Henrich, P. P., Gulati, S., Lewis, R. E., Manary, M. J., Winzeler, E. A., Sinnis, P., Prigge, S. T., Heussler, V., Deschermeier, C. & Fidock, D., Sep 1 2013, In : Cellular microbiology. 15, 9, p. 1585-1604 20 p.

Research output: Contribution to journalArticle

Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry

Sinnis, P., De La Vega, P., Coppi, A., Krzych, U. & Mota, M. M., 2013, Malaria: Methods and Protocols. Humana Press Inc., p. 385-400 16 p. (Methods in Molecular Biology; vol. 923).

Research output: Chapter in Book/Report/Conference proceedingChapter

Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry.

Sinnis, P., De La Vega, P., Coppi, A., Krzych, U. & Mota, M. M., 2013, In : Methods in molecular biology (Clifton, N.J.). 923, p. 385-400 16 p.

Research output: Contribution to journalArticle

The effect of antiretrovirals on Plasmodium falciparum liver stages

Hobbs, C. V., De La Vega, P., Penzak, S. R., Van Vliet, J., Krzych, U., Sinnis, P., Borkowsky, W. & Duffy, P. E., Jun 19 2013, In : AIDS. 27, 10, p. 1674-1677 4 p.

Research output: Contribution to journalArticle

Total and putative surface proteomics of malaria parasite salivary gland sporozoites

Lindner, S. E., Swearingen, K. E., Harupa, A., Vaughan, A. M., Sinnis, P., Moritz, R. L. & Kappe, S. H. I., May 1 2013, In : Molecular and Cellular Proteomics. 12, 5, p. 1127-1143 17 p.

Research output: Contribution to journalArticle

2012

HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim- sulfamethoxazole inhibit plasmodium liver stages

Hobbs, C. V., Voza, T., De La Vega, P., Vanvliet, J., Conteh, S., Penzak, S. R., Fay, M. P., Anders, N., Ilmet, T., Li, Y., Borkowsky, W., Krzych, U., Duffy, P. E. & Sinnis, P., Dec 1 2012, In : Journal of Infectious Diseases. 206, 11, p. 1706-1714 9 p.

Research output: Contribution to journalArticle

Malaria in India: The Center for the Study of Complex Malaria in India

Das, A., Anvikar, A. R., Cator, L. J., Dhiman, R. C., Eapen, A., Mishra, N., Nagpal, B. N., Nanda, N., Raghavendra, K., Read, A. F., Sharma, S. K., Singh, O. P., Singh, V., Sinnis, P., Srivastava, H. C., Sullivan, S. A., Sutton, P. L., Thomas, M. B., Carlton, J. M. & Valecha, N., Mar 1 2012, In : Acta Tropica. 121, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

Platelet factor 4 activity against P. Falciparum and its translation to nonpeptidic mimics as antimalarials

Love, M. S., Millholland, M. G., Mishra, S., Kulkarni, S., Freeman, K. B., Pan, W., Kavash, R. W., Costanzo, M. J., Jo, H., Daly, T. M., Williams, D. R., Kowalska, M. A., Bergman, L. W., Poncz, M., Degrado, W. F., Sinnis, P., Scott, R. W. & Greenbaum, D. C., Dec 13 2012, In : Cell Host and Microbe. 12, 6, p. 815-823 9 p.

Research output: Contribution to journalArticle

Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity

Ejigiri, I., Ragheb, D. R. T., Pino, P., Coppi, A., Bennett, B. L., Soldati-Favre, D. & Sinnis, P., Jul 1 2012, In : PLoS pathogens. 8, 7, 1 p., e1002725.

Research output: Contribution to journalArticle

The skin: Where malaria infection and the host immune response begin

Sinnis, P. & Zavala, F., Nov 1 2012, In : Seminars in Immunopathology. 34, 6, p. 787-792 6 p.

Research output: Contribution to journalReview article

2011

Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo

Cockburn, I. A., Tse, S. W., Radtke, A. J., Srinivasan, P., Chen, Y. C., Sinnis, P. & Zavala, F., Mar 1 2011, In : PLoS pathogens. 7, 3, e1001318.

Research output: Contribution to journalArticle

Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes

Ecker, A., Lakshmanan, V., Sinnis, P., Coppens, I. & Fidock, D. A., Jan 15 2011, In : Journal of Infectious Diseases. 203, 2, p. 228-236 9 p.

Research output: Contribution to journalArticle

Plasmodium protease rom1 is important for proper formation of the parasitophorous vacuole

Vera, I. M., Beatty, W. L., Sinnis, P. & Kim, K., Sep 1 2011, In : PLoS pathogens. 7, 9, e1002197.

Research output: Contribution to journalArticle

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

Coppi, A., Natarajan, R., Pradel, G., Bennett, B. L., James, E. R., Roggero, M. A., Corradin, G., Persson, C., Tewari, R. & Sinnis, P., Feb 14 2011, In : Journal of Experimental Medicine. 208, 2, p. 341-356 16 p.

Research output: Contribution to journalArticle