Philip Chun Wong

Professor

1990 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1990 2019

2019

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model

Müller, H. P., Brenner, D., Roselli, F., Wiesner, D., Abaei, A., Gorges, M., Danzer, K. M., Ludolph, A. C., Tsao, W., Wong, P. C., Rasche, V., Weishaupt, J. H. & Kassubek, J., Aug 30 2019, In : Translational Neurodegeneration. 8, 1, 27.

Research output: Contribution to journalArticle

Open Access
Pyramidal Tracts
Diffusion Magnetic Resonance Imaging
Corpus Callosum
Amyotrophic Lateral Sclerosis
Cohort Studies

Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI

Chen, L., Wei, Z., Chan, K. W. Y., Cai, S., Liu, G., Lu, H., Wong, P. C., Van Zijl, P. C., Li, T. & Xu, J., Mar 1 2019, In : NeuroImage. 188, p. 380-390 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Proteins
Protons
Water
Brain

Splicing repression is a major function of TDP-43 in motor neurons

Donde, A., Sun, M., Ling, J. P., Braunstein, K. E., Pang, B., Wen, X., Cheng, X., Chen, L. L. & Wong, P. C., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

Motor Neurons
Amyotrophic Lateral Sclerosis
RNA-Binding Proteins
Transcriptome
Drosophila

Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43

Donde, A., Sun, M., Jeong, Y. H., Wen, X., Ling, J., Lin, S., Braunstein, K., Nie, S., Wang, S., Chen, L. L. & Wong, P. C., Jan 1 2019, In : Autophagy.

Research output: Contribution to journalArticle

Autophagy
Motor Neurons
Up-Regulation
Amyotrophic Lateral Sclerosis
Frontotemporal Dementia
2018

Reversible induction of TDP-43 granules in cortical neurons after traumatic injury

Wiesner, D., Tar, L., Linkus, B., Chandrasekar, A., olde Heuvel, F., Dupuis, L., Tsao, W., Wong, P. C., Ludolph, A. & Roselli, F., Jan 1 2018, In : Experimental Neurology. 299, p. 15-25 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Neurons
Wounds and Injuries
Pathology
Stab Wounds
2017

An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks

Bedont, J. L., LeGates, T. A., Buhr, E., Bathini, A., Ling, J. P., Bell, B., Wu, M., Wong, P. C., Van Gelder, R. N., Mongrain, V., Hattar, S. & Blackshaw, S., Jan 9 2017, In : Current Biology. 27, 1, p. 128-136 9 p.

Research output: Contribution to journalArticle

vasoactive intestinal peptide
Suprachiasmatic Nucleus
Gene Regulatory Networks
Vasoactive Intestinal Peptide
sleep

Challenges and advances in gene therapy approaches for neurodegenerative disorders

Donde, A., Wong, P. C. & Chen, L. L., Jun 1 2017, In : Current Gene Therapy. 17, 3, p. 187-193 7 p.

Research output: Contribution to journalReview article

Antisense Oligonucleotides
Neurodegenerative Diseases
Genetic Therapy
Spinal Muscular Atrophy
United States Food and Drug Administration

Cryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43

Sun, M., Bell, W., LaClair, K. D., Ling, J. P., Han, H., Kageyama, Y., Pletnikova, O., Troncoso, J. C., Wong, P. C. & Chen, L. L., Mar 22 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-9 9 p.

Research output: Contribution to journalArticle

Intranuclear Inclusion Bodies
Exons
Alzheimer Disease
Brain
TDP-43 Proteinopathies

Tdp-43 cryptic exons are highly variable between cell types

Jeong, Y. H., Ling, J. P., Lin, S. Z., Donde, A. N., Braunstein, K. E., Majounie, E., Traynor, B. J., LaClair, K. D., Lloyd, T. & Wong, P. C., Feb 2 2017, In : Molecular Neurodegeneration. 12, 1, 13.

Research output: Contribution to journalArticle

Exons
TDP-43 Proteinopathies
Inclusion Body Myositis
Neurons
Skeletal Muscle Fibers
2016

Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model

LaClair, K. D., Donde, A., Ling, J. P., Jeong, Y. H., Chhabra, R., Martin, L. J. & Wong, P. C., Dec 1 2016, In : Acta Neuropathologica. 132, 6, p. 859-873 15 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Alzheimer Disease
TDP-43 Proteinopathies
Prosencephalon

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations

Le, N. T. T., Chang, L., Kovlyagina, I., Georgiou, P., Safren, N., Braunstein, K. E., Kvarta, M. D., Dyke, A. M. V., Legates, T. A., Philips, T., Morrison, B., Thompson, S. M., Puche, A. C., Gould, T. D., Rothstein, J. D., Wong, P. C. & Monteiro, M. J., Nov 22 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 47, p. E7580-E7589

Research output: Contribution to journalArticle

Frontotemporal Dementia
Motor Neuron Disease
Memory Disorders
Pathology
Mutation

PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons

Ling, J. P., Chhabra, R., Merran, J. D., Schaughency, P. M., Wheelan, S., Corden, J. L. & Wong, P. C., Sep 27 2016, In : Cell Reports. 17, 1, p. 104-113 10 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Exons
Microsatellite Repeats
Neurodegenerative diseases
RNA Splicing

Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis

El Oussini, H., Bayer, H., Scekic-Zahirovic, J., Vercruysse, P., Sinniger, J., Dirrig-Grosch, S., Dieterlé, S., Echaniz-Laguna, A., Larmet, Y., Müller, K., Weishaupt, J. H., Thal, D. R., van Rheenen, W., van Eijk, K., Lawson, R., Monassier, L., Maroteaux, L., Roumier, A., Wong, P. C., van den Berg, L. H. & 4 others, Ludolph, A. C., Veldink, J. H., Witting, A. & Dupuis, L., Mar 1 2016, In : Acta Neuropathologica. 131, 3, p. 465-480 16 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2B
Amyotrophic Lateral Sclerosis
Phagocytes
Disease Progression
Spinal Cord

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model

Li, T., Braunstein, K. E., Zhang, J., Lau, A., Sibener, L., Deeble, C. & Wong, P. C., Jul 4 2016, In : Nature Communications. 7, 12082.

Research output: Contribution to journalArticle

Amyloid Plaques
mice
Alzheimer Disease
Pathology
Amyloid
2015

Defective age-dependent metaplasticity in a mouse model of alzheimer’s disease

Megill, A., Tran, T., Eldred, K., Lee, N. J., Wong, P. C., Hoe, H. S., Kirkwood, A. & Lee, H-K., Aug 12 2015, In : Journal of Neuroscience. 35, 32, p. 11346-11357 12 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Alzheimer Disease
Depression
Transgenic Mice
AMPA Receptors

Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease

Heiman-Patterson, T. D., Blankenhorn, E. P., Sher, R. B., Jiang, J., Welsh, P., Dixon, M. C., Jeffrey, J. I., Wong, P. C., Cox, G. A. & Alexander, G. M., Mar 12 2015, In : PLoS One. 10, 3, e0117848.

Research output: Contribution to journalArticle

Motor Neuron Disease
motor neurons
genetic background
Neurons
animal models

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

Freibaum, B. D., Lu, Y., Lopez-Gonzalez, R., Kim, N. C., Almeida, S., Lee, K. H., Badders, N., Valentine, M., Miller, B. L., Wong, P. C., Petrucelli, L., Kim, H. J., Gao, F. B. & Taylor, J. P., Sep 3 2015, In : Nature. 525, 7567, p. 129-133 5 p.

Research output: Contribution to journalArticle

Nuclear Pore
Cell Nucleus Active Transport
RNA
Nuclear RNA
Induced Pluripotent Stem Cells

Intraventricular delivery of siRNA nanoparticles to the central nervous system

Shyam, R., Ren, Y., Lee, J., Braunstein, K. E., Mao, H. Q. & Wong, P. C., May 1 2015, In : Molecular Therapy - Nucleic Acids. 4, 5, e242.

Research output: Contribution to journalArticle

Nanoparticles
Small Interfering RNA
Central Nervous System
Polyethyleneimine
Alzheimer Disease

Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration

Wiesner, D., Sinniger, J., Henriques, A., Dieterlé, S., Müller, H. P., Rasche, V., Ferger, B., Dirrig-Grosch, S., Soylu-Kucharz, R., Petersén, A., Walther, P., Linkus, B., Kassubek, J., Wong, P. C., Ludolph, A. C. & Dupuis, L., Apr 15 2015, In : Human Molecular Genetics. 24, 8, p. 2228-2240 13 p., ddu741.

Research output: Contribution to journalArticle

Dyneins
Dietary Proteins
Autophagy
Diet Therapy
Mutation

TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

Ling, J. P., Pletnikova, O., Troncoso, J. C. & Wong, P. C., Aug 7 2015, In : Science. 349, 6248, p. 650-655 6 p.

Research output: Contribution to journalArticle

Exons
TDP-43 Proteinopathies
RNA-Binding Proteins
Introns
Cell Death
2014

Alzheimer Disease

Savonenko, A., Melnikova, T., Li, T., Price, D. L. & Wong, P. C., Dec 3 2014, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier Inc., p. 321-338 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alzheimer Disease
Neurons
tau Proteins
Neurofibrillary Tangles
Neurobiology

Function, therapeutic potential and cell biology of BACE proteases: Current status and future prospects

Vassar, R., Kuhn, P. H., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C. & Lichtenthaler, S. F., 2014, In : Journal of Neurochemistry. 130, 1, p. 4-28 25 p.

Research output: Contribution to journalArticle

Cytology
Amyloid beta-Protein Precursor
Cell Biology
Peptide Hydrolases
Nervous System

Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice

Wang, H., Megill, A., Wong, P. C., Kirkwood, A. & Lee, H-K., Mar 17 2014, In : PLoS One. 9, 3, e92279.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
amyloid
Knockout Mice
mice
Enzymes
2013

Altered astrocytic expression of TDP-43 does not influence motor neuron survival

Haidet-Phillips, A. M., Gross, S. K., Williams, T., Tuteja, A., Sherman, A., Ko, M., Jeong, Y. H., Wong, P. C. & Maragakis, N. J., Dec 2013, In : Experimental Neurology. 250, p. 250-259 10 p.

Research output: Contribution to journalArticle

Tars
DNA-Binding Proteins
Motor Neurons
Astrocytes
Amyotrophic Lateral Sclerosis
Apolipoproteins E
bexarotene

Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients

Hatzimanolis, A., McGrath, J. A., Wang, R., Li, T., Wong, P. C., Nestadt, G., Wolyniec, P. S., Valle, D., Pulver, A. E. & Avramopoulos, D., 2013, In : Translational Psychiatry. 3, e264.

Research output: Contribution to journalArticle

Neuregulins
Schizophrenia
Amyloid Precursor Protein Secretases
Genes
Gene Components

The dynactin p150 subunit: Cell biology studies of sequence changes found in ALS/MND and Parkinsonian Syndromes

Stockmann, M., Meyer-Ohlendorf, M., Achberger, K., Putz, S., Demestre, M., Yin, H., Hendrich, C., Linta, L., Heinrich, J., Brunner, C., Proepper, C., Kuh, G. F., Baumann, B., Langer, T., Schwalenstöcker, B., Braunstein, K. E., Von Arnim, C., Schneuwly, S., Meyer, T., Wong, P. C. & 3 others, Boeckers, T. M., Ludolph, A. C. & Liebau, S., May 2013, In : Journal of Neural Transmission. 120, 5, p. 785-798 14 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Motor Neurons
Cell Biology
Dyneins
Axonal Transport

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

Laclair, K. D., Manaye, K. F., Lee, D. L., Allard, J. S., Savonenko, A., Troncoso, J. C. & Wong, P. C., 2013, In : Molecular Neurodegeneration. 8, 1, 18.

Research output: Contribution to journalArticle

Apolipoproteins E
Retinoid X Receptors
Alzheimer Disease
Brain
Amyloidosis
2012

Alzheimer's therapeutics: Translation of preclinical science to clinical drug development

Savonenko, A., Melnikova, T., Hiatt, A., Li, T., Worley, P. F., Troncoso, J. C., Wong, P. C. & Price, D. L., Jan 2012, In : Neuropsychopharmacology. 37, 1, p. 261-277 17 p.

Research output: Contribution to journalArticle

Clinical Trials
Pharmaceutical Preparations
Amyloid Precursor Protein Secretases
Translational Medical Research
Neurobiology

Alzheimer’s disease

Price, D. L., Savonenko, A., Li, T. & Wong, P. C., Jan 1 2012, Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. Cambridge University Press, p. 149-167 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurofibrillary Tangles
Alzheimer Disease
Neurons
Synapses
Microtubule-Associated Proteins

Motor Neuron Diseases

Wong, P. C., Chiang, P. M., Martin, L. J., Koliatsos, V. E. & Price, D. L., 2012, Basic Neurochemistry. Elsevier, p. 801-814 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Motor Neuron Disease

Neurobiology of Alzheimer's Disease

Wong, P. C., Savonenko, A., Li, T. & Price, D. L., 2012, Basic Neurochemistry. Elsevier, p. 815-828 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurobiology
Alzheimer Disease

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

Hayashi, I., Takatori, S., Urano, Y., Miyake, Y., Takagi, J., Sakata-Yanagimoto, M., Iwanari, H., Osawa, S., Morohashi, Y., Li, T., Wong, P. C., Chiba, S., Kodama, T., Hamakubo, T., Tomita, T. & Iwatsubo, T., Feb 2012, In : Oncogene. 31, 6, p. 787-798 12 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Monoclonal Antibodies
Presenilins
Notch Receptors
Neoplasms

Rodent models of TDP-43: Recent advances

Tsao, W., Jeong, Y. H., Lin, S., Ling, J., Price, D. L., Chiang, P. M. & Wong, P. C., Jun 26 2012, In : Brain Research. 1462, p. 26-39 14 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Rodentia
Genetic Association Studies
Motor Neurons
Missense Mutation

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin

Chiang, P. M., Fortna, R. R., Price, D. L., Li, T. & Wong, P. C., Feb 2012, In : Neurobiology of Aging. 33, 2, p. 277-285 9 p.

Research output: Contribution to journalArticle

Presenilins
Pharynx
Amyloid Precursor Protein Secretases
Mutation
Presenilin-2
2011

Amyloid precursor protein processing and alzheimer's disease

O'Brien, R. J. & Wong, P. C., Jul 21 2011, In : Annual Review of Neuroscience. 34, p. 185-204 20 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Brain
Behavioral Research
Serum Amyloid A Protein

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

Wu, J., Petralia, R. S., Kurushima, H., Patel, H., Jung, M. Y., Volk, L., Chowdhury, S., Shepherd, J. D., Dehoff, M., Li, Y., Kuhl, D., Huganir, R. L., Price, D. L., Scannevin, R., Troncoso, J. C., Wong, P. C. & Worley, P. F., Oct 28 2011, In : Cell. 147, 3, p. 615-628 14 p.

Research output: Contribution to journalArticle

Amyloid
Amyloid Precursor Protein Secretases
Alzheimer Disease
Endosomes
Dynamin III

Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4

Chiang, P. M. & Wong, P. C., Jul 1 2011, In : Development. 138, 13, p. 2833-2843 11 p.

Research output: Contribution to journalArticle

Hemangioblasts
Bone Morphogenetic Protein 4
Embryonic Stem Cells
Embryoid Bodies
Feeder Cells

Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA micellar nanoparticles by Co-condensation with sodium triphosphate

Nakanishi, M., Patil, R., Ren, Y., Shyam, R., Wong, P. C. & Mao, H. Q., Jul 2011, In : Pharmaceutical Research. 28, 7, p. 1723-1732 10 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Nanoparticles
Small Interfering RNA
Polyethylene glycols
Condensation

Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo

Li, T., Li, Y. M., Ahn, K., Price, D. L., Sisodia, S. S. & Wong, P. C., Nov 29 2011, In : PLoS One. 6, 11, e28179.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Alzheimer disease
mutants
brain
risk factors

Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system

Farah, M. H., Pan, B., Hoffman, P. N., Ferraris, D., Tsukamoto, T., Nguyen, T., Wong, P. C., Price, D. L., Slusher, B. & Griffin, J. W., Apr 13 2011, In : Journal of Neuroscience. 31, 15, p. 5744-5754 11 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Peripheral Nervous System
Myelin Sheath
Axons
Regeneration

Selectivity to amyloid- precursor protein cleavage provides hope against Alzheimer's

Tomita, T. & Wong, P. C., 2011, In : Alzheimer's Research and Therapy. 3, 2, 7.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Amyloid
Alzheimer Disease
Pharmaceutical Preparations
2010

Aging of the Brain and Alzheimer's Disease

Price, D. L., Savonenko, A., Albert, M., Troncoso, J. C. & Wong, P. C., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 187-195 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain Diseases
Alzheimer Disease
Amyloid Precursor Protein Secretases
Peptides
Amyloid

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice

Shan, X., Chiang, P. M., Price, D. L. & Wong, P. C., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16325-16330 6 p.

Research output: Contribution to journalArticle

Gemini of Coiled Bodies
DNA-Binding Proteins
Motor Neurons
Transgenic Mice
Mitochondria

Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics

Price, D. L., Savonenko, A., Li, T., Lee, M. K. & Wong, P. C., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 231-258 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid Precursor Protein Secretases
Alzheimer Disease
Theoretical Models
Proteins
Therapeutics

An overview of APP processing enzymes and products.

Chow, V. W., Mattson, M. P., Wong, P. C. & Gleichmann, M., Mar 2010, In : NeuroMolecular Medicine. 12, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Enzymes
Amyloid Precursor Protein Secretases
Alzheimer Disease

Axonal Transport Disorders

Hoffman, P. N., Wong, P. C., Griffin, J. W. & Price, D. L., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 1205-1208 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Axonal Transport
Presynaptic Terminals
Proteins
Dendrites
Neurons

BACE1 deficiency causes altered neuronal activity and neurodegeneration

Hu, X., Zhou, X., He, W., Yang, J., Xiong, W., Wong, P. C., Wilson, C. G. & Yan, R., Jun 30 2010, In : Journal of Neuroscience. 30, 26, p. 8819-8829 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Neurons
Seizures
Amyloid
Epilepsy

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Adipose Tissue
Down-Regulation
Obesity
DNA-Binding Proteins

Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

Seshadri, S., Kamiya, A., Yokota, Y., Prikulis, I., Kano, S., Hayashi-Takagi, A., Stanco, A., Eom, T. Y., Rao, S., Ishizuka, K., Wong, P. C., Korth, C., Anton, E. S. & Sawa, A., Mar 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5622-5627 6 p.

Research output: Contribution to journalArticle

Neuregulin-1
Amyloid beta-Protein Precursor
Schizophrenia
Enzymes
Phosphatidylinositol 3-Kinases