Paula Hurley

Assistant Professor

20042019

Research output per year

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Research Output

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2019

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host

Simons, B. W., Kothari, V., Benzon, B., Ghabili, K., Hughes, R., Zarif, J., Ross, A. E., Hurley, P. J. & Schaeffer, E. M., Jan 1 2019, In : Oncotarget. 10, 64, p. 6845-6854 10 p.

Research output: Contribution to journalArticle

A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer

Ross, A. E., Hurley, P. J., Tran, P. T., Rowe, S. P., Benzon, B., Neal, T. O., Chapman, C., Harb, R., Milman, Y., Trock, B. J., Drake, C. G. & Antonarakis, E. S., Jan 1 2019, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S. S., Riddle, R. C., Thorek, D. L. J., Garraway, I. P., Fertig, E. J., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P. J., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access

Genetic alterations detected in cell-free DNA are associated with enzalutamide and abiraterone resistance in castration-resistant prostate cancer

Torquato, S., Pallavajjala, A., Goldstein, A., Toro, P. V., Silberstein, J. L., Lee, J., Nakazawa, M., Waters, I., Chu, D., Shinn, D., Groginski, T., Hughes, R. M., Simons, B. W., Khan, H., Feng, Z., Carducci, M. A., Paller, C. J., Denmeade, S. R., Kressel, B., Eisenberger, M. A. & 4 others, Antonarakis, E. S., Trock, B. J., Park, B. H. & Hurley, P. J., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

Open Access

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

Brian Dalton, W., Helmenstine, E., Walsh, N., Gondek, L. P., Kelkar, D. S., Read, A., Natrajan, R., Christenson, E. S., Roman, B., Das, S., Zhao, L., Leone, R. D., Shinn, D., Groginski, T., Madugundu, A. K., Patil, A., Zabransky, D. J., Medford, A., Lee, J., Cole, A. J. & 12 others, Rosen, M., Thakar, M., Ambinder, A., Donaldson, J., DeZern, A. E., Cravero, K., Chu, D., Madero-Marroquin, R., Pandey, A., Hurley, P. J., Lauring, J. & Park, B. H., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4708-4723 16 p.

Research output: Contribution to journalArticle

TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties

Kyker-Snowman, K., Hughes, R. M., Yankaskas, C. L., Cravero, K., Karthikeyan, S., Button, B., Waters, I., Rosen, D. M., Dennison, L., Hunter, N., Donaldson, J., Christenson, E. S., Konstantopoulos, K., Hurley, P. J., Croessmann, S. & Park, B. H., Jan 1 2019, (Accepted/In press) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

2018

Combining immune check-point blockade and cryoablation in an immunocompetent hormone sensitive murine model of prostate cancer

Benzon, B., Glavaris, S. A., Simons, B. W., Hughes, R. M., Ghabili, K., Mullane, P., Miller, R., Nugent, K., Shinder, B., Tosoian, J., Fuchs, E. J., Tran, P. T., Hurley, P., Vuica-Ross, M., Schaeffer, E. M., Drake, C. G. & Ross, A. E., Mar 20 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-11 11 p.

Research output: Contribution to journalArticle

2017

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P., Simons, B. W., Schaeffer, E. M., Lotan, T., Isaacs, W. B., Netto, G. J., Demarzo, A. M. & 3 others, Nelson, W. G., An, S. & Yegnasubramanian, S., Dec 1 2017, In : Nature Communications. 8, 1, 142.

Research output: Contribution to journalArticle

Detection fidelity of AR mutations in plasma derived cell-free DNA

Goldstein, A., Toro, P. V., Lee, J., Silberstein, J. L., Nakazawa, M., Waters, I., Cravero, K., Chu, D., Cochran, R. L., Kim, M., Shinn, D., Torquato, S., Hughes, R. M., Pallavajjalla, A., Carducci, M. A., Paller, C., Denmeade, S. R., Kressel, B., Trock, B., Eisenberger, M. & 3 others, Antonarakis, E., Park, B. H. & Hurley, P., 2017, In : Oncotarget. 8, 9, p. 15651-15662 12 p.

Research output: Contribution to journalArticle

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

Ross, A. E., Hughes, R. M., Glavaris, S., Ghabili, K., He, P., Anders, N., Harb, R., Tosoian, J. J., Marchionni, L., Schaeffer, E. M., Partin, A. W., Allaf, M. E., Bivalacqua, T., Chapman, C., O'Neal, T., Demarzo, A. M., Hurley, P., Rudek-Renaut, M. & Antonarakis, E., Jan 1 2017, In : Oncotarget. 8, 61, p. 104182-104192 11 p.

Research output: Contribution to journalArticle

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Rosen, D. M., Cidado, J., Cochran, R. L., Dalton, W., Erlanger, B., Cravero, K., Button, B., Kyker-Snowman, K., Hurley, P., Lauring, J. & Park, B. H., Feb 11 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-14 14 p.

Research output: Contribution to journalArticle

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S., DeWeese, T., Ross, A. E., Schaeffer, E. M., Pienta, K., Hurley, P., Morrissey, C. & Tran, P. T., Jun 15 2017, In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Contribution to journalArticle

2016

Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis

Benzon, B., Zhao, S. G., Haffner, M. C., Takhar, M., Erho, N., Yousefi, K., Hurley, P., Bishop, J. L., Tosoian, J., Ghabili, K., Alshalalfa, M., Glavaris, S., Simons, B. W., Tran, P. T., Davicioni, E., Karnes, R. J., Boudadi, K., Antonarakis, E., Schaeffer, E. M., Drake, C. G. & 2 others, Feng, F. & Ross, A. E., Nov 1 2016, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients

Chu, D., Paoletti, C., Gersch, C., VanDenBerg, D. A., Zabransky, D. J., Cochran, R. L., Wong, H. Y., Toro, P. V., Cidado, J., Croessmann, S., Erlanger, B., Cravero, K., Kyker-Snowman, K., Button, B., Parsons, H. A., Dalton, W., Gillani, R., Medford, A., Aung, K., Tokudome, N. & 9 others, Chinnaiyan, A. M., Schott, A., Robinson, D., Jacks, K. S., Lauring, J., Hurley, P., Hayes, D. F., Rae, J. M. & Park, B. H., Feb 15 2016, In : Clinical Cancer Research. 22, 4, p. 993-999 7 p.

Research output: Contribution to journalArticle

Germline variants in asporin vary by race, modulate the tumor microenvironment, and are differentially associated with metastatic prostate cancer

Hurley, P., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A. & 7 others, Huang, J., An, S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. & Schaeffer, E. M., Jan 15 2016, In : Clinical Cancer Research. 22, 2, p. 448-458 11 p.

Research output: Contribution to journalArticle

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

Cidado, J., Wong, H. Y., Marc Rosen, D., Cimino-Mathews, A. M., Garay, J. P., Fessler, A. G., Rasheed, Z. A., Hicks, J., Cochran, R. L., Croessmann, S., Zabransky, D. J., Mohseni, M., Beaver, J., Chu, D., Cravero, K., Christenson, E. S., Medford, A., Mattox, A., Demarzo, A. M., Argani, P. & 4 others, Chawla, A., Hurley, P., Lauring, J. & Park, B. H., 2016, In : Oncotarget. 7, 5, p. 6281-6293 13 p.

Research output: Contribution to journalArticle

2015

A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression

Simons, B. W., Durham, N. M., Bruno, T. C., Grosso, J. F., Schaeffer, A. J., Ross, A. E., Hurley, P., Berman, D. M., Drake, C. G., Thumbikat, P. & Schaeffer, E. M., Feb 1 2015, In : Journal of Pathology. 235, 3, p. 478-489 12 p.

Research output: Contribution to journalArticle

Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression

Hurley, P., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. & Schaeffer, E. M., Oct 15 2015, In : Cancer Research. 75, 20, p. 4322-4334 13 p.

Research output: Contribution to journalArticle

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA

Toro, P. V., Erlanger, B., Beaver, J., Cochran, R. L., VanDenBerg, D. A., Yakim, E., Cravero, K., Chu, D., Zabransky, D. J., Wong, H. Y., Croessmann, S., Parsons, H., Hurley, P., Lauring, J. & Park, B. H., Oct 1 2015, In : Clinical Biochemistry. 48, 15, p. 993-998 6 p.

Research output: Contribution to journalArticle

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharmaa, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J., Kachhap, S., Hurley, P. & 2 others, Lauring, J. & Park, B. H., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11583-11588 6 p.

Research output: Contribution to journalArticle

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

Wong, H. Y., Wang, G. M., Croessmann, S., Zabransky, D. J., Chu, D., Garay, J. P., Cidado, J., Cochran, R. L., Beaver, J., Aggarwal, A., Liu, M. L., Argani, P., Meeker, A. K., Hurley, P., Lauring, J. & Park, B. H., 2015, In : Oncotarget. 6, 42, p. 44927-44940 14 p.

Research output: Contribution to journalArticle

2014

Detection of cancer DNA in plasma of patients with early-stage breast cancer

Beaver, J., Jelovac, D., Balukrishna, S., Cochran, R. L., Croessmann, S., Zabransky, D. J., Wong, H. Y., Toro, P. V., Cidado, J., Blair, B. G., Chu, D., Burns, T., Higgins, M. J., Stearns, V., Jacobs, L., Habibi, M., Lange, J. R., Hurley, P., Lauring, J., VanDenBerg, D. A. & 9 others, Kessler, J., Jeter, S., Samuels, M. L., Maar, D., Cope, L., Cimino-Mathews, A. M., Argani, P., Wolff, A. C. & Park, B. H., May 15 2014, In : Clinical Cancer Research. 20, 10, p. 2643-2650 8 p.

Research output: Contribution to journalArticle

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

Mohseni, M., Cidado, J., Croessmann, S., Cravero, K., Cimino-Mathews, A. M., Wong, H. Y., Scharpf, R. B., Zabransky, D. J., Abukhdeir, A. M., Garay, J. P., Wang, G. M., Beaver, J., Cochran, R. L., Blair, B. G., Rosen, D. M., Erlanger, B., Argani, P., Hurley, P., Lauring, J. & Park, B. H., Dec 9 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17606-17611 6 p.

Research output: Contribution to journalArticle

Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction

Li, J., Ma, W., Wang, P. Y., Hurley, P., Bunz, F. & Hwang, P. M., 2014, In : Free Radical Biology and Medicine. 73, p. 270-277 8 p.

Research output: Contribution to journalArticle

2012

Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome

Hurley, P., Marchionni, L., Simons, B. W., Ross, A. E., Peskoe, S. B., Miller, R. M., Erho, N., Vergara, I. A., Ghadessi, M., Huang, Z., Gurel, B., Park, B. H., Davicioni, E., Jenkins, R. B., Platz, E. A., Berman, D. M. & Schaeffer, E. M., Sep 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14977-14982 6 p.

Research output: Contribution to journalArticle

Sox9 is required for prostate development and prostate cancer initiation

Huang, Z., Hurley, P., Simons, B. W., Marchionni, L., Berman, D. M., Ross, A. E. & Schaeffer, E. M., Jun 2012, In : Oncotarget. 3, 6, p. 651-663 13 p.

Research output: Contribution to journalArticle

Wnt signaling though beta-catenin is required for prostate lineage specification

Simons, B. W., Hurley, P., Huang, Z., Ross, A. E., Miller, R., Marchionni, L., Berman, D. M. & Schaeffer, E. M., Nov 15 2012, In : Developmental Biology. 371, 2, p. 246-255 10 p.

Research output: Contribution to journalArticle

2011

Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity

Ross, A. E., Emadi, A., Marchionni, L., Hurley, P., Simons, B. W., Schaeffer, E. M. & Vuica-Ross, M., Aug 2011, In : BJU International. 108, 3, p. 447-454 8 p.

Research output: Contribution to journalArticle

Molecular effects of genistein on male urethral development

Ross, A. E., Marchionni, L., Phillips, T. M., Miller, R. M., Hurley, P., Simons, B. W., Salmasi, A. H., Schaeffer, A. J., Gearhart, J. P. & Schaeffer, E. M., May 2011, In : Journal of Urology. 185, 5, p. 1894-1898 5 p.

Research output: Contribution to journalArticle

2007

ATM and ATR: Components of an integrated circuit

Hurley, P. & Bunz, F., Feb 15 2007, In : Cell cycle (Georgetown, Tex.). 6, 4, p. 414-417 4 p.

Research output: Contribution to journalArticle

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation

Hurley, P., Wilsker, D. & Bunz, F., Apr 19 2007, In : Oncogene. 26, 18, p. 2535-2542 8 p.

Research output: Contribution to journalArticle

2006

p53 regulates mitochondrial respiration

Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P., Bunz, F. & Hwang, P. M., Jun 16 2006, In : Science. 312, 5780, p. 1650-1653 4 p.

Research output: Contribution to journalArticle

2005

Improved methods for the generation of human gene knockout and knockin cell lines

Topaloglu, O., Hurley, P., Yildirim, O., Civin, C. I. & Bunz, F., 2005, In : Nucleic Acids Research. 33, 18, p. 1-7 7 p.

Research output: Contribution to journalArticle

2004

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R. C., Wheeler, M. T., Tsui, C., Hurley, P., Chien, M., Chai, S., Hitotsumatsu, O., McNally, E., Pickart, C. & Ma, A., Oct 1 2004, In : Nature Immunology. 5, 10, p. 1052-1060 9 p.

Research output: Contribution to journalArticle