Paul T Winnard

Research Associate

1989 …2019

Research output per year

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Research Output

2019

Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33

Tantravedi, S., Vesuna, F., Winnard, P. T., Martin, A., Lim, M., Eberhart, C. G., Berlinicke, C., Raabe, E., van Diest, P. J. & Raman, V., Jan 2019, In : Translational Oncology. 12, 1, p. 96-105 10 p.

Research output: Contribution to journalArticle

2018

Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations

Zhang, C., Winnard, P. T., Dasari, S., Kominsky, S., Doucet, M., Jayaraman, S., Raman, V. & Barman, I., Jan 1 2018, In : Chemical Science. 9, 3, p. 743-753 11 p.

Research output: Contribution to journalArticle

2017

Delayed progression of lung metastases following delivery of a prodrug-activating enzyme

Dore-Savard, L., Chen, Z., Winnard, P. T., Krishnamachary, B., Raman, V., Black, M. E. & Bhujwalla, Z. M., May 2017, In : Anticancer research. 37, 5, p. 2195-2200 6 p.

Research output: Contribution to journalArticle

Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes

Winnard, P. T., Zhang, C., Vesuna, F., Kang, J. W., Garry, J., Dasari, R. R., Barman, I. & Raman, V., 2017, In : Oncotarget. 8, 12, p. 20266-20287 22 p.

Research output: Contribution to journalArticle

Role of DDX3 in the pathogenesis of inflammatory bowel disease

Tantravedi, S., Vesuna, F., Winnard, P. T., van Voss, M. R. H., van Diest, P. J. & Raman, V., Jan 1 2017, In : Oncotarget. 8, 70, p. 115280-115289 10 p.

Research output: Contribution to journalArticle

2016

Detection of pancreatic cancer-induced cachexia using a fluorescent myoblast reporter system and analysis of metabolite abundance

Winnard, P. T., Bharti, S., Penet, M-F., Marik, R., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M., Mar 15 2016, In : Cancer Research. 76, 6, p. 1441-1450 10 p.

Research output: Contribution to journalArticle

2015

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

Xie, M., Vesuna, F., Botlagunta, M., Bol, G. M., Irving, A., Bergman, Y., Hosmane, R. S., Kato, Y., Winnard, P. T. & Raman, V., Jan 1 2015, In : Oncotarget. 6, 30, p. 29901-29913 13 p.

Research output: Contribution to journalArticle

2014

Direct facile screening of recombinant DNA vector constructs

Winnard, P. T., Challa, R., Bhujwalla, Z. M. & Raman, V., Apr 1 2014, In : Analytical biochemistry. 450, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

2013

Combined MR, fluorescence and histology imaging strategy in a human breast tumor xenograft model

Jiang, L., Greenwood, T. R., Van Hove, E. R. A., Chughtai, K., Raman, V., Winnard, P. T., Heeren, R. M. A., Artemov, D. & Glunde, K., Mar 1 2013, In : NMR in biomedicine. 26, 3, p. 285-298 14 p.

Research output: Contribution to journalArticle

Mass spectrometric imaging of red fluorescent protein in breast tumor xenografts

Chughtai, K., Jiang, L., Post, H., Winnard, P. T., Greenwood, T. R., Raman, V., Bhujwalla, Z. M., Heeren, R. M. A. & Glunde, K., May 1 2013, In : Journal of the American Society for Mass Spectrometry. 24, 5, p. 711-717 7 p.

Research output: Contribution to journalArticle

2012

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L., Apr 5 2012, In : Oncogene. 31, 14, p. 1757-1770 14 p.

Research output: Contribution to journalArticle

Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models

Jiang, L., Greenwood, T. R., Artemov, D., Raman, V., Winnard, P. T., Heeren, R. M. A., Bhujwalla, Z. M. & Glunde, K., Aug 2012, In : Neoplasia (United States). 14, 8, p. 732-741 10 p.

Research output: Contribution to journalArticle

2011

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard, P. T., Bol, G. M., Patel, A. H. & Raman, V., Mar 28 2011, In : PloS one. 6, 3, e17563.

Research output: Contribution to journalArticle

2010

Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells

Shah, T., Wildes, F., Penet, M. F., Winnard, P. T., Glunde, K., Artemov, D., Ackerstaff, E., Gimi, B., Kakkad, S., Raman, V. & Bhujwalla, Z. M., Jul 2010, In : NMR in biomedicine. 23, 6, p. 633-642 10 p.

Research output: Contribution to journalArticle

Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)

Chen, Y., Yuan, S., Wierwille, J., Naphas, R., Li, Q., Blackwell, T. R., Winnard, P. T., Raman, V. & Glunde, K., Jul 1 2010, In : IEEE Journal on Selected Topics in Quantum Electronics. 16, 4, p. 755-766 12 p., 5438778.

Research output: Contribution to journalArticle

Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy

Li, C., Penet, M. F., Wildes, F., Takagi, T., Chen, Z., Winnard, P. T., Artemov, D. & Bhujwalla, Z. M., Nov 23 2010, In : ACS Nano. 4, 11, p. 6707-6716 10 p.

Research output: Contribution to journalArticle

Neoplastic transformation of breast epithelial cells by genotoxic stress

Botlagunta, M., Winnard, P. T. & Raman, V., Jun 30 2010, In : BMC cancer. 10, 343.

Research output: Contribution to journalArticle

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

Satoh, H., Moriguchi, T., Taguchi, K., Takai, J., Maher, J. M., Suzuki, T., Winnard, P. T., Raman, V., Ebina, M., Nukiwa, T. & Yamamoto, M., May 31 2010, In : Carcinogenesis. 31, 10, p. 1833-1843 11 p.

Research output: Contribution to journalArticle

2009

Development of needle-based microendoscopy for fluorescence molecular imaging of breast tumor models

Chen, C. W., Blackwell, T. R., Naphas, R., Winnard, P. T., Raman, V., Glunde, K. & Chen, Y., Oct 1 2009, In : Journal of Innovative Optical Health Sciences. 2, 4, p. 343-352 10 p.

Research output: Contribution to journalArticle

2008

A PET rat model for assessing the effectiveness of new chemotherapies

Winnard, P. T. & Sukumar, S., Apr 1 2008, In : Cancer Biology and Therapy. 7, 4, p. 538-539 2 p.

Research output: Contribution to journalComment/debate

Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model

Winnard, P. T., Botlagunta, M., Kluth, J. B., Mukadam, S., Krishnamachary, B., Vesuna, F. & Raman, V., Oct 1 2008, In : Cancer Gene Therapy. 15, 10, p. 645-654 10 p.

Research output: Contribution to journalArticle

Image-guided enzyme/prodrug cancer therapy

Li, C., Penet, M. F., Winnard, P., Artemov, D. & Bhujwalla, Z. M., Jan 15 2008, In : Clinical Cancer Research. 14, 2, p. 515-522 8 p.

Research output: Contribution to journalArticle

Molecular imaging of metastatic potential

Winnard, P. T., Pathak, A. P., Dhara, S., Cho, S. Y., Raman, V. & Pomper, M. G., Jun 1 2008, In : Journal of Nuclear Medicine. 49, SUPPL.6, p. 96S-112S

Research output: Contribution to journalReview article

Oncogenic role of DDX3 in breast cancer biogenesis

Botlagunta, M., Vesuna, F., Mironchik, Y., Raman, A., Lisok, A., Winnard, P., Mukadam, S., Van Diest, P., Chen, J. H., Farabaugh, P., Patel, A. H. & Raman, V., Jun 26 2008, In : Oncogene. 27, 28, p. 3912-3922 11 p.

Research output: Contribution to journalArticle

2007

Artificial reporter gene providing MRI contrast based on proton exchange

Gilad, A. A., McMahon, M. T., Walczak, P., Winnard, P. T., Raman, V., Van Laarhoven, H. W. M., Skoglund, C. M., Bulte, J. W. M. & Van Zijl, P. C. M., Feb 1 2007, In : Nature biotechnology. 25, 2, p. 217-219 3 p.

Research output: Contribution to journalArticle

Developing MR reporter genes: Promises and pitfalls

Gilad, A. A., Winnard, P. T., van Zijl, P. C. M. & Bulte, J. W. M., May 1 2007, In : NMR in biomedicine. 20, 3, p. 275-290 16 p.

Research output: Contribution to journalReview article

Development of novel chimeric transmembrane proteins for multimodality imaging of cancer cells

Winnard, P. T., Kluth, J. B., Kato, Y., Artemov, D. & Raman, V., Dec 2007, In : Cancer Biology and Therapy. 6, 12, p. 1889-1899 11 p.

Research output: Contribution to journalArticle

Open Access
2006

HOXA5 regulates hMLH1 expression in breast cancer cells

Duriseti, S., Winnard, P. T., Mironchik, Y., Vesuna, F., Raman, A. & Raman, V., Apr 2006, In : Neoplasia. 8, 4, p. 250-258 9 p.

Research output: Contribution to journalArticle

Multimodal image-guided enzyme/prodrug cancer therapy

Li, C., Winnard, P. T., Takagi, T., Artemov, D. & Bhujwalla, Z. M., Nov 29 2006, In : Journal of the American Chemical Society. 128, 47, p. 15072-15073 2 p.

Research output: Contribution to journalArticle

Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer

Winnard, P. T., Kluth, J. B. & Raman, V., Oct 2006, In : Neoplasia. 8, 10, p. 796-806 11 p.

Research output: Contribution to journalArticle

Stable integration of an empty vector in MCF-7 cells greatly alters the karyotype [2]

Winnard, P., Glackin, C. & Raman, V., Jan 15 2006, In : Cancer Genetics and Cytogenetics. 164, 2, p. 174-176 3 p.

Research output: Contribution to journalLetter

Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7

Vesuna, F., Winnard, P., Raman, V. & Glackin, C., Jun 1 2006, In : Cancer Genetics and Cytogenetics. 167, 2, p. 189-191 3 p.

Research output: Contribution to journalLetter

2005

Enhanced green fluorescent protein as an alternative control reporter to Renilla luciferase

Vesuna, F., Winnard, P. & Raman, V., Jul 15 2005, In : Analytical biochemistry. 342, 2, p. 345-347 3 p.

Research output: Contribution to journalArticle

HOXA5-twist interaction alters p53 homeostasis in breast cancer cells

Stasinopoulos, I. A., Mironchik, Y., Raman, A., Wildes, F., Winnard, P. & Raman, V., Jan 21 2005, In : Journal of Biological Chemistry. 280, 3, p. 2294-2299 6 p.

Research output: Contribution to journalArticle

Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer

Mironchik, Y., Winnard, P. T., Vesuna, F., Kato, Y., Wildes, F., Pathak, A. P., Kominsky, S., Artemov, D., Bhujwalla, Z., Van Diest, P., Burger, H., Glackin, C. & Raman, V., Dec 1 2005, In : Cancer Research. 65, 23, p. 10801-10809 9 p.

Research output: Contribution to journalArticle

2004

Robust expression of transgenes in MCF-7 breast cancer cells is expression vector-dependent

Winnard, P., Mironchik, Y. & Raman, V., Sep 2004, In : BioTechniques. 37, 3, p. 370-374 5 p.

Research output: Contribution to journalArticle

Open Access
2003

Real time non-invasive imaging of receptor - Ligand interactions in vivo

Winnard, P. & Raman, V., Oct 15 2003, In : Journal of cellular biochemistry. 90, 3, p. 454-463 10 p.

Research output: Contribution to journalReview article

2002

Teleost introns are characterized by a high A+T content

Winnard, P., Sidell, B. D. & Vayda, M. E., Oct 1 2002, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 133, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

1999

Pretargeting of bacterial endocarditis in rats with streptavidin and 111In-labeled biotin

Fogarasi, M., Pullman, J., Winnard, P., Hnatowich, D. J. & Rusckowski, M., Mar 1 1999, In : Journal of Nuclear Medicine. 40, 3, p. 484-490 7 p.

Research output: Contribution to journalArticle

1997

Preparation and use of NHS-MAG3 for technetium-99m labeling of DNA

Winnard, P. T., Chang, F., Rusckowski, M., Mardirossian, G. & Hnatowich, D. J., Jan 1 1997, In : Nuclear Medicine and Biology. 24, 5, p. 425-432 8 p.

Research output: Contribution to journalArticle

Preparation and use of NHS-MAG3 for technetium-99m labeling of DNA

Winnard, P. T., Chang, F., Rusckowski, M., Mardirossian, G. & Hnatowich, D. J., Jul 1997, In : Nuclear Medicine and Biology. 24, 5, p. 425-432 8 p.

Research output: Contribution to journalArticle