Paula Hurley

Assistant Professor

20042019
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Fingerprint Dive into the research topics where Paula Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Prostatic Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Prostate Medicine & Life Sciences
Tumor Microenvironment Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Androgens Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
DNA Medicine & Life Sciences

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Research Output 2004 2019

A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer

Ross, A. E., Hurley, P. J., Tran, P. T., Rowe, S. P., Benzon, B., Neal, T. O., Chapman, C., Harb, R., Milman, Y., Trock, B. J., Drake, C. G. & Antonarakis, E. S., Jan 1 2019, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Cryotherapy
Prostatic Neoplasms
Hormones
Androgens
Prostate

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S., Riddle, R., Thorek, D. L. J., Garraway, I. P., Fertig, E., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Mesenchymal Stromal Cells
Cell Differentiation
Neoplasms
Neoplasm Metastasis

Combining immune check-point blockade and cryoablation in an immunocompetent hormone sensitive murine model of prostate cancer

Benzon, B., Glavaris, S. A., Simons, B. W., Hughes, R. M., Ghabili, K., Mullane, P., Miller, R., Nugent, K., Shinder, B., Tosoian, J., Fuchs, E. J., Tran, P. T., Hurley, P., Vuica-Ross, M., Schaeffer, E. M., Drake, C. G. & Ross, A. E., Mar 20 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-11 11 p.

Research output: Contribution to journalArticle

Cryosurgery
Prostatic Neoplasms
Hormones
Neoplasms
Blocking Antibodies

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P., Simons, B. W., Schaeffer, E. M., Lotan, T., Isaacs, W. B., Netto, G. J., Demarzo, A. M. & 3 others, Nelson, W. G., An, S. & Yegnasubramanian, S., Dec 1 2017, In : Nature Communications. 8, 1, 142.

Research output: Contribution to journalArticle

Microfilament Proteins
Cell Movement
Actins
Melanoma
cancer

Detection fidelity of AR mutations in plasma derived cell-free DNA

Goldstein, A., Toro, P. V., Lee, J., Silberstein, J. L., Nakazawa, M., Waters, I., Cravero, K., Chu, D., Cochran, R. L., Kim, M., Shinn, D., Torquato, S., Hughes, R. M., Pallavajjalla, A., Carducci, M. A., Paller, C., Denmeade, S. R., Kressel, B., Trock, B., Eisenberger, M. & 3 others, Antonarakis, E., Park, B. H. & Hurley, P., 2017, In : Oncotarget. 8, 9, p. 15651-15662 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Plasma Cells
Mutation
Castration
DNA