Peter L Pedersen

Professor

1965 …2018
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Research Output 1965 2018

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Article
2018

3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Ko, Y. H., Niedźwiecka, K., Casal, M., Pedersen, P. L. & Ułaszewski, S., Jan 1 2018, (Accepted/In press) In : Yeast.

Research output: Contribution to journalArticle

Cells
Data storage equipment
Adenosinetriphosphate
Cell death
Fungi
2016

Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma

Niedzwiecka, K., Dylag, M., Augustyniak, D., Majkowska-Skrobek, G., Cal-Bakowska, M., Ko, Y. H., Pedersen, P. L., Goffeau, A. & Ulaszewski, S., 2016, In : Oncotarget. 7, 40, p. 65614-65626 13 p.

Research output: Contribution to journalArticle

Mycoses
Clinical Protocols
Multiple Myeloma
Glutathione
Buthionine Sulfoximine

Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate

Lis, P., Jurkiewicz, P., Cal-Bakowska, M., Ko, Y. H., Pedersen, P. L., Goffeau, A. & Ułaszewski, S., 2016, In : Oncotarget. 7, 9, p. 10153-10173 21 p.

Research output: Contribution to journalArticle

Yeasts
Genome
Neoplasms
Gene Deletion
Enzymes

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

Azevedo-Silva, J., Queirós, O., Baltazar, F., Ułaszewski, S., Goffeau, A., Ko, Y. H., Pedersen, P. L., Preto, A. & Casal, M., Jul 25 2016, (Accepted/In press) In : Journal of Bioenergetics and Biomembranes. p. 1-14 14 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Neoplasms
Bystander Effect
bromopyruvate
Therapeutics
2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block, K. I., Gyllenhaal, C., Lowe, L., Amedei, A., Ruhul Amin, A. R. M., Amin, A., Aquilano, K., Arbiser, J., Arreola, A., Arzumanyan, A., Salman Ashraf, S., Azmi, A. S., Benencia, F., Bhakta, D., Bilsland, A., Bishayee, A., Blain, S. W., Block, P. B., Boosani, C. S., Carey, T. E. & 160 othersCarnero, A., Carotenuto, M., Casey, S. C., Chakrabarti, M., Chaturvedi, R., Chen, G. Z., Chen, H., Chen, S., Chen, Y. C., Choi, B. K., Ciriolo, M. R., Coley, H. M., Collins, A. R., Connell, M., Crawford, S., Curran, C. S., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, R. J., Decker, W. K., Dhawan, P., Diehl, A. M. E., Dong, J. T., Dou, Q. P., Drewa, J. E., Elkord, E., El-Rayes, B., Feitelson, M. A., Felsheru, D. W., Ferguson, L. R., Fimognari, C., Firestone, G. L., Frezza, C., Fujii, H., Fuster, M. M., Generali, D., Georgakilas, A. G., Gieseler, F., Gilbertson, M., Green, M. F., Grue, B., Guhal, G., Halicka, D., Helferich, W. G., Heneberg, P., Hentosh, P., Hirschey, M. D., Hofseth, L. J., Holcombe, R. F., Honoki, K., Hsu, H. Y., Huang, G. S., Jensen, L. D., Jiang, W. G., Jones, L. W., Karpowicz, P. A., Keith, W. N., Kerkar, S. P., Khan, G. N., Khatami, M., Ko, Y. H., Kucuk, O., Kulathinal, R. J., Kumar, N. B., Kwon, B. S., Leb, A., Leab, M. A., Lee, H. Y., Lichtor, T., Lin, L. T., Locasale, J. W., Lokeshwar, B. L., Longo, V. D., Lyssiotis, C. A., MacKenzie, K. L., Malhotra, M., Marino, M., Martinez-Chantar, M. L., Matheu, A., Maxwellx, C., McDonnell, E., Meeker, A. K., Mehrmohamadi, M., Mehta, K., Michelotti, G. A., Mohammad, R. M., Mohammed, S. I., Morre, D. J., Muqbil, I., Muralidharcq, V., Murphy, M. P., Nagaraju, G. P., Nahta, R., Niccolai, E., Nowsheen, S., Panis, C., Pantano, F., Parslow, V. R., Pawelec, G., Pedersen, P. L., Poore, B., Poudyal, D., Prakash, S., Prince, M., Raffaghello, L., Rathmell, J. C., Rathmell, W. K., Ray, S. K., Reichrath, J., Rezazadeh, S., Ribatti, D., Ricciardiello, L., Robeydf, R. B., Rodierdh, F., Rupasinghe, H. P. V., Russo, G. L., Ryan, E. P., Samadi, A. K., Sanchez-Garcia, I., Sanders, A. J., Santini, D., Sarkar, M., Sasada, T., Saxena, N. K., Shackelford, R. E., Shantha Kumara, H. M. C., Sharma, D., Shin, D. M., Sidransky, D., Siegelin, M. D., Signori, E., Singh, N., Sivanand, S., Sliva, D., Smythe, C., Spagnuolo, C., Stafforini, D. M., Stagg, J., Subbarayan, P. R., Sundin, T., Talib, W. H., Thompson, S. K., Tran, P. T., Ungefroren, H., Vander Heiden, M. G., Venkateswaran, V., Vinay, D. S., Vlachostergios, P. J., Wang, Z., Wellen, K. E., Whelan, R. L., Yang, E. S., Yang, H., Yang, X., Yaswen, P., Yedjou, C., Yin, X., Zhu, J. & Zollo, M., 2015, In : Seminars in Cancer Biology. 35, p. S276-S304

Research output: Contribution to journalArticle

Tumor Microenvironment
Recurrence
Neoplasms
Genetic Heterogeneity
Poisons

The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH

Azevedo-Silva, J. Ã., Queirós, O., Ribeiro, A., Baltazar, F., Young, K. H., Pedersen, P. L., Pretoand, A. & Casal, M., Apr 15 2015, In : Biochemical Journal. 467, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

Cytotoxicity
Cells
Breast Neoplasms
Cell Line
Neoplasms
2014

Killing multiple myeloma cells with the small molecule 3-bromopyruvate: Implications for therapy

Majkowska-Skrobek, G., Augustyniak, D., Lis, P., Bartkowiak, A., Gonchar, M., Ko, Y. H., Pedersen, P. L., Goffeau, A. & Ułaszewski, S., 2014, In : Anti-Cancer Drugs. 25, 6, p. 673-682 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Therapeutics
bromopyruvate
Blood Cells
Buthionine Sulfoximine
2013

3-Bromopyruvate: A novel antifungal agent against the human pathogen Cryptococcus neoformans

Dylag, M., Lis, P., Niedźwiecka, K., Ko, Y. H., Pedersen, P. L., Goffeau, A. & Ułaszewski, S., May 3 2013, In : Biochemical and Biophysical Research Communications. 434, 2, p. 322-327 6 p.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Antifungal Agents
Pathogens
Yeast
Yeasts
2012
Hexokinase
Neoplasms
Glucose
Antineoplastic Agents
Lactic Acid

A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: From bench side to bedside

Ko, Y. H., Verhoeven, H. A., Lee, M. J., Corbin, D. J., Vogl, T. J. & Pedersen, P. L., Feb 2012, In : Journal of Bioenergetics and Biomembranes. 44, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Neoplasms
Translational Medical Research
Oxidative Phosphorylation
Glycolysis

Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate

Queirós, O., Preto, A., Pacheco, A., Pinheiro, C., Azevedo-Silva, J., Moreira, R., Pedro, M., Ko, Y. H., Pedersen, P. L., Baltazar, F. & Casal, M., Feb 2012, In : Journal of Bioenergetics and Biomembranes. 44, 1, p. 141-153 13 p.

Research output: Contribution to journalArticle

Butyrates
Breast Neoplasms
Lactic Acid
bromopyruvate
Cell Line
Mitochondria
Neoplasm Metastasis
Neoplasms
Research Personnel
Circulating Neoplastic Cells
Mitochondrial Proton-Translocating ATPases
Adenosine Triphosphate
Vanadates
Phosphates
Catalytic Domain

Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae

Lis, P., Zarzycki, M., Ko, Y. H., Casal, M., Pedersen, P. L., Goffeau, A. & Ułaszewski, S., Feb 2012, In : Journal of Bioenergetics and Biomembranes. 44, 1, p. 155-161 7 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Yeasts
Pharmaceutical Preparations
Buthionine Sulfoximine
Symporters
2011

Bcl-x L regulates mitochondrial energetics by stabilizing the inner membrane potential

Chen, Y. B., Aon, M. A., Hsu, Y. T., Soane, L., Teng, X., McCaffery, J. M., Cheng, W. C., Qi, B., Li, H., Alavian, K. N., Dayhoff-Brannigan, M., Zou, S., Pineda, F. J., O'Rourke, B., Ko, Y. H., Pedersen, P. L., Kaczmarek, L. K., Jonas, E. A. & Hardwick, J. M., Oct 17 2011, In : Journal of Cell Biology. 195, 2, p. 263-276 14 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Membrane Potentials
Mitochondrial Membrane Potential
Mitochondrial Proton-Translocating ATPases
Ions
2010

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

Mathupala, S. P., Ko, Y. H. & Pedersen, P. L., Jun 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 6-7, p. 1225-1230 6 p.

Research output: Contribution to journalArticle

Mitochondria
Tumors
Neoplasms
Glycolysis
Therapeutics

Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target

Mathupala, S. P. & Pedersen, P. L., Jun 15 2010, In : Cancer Biology and Therapy. 9, 12, p. 1053-1056 4 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 1
Mitochondrial Membranes
RNA Interference
Small Interfering RNA
Apoptosis
2009

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "Warburg effect" and a pivotal target for effective therapy

Mathupala, S. P., Ko, Y. H. & Pedersen, P. L., Feb 2009, In : Seminars in Cancer Biology. 19, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Hexokinase
Mitochondria
Neoplasms
Therapeutics
Adenosine Triphosphate
Amyloid
Alzheimer Disease
Mitochondria
Brain
Neurodegenerative Diseases
Glycolysis
Oxygen
Adenine Nucleotides
Oxidative Phosphorylation
Hemoglobins
2008
Proton-Translocating ATPases
Enzyme Inhibitors
Adenosine Triphosphate
Health
Proteins
Voltage-Dependent Anion Channels
Hexokinase
Mitochondria
Neoplasms
Glycolysis
2007

The cancer cell's "power plants" as promising therapeutic targets: An overview

Pedersen, P. L., Feb 2007, In : Journal of Bioenergetics and Biomembranes. 39, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Power Plants
Neoplasms
Therapeutics
Cell Death
Mitochondria
Adenosine Triphosphatases
Health
Adenosine Triphosphate
ATP Translocases Mitochondrial ADP
Mitochondrial Diseases
2006

Expanding the subproteome of the inner mitochondria using protein separation technologies: One-and two-dimensional liquid chromatography and two-dimensional gel electrophoresis

McDonald, T., Sheng, S., Stanley, B., Chen, D., Ko, Y., Cole, R. N., Pedersen, P. L. & Van Eyk, J. E., Dec 2006, In : Molecular and Cellular Proteomics. 5, 12, p. 2392-2411 20 p.

Research output: Contribution to journalArticle

Mitochondria
Liquid chromatography
Electrophoresis, Gel, Two-Dimensional
Electrophoresis
Liquid Chromatography

Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

Mathupala, S. P., Ko, Y. H. & Pedersen, P. L., Aug 7 2006, In : Oncogene. 25, 34, p. 4777-4786 10 p.

Research output: Contribution to journalArticle

Hexokinase
Mitochondria
Neoplasms
Adenosine Triphosphate
Phenotype

Mitochondrial ATP synthase: Crystal structure of the catalytic F 1 unit in a vanadate-induced transition-like state and implications for mechanism

Chen, C., Saxena, A. K., Simcoke, W. N., Garboczi, D. N., Pedersen, P. L. & Ko, Y. H., May 12 2006, In : Journal of Biological Chemistry. 281, 19, p. 13777-13783 7 p.

Research output: Contribution to journalArticle

Mitochondrial Proton-Translocating ATPases
Vanadates
Adenosine Triphosphate
Crystal structure
Catalytic Domain

Proteomic analysis of pharmacological preconditioning: Novel protein targets converge to mitochondrial metabolism pathways

Arrell, D. K., Elliott, S. T., Kane, L. A., Guo, Y., Ko, Y. H., Pedersen, P. L., Robinson, J., Murata, M., Murphy, A. M., Marbán, E. & Van Eyk, J. E., Oct 2006, In : Circulation Research. 99, 7, p. 706-714 9 p.

Research output: Contribution to journalArticle

Proteomics
Pharmacology
Adenosine
Diazoxide
Proteins
2005

Transport ATPases: Structure, motors, mechanism and medicine: A brief overview

Pedersen, P. L., Dec 2005, In : Journal of Bioenergetics and Biomembranes. 37, 6, p. 349-357 9 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Medicine
Cystic Fibrosis
Adenosine Triphosphate
Darier Disease
2004

Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP

Ko, Y. H., Smith, B. L., Wang, Y., Pomper, M. G., Rini, D. A., Torbenson, M. S., Hullihen, J. & Pedersen, P. L., Nov 5 2004, In : Biochemical and Biophysical Research Communications. 324, 1, p. 269-275 7 p.

Research output: Contribution to journalArticle

Lactic Acid
Adenosine Triphosphate
Alkylating Agents
Cell death
Pyruvic Acid
Mitochondrial Proton-Translocating ATPases
Computational Biology
Protein Subunits
Mitochondrial Membranes
Adenosine Diphosphate

Mitochondrial ATP synthasome. Three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for P i and ADP/ATP

Chen, C., Ko, Y., Delannoy, M., Ludtke, S. J., Chiu, W. & Pedersen, P. L., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31761-31768 8 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Electron microscopy
Electron Microscopy
Adenine Nucleotides
Adenosine Triphosphate
Hepatocellular Carcinoma
Neoplasms
Hexokinase
Enzymes
Deoxyglucose
2003

ATP synthases: Insights into their motor functions from sequence and structural analyses

Hong, S. & Pedersen, P. L., Apr 2003, In : Journal of Bioenergetics and Biomembranes. 35, 2, p. 95-120 26 p.

Research output: Contribution to journalArticle

Sequence Analysis
Adenosine Triphosphate
Chloroplasts
Bacterial Proteins
Protein Sequence Analysis
Ca(2+) Mg(2+)-ATPase
Cystic Fibrosis Transmembrane Conductance Regulator
Vanadates
Nucleotides
Cystic Fibrosis
Sp1 Transcription Factor
Hexokinase
Cell death
Genetic Promoter Regions
Metabolism

Glucose metabolism in cancer: Evidence that demethylation events play a role in activating type II hexokinase gene expression

Goel, A., Mathupala, S. P. & Pedersen, P. L., Apr 25 2003, In : Journal of Biological Chemistry. 278, 17, p. 15333-15340 8 p.

Research output: Contribution to journalArticle

Hexokinase
Metabolism
Gene expression
Hepatocytes
Genes
ATP Translocases Mitochondrial ADP
Detergents
Adenosine Diphosphate
Assays
Screening
Phosphopeptides
Bioinformatics
Computational Biology
Brain
Adenosine Triphosphate
2002
Yeast
Adenosine Triphosphate
Yeasts
Peptides
Modulators
Organelle Biogenesis
Copper
copper-transporting ATPases

Mitochondrial bound type II hexokinase: A key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

Pedersen, P. L., Mathupala, S., Rempel, A., Geschwind, J. F. & Ko, Y. H., Sep 10 2002, In : Biochimica et Biophysica Acta - Bioenergetics. 1555, 1-3, p. 14-20 7 p.

Research output: Contribution to journalArticle

Hexokinase
Growth
Neoplasms
Tumors
Cytology

Novel therapy for liver cancer: Direct intraarterial injection of a potent inhibitor of ATP production

Geschwind, J. F. H., Ko, Y. H., Torbenson, M. S., Magee, C. & Pedersen, P. L., Jul 15 2002, In : Cancer Research. 62, 14, p. 3909-3913 5 p.

Research output: Contribution to journalArticle

Intra-Arterial Injections
Liver Neoplasms
Adenosine Triphosphate
Neoplasms
Therapeutics
Mitochondrial Proton-Translocating ATPases
Platelet-Derived Growth Factor
Tyrosine
Signal Transduction
Phosphorylation
Adenosine Triphosphatases
Enzymes
Research
2001

ATP synthase motor components: Proposal and animation of two dynamic models for stator function

Blum, D. J., Ko, Y. H., Hong, S., Rini, D. A. & Pedersen, P. L., Oct 5 2001, In : Biochemical and Biophysical Research Communications. 287, 4, p. 801-807 7 p.

Research output: Contribution to journalArticle

Animation
Stators
Dynamic models
Adenosine Triphosphate
Protons
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Research
Mutation
Nucleotides
Hexokinase
Hepatocellular Carcinoma
Genes
Chemical activation
Cells

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase

Ko, Y. H., Pedersen, P. L. & Geschwind, J. F., Oct 8 2001, In : Cancer Letters. 173, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Hexokinase
Liver Neoplasms
Hepatocellular Carcinoma
Rabbits
Glucose