Paula Hurley

Assistant Professor

20042019
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Research Output 2004 2019

2019

A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer

Ross, A. E., Hurley, P. J., Tran, P. T., Rowe, S. P., Benzon, B., Neal, T. O., Chapman, C., Harb, R., Milman, Y., Trock, B. J., Drake, C. G. & Antonarakis, E. S., Jan 1 2019, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Cryotherapy
Prostatic Neoplasms
Hormones
Androgens
Prostate

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S. S., Riddle, R. C., Thorek, D. L. J., Garraway, I. P., Fertig, E. J., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P. J., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Mesenchymal Stromal Cells
Cell Differentiation
Neoplasms
Neoplasm Metastasis

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

Brian Dalton, W., Helmenstine, E., Walsh, N., Gondek, L. P., Kelkar, D. S., Read, A., Natrajan, R., Christenson, E. S., Roman, B., Das, S., Zhao, L., Leone, R. D., Shinn, D., Groginski, T., Madugundu, A. K., Patil, A., Zabransky, D. J., Medford, A., Lee, J., Cole, A. J. & 12 others, Rosen, M., Thakar, M., Ambinder, A., Donaldson, J., DeZern, A. E., Cravero, K., Chu, D., Madero-Marroquin, R., Pandey, A., Hurley, P. J., Lauring, J. & Park, B. H., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4708-4723 16 p.

Research output: Contribution to journalArticle

Serine
Mutation
Down-Regulation
Spliceosomes
Mitochondrial Genes
2018

Combining immune check-point blockade and cryoablation in an immunocompetent hormone sensitive murine model of prostate cancer

Benzon, B., Glavaris, S. A., Simons, B. W., Hughes, R. M., Ghabili, K., Mullane, P., Miller, R., Nugent, K., Shinder, B., Tosoian, J., Fuchs, E. J., Tran, P. T., Hurley, P., Vuica-Ross, M., Schaeffer, E. M., Drake, C. G. & Ross, A. E., Mar 20 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-11 11 p.

Research output: Contribution to journalArticle

Cryosurgery
Prostatic Neoplasms
Hormones
Neoplasms
Blocking Antibodies
2017

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P., Simons, B. W., Schaeffer, E. M., Lotan, T., Isaacs, W. B., Netto, G. J., Demarzo, A. M. & 3 others, Nelson, W. G., An, S. & Yegnasubramanian, S., Dec 1 2017, In : Nature Communications. 8, 1, 142.

Research output: Contribution to journalArticle

Microfilament Proteins
Cell Movement
Actins
Melanoma
cancer

Detection fidelity of AR mutations in plasma derived cell-free DNA

Goldstein, A., Toro, P. V., Lee, J., Silberstein, J. L., Nakazawa, M., Waters, I., Cravero, K., Chu, D., Cochran, R. L., Kim, M., Shinn, D., Torquato, S., Hughes, R. M., Pallavajjalla, A., Carducci, M. A., Paller, C., Denmeade, S. R., Kressel, B., Trock, B., Eisenberger, M. & 3 others, Antonarakis, E., Park, B. H. & Hurley, P., 2017, In : Oncotarget. 8, 9, p. 15651-15662 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Plasma Cells
Mutation
Castration
DNA
Nerve Growth Factors
Ganglia
Type 2 Diabetes Mellitus
Down-Regulation
Gene Expression

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

Ross, A. E., Hughes, R. M., Glavaris, S., Ghabili, K., He, P., Anders, N., Harb, R., Tosoian, J. J., Marchionni, L., Schaeffer, E. M., Partin, A. W., Allaf, M. E., Bivalacqua, T., Chapman, C., O'Neal, T., Demarzo, A. M., Hurley, P., Rudek-Renaut, M. & Antonarakis, E., Jan 1 2017, In : Oncotarget. 8, 61, p. 104182-104192 11 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pharmacokinetics
Observation
Neoplasms

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Rosen, D. M., Cidado, J., Cochran, R. L., Dalton, W., Erlanger, B., Cravero, K., Button, B., Kyker-Snowman, K., Hurley, P., Lauring, J. & Park, B. H., Feb 11 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-14 14 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Cell Line
Neoplasms
Carcinogenesis

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S., DeWeese, T., Ross, A. E., Schaeffer, E. M., Pienta, K., Hurley, P., Morrissey, C. & Tran, P. T., Jun 15 2017, In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Contribution to journalArticle

Chromatin
Prostatic Neoplasms
Neoplasm Metastasis
Prostate
Long Noncoding RNA
2016

Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis

Benzon, B., Zhao, S. G., Haffner, M. C., Takhar, M., Erho, N., Yousefi, K., Hurley, P., Bishop, J. L., Tosoian, J., Ghabili, K., Alshalalfa, M., Glavaris, S., Simons, B. W., Tran, P. T., Davicioni, E., Karnes, R. J., Boudadi, K., Antonarakis, E., Schaeffer, E. M., Drake, C. G. & 2 others, Feng, F. & Ross, A. E., Nov 1 2016, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgens
Chromatin Immunoprecipitation
Prostatectomy

ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients

Chu, D., Paoletti, C., Gersch, C., VanDenBerg, D. A., Zabransky, D. J., Cochran, R. L., Wong, H. Y., Toro, P. V., Cidado, J., Croessmann, S., Erlanger, B., Cravero, K., Kyker-Snowman, K., Button, B., Parsons, H. A., Dalton, W., Gillani, R., Medford, A., Aung, K., Tokudome, N. & 9 others, Chinnaiyan, A. M., Schott, A., Robinson, D., Jacks, K. S., Lauring, J., Hurley, P., Hayes, D. F., Rae, J. M. & Park, B. H., Feb 15 2016, In : Clinical Cancer Research. 22, 4, p. 993-999 7 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
DNA
Neoplasms
Estrogen Receptors

Germline variants in asporin vary by race, modulate the tumor microenvironment, and are differentially associated with metastatic prostate cancer

Hurley, P., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A. & 7 others, Huang, J., An, S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. & Schaeffer, E. M., Jan 15 2016, In : Clinical Cancer Research. 22, 2, p. 448-458 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Prostatic Neoplasms
Confidence Intervals
Heterografts
Neoplasm Metastasis

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

Cidado, J., Wong, H. Y., Marc Rosen, D., Cimino-Mathews, A. M., Garay, J. P., Fessler, A. G., Rasheed, Z. A., Hicks, J., Cochran, R. L., Croessmann, S., Zabransky, D. J., Mohseni, M., Beaver, J., Chu, D., Cravero, K., Christenson, E. S., Medford, A., Mattox, A., Demarzo, A. M., Argani, P. & 4 others, Chawla, A., Hurley, P., Lauring, J. & Park, B. H., 2016, In : Oncotarget. 7, 5, p. 6281-6293 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Maintenance
Cell Proliferation
Stem Cell Niche
Null Lymphocytes
2015

A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression

Simons, B. W., Durham, N. M., Bruno, T. C., Grosso, J. F., Schaeffer, A. J., Ross, A. E., Hurley, P., Berman, D. M., Drake, C. G., Thumbikat, P. & Schaeffer, E. M., Feb 1 2015, In : Journal of Pathology. 235, 3, p. 478-489 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Prostate
Inflammation
Hyperplasia
Cytokines

Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression

Hurley, P., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. & Schaeffer, E. M., Oct 15 2015, In : Cancer Research. 75, 20, p. 4322-4334 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Androgens
Cysteine
Androgen Receptors
Prostatic Neoplasms

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA

Toro, P. V., Erlanger, B., Beaver, J., Cochran, R. L., VanDenBerg, D. A., Yakim, E., Cravero, K., Chu, D., Zabransky, D. J., Wong, H. Y., Croessmann, S., Parsons, H., Hurley, P., Lauring, J. & Park, B. H., Oct 1 2015, In : Clinical Biochemistry. 48, 15, p. 993-998 6 p.

Research output: Contribution to journalArticle

Tumors
Blood Cells
Blood
Plasmas
DNA

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharmaa, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J., Kachhap, S., Hurley, P. & 2 others, Lauring, J. & Park, B. H., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11583-11588 6 p.

Research output: Contribution to journalArticle

Centrosome
Genomic Instability
Homeostasis
Genes
Neoplasms

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

Wong, H. Y., Wang, G. M., Croessmann, S., Zabransky, D. J., Chu, D., Garay, J. P., Cidado, J., Cochran, R. L., Beaver, J., Aggarwal, A., Liu, M. L., Argani, P., Meeker, A. K., Hurley, P., Lauring, J. & Park, B. H., 2015, In : Oncotarget. 6, 42, p. 44927-44940 14 p.

Research output: Contribution to journalArticle

Male Breast Neoplasms
Y Chromosome
Neoplasms
Breast
Y-Linked Genes
2014

Detection of cancer DNA in plasma of patients with early-stage breast cancer

Beaver, J., Jelovac, D., Balukrishna, S., Cochran, R. L., Croessmann, S., Zabransky, D. J., Wong, H. Y., Toro, P. V., Cidado, J., Blair, B. G., Chu, D., Burns, T., Higgins, M. J., Stearns, V., Jacobs, L., Habibi, M., Lange, J. R., Hurley, P., Lauring, J., VanDenBerg, D. A. & 9 others, Kessler, J., Jeter, S., Samuels, M. L., Maar, D., Cope, L., Cimino-Mathews, A. M., Argani, P., Wolff, A. C. & Park, B. H., May 15 2014, In : Clinical Cancer Research. 20, 10, p. 2643-2650 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
DNA
Mutation
Neoplasms
Polymerase Chain Reaction

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

Mohseni, M., Cidado, J., Croessmann, S., Cravero, K., Cimino-Mathews, A. M., Wong, H. Y., Scharpf, R. B., Zabransky, D. J., Abukhdeir, A. M., Garay, J. P., Wang, G. M., Beaver, J., Cochran, R. L., Blair, B. G., Rosen, D. M., Erlanger, B., Argani, P., Hurley, P., Lauring, J. & Park, B. H., Dec 9 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17606-17611 6 p.

Research output: Contribution to journalArticle

Tamoxifen
Estrogens
Breast Neoplasms
Growth
Estrogen Receptor alpha

Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction

Li, J., Ma, W., Wang, P. Y., Hurley, P., Bunz, F. & Hwang, P. M., 2014, In : Free Radical Biology and Medicine. 73, p. 270-277 8 p.

Research output: Contribution to journalArticle

Cell Survival
Phosphotransferases
Antioxidants
Cells
Neurodegenerative diseases
2012

Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome

Hurley, P., Marchionni, L., Simons, B. W., Ross, A. E., Peskoe, S. B., Miller, R. M., Erho, N., Vergara, I. A., Ghadessi, M., Huang, Z., Gurel, B., Park, B. H., Davicioni, E., Jenkins, R. B., Platz, E. A., Berman, D. M. & Schaeffer, E. M., Sep 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14977-14982 6 p.

Research output: Contribution to journalArticle

Cysteine
Prostatic Neoplasms
Proteins
Recurrence
Prostate

Sox9 is required for prostate development and prostate cancer initiation

Huang, Z., Hurley, P., Simons, B. W., Marchionni, L., Berman, D. M., Ross, A. E. & Schaeffer, E. M., Jun 2012, In : Oncotarget. 3, 6, p. 651-663 13 p.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Carcinogenesis
Neoplasms
Cell Polarity

Wnt signaling though beta-catenin is required for prostate lineage specification

Simons, B. W., Hurley, P., Huang, Z., Ross, A. E., Miller, R., Marchionni, L., Berman, D. M. & Schaeffer, E. M., Nov 15 2012, In : Developmental Biology. 371, 2, p. 246-255 10 p.

Research output: Contribution to journalArticle

beta Catenin
Prostate
Organogenesis
Androgens
Homeostasis
2011

Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity

Ross, A. E., Emadi, A., Marchionni, L., Hurley, P., Simons, B. W., Schaeffer, E. M. & Vuica-Ross, M., Aug 2011, In : BJU International. 108, 3, p. 447-454 8 p.

Research output: Contribution to journalArticle

Naphthoquinones
docetaxel
Prostatic Neoplasms
Prostate
Epithelial Cells

Molecular effects of genistein on male urethral development

Ross, A. E., Marchionni, L., Phillips, T. M., Miller, R. M., Hurley, P., Simons, B. W., Salmasi, A. H., Schaeffer, A. J., Gearhart, J. P. & Schaeffer, E. M., May 2011, In : Journal of Urology. 185, 5, p. 1894-1898 5 p.

Research output: Contribution to journalArticle

Genistein
Diet
Endocrine Disruptors
Phytoestrogens
Hypospadias
2007

ATM and ATR: Components of an integrated circuit

Hurley, P. & Bunz, F., Feb 15 2007, In : Cell cycle (Georgetown, Tex.). 6, 4, p. 414-417 4 p.

Research output: Contribution to journalArticle

Automatic teller machines
DNA Damage
Integrated circuits
DNA
Phosphatidylinositol 3-Kinase

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation

Hurley, P., Wilsker, D. & Bunz, F., Apr 19 2007, In : Oncogene. 26, 18, p. 2535-2542 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Ionizing Radiation
Cell Cycle
S Phase
Neoplasms
2006

p53 regulates mitochondrial respiration

Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P., Bunz, F. & Hwang, P. M., Jun 16 2006, In : Science. 312, 5780, p. 1650-1653 4 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Respiration
Glycolysis
Neoplasms
Neoplasm Genes
2005

Erratum: The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses (Nature Immunology (2004) vol. 5 (1052-1060))

Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R. C., Wheeler, M. T., Tsui, C., Hurley, P., Chien, M., Chai, S., Hitotsumatsu, O., McNally, E., Pickart, C. & Ma, A., Jan 1 2005, In : Nature Immunology. 6, 1, 1 p.

Research output: Contribution to journalComment/debate

Toll-Like Receptors
Ubiquitin
Allergy and Immunology
Enzymes

Improved methods for the generation of human gene knockout and knockin cell lines

Topaloglu, O., Hurley, P., Yildirim, O., Civin, C. I. & Bunz, F., 2005, In : Nucleic Acids Research. 33, 18, p. 1-7 7 p.

Research output: Contribution to journalArticle

Gene Knockout Techniques
Exons
Cell Line
Plasmids
Catenins
2004

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R. C., Wheeler, M. T., Tsui, C., Hurley, P., Chien, M., Chai, S., Hitotsumatsu, O., McNally, E., Pickart, C. & Ma, A., Oct 1 2004, In : Nature Immunology. 5, 10, p. 1052-1060 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Ubiquitin
Tumor Necrosis Factor-alpha
Enzymes
TNF Receptor-Associated Factor 6