Peter N Devreotes

Professor

1975 …2020

Research output per year

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Research Output

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2008

tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis

Tang, L., Franca-Koh, J., Xiong, Y., Chen, M. Y., Long, Y., Bickford, R. M., Knecht, D. A., Iglesias, P. A. & Devreotes, P. N., Aug 15 2008, In : Genes and Development. 22, 16, p. 2278-2290 13 p.

Research output: Contribution to journalArticle

2007

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

Sasaki, A. T., Janetopoulos, C., Lee, S., Charest, P. G., Takeda, K., Sundheimer, L. W., Meili, R., Devreotes, P. N. & Firtel, R. A., Jul 16 2007, In : Journal of Cell Biology. 178, 2, p. 185-191 7 p.

Research output: Contribution to journalArticle

Leading-edge research: PtdIns(3,4,5)P3 and directed migration

Franca-Koh, J., Kamimura, Y. & Devreotes, P. N., Jan 1 2007, In : Nature cell biology. 9, 1, p. 15-17 3 p.

Research output: Contribution to journalArticle

PLA2 and PI3K/PTEN Pathways Act in Parallel to Mediate Chemotaxis

Chen, L., Iijima, M., Tang, M., Landree, M. A., Huang, Y. E., Xiong, Y., Iglesias, P. A. & Devreotes, P. N., Apr 1 2007, In : Developmental Cell. 12, 4, p. 603-614 12 p.

Research output: Contribution to journalArticle

2006

Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin

Somesh, B. P., Neffgen, C., Iijima, M., Devreotes, P. & Rivero, F., Sep 1 2006, In : Traffic. 7, 9, p. 1194-1212 19 p.

Research output: Contribution to journalArticle

Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: A quantitative in vivo analysis by inhibition of PI3-kinase

Loovers, H. M., Postma, M., Keizer-Gunnink, I., Huang, Y. E., Devreotes, P. N. & Van Haastert, P. J. M., Apr 1 2006, In : Molecular biology of the cell. 17, 4, p. 1503-1513 11 p.

Research output: Contribution to journalArticle

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Gu, Y., Sasaki, T., Suzuki, A., Forrester, J. V., Bourne, H. R., Devreotes, P. N., McCaig, C. D. & Penninger, J. M., Jul 27 2006, In : Nature. 442, 7101, p. 457-460 4 p.

Research output: Contribution to journalArticle

RacG regulates morphology, phagocytosis, and chemotaxis

Somesh, B. P., Vlahou, G., Iijima, M., Insall, R. H., Devreotes, P. & Rivero, F., Oct 1 2006, In : Eukaryotic Cell. 5, 10, p. 1648-1663 16 p.

Research output: Contribution to journalArticle

Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein

Matsuoka, S., Iijima, M., Watanabe, T. M., Kuwayama, H., Yanagida, T., Devreotes, P. N. & Ueda, M., Mar 15 2006, In : Journal of cell science. 119, 6, p. 1071-1079 9 p.

Research output: Contribution to journalArticle

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

Vazquez, F., Matsuoka, S., Sellers, W. R., Yanagida, T., Ueda, M. & Devreotes, P. N., Mar 7 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3633-3638 6 p.

Research output: Contribution to journalArticle

2005

Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility

Fache, S., Dalous, J., Engelund, M., Hansen, C., Chamaraux, F., Fourcade, B., Satre, M., Devreotes, P. & Bruckert, F., Aug 1 2005, In : Journal of cell science. 118, 15, p. 3445-3457 13 p.

Research output: Contribution to journalArticle

Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis

Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M. & Devreotes, P., Apr 1 2005, In : Developmental Cell. 8, 4, p. 467-477 11 p.

Research output: Contribution to journalArticle

2004

Analyzing chemotaxis using Dictyostelium discoideum as a model system.

Landree, M. A. & Devreotes, P. N., 2004, In : Methods in molecular biology (Clifton, N.J.). 239, p. 91-104 14 p.

Research output: Contribution to journalArticle

Novel Mechanism of PTEN Regulation by Its Phosphatidylinositol 4,5-Bisphosphate Binding Motif Is Critical for Chemotaxis

Iijima, M., Huang, Y. E., Luo, H. R., Vazquez, F. & Devreotes, P. N., Apr 16 2004, In : Journal of Biological Chemistry. 279, 16, p. 16606-16613 8 p.

Research output: Contribution to journalArticle

Visualization of G protein βγ dimers using bimolecular fluorescence complementation demonstrates roles for both β and γ in subcellular targeting

Hynes, T. R., Tang, L., Mervine, S. M., Sabo, J. L., Yost, E. A., Devreotes, P. N. & Berlot, C. H., Jul 16 2004, In : Journal of Biological Chemistry. 279, 29, p. 30279-30286 8 p.

Research output: Contribution to journalArticle

2003

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-Ptdins(3,4,5)P3 interactions

Luo, H. R., Huang, Y. E., Chen, J. C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P. & Snyder, S. H., Sep 5 2003, In : Cell. 114, 5, p. 559-572 14 p.

Research output: Contribution to journalArticle

Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells

Huang, Y. E., Iijima, M., Parent, C. A., Funamoto, S., Firtel, R. A. & Devreotes, P., May 1 2003, In : Molecular biology of the cell. 14, 5, p. 1913-1922 10 p.

Research output: Contribution to journalArticle

Two Phases of Actin Polymerization Display Different Dependencies on PI(3,4,5)P3 Accumulation and Have Unique Roles during Chemotaxis

Chen, L., Janetopoulos, C., Huang, Y. E., Iijima, M., Borleis, J. & Devreotes, P. N., Dec 1 2003, In : Molecular biology of the cell. 14, 12, p. 5028-5037 10 p.

Research output: Contribution to journalArticle

2002

Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in Dictyostelium

Zhang, N., Long, Y. & Devreotes, P. N., Jan 1 2002, In : Developmental biology. 248, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis

Zhao, M., Jin, T., McCaig, C. D., Forrester, J. V. & Devreotes, P. N., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 921-927 7 p.

Research output: Contribution to journalArticle

Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer

Janetopoulos, C. & Devreotes, P., Oct 12 2002, In : Methods. 27, 4, p. 366-373 8 p.

Research output: Contribution to journalArticle

Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains

Parent, C. A., Borleis, J. & Devreotes, P. N., Jan 11 2002, In : Journal of Biological Chemistry. 277, 2, p. 1354-1360 7 p.

Research output: Contribution to journalArticle

Temperature-sensitive inhibition of development in Dictyostelium due to a point mutation in the piaA gene

Pergolizzi, B., Peracino, B., Silverman, J., Ceccarelli, A., Noegel, A., Devreotes, P. & Bozzaro, S., Jan 1 2002, In : Developmental biology. 251, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Tumor suppressor PTEN mediates sensing of chemoattractant gradients

Iijima, M. & Devreotes, P., May 31 2002, In : Cell. 109, 5, p. 599-610 12 p.

Research output: Contribution to journalArticle

Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development

Dormann, D., Weijer, G., Parent, C. A., Devreotes, P. N. & Weijer, C. J., Jul 23 2002, In : Current Biology. 12, 14, p. 1178-1188 11 p.

Research output: Contribution to journalArticle

2001

Adenylyl cyclase A expression is tip-specific in Dictyostelium slugs and directs StatA nuclear translocation and CudA gene expression

Wijk, I. V. V., Fukuzawa, M., Devreotes, P. N. & Schaap, P., Jun 1 2001, In : Developmental biology. 234, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium

Dormann, D., Kim, J. Y., Devreotes, P. N. & Weijer, C. J., Aug 8 2001, In : Journal of cell science. 114, 13, p. 2513-2523 11 p.

Research output: Contribution to journalArticle

Gγ in Dictyostelium: Its role in localization of Gβγ to the membrane is required for chemotaxis in shallow gradients

Zhang, N., Long, Y. & Devreotes, P. N., Jan 1 2001, In : Molecular biology of the cell. 12, 10, p. 3204-3213 10 p.

Research output: Contribution to journalArticle

Receptor-mediated activation of heterotrimeric G-proteins in living cells

Janetopoulos, C., Jin, T. & Devreotes, P., Mar 23 2001, In : Science. 291, 5512, p. 2408-2411 4 p.

Research output: Contribution to journalArticle

Single-molecule analysis of chemotactic signaling in Dictyostelium cells

Ueda, M., Sako, Y., Tanaka, T., Devreotes, P. & Yanagida, T., Oct 26 2001, In : Science. 294, 5543, p. 864-867 4 p.

Research output: Contribution to journalArticle

The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation

Briscoe, C., Moniakis, J., Kim, J. Y., Brown, J. M., Hereld, D., Devreotes, P. N. & Firtel, R. A., May 1 2001, In : Developmental biology. 233, 1, p. 225-236 12 p.

Research output: Contribution to journalArticle

The Protein Kinase YakA Regulates G-protein-linked Signaling Responses during Growth and Development of Dictyostelium

Van Es, S., Weening, K. E. & Devreotes, P. N., Aug 17 2001, In : Journal of Biological Chemistry. 276, 33, p. 30761-30765 5 p.

Research output: Contribution to journalArticle

Tortoise, a novel mitochondrial protein, is required for directional responses of Dictyostelium in chemotactic gradients

Van Es, S., Wessels, D., Soll, D. R., Borleis, J. & Devreotes, P. N., Apr 30 2001, In : Journal of Cell Biology. 153, 3, p. 621-632 12 p.

Research output: Contribution to journalArticle

2000

A temperature-sensitive adenylyl cyclase mutant of Dictyostelium

Patel, H., Guo, K., Parent, C., Gross, J., Devreotes, P. N. & Weijer, C. J., May 15 2000, In : EMBO Journal. 19, 10, p. 2247-2256 10 p.

Research output: Contribution to journalArticle

Differential developmental expression and cell type specificity of Dictyostelium catalases and their response to oxidative stress and UV-light

Garcia, M. X. U., Foote, C., Van Es, S., Devreotes, P. N., Alexander, S. & Alexander, H., Jul 24 2000, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1492, 2-3, p. 295-310 16 p.

Research output: Contribution to journalArticle

Localization of the G protein βγ complex in living cells during chemotaxis

Jin, T., Zhang, N., Long, Y., Parent, C. A. & Devreotes, P. N., Feb 11 2000, In : Science. 287, 5455, p. 1034-1036 3 p.

Research output: Contribution to journalArticle

1999
1998

Functional promiscuity of gene regulation by serpentine receptors in Dictyostelium discoideum

Verkerke-Van Wijk, I., Kjm, J. I. Y., Brandt, R., Devreotes, P. N. & Schaap, P., Jan 1 1998, In : Molecular and cellular biology. 18, 10, p. 5744-5749 6 p.

Research output: Contribution to journalArticle

Open Access

G protein signaling events are activated at the leading edge of chemotactic cells

Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B. & Devreotes, P. N., Oct 2 1998, In : Cell. 95, 1, p. 81-91 11 p.

Research output: Contribution to journalArticle

G protein β subunit-null mutants are impaired in phagocytosis and chemotaxis due to inappropriate regulation of the actin cytoskeleton

Peracino, B., Borleis, J., Jin, T., Westphal, M., Schwartz, J. M., Wu, L., Bracco, E., Gerisch, G., Devreotes, P. & Bozzaro, S., Jun 29 1998, In : Journal of Cell Biology. 141, 7, p. 1529-1537 9 p.

Research output: Contribution to journalArticle

Identification of darlin, a Dictyostelium protein with armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells

Vithalani, K. K., Parent, C. A., Thorn, E. M., Penn, M., Larochelle, D. A., Devreotes, P. N. & De Lozanne, A., Nov 1998, In : Molecular biology of the cell. 9, 11, p. 3095-3106 12 p.

Research output: Contribution to journalArticle

Temperature-sensitive Gβ mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors

Jin, T., Soede, R. D. M., Liu, J., Kimmel, A. R., Devreotes, P. N. & Schaap, P., Sep 1 1998, In : EMBO Journal. 17, 17, p. 5076-5084 9 p.

Research output: Contribution to journalArticle

1997
Open Access

Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation

Xiao, Z., Zhang, N., Murphy, D. B. & Devreotes, P. N., Oct 20 1997, In : Journal of Cell Biology. 139, 2, p. 365-374 10 p.

Research output: Contribution to journalArticle