Peter N Devreotes

Professor

1975 …2020

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2020

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Jiao, Z., Cai, H., Long, Y., Sirka, O. K., Padmanaban, V., Ewald, A. J. & Devreotes, P. N., Feb 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4158-4168 11 p.

Research output: Contribution to journalArticle

2019

A minimal computational model for three-dimensional cell migration

Cao, Y., Ghabache, E., Miao, Y., Niman, C., Hakozaki, H., Reck-Peterson, S. L., Devreotes, P. N. & Rappel, W. J., Dec 1 2019, In : Journal of the Royal Society Interface. 16, 161, 20190619.

Research output: Contribution to journalArticle

Open Access

Cell migration directionality and speed are independently regulated by RasG and Gβ in Dictyostelium cells in electrotaxis

Jeon, T. J., Gao, R., Kim, H., Lee, A., Jeon, P., Devreotes, P. N. & Zhao, M., Jan 1 2019, In : Biology Open. 8, 7, bio042457.

Research output: Contribution to journalArticle

Open Access

Moving toward molecular mechanisms for chemotaxis in eukaryotic cells

Devreotes, P., Nov 1 2019, In : Molecular biology of the cell. 30, 23, p. 2873-2877 5 p.

Research output: Contribution to journalArticle

Open Access

The excitable signal transduction networks: Movers and shapers of eukaryotic cell migration

Pal, D. S., Li, X., Banerjee, T., Miao, Y. & Devreotes, P. N., Jan 1 2019, In : International Journal of Developmental Biology. 63, 9-10, p. 407-416 10 p.

Research output: Contribution to journalArticle

Open Access

Wave patterns organize cellular protrusions and control cortical dynamics

Miao, Y., Bhattacharya, S., Banerjee, T., Abubaker-Sharif, B., Long, Y., Inoue, T., Iglesias, P. A. & Devreotes, P. N., Mar 2019, In : Molecular systems biology. 15, 3, e8585.

Research output: Contribution to journalArticle

Open Access
2018

Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis

Miyanaga, Y., Kamimura, Y., Kuwayama, H., Devreotes, P. N. & Ueda, M., Dec 9 2018, In : Biochemical and Biophysical Research Communications. 507, 1-4, p. 304-310 7 p.

Research output: Contribution to journalArticle

Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation

Neumann, N. M., Perrone, M. C., Veldhuis, J. H., Huebner, R. J., Zhan, H., Devreotes, P. N., Brodland, G. W. & Ewald, A., Apr 9 2018, In : Developmental Cell. 45, 1, p. 67-82.e6

Research output: Contribution to journalArticle

Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum

Edwards, M., Cai, H., Abubaker-Sharif, B., Long, Y., Lampert, T. J. & Devreotes, P. N., Apr 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3722-E3730

Research output: Contribution to journalArticle

Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration

Li, X., Edwards, M., Swaney, K. F., Singh, N., Bhattacharya, S., Borleis, J., Long, Y., Iglesias, P. A., Chen, J. & Devreotes, P. N., Sep 25 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9125-E9134

Research output: Contribution to journalArticle

2017

Altering the threshold of an excitable signal transduction network changes cell migratory modes

Miao, Y., Bhattacharya, S., Edwards, M., Cai, H., Inoue, T., Iglesias, P. A. & Devreotes, P. N., Mar 27 2017, (Accepted/In press) In : Nature Cell Biology.

Research output: Contribution to journalArticle

Assessment of Dictyostelium discoideum response to acute mechanical stimulation

Artemenko, Y. & Devreotes, P. N., Nov 9 2017, In : Journal of Visualized Experiments. 2017, 129, e56411.

Research output: Contribution to journalArticle

A Tunable Brake for HECT Ubiquitin Ligases

Chen, Z., Jiang, H., Xu, W., Li, X., Dempsey, D. R., Zhang, X., Devreotes, P. N., Wolberger, C., Amzel, M. L., Gabelli, S. B. & Cole, P. A., May 4 2017, In : Molecular Cell. 66, 3, p. 345-357.e6

Research output: Contribution to journalArticle

Excitable signal transduction networks in directed cell migration

Devreotes, P. N., Bhattacharya, S., Edwards, M., Iglesias, P. A., Lampert, T. & Miao, Y., Oct 6 2017, In : Annual Review of Cell and Developmental Biology. 33, p. 103-125 23 p.

Research output: Contribution to journalArticle

Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity

Lampert, T. J., Kamprad, N., Edwards, M., Borleis, J., Watson, A. J., Tarantola, M. & Devreotes, P. N., Sep 12 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 37, p. E7727-E7736

Research output: Contribution to journalArticle

2016

Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks

Artemenko, Y., Axiotakis, L., Borleis, J., Iglesias, P. A. & Devreotes, P. N., Nov 22 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 47, p. E7500-E7509

Research output: Contribution to journalArticle

Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration

Hoeller, O., Toettcher, J. E., Cai, H., Sun, Y., Huang, C. H., Freyre, M., Zhao, M., Devreotes, P. N. & Weiner, O. D., Feb 18 2016, In : PLoS biology. 14, 2, e1002381.

Research output: Contribution to journalArticle

MyTH4-FERM myosins have an ancient and conserved role in filopod formation

Petersen, K. J., Goodson, H. V., Arthur, A. L., Luxton, G. W. G., Houdusse, A., Titus, M. A. & Devreotes, P. N., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8059-E8068

Research output: Contribution to journalArticle

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin

Schiapparelli, P., Guerrero-Cazares, H., Magaña-Maldonado, R., Hamilla, S. M., Ganaha, S., Goulin Lippi Fernandes, E., Huang, C. H., Aranda-Espinoza, H., Devreotes, P. N. & Quinones-Hinojosa, A., 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

2015

A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum

Gao, R., Zhao, S., Jiang, X., Sun, Y., Zhao, S., Gao, J., Borleis, J., Willard, S., Tang, M., Cai, H., Kamimura, Y., Huang, Y., Jiang, J., Huang, Z., Mogilner, A., Pan, T., Devreotes, P. N. & Zhao, M., May 26 2015, In : Science signaling. 8, 378

Research output: Contribution to journalArticle

A new class of cancer-associated PTEN mutations defined by membrane translocation defects

Nguyen, H. N., Yang, J. M., Rahdar, M., Keniry, M., Swaney, K. F., Parsons, R., Park, B. H., Sesaki, H., Devreotes, P. N. & Iijima, M., Jul 1 2015, In : Oncogene. 34, 28, p. 3737-3743 7 p.

Research output: Contribution to journalArticle

Engineering PTEN function: Membrane association and activity

Yang, J. M., Nguyen, H. N., Sesaki, H., Devreotes, P. N. & Iijima, M., May 1 2015, In : Methods. 77, p. 119-124 6 p.

Research output: Contribution to journalArticle

Novel protein Callipygian defines the back of migrating cells

Swaney, K. F., Borleis, J., Iglesias, P. A. & Devreotes, P. N., Jul 21 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. E3845-E3854

Research output: Contribution to journalArticle

Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN

Nguyen, H. N., Yang, J. M., Miyamoto, T., Itoh, K., Rho, E., Zhang, Q., Inoue, T., Devreotes, P. N., Sesaki, H. & Iijima, M., Jul 28 2015, In : Scientific reports. 5, 12600.

Research output: Contribution to journalArticle

Science signaling podcast: 26 May 2015

Zhao, M., Devreotes, P. N. & Van Hook, A. M., May 26 2015, In : Science signaling. 8, 378

Research output: Contribution to journalArticle

Signaling networks that regulate cell migration

Devreotes, P. & Horwitz, A. R., Aug 1 2015, In : Cold Spring Harbor Perspectives in Biology. 7, 8

Research output: Contribution to journalArticle

The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium

Santhanam, B., Cai, H., Devreotes, P. N., Shaulsky, G. & Katoh-Kurasawa, M., Jul 6 2015, In : Nature communications. 6, 7551.

Research output: Contribution to journalArticle

2014

Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities

Nguyen, H. N., Yang, J. M., Afkari, Y., Park, B. H., Sesaki, H., Devreotes, P. N. & Iijima, M., Jul 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 26, p. E2684-E2693

Research output: Contribution to journalArticle

Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium

Nguyen, H. N., Afkari, Y., Senoo, H., Sesaki, H., Devreotes, P. N. & Iijima, M., Dec 11 2014, In : Oncogene. 33, 50, p. 5688-5696 9 p.

Research output: Contribution to journalArticle

Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer

Cai, H., Katoh-Kurasawa, M., Muramoto, T., Santhanam, B., Long, Y., Li, L., Ueda, M., Iglesias, P. A., Shaulsky, G. & Devreotes, P. N., Jan 1 2014, In : Science. 343, 6177, 1249531.

Research output: Contribution to journalArticle

The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient

Wang, M. J., Artemenko, Y., Cai, W. J., Iglesias, P. A. & Devreotes, P. N., Jan 1 2014, In : Cell Reports. 9, 3, p. 1110-1121 12 p.

Research output: Contribution to journalArticle

2013

3D arrays for high throughput assay of cell migration and electrotaxis

Zhao, S., Gao, R., Devreotes, P. N., Mogilner, A. & Zhao, M., May 13 2013, In : Cell biology international. 37, 9, p. 995-1002 8 p.

Research output: Contribution to journalArticle

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

Huang, C. H., Tang, M., Shi, C., Iglesias, P. A. & Devreotes, P. N., Nov 1 2013, In : Nature cell biology. 15, 11, p. 1307-1316 10 p.

Research output: Contribution to journalArticle

Multiple Host Kinases Contribute to Akt Activation during Salmonella Infection

Roppenser, B., Kwon, H., Canadien, V., Xu, R., Devreotes, P. N., Grinstein, S. & Brumell, J. H., Aug 22 2013, In : PloS one. 8, 8, e71015.

Research output: Contribution to journalArticle

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

Bolduc, D., Rahdar, M., Tu-Sekine, B., Sivakumaren, S. C., Raben, D., Amzel, L. M., Devreotes, P., Gabelli, S. B. & Cole, P., Jul 9 2013, In : eLife. 2013, 2, e00691.

Research output: Contribution to journalArticle

2012

Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications

Galloway, J. F., Winter, A., Lee, K. H., Park, J. H., Dvoracek, C. M., Devreotes, P. & Searson, P. C., Oct 1 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 7, p. 1190-1199 10 p.

Research output: Contribution to journalArticle

Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion

Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sanséau, D., Willard, S. S., Schleicher, M. & Devreotes, P. N., Aug 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 34, p. 13632-13637 6 p.

Research output: Contribution to journalArticle

2011

Different roles of membrane potentials in electrotaxis and chemotaxis of Dictyostelium cells

Gao, R. C., Zhang, X. D., Sun, Y. H., Kamimura, Y., Mogilner, A., Devreotes, P. N. & Zhao, M., Sep 1 2011, In : Eukaryotic Cell. 10, 9, p. 1251-1256 6 p.

Research output: Contribution to journalArticle

Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane

De Keijzer, S., Galloway, J., Harms, G. S., Devreotes, P. N. & Iglesias, P. A., Jun 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 6, p. 1701-1708 8 p.

Research output: Contribution to journalArticle

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

Tang, M., Iijima, M., Kamimura, Y., Chen, L., Long, Y. & Devreotes, P., Feb 15 2011, In : Molecular biology of the cell. 22, 4, p. 437-447 11 p.

Research output: Contribution to journalArticle

2010

Automated characterization of cell shape changes during amoeboid motility by skeletonization

Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P. N., Robinson, D. N. & Iglesias, P. A., Mar 24 2010, In : BMC Systems Biology. 4, 33.

Research output: Contribution to journalArticle

Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis

Cai, H., Das, S., Kamimura, Y., Long, Y., Parent, C. A. & Devreotes, P. N., Jul 26 2010, In : Journal of Cell Biology. 190, 2, p. 233-245 13 p.

Research output: Contribution to journalArticle

TORC2 and chemotaxis in Dictyostelium discoideum

Kamimura, Y., Cai, H. & Devreotes, P. N., Oct 5 2010, In : Enzymes. 28, C, p. 125-142 18 p.

Research output: Contribution to journalArticle

2009
2008

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

Kamimura, Y., Xiong, Y., Iglesias, P. A., Hoeller, O., Bolourani, P. & Devreotes, P. N., Jul 22 2008, In : Current Biology. 18, 14, p. 1034-1043 10 p.

Research output: Contribution to journalArticle