Paula Hurley

Assistant Professor

20042019
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Fingerprint Dive into the research topics where Paula Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Prostatic Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Prostate Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Tumor Microenvironment Medicine & Life Sciences
Androgens Medicine & Life Sciences
Mutation Medicine & Life Sciences
DNA Medicine & Life Sciences

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Research Output 2004 2019

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host

Simons, B. W., Kothari, V., Benzon, B., Ghabili, K., Hughes, R., Zarif, J., Ross, A. E., Hurley, P. J. & Schaeffer, E. M., Jan 1 2019, In : Oncotarget. 10, 64, p. 6845-6854 10 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Prostatic Neoplasms
Neoplasm Metastasis
Castration
Neoplasms

A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer

Ross, A. E., Hurley, P. J., Tran, P. T., Rowe, S. P., Benzon, B., Neal, T. O., Chapman, C., Harb, R., Milman, Y., Trock, B. J., Drake, C. G. & Antonarakis, E. S., Jan 1 2019, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Cryotherapy
Prostatic Neoplasms
Hormones
Androgens
Prostate

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S. S., Riddle, R. C., Thorek, D. L. J., Garraway, I. P., Fertig, E. J., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P. J., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Mesenchymal Stromal Cells
Cell Differentiation
Neoplasms
Neoplasm Metastasis

Genetic alterations detected in cell-free DNA are associated with enzalutamide and abiraterone resistance in castration-resistant prostate cancer

Torquato, S., Pallavajjala, A., Goldstein, A., Toro, P. V., Silberstein, J. L., Lee, J., Nakazawa, M., Waters, I., Chu, D., Shinn, D., Groginski, T., Hughes, R. M., Simons, B. W., Khan, H., Feng, Z., Carducci, M. A., Paller, C. J., Denmeade, S. R., Kressel, B., Eisenberger, M. A. & 4 others, Antonarakis, E. S., Trock, B. J., Park, B. H. & Hurley, P. J., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

Open Access
Castration
Androgen Receptors
Prostatic Neoplasms
Disease-Free Survival
DNA

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

Brian Dalton, W., Helmenstine, E., Walsh, N., Gondek, L. P., Kelkar, D. S., Read, A., Natrajan, R., Christenson, E. S., Roman, B., Das, S., Zhao, L., Leone, R. D., Shinn, D., Groginski, T., Madugundu, A. K., Patil, A., Zabransky, D. J., Medford, A., Lee, J., Cole, A. J. & 12 others, Rosen, M., Thakar, M., Ambinder, A., Donaldson, J., DeZern, A. E., Cravero, K., Chu, D., Madero-Marroquin, R., Pandey, A., Hurley, P. J., Lauring, J. & Park, B. H., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4708-4723 16 p.

Research output: Contribution to journalArticle

Serine
Mutation
Down-Regulation
Spliceosomes
Mitochondrial Genes