Paul B Rosenberg

Professor

1991 …2019
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Research Output 1991 2019

2019

Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits

Kanellopoulos, D., Rosenberg, P., Ravdin, L. D., Maldonado, D., Jamil, N., Quinn, C. & Kiosses, D. N., Jan 1 2019, (Accepted/In press) In : International psychogeriatrics.

Research output: Contribution to journalArticle

Depression
Therapeutics
Appointments and Schedules
Dementia
Geriatric Psychiatry

Depression Synergy with Amyloid and Increased Risk of Cognitive Decline in Preclinical Alzheimer Disease

Chan, C. & Rosenberg, P. B., Jan 1 2019, (Accepted/In press) In : JAMA Network Open.

Research output: Contribution to journalShort survey

Open Access
Amyloid
Alzheimer Disease
Depression
Cognitive Dysfunction
Citalopram
Multicenter Studies
Alzheimer Disease
Randomized Controlled Trials
Research Personnel

Fornix-region deep brain stimulation–induced memory flashbacks in Alzheimer’s disease

Deeb, W., Salvato, B., Almeida, L., Foote, K. D., Amaral, R., Germann, J., Rosenberg, P. B., Tang-Wai, D. F., Wolk, D. A., Burke, A. D., Salloway, S., Sabbagh, M. N., Chakravarty, M. M., Smith, G., Lyketsos, C. G., Lozano, A. M. & Okun, M. S., Aug 22 2019, In : New England Journal of Medicine. 381, 8, p. 783-785 3 p.

Research output: Contribution to journalLetter

Deep Brain Stimulation
Alzheimer Disease

Improving environmental interventions for neuropsychiatric symptoms in dementia

Kiosses, D. N. & Rosenberg, P. B., Aug 1 2019, In : International psychogeriatrics. 31, 8, p. 1077-1080 4 p.

Research output: Contribution to journalComment/debate

Dementia
Equipment and Supplies
Dementia
Alzheimer Disease
Anxiety
Cognitive Dysfunction

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO2

Jiang, D., Lin, Z., Liu, P., Sur, S., Xu, C., Hazel, K., Pottanat, G., Yasar, S., Rosenberg, P., Albert, M. & Lu, H., Jan 1 2019, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Oxygen
Brain
Blood Pressure
Biomarkers
Sickle Cell Anemia

Tetrahydrocannabinol Has Potential for Treating Agitation in Alzheimer's Disease

Rosenberg, P. B., Outen, J. D., Amjad, H., Burhanullah, M. H., Vandrey, R. G., Monette, P. J. & Forester, B. P., Jan 1 2019, In : American Journal of Geriatric Psychiatry.

Research output: Contribution to journalEditorial

Dronabinol
Alzheimer Disease

The Potential of Actigraphy to Assess Agitation in Dementia

Rosenberg, P. B., Wanigatunga, S. K. & Spira, A. P., Jan 1 2019, In : American Journal of Geriatric Psychiatry.

Research output: Contribution to journalEditorial

Actigraphy
Circadian Rhythm
Dementia
Open Access
Neurobehavioral Manifestations
Dementia
Volunteers
Focus Groups
Healthy Volunteers
2018

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

Oh, E., Blennow, K., Bigelow, G., Inouye, S. K., Marcantonio, E. R., Neufeld, K. J., Rosenberg, P. B., Troncoso, J. C., Wang, N. Y., Zetterberg, H., Sieber, F. & Lyketsos, C. G., Sep 1 2018, In : PLoS One. 13, 9, e0204695.

Research output: Contribution to journalArticle

hip fractures
Cerebrospinal fluid
dementia
Hip Fractures
cerebrospinal fluid

A Review of Diagnostic Impact of Amyloid Positron Emission Tomography Imaging in Clinical Practice

Kim, Y., Rosenberg, P. B. & Oh, E., Jan 1 2018, (Accepted/In press) In : Dementia and Geriatric Cognitive Disorders. p. 154-167 14 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Alzheimer Disease
Molecular Imaging
United States Food and Drug Administration

Characterization of 3 novel tau radiopharmaceuticals,11C-RO-963,11C-RO-643, and18F-RO-948, in healthy controls and in Alzheimer subjects

Wong, D. F., Comley, R. A., Kuwabara, H., Rosenberg, P. B., Resnick, S. M., Ostrowitzki, S., Vozzi, C., Boess, F., Oh, E., Lyketsos, C. G., Honer, M., Gobbi, L., Klein, G., George, N., Gapasin, L., Kitzmiller, K., Roberts, J., Sevigny, J., Nandi, A., Brasic, J. R. & 7 others, Mishra, C., Thambisetty, M., Mogekar, A., Mathur, A., Albert, M., Dannals, R. F. & Borroni, E., Dec 1 2018, In : Journal of Nuclear Medicine. 59, 12, p. 1869-1876 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Alzheimer Disease
Whole Body Imaging
Brain
Temporal Lobe

Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation

Leoutsakos, J-M. S., Yan, H., Anderson, W. S., Asaad, W. F., Baltuch, G., Burke, A., Chakravarty, M. M., Drake, K. E., Foote, K. D., Fosdick, L., Giacobbe, P., Mari, Z., McAndrews, M. P., Munro, C., Oh, E., Okun, M. S., Pendergrass, J. C., Ponce, F. A., Rosenberg, P. B., Sabbagh, M. N. & 7 others, Salloway, S., Tang-Wai, D. F., Targum, S. D., Wolk, D., Lozano, A. M., Smith, G. & Lyketsos, C. G., Jan 1 2018, In : Journal of Alzheimer's Disease. 64, 2, p. 597-606 10 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Alzheimer Disease
Safety
Therapeutics
Electrodes

Depressive symptoms in relation to clinical symptom onset of mild cognitive impairment

Chan, C. K., Soldan, A., Pettigrew, C., Wang, M. C., Wang, J., Albert, M. & Rosenberg, P. B., Jan 1 2018, (Accepted/In press) In : International Psychogeriatrics. p. 1-9 9 p.

Research output: Contribution to journalArticle

Depression
Cognition
Cognitive Dysfunction
Proportional Hazards Models
Alzheimer Disease
Delirium
Hip Fractures
Randomized Controlled Trials
Incidence
Comorbidity

Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force

Sano, M., Soto, M., Carrillo, M., Cummings, J., Hendrix, S., Mintzer, J., Porsteinsson, A., Rosenberg, P., Schneider, L., Touchon, J., Aisen, P., Vellas, B. & Lyketsos, C., Jan 1 2018, In : The journal of prevention of Alzheimer's disease. 5, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Advisory Committees
Caregivers
Dementia
Outcome Assessment (Health Care)
Clinical Trials

New Clues to Preclinical Alzheimer’s Disease

Rosenberg, P. B. & Lyketsos, C. G., Jun 1 2018, In : American Journal of Psychiatry. 175, 6, p. 493-494 2 p.

Research output: Contribution to journalEditorial

Alzheimer Disease

Psychometric Properties of Apathy Scales in Dementia: A Systematic Review

Mohammad, D., Ellis, C., Rau, A., Rosenberg, P. B., Mintzer, J., Ruthirakuhan, M., Herrmann, N. & Lanctôt, K. L., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1065-1082 18 p.

Research output: Contribution to journalReview article

Apathy
Psychometrics
Dementia
Clinical Trials
Alzheimer Disease

Sex Differences in the Neuropsychiatric Symptoms of Patients With Alzheimer’s Disease

Tao, Y., Peters, M., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J., Lyketsos, C. G., Munro, C. & for the CitAD Research Group, T. CD. R. G., Jan 1 2018, (Accepted/In press) In : American Journal of Alzheimer's Disease and other Dementias.

Research output: Contribution to journalArticle

Sex Characteristics
Alzheimer Disease
Equipment and Supplies
Citalopram
Multicenter Studies

The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): Study protocol for a randomized controlled trial

the ADMET 2 Research Group, Jan 18 2018, In : Trials. 19, 1, 46.

Research output: Contribution to journalArticle

Apathy
Methylphenidate
Dementia
Randomized Controlled Trials
Alzheimer Disease
2017

Characterizing Highly Benefited Patients in Randomized Clinical Trials

Charu, V., Rosenberg, P. B., Schneider, L. S., Drye, L. T., Rein, L., Shade, D., Lyketsos, C. G. & Frangakis, C., 2017, In : International Journal of Biostatistics. 13, 1, 20160045.

Research output: Contribution to journalArticle

Randomized Clinical Trial
Randomized Controlled Trials
Randomized Controlled Trial
Predictors
Covariates

Clinical evaluation of brief cognitive assessment measures for patients with severe dementia

Dixon, J. S., Saddington, D. G., Shiles, C. J., Sreevalsan, K. P., Munro, C. & Rosenberg, P. B., Mar 29 2017, (Accepted/In press) In : International Psychogeriatrics. p. 1-6 6 p.

Research output: Contribution to journalArticle

Dementia
Frustration
Cognition
Fatigue
Inpatients
Dementia
Alzheimer Disease
Kidney
Transplants
Mortality

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials

Aisen, P., Touchon, J., Amariglio, R., Andrieu, S., Bateman, R., Breitner, J., Donohue, M., Dunn, B., Doody, R., Fox, N., Gauthier, S., Grundman, M., Hendrix, S., Ho, C., Isaac, M., Raman, R., Rosenberg, P., Schindler, R., Schneider, L., Sperling, R. & 4 others, Tariot, P., Welsh-Bohmer, K., Weiner, M. & Vellas, B., Jan 1 2017, In : The journal of prevention of Alzheimer's disease. 4, 2, p. 116-124 9 p.

Research output: Contribution to journalArticle

Advisory Committees
Alzheimer Disease
Clinical Trials
Cognition
Disease Progression

Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

Lanctôt, K. L., Amatniek, J., Ancoli-Israel, S., Arnold, S. E., Ballard, C., Cohen-Mansfield, J., Ismail, Z., Lyketsos, C. G., Miller, D. S., Musiek, E., Osorio, R. S., Rosenberg, P. B., Satlin, A., Steffens, D., Tariot, P., Bain, L. J., Carrillo, M. C., Hendrix, J. A., Jurgens, H. & Boot, B., Sep 1 2017, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3, 3, p. 440-449 10 p.

Research output: Contribution to journalReview article

Signs and Symptoms
Alzheimer Disease
Apathy
Institutionalization
Neurobiology
Alzheimer Disease
Brain

Sleep Disturbance, Cognitive Decline, and Dementia: A Review

Wennberg, A. M. V., Wu, M., Rosenberg, P. B. & Spira, A. P., Aug 1 2017, In : Seminars in Neurology. 37, 4, p. 395-406 12 p.

Research output: Contribution to journalReview article

Dementia
Sleep
Cognitive Dysfunction
REM Sleep Behavior Disorder
Sleep Deprivation

The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations

Ismail, Z., Agüera-Ortiz, L., Brodaty, H., Cieslak, A., Cummings, J., Fischer, C. E., Gauthier, S., Geda, Y. E., Herrmann, N., Kanji, J., Lanctôt, K. L., Miller, D. S., Mortby, M. E., Onyike, C. U., Rosenberg, P. B., Smith, E. E., Smith, G., Sultzer, D. L. & Lyketsos, C. G., 2017, In : Journal of Alzheimer's Disease. 56, 3, p. 929-938 10 p.

Research output: Contribution to journalArticle

Checklist
Dementia
Research
Population
Behavioral Symptoms
2016

Apathy associated with neurocognitive disorders: Recent progress and future directions

Lanctôt, K. L., Agüera-Ortiz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., Marshall, G. A., Mortby, M. E., Onyike, C. U., Padala, P. R., Politis, A., Rosenberg, P. B., Siegel, E., Sultzer, D. L. & Abraham, E. H., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Apathy
Research
Neurobiology
Direction compound
Neurocognitive Disorders

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease

Lozano, A. M., Fosdick, L., Chakravarty, M. M., Leoutsakos, J-M. S., Munro, C., Oh, E., Drake, K. E., Lyman, C. H., Rosenberg, P. B., Anderson, W. S., Tang-Wai, D. F., Pendergrass, J. C., Salloway, S., Asaad, W. F., Ponce, F. A., Burke, A., Sabbagh, M., Wolk, D. A., Baltuch, G., Okun, M. S. & 6 others, Foote, K. D., McAndrews, M. P., Giacobbe, P., Targum, S. D., Lyketsos, C. G. & Smith, G., Sep 6 2016, In : Journal of Alzheimer's Disease. 54, 2, p. 777-787 11 p.

Research output: Contribution to journalArticle

Brain Fornix
Deep Brain Stimulation
Alzheimer Disease
Glucose
Brain

Changes in neuropsychiatric inventory associated with semagacestat treatment of Alzheimer's disease

Rosenberg, P. B., Lanctot, K. L., Herrmann, N., Mintzer, J. E., Porsteinsson, A. P., Sun, X. & Raman, R., Aug 23 2016, In : Journal of Alzheimer's Disease. 54, 1, p. 373-381 9 p.

Research output: Contribution to journalArticle

N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Alzheimer Disease
Equipment and Supplies
Amyloid Precursor Protein Secretases
Therapeutics

Citalopram for the Treatment of Agitation in Alzheimer Dementia

Peters, M., Vaidya, V., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J., Lyketsos, C. G. & Avramopoulos, D., Mar 1 2016, In : Journal of Geriatric Psychiatry and Neurology. 29, 2, p. 59-64 6 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Equipment and Supplies
Therapeutics
Apolipoprotein E2

Effects of citalopram on neuropsychiatric symptoms in Alzheimer's dementia: Evidence from the CitAD study

For the CitAD Research Group, May 1 2016, In : American Journal of Psychiatry. 173, 5, p. 473-480 8 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Delusions
Hallucinations
Odds Ratio

Heterogeneity of treatment response to citalopram for patients with Alzheimer's disease with aggression or agitation: The citad randomized clinical trial

For the CitAD Research Group & Marano, C. M., May 1 2016, In : American Journal of Psychiatry. 173, 5, p. 465-472 8 p.

Research output: Contribution to journalArticle

Citalopram
Aggression
Alzheimer Disease
Randomized Controlled Trials
Therapeutics

Loneliness as a marker of brain amyloid burden and preclinical Alzheimer disease

Rosenberg, P. B., Dec 1 2016, In : JAMA Psychiatry. 73, 12, p. 1237-1238 2 p.

Research output: Contribution to journalComment/debate

Loneliness
Amyloid
Alzheimer Disease
Brain

Principal components analysis of agitation outcomes in Alzheimer's disease

For the CitAD Research Group & Drye, L. T., Aug 1 2016, In : Journal of Psychiatric Research. 79, p. 4-7 4 p.

Research output: Contribution to journalArticle

Citalopram
Principal Component Analysis
Alzheimer Disease
Equipment and Supplies
Alzheimer's Disease

Proceedings of the fourth annual deep brain stimulation think tank: A review of emerging issues and technologies

Deeb, W., Giordano, J. J., Rossi, P. J., Mogilner, A. Y., Gunduz, A., Judy, J. W., Klassen, B. T., Butson, C. R., Horne, C. V., Deny, D., Dougherty, D. D., Rowell, D., Gerhardt, G. A., Smith, G., Ponce, F. A., Walker, H. C., Bronte-Stewart, H. M., Mayberg, H. S., Chizeck, H. J., Langevin, J. P. & 17 others, Volkmann, J., Ostrem, J. L., Shute, J. B., Jimenez-Shahed, J., Foote, K. D., Shukla, A. W., Rossi, M. A., Oh, M., Pourfar, M., Rosenberg, P. B., Silburn, P. A., De Hemptine, C., Starr, P. A., Denison, T., Akbar, U., Grill, W. M. & Okun, M. S., Nov 22 2016, In : Frontiers in Integrative Neuroscience. 10, NOV2016, 38.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Technology
Essential Tremor
Tourette Syndrome
Movement Disorders

Sedation mediates part of Citalopram's effect on agitation in Alzheimer's disease

CitAD Research Group & Drye, L. T., Mar 1 2016, In : Journal of Psychiatric Research. 74, p. 17-21 5 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Placebos
Hypnotics and Sedatives
Canada
Dementia
Aptitude
Databases
Taxes
Cognitive Dysfunction
2015

Benzodiazepine exposure increases risk of Alzheimer's disease

Rosenberg, P. B., Apr 1 2015, In : Evidence-Based Medicine. 20, 2, p. 75 1 p.

Research output: Contribution to journalArticle

Benzodiazepines
Alzheimer Disease

Change in agitation in Alzheimer's disease in the placebo arm of a nine-week controlled trial

Rosenberg, P. B., Drye, L. T., Porsteinsson, A. P., Pollock, B. G., Devanand, D. P., Frangakis, C., Ismail, Z., Marano, C., Meinert, C. L., Mintzer, J. E., Munro, C., Pelton, G., Rabins, P. V., Schneider, L. S., Shade, D., Weintraub, D., Newell, J., Yesavage, J. & Lyketsos, C. G., Dec 1 2015, In : International Psychogeriatrics. 27, 12, p. 2059-2067 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Placebos
Equipment and Supplies
Citalopram
Activities of Daily Living

Deep brain stimulation targeting the fornix for mild Alzheimer dementia: Design of the ADvance randomized controlled trial

Holroyd, K. B., Fosdick, L., Smith, G., Leoutsakos, J-M. S., Munro, C., Oh, E., Drake, K. E., Rosenberg, P. B., Anderson, W. S., Salloway, S., Pendergrass, J. C., Burke, A. D., Wolk, D. A., Tang-Wai, D. F., Ponce, F. A., Asaad, W. F., Sabbagh, M. N., Okun, M. S., Baltuch, G., Foote, K. D. & 3 others, Targum, S. D., Lozano, A. M. & Lyketsos, C. G., Jul 10 2015, In : Open Access Journal of Clinical Trials. 7, p. 63-76 14 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Alzheimer Disease
Randomized Controlled Trials
Dementia
Brain Fornix

Depression and suicidal ideation during two psychosocial treatments in older adults with major depression and dementia

Kiosses, D. N., Rosenberg, P. B., McGovern, A., Fonzetti, P., Zaydens, H. & Alexopoulos, G. S., Jan 1 2015, Handbook of Depression in Alzheimer's Disease. IOS Press, p. 367-376 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suicidal Ideation
Dementia
Depression
Therapeutics
Antidepressive Agents

Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia

Kiosses, D. N., Rosenberg, P. B., McGovern, A., Fonzetti, P., Zaydens, H. & Alexopoulos, G. S., Sep 9 2015, In : Journal of Alzheimer's Disease. 48, 2, p. 453-462 10 p.

Research output: Contribution to journalArticle

Suicidal Ideation
Dementia
Depression
Therapeutics
Antidepressive Agents

Interventions for Neuropsychiatric symptoms in Neurocognitive impairment due to Alzheimer's disease: A review of the literature

McClam, T. D., Marano, C. M., Rosenberg, P. B. & Lyketsos, C. G., Sep 19 2015, In : Harvard Review of Psychiatry. 23, 5, p. 377-393 17 p.

Research output: Contribution to journalArticle

Electroconvulsive Therapy
Dronabinol
Alzheimer Disease
Randomized Controlled Trials
Outcome Assessment (Health Care)

Markers of Impaired Decision Making in Nursing Home Residents: Assessment by Nursing Home Staff in a Population-Based Study

Fain, K. M., Rosenberg, P. B., Pirard, S., Bogunovic, O. & Spira, A. P., Jul 1 2015, In : Journal of the American Medical Directors Association. 16, 7, p. 563-567 5 p.

Research output: Contribution to journalArticle

Nursing Staff
Nursing Homes
Decision Making
Odds Ratio
Confidence Intervals

Medication development for agitation and aggression in Alzheimer disease: Review and discussion of recent randomized clinical trial design

Soto, M., Andrieu, S., Nourhashemi, F., Ousset, P. J., Ballard, C., Robert, P., Vellas, B., Lyketsos, C. G. & Rosenberg, P. B., Jul 3 2015, In : International Psychogeriatrics. 27, 2, p. 181-197 17 p.

Research output: Contribution to journalArticle

Aggression
Alzheimer Disease
Randomized Controlled Trials
Caregivers
Placebos