Paul B Rosenberg

Professor

1991 …2019
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Research Output 1991 2019

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2019

Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits

Kanellopoulos, D., Rosenberg, P., Ravdin, L. D., Maldonado, D., Jamil, N., Quinn, C. & Kiosses, D. N., Jan 1 2019, (Accepted/In press) In : International psychogeriatrics.

Research output: Contribution to journalArticle

Depression
Therapeutics
Appointments and Schedules
Dementia
Geriatric Psychiatry
Citalopram
Multicenter Studies
Alzheimer Disease
Randomized Controlled Trials
Research Personnel
Equipment and Supplies
Dementia
Alzheimer Disease
Anxiety
Cognitive Dysfunction

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO2

Jiang, D., Lin, Z., Liu, P., Sur, S., Xu, C., Hazel, K., Pottanat, G., Yasar, S., Rosenberg, P., Albert, M. & Lu, H., Jan 1 2019, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Oxygen
Brain
Blood Pressure
Biomarkers
Sickle Cell Anemia
Open Access
Neurobehavioral Manifestations
Dementia
Volunteers
Focus Groups
Healthy Volunteers
2018

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

Oh, E., Blennow, K., Bigelow, G., Inouye, S. K., Marcantonio, E. R., Neufeld, K. J., Rosenberg, P. B., Troncoso, J. C., Wang, N. Y., Zetterberg, H., Sieber, F. & Lyketsos, C. G., Sep 1 2018, In : PLoS One. 13, 9, e0204695.

Research output: Contribution to journalArticle

hip fractures
Cerebrospinal fluid
dementia
Hip Fractures
cerebrospinal fluid

A Review of Diagnostic Impact of Amyloid Positron Emission Tomography Imaging in Clinical Practice

Kim, Y., Rosenberg, P. B. & Oh, E., Jan 1 2018, (Accepted/In press) In : Dementia and Geriatric Cognitive Disorders. p. 154-167 14 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Alzheimer Disease
Molecular Imaging
United States Food and Drug Administration

Characterization of 3 novel tau radiopharmaceuticals,11C-RO-963,11C-RO-643, and18F-RO-948, in healthy controls and in Alzheimer subjects

Wong, D. F., Comley, R. A., Kuwabara, H., Rosenberg, P. B., Resnick, S. M., Ostrowitzki, S., Vozzi, C., Boess, F., Oh, E., Lyketsos, C. G., Honer, M., Gobbi, L., Klein, G., George, N., Gapasin, L., Kitzmiller, K., Roberts, J., Sevigny, J., Nandi, A., Brasic, J. R. & 7 others, Mishra, C., Thambisetty, M., Mogekar, A., Mathur, A., Albert, M., Dannals, R. F. & Borroni, E., Dec 1 2018, In : Journal of Nuclear Medicine. 59, 12, p. 1869-1876 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Alzheimer Disease
Whole Body Imaging
Brain
Temporal Lobe

Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation

Leoutsakos, J-M. S., Yan, H., Anderson, W. S., Asaad, W. F., Baltuch, G., Burke, A., Chakravarty, M. M., Drake, K. E., Foote, K. D., Fosdick, L., Giacobbe, P., Mari, Z., McAndrews, M. P., Munro, C., Oh, E., Okun, M. S., Pendergrass, J. C., Ponce, F. A., Rosenberg, P. B., Sabbagh, M. N. & 7 others, Salloway, S., Tang-Wai, D. F., Targum, S. D., Wolk, D., Lozano, A. M., Smith, G. & Lyketsos, C. G., Jan 1 2018, In : Journal of Alzheimer's Disease. 64, 2, p. 597-606 10 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Alzheimer Disease
Safety
Therapeutics
Electrodes

Depressive symptoms in relation to clinical symptom onset of mild cognitive impairment

Chan, C. K., Soldan, A., Pettigrew, C., Wang, M. C., Wang, J., Albert, M. & Rosenberg, P. B., Jan 1 2018, (Accepted/In press) In : International Psychogeriatrics. p. 1-9 9 p.

Research output: Contribution to journalArticle

Depression
Cognition
Cognitive Dysfunction
Proportional Hazards Models
Alzheimer Disease
Delirium
Hip Fractures
Randomized Controlled Trials
Incidence
Comorbidity

Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force

Sano, M., Soto, M., Carrillo, M., Cummings, J., Hendrix, S., Mintzer, J., Porsteinsson, A., Rosenberg, P., Schneider, L., Touchon, J., Aisen, P., Vellas, B. & Lyketsos, C., Jan 1 2018, In : The journal of prevention of Alzheimer's disease. 5, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Advisory Committees
Caregivers
Dementia
Outcome Assessment (Health Care)
Clinical Trials

Sex Differences in the Neuropsychiatric Symptoms of Patients With Alzheimer’s Disease

Tao, Y., Peters, M., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J., Lyketsos, C. G., Munro, C. & for the CitAD Research Group, T. CD. R. G., Jan 1 2018, (Accepted/In press) In : American Journal of Alzheimer's Disease and other Dementias.

Research output: Contribution to journalArticle

Sex Characteristics
Alzheimer Disease
Equipment and Supplies
Citalopram
Multicenter Studies

The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): Study protocol for a randomized controlled trial

the ADMET 2 Research Group, Jan 18 2018, In : Trials. 19, 1, 46.

Research output: Contribution to journalArticle

Apathy
Methylphenidate
Dementia
Randomized Controlled Trials
Alzheimer Disease
2017

Characterizing Highly Benefited Patients in Randomized Clinical Trials

Charu, V., Rosenberg, P. B., Schneider, L. S., Drye, L. T., Rein, L., Shade, D., Lyketsos, C. G. & Frangakis, C., 2017, In : International Journal of Biostatistics. 13, 1, 20160045.

Research output: Contribution to journalArticle

Randomized Clinical Trial
Randomized Controlled Trials
Randomized Controlled Trial
Predictors
Covariates

Clinical evaluation of brief cognitive assessment measures for patients with severe dementia

Dixon, J. S., Saddington, D. G., Shiles, C. J., Sreevalsan, K. P., Munro, C. & Rosenberg, P. B., Mar 29 2017, (Accepted/In press) In : International Psychogeriatrics. p. 1-6 6 p.

Research output: Contribution to journalArticle

Dementia
Frustration
Cognition
Fatigue
Inpatients
Dementia
Alzheimer Disease
Kidney
Transplants
Mortality

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials

Aisen, P., Touchon, J., Amariglio, R., Andrieu, S., Bateman, R., Breitner, J., Donohue, M., Dunn, B., Doody, R., Fox, N., Gauthier, S., Grundman, M., Hendrix, S., Ho, C., Isaac, M., Raman, R., Rosenberg, P., Schindler, R., Schneider, L., Sperling, R. & 4 others, Tariot, P., Welsh-Bohmer, K., Weiner, M. & Vellas, B., Jan 1 2017, In : The journal of prevention of Alzheimer's disease. 4, 2, p. 116-124 9 p.

Research output: Contribution to journalArticle

Advisory Committees
Alzheimer Disease
Clinical Trials
Cognition
Disease Progression

The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations

Ismail, Z., Agüera-Ortiz, L., Brodaty, H., Cieslak, A., Cummings, J., Fischer, C. E., Gauthier, S., Geda, Y. E., Herrmann, N., Kanji, J., Lanctôt, K. L., Miller, D. S., Mortby, M. E., Onyike, C. U., Rosenberg, P. B., Smith, E. E., Smith, G., Sultzer, D. L. & Lyketsos, C. G., 2017, In : Journal of Alzheimer's Disease. 56, 3, p. 929-938 10 p.

Research output: Contribution to journalArticle

Checklist
Dementia
Research
Population
Behavioral Symptoms
2016

Apathy associated with neurocognitive disorders: Recent progress and future directions

Lanctôt, K. L., Agüera-Ortiz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., Marshall, G. A., Mortby, M. E., Onyike, C. U., Padala, P. R., Politis, A., Rosenberg, P. B., Siegel, E., Sultzer, D. L. & Abraham, E. H., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Apathy
Research
Neurobiology
Direction compound
Neurocognitive Disorders

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease

Lozano, A. M., Fosdick, L., Chakravarty, M. M., Leoutsakos, J-M. S., Munro, C., Oh, E., Drake, K. E., Lyman, C. H., Rosenberg, P. B., Anderson, W. S., Tang-Wai, D. F., Pendergrass, J. C., Salloway, S., Asaad, W. F., Ponce, F. A., Burke, A., Sabbagh, M., Wolk, D. A., Baltuch, G., Okun, M. S. & 6 others, Foote, K. D., McAndrews, M. P., Giacobbe, P., Targum, S. D., Lyketsos, C. G. & Smith, G., Sep 6 2016, In : Journal of Alzheimer's Disease. 54, 2, p. 777-787 11 p.

Research output: Contribution to journalArticle

Brain Fornix
Deep Brain Stimulation
Alzheimer Disease
Glucose
Brain

Changes in neuropsychiatric inventory associated with semagacestat treatment of Alzheimer's disease

Rosenberg, P. B., Lanctot, K. L., Herrmann, N., Mintzer, J. E., Porsteinsson, A. P., Sun, X. & Raman, R., Aug 23 2016, In : Journal of Alzheimer's Disease. 54, 1, p. 373-381 9 p.

Research output: Contribution to journalArticle

N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Alzheimer Disease
Equipment and Supplies
Amyloid Precursor Protein Secretases
Therapeutics

Citalopram for the Treatment of Agitation in Alzheimer Dementia

Peters, M., Vaidya, V., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J., Lyketsos, C. G. & Avramopoulos, D., Mar 1 2016, In : Journal of Geriatric Psychiatry and Neurology. 29, 2, p. 59-64 6 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Equipment and Supplies
Therapeutics
Apolipoprotein E2

Effects of citalopram on neuropsychiatric symptoms in Alzheimer's dementia: Evidence from the CitAD study

For the CitAD Research Group, May 1 2016, In : American Journal of Psychiatry. 173, 5, p. 473-480 8 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Delusions
Hallucinations
Odds Ratio

Heterogeneity of treatment response to citalopram for patients with Alzheimer's disease with aggression or agitation: The citad randomized clinical trial

For the CitAD Research Group & Marano, C. M., May 1 2016, In : American Journal of Psychiatry. 173, 5, p. 465-472 8 p.

Research output: Contribution to journalArticle

Citalopram
Aggression
Alzheimer Disease
Randomized Controlled Trials
Therapeutics

Principal components analysis of agitation outcomes in Alzheimer's disease

For the CitAD Research Group & Drye, L. T., Aug 1 2016, In : Journal of Psychiatric Research. 79, p. 4-7 4 p.

Research output: Contribution to journalArticle

Citalopram
Principal Component Analysis
Alzheimer Disease
Equipment and Supplies
Alzheimer's Disease

Proceedings of the fourth annual deep brain stimulation think tank: A review of emerging issues and technologies

Deeb, W., Giordano, J. J., Rossi, P. J., Mogilner, A. Y., Gunduz, A., Judy, J. W., Klassen, B. T., Butson, C. R., Horne, C. V., Deny, D., Dougherty, D. D., Rowell, D., Gerhardt, G. A., Smith, G., Ponce, F. A., Walker, H. C., Bronte-Stewart, H. M., Mayberg, H. S., Chizeck, H. J., Langevin, J. P. & 17 others, Volkmann, J., Ostrem, J. L., Shute, J. B., Jimenez-Shahed, J., Foote, K. D., Shukla, A. W., Rossi, M. A., Oh, M., Pourfar, M., Rosenberg, P. B., Silburn, P. A., De Hemptine, C., Starr, P. A., Denison, T., Akbar, U., Grill, W. M. & Okun, M. S., Nov 22 2016, In : Frontiers in Integrative Neuroscience. 10, NOV2016, 38.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Technology
Essential Tremor
Tourette Syndrome
Movement Disorders

Sedation mediates part of Citalopram's effect on agitation in Alzheimer's disease

CitAD Research Group & Drye, L. T., Mar 1 2016, In : Journal of Psychiatric Research. 74, p. 17-21 5 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Placebos
Hypnotics and Sedatives
Canada
Dementia
Aptitude
Databases
Taxes
Cognitive Dysfunction
2015

Benzodiazepine exposure increases risk of Alzheimer's disease

Rosenberg, P. B., Apr 1 2015, In : Evidence-Based Medicine. 20, 2, p. 75 1 p.

Research output: Contribution to journalArticle

Benzodiazepines
Alzheimer Disease

Change in agitation in Alzheimer's disease in the placebo arm of a nine-week controlled trial

Rosenberg, P. B., Drye, L. T., Porsteinsson, A. P., Pollock, B. G., Devanand, D. P., Frangakis, C., Ismail, Z., Marano, C., Meinert, C. L., Mintzer, J. E., Munro, C., Pelton, G., Rabins, P. V., Schneider, L. S., Shade, D., Weintraub, D., Newell, J., Yesavage, J. & Lyketsos, C. G., Dec 1 2015, In : International Psychogeriatrics. 27, 12, p. 2059-2067 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Placebos
Equipment and Supplies
Citalopram
Activities of Daily Living

Deep brain stimulation targeting the fornix for mild Alzheimer dementia: Design of the ADvance randomized controlled trial

Holroyd, K. B., Fosdick, L., Smith, G., Leoutsakos, J-M. S., Munro, C., Oh, E., Drake, K. E., Rosenberg, P. B., Anderson, W. S., Salloway, S., Pendergrass, J. C., Burke, A. D., Wolk, D. A., Tang-Wai, D. F., Ponce, F. A., Asaad, W. F., Sabbagh, M. N., Okun, M. S., Baltuch, G., Foote, K. D. & 3 others, Targum, S. D., Lozano, A. M. & Lyketsos, C. G., Jul 10 2015, In : Open Access Journal of Clinical Trials. 7, p. 63-76 14 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Alzheimer Disease
Randomized Controlled Trials
Dementia
Brain Fornix

Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia

Kiosses, D. N., Rosenberg, P. B., McGovern, A., Fonzetti, P., Zaydens, H. & Alexopoulos, G. S., Sep 9 2015, In : Journal of Alzheimer's Disease. 48, 2, p. 453-462 10 p.

Research output: Contribution to journalArticle

Suicidal Ideation
Dementia
Depression
Therapeutics
Antidepressive Agents

Interventions for Neuropsychiatric symptoms in Neurocognitive impairment due to Alzheimer's disease: A review of the literature

McClam, T. D., Marano, C. M., Rosenberg, P. B. & Lyketsos, C. G., Sep 19 2015, In : Harvard Review of Psychiatry. 23, 5, p. 377-393 17 p.

Research output: Contribution to journalArticle

Electroconvulsive Therapy
Dronabinol
Alzheimer Disease
Randomized Controlled Trials
Outcome Assessment (Health Care)

Markers of Impaired Decision Making in Nursing Home Residents: Assessment by Nursing Home Staff in a Population-Based Study

Fain, K. M., Rosenberg, P. B., Pirard, S., Bogunovic, O. & Spira, A. P., Jul 1 2015, In : Journal of the American Medical Directors Association. 16, 7, p. 563-567 5 p.

Research output: Contribution to journalArticle

Nursing Staff
Nursing Homes
Decision Making
Odds Ratio
Confidence Intervals

Medication development for agitation and aggression in Alzheimer disease: Review and discussion of recent randomized clinical trial design

Soto, M., Andrieu, S., Nourhashemi, F., Ousset, P. J., Ballard, C., Robert, P., Vellas, B., Lyketsos, C. G. & Rosenberg, P. B., Jul 3 2015, In : International Psychogeriatrics. 27, 2, p. 181-197 17 p.

Research output: Contribution to journalArticle

Aggression
Alzheimer Disease
Randomized Controlled Trials
Caregivers
Placebos
Gyrus Cinguli
Apathy
Brain
Alzheimer Disease
Delusions
Alzheimer Disease
Apathy
Depression
Delusions
Hallucinations

Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial

Van Den Elsen, G. A. H., Ahmed, A. I. A., Verkes, R. J., Kramers, C., Feuth, T., Rosenberg, P. B., Van Der Marck, M. A. & Olde Rikkert, M. G. M., Jun 9 2015, In : Neurology. 84, 23, p. 2338-2346 9 p.

Research output: Contribution to journalArticle

Dronabinol
Dementia
Randomized Controlled Trials
Placebos
Confidence Intervals
Alzheimer Disease
Diffusion Tensor Imaging
Diencephalon
Pathologic Processes
Temporal Lobe

Time to Response to Citalopram Treatment for Agitation in Alzheimer Disease

CitAD Research Group, Drye, L. T. & Marano, C., Nov 1 2015, In : American Journal of Geriatric Psychiatry. 23, 11, p. 1127-1133 7 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Placebos
Therapeutics
Clinical Trials
2014
Geriatric Psychiatry
geriatrics
Benzodiazepines
withdrawal
regression

Changes in QTc interval in the Citalopram for agitation in Alzheimer's Disease (CitAD) randomized trial

Drye, L. T., Spragg, D. D., Devanand, D. P., Frangakis, C., Marano, C., Meinert, C. L., Mintzer, J. E., Munro, C., Pelton, G., Pollock, B. G., Porsteinsson, A. P., Rabins, P. V., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J. & Lyketsos, C. G., Jun 10 2014, In : PLoS One. 9, 6, e98426.

Research output: Contribution to journalArticle

Citalopram
agitation
Alzheimer disease
placebos
Alzheimer Disease

Effect of citalopram on agitation in Alzheimer disease: The CitAD randomized clinical trial

Porsteinsson, A. P., Drye, L. T., Pollock, B. G., Devanand, D. P., Frangakis, C., Ismail, Z., Marano, C., Meinert, C. L., Mintzer, J. E., Munro, C., Pelton, G., Rabins, P. V., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J. & Lyketsos, C. G., 2014, In : Journal of the American Medical Association. 311, 7, p. 682-691 10 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Randomized Controlled Trials
Placebos
Caregivers

Effect of medications on physical function and cognition in nursing home residents with dementia

Dutcher, S. K., Rattinger, G. B., Langenberg, P., Chhabra, P. T., Liu, X., Rosenberg, P. B., Leoutsakos, J-M. S., Simoni-Wastila, L., Walker, L. D., Franey, C. S. & Zuckerman, I. H., 2014, In : Journal of the American Geriatrics Society. 62, 6, p. 1046-1055 10 p.

Research output: Contribution to journalArticle

Activities of Daily Living
Nursing Homes
Cognition
Dementia
Antidepressive Agents

Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial

Lanctôt, K. L., Chau, S. A., Herrmann, N., Drye, L. T., Rosenberg, P. B., Scherer, R., Black, S. E., Vaidya, V., Bachman, D. L. & Mintzer, J. E., Feb 2014, In : International Psychogeriatrics. 26, 2, p. 239-246 8 p.

Research output: Contribution to journalArticle

Apathy
Methylphenidate
Alzheimer Disease
Randomized Controlled Trials
Placebos

Is sertraline treatment or depression remission in depressed alzheimer patients associated with improved caregiver well being? depression in alzheimer's disease study 2

Flynn Longmire, C. V., Drye, L. T., Frangakis, C., Martin, B. K., Meinert, C. L., Mintzer, J. E., Munro, C., Porsteinsson, A. P., Rabins, P. V., Rosenberg, P. B., Schneider, L. S., Weintraub, D. & Lyketsos, C. G., 2014, In : American Journal of Geriatric Psychiatry. 22, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

Sertraline
Caregivers
Depression
Therapeutics
Placebos
2013

Cocoa, neurovascular coupling, and neurodegeneration the good, the bad, and the ugly

Rosenberg, P. B. & Tan, C. O., Sep 3 2013, In : Neurology. 81, 10, p. 863-864 2 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Myelinated Nerve Fibers
Cacao
Neuropsychological Tests
Beverages