Research Output 1977 2017

2017

Antioxidant capacity and superoxide dismutase activity in adrenoleukodystrophy

Turk, B. R., Theisen, B. E., Nemeth, C. L., Marx, J. S., Shi, X., Rosen, M., Jones, R. O., Moser, A. B., Watkins, P. A., Raymond, G. V., Tiffany, C. & Fatemi, A. May 1 2017 In : JAMA Neurology. 74, 5, p. 519-524 6 p.

Research output: Research - peer-reviewArticle

Adrenoleukodystrophy
Superoxide Dismutase
Antioxidants
Heterozygote
Proteins
2016

Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)

Recuero-Checa, M. A., Sharma, M., Lau, C., Watkins, P. A., Gaydos, C. A. & Dean, D. Mar 18 2016 In : Scientific Reports. 6, 23148

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Acyl Coenzyme A
Chlamydia trachomatis
Growth and Development
Growth

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

Bowman, C. E., Rodriguez, S., Selen Alpergin, E. S., Acoba, M. G., Zhao, L., Hartung, T., Claypool, S. M., Watkins, P. A. & Wolfgang, M. J. Nov 10 2016 (Accepted/In press) In : Cell Chemical Biology.

Research output: Research - peer-reviewArticle

Malonyl Coenzyme A
Mitochondrial Proteins
malonic acid
malonyl-CoA synthetase
Metabolism
2014

Effects of hematopoietic stem cell transplantation on acyl-CoA oxidase deficiency: a sibling comparison study

Wang, R. Y., Monuki, E. S., Powers, J., Schwartz, P. H., Watkins, P. A., Shi, Y., Moser, A., Shrier, D. A., Waterham, H. R., Nugent, D. J. & Abdenur, J. E. Sep 1 2014 In : Journal of Inherited Metabolic Disease. 37, 5, p. 791-799 9 p.

Research output: Research - peer-reviewArticle

Acyl-CoA Oxidase
Hematopoietic Stem Cell Transplantation
Siblings
Fatty Acids
White Matter

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Sun, P., Xia, S., Lal, B., Shi, X., Yang, K. S., Watkins, P. A. & Laterra, J. Jun 4 2014 In : BMC Cancer. 14, 1, 401

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Glioblastoma
Lipid Metabolism
Stem Cells
Maintenance

The Pex1-G844D mouse: A model for mild human Zellweger spectrum disorder

Hiebler, S., Masuda, T., Hacia, J. G., Moser, A. B., Faust, P. L., Liu, A., Chowdhury, N., Huang, N., Lauer, A., Bennett, J., Watkins, P. A., Zack, D. J., Braverman, N. E., Raymond, G. V. & Steinberg, S. J. 2014 In : Molecular Genetics and Metabolism. 111, 4, p. 522-532 11 p.

Research output: Research - peer-reviewArticle

Zellweger Syndrome
Alleles
Liver
Therapeutics
Electrophysiology
2013

Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles

Nchoutmboube, J. A., Viktorova, E. G., Scott, A. J., Ford, L. A., Pei, Z., Watkins, P. A., Ernst, R. K. & Belov, G. A. Jun 2013 In : PLoS Pathogens. 9, 6, e1003401

Research output: Research - peer-reviewArticle

Picornaviridae
Fatty Acid Synthases
Organelles
Fatty Acids
Membranes

Very Long-Chain Acyl-CoA Synthetase 3: Overexpression and Growth Dependence in Lung Cancer

Pei, Z., Fraisl, P., Shi, X., Gabrielson, E., Forss-Petter, S., Berger, J. & Watkins, P. A. Jul 23 2013 In : PLoS One. 8, 7, e69392

Research output: Research - peer-reviewArticle

Cells
long-chain-fatty-acid-CoA ligase
Lung Neoplasms
Growth
lung neoplasms
2012
Sturge-Weber Syndrome
Oxidative Stress
Fibroblasts
Cell Proliferation
Proteins

Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase

Montgomery, C., Pei, Z., Watkins, P. A. & Miziorko, H. M. Sep 28 2012 In : Journal of Biological Chemistry. 287, 40, p. 33227-33236 10 p.

Research output: Research - peer-reviewArticle

Lyases
Proteins
3-hydroxy-3-methylglutaryl-coenzyme A
3-hydroxy-3-methylglutaryl-coenzyme A lyase
Plasmids

Peroxisomal acyl-CoA synthetases

Watkins, P. A. & Ellis, J. M. Sep 2012 In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822, 9, p. 1411-1420 10 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Peroxisomes
Metabolic Networks and Pathways
Lipid Metabolism
Lipids
2011

Human and great ape red blood cells differ in plasmalogen levels and composition

Moser, A. B., Steinberg, S. J., Watkins, P. A., Moser, H. W., Ramaswamy, K., Siegmund, K. D., Lee, D. R., Ely, J. J., Ryder, O. A. & Hacia, J. G. 2011 In : Lipids in Health and Disease. 10, 101

Research output: Research - peer-reviewArticle

Plasmalogens
Blood
Cells
Chemical analysis
Hominidae

Human fatty acid transport protein 2a/very long chain Acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol

Melton, E. M., Cerny, R. L., Watkins, P. A., DiRusso, C. C. & Black, P. N. Sep 2 2011 In : Journal of Biological Chemistry. 286, 35, p. 30670-30679 10 p.

Research output: Research - peer-reviewArticle

Fatty Acid Transport Proteins
Omega-3 Fatty Acids
Phosphatidylinositols
Fatty Acids
long-chain-fatty-acid-CoA ligase

Identification and characterization of new long chain Acyl-CoA dehydrogenases

He, M., Pei, Z., Mohsen, A. W., Watkins, P., Murdoch, G., Van Veldhoven, P. P., Ensenauer, R. & Vockley, J. Apr 2011 In : Molecular Genetics and Metabolism. 102, 4, p. 418-429 12 p.

Research output: Research - peer-reviewArticle

Acyl-CoA Dehydrogenases
Long-Chain Acyl-CoA Dehydrogenase
Fatty Acids
Oxidation
Brain

Peroxisomal diseases

Watkins, P. A. & Schwarz, K. B. Jan 1 2011 Liver Disease in Children, Fourth Edition. Cambridge University Press, p. 649-663 15 p.

Research output: ResearchChapter

Peroxisomes
Organelles
Enzymes
Microbodies
Urate Oxidase

X-linked adrenoleukodystrophy: ABCD1 de novo mutations and mosaicism

Wang, Y., Busin, R., Reeves, C., Bezman, L., Raymond, G., Toomer, C. J., Watkins, P. A., Snowden, A., Moser, A., Naidu, S., Bibat, G., Hewson, S., Tam, K., Clarke, J. T. R., Charnas, L., Stetten, G., Karczeski, B., Cutting, G. & Steinberg, S. Sep 2011 In : Molecular Genetics and Metabolism. 104, 1-2, p. 160-166 7 p.

Research output: Research - peer-reviewArticle

Adrenoleukodystrophy
Mosaicism
Mutation
Fatty Acids
Genes
2010

Fatty acids | Metabolism

Watkins, P. A. 2010 Encyclopedia of Human Nutrition. Elsevier Ltd, p. 186-198 13 p.

Research output: ResearchChapter

Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions

Watkins, P. A., Moser, A. B., Toomer, C. B., Steinberg, S. J., Moser, H. W., Karaman, M. W., Ramaswamy, K., Siegmund, K. D., Lee, D. R., Ely, J. J., Ryder, O. A. & Hacia, J. G. 2010 In : BMC Physiology. 10, 1, 19

Research output: Research - peer-reviewArticle

Phytanic Acid
Hominidae
Transcriptome
Lipid Metabolism
Sex Characteristics
2009

Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity

Pei, Z., Sun, P., Huang, P., Lal, B., Laterra, J. & Watkins, P. A. Dec 15 2009 In : Cancer Research. 69, 24, p. 9175-9182 8 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Glioma
Cell Proliferation
Heterografts
Growth

A PEX10 defect in a patient with no detectable defect in peroxisome assembly or metabolism in cultured fibroblasts

Steinberg, S. J., Snowden, A., Braverman, N. E., Chen, L., Watkins, P. A., Clayton, P. T., Setchell, K. D. R., Heubi, J. E., Raymond, G. V., Moser, A. B. & Moser, H. W. 2009 In : Journal of Inherited Metabolic Disease. 32, 1, p. 109-119 11 p.

Research output: Research - peer-reviewArticle

Peroxisomes
Fibroblasts
Genes
Zellweger Syndrome
Bile Acids and Salts

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K. Feb 2009 In : Neuroendocrinology. 89, 2, p. 152-162 11 p.

Research output: Research - peer-reviewArticle

Zucker Rats
Leptin Receptors
Hyperphagia
Dopamine Plasma Membrane Transport Proteins
Bromocriptine
2008

Very-long-chain acyl-CoA synthetases

Watkins, P. A. Jan 25 2008 In : Journal of Biological Chemistry. 283, 4, p. 1773-1777 5 p.

Research output: Research - peer-reviewArticle

2007

A new genetic disorder in mitochondrial fatty acid β-oxidation: ACAD9 deficiency

He, M., Rutledge, S. L., Kelly, D. R., Palmer, C. A., Murdoch, G., Majumder, N., Nicholls, R. D., Pei, Z., Watkins, P. A. & Vockley, J. Jul 2007 In : American Journal of Human Genetics. 81, 1, p. 87-103 17 p.

Research output: Research - peer-reviewArticle

Acyl-CoA Dehydrogenase
Inborn Genetic Diseases
Fatty Acids
Acyl-CoA Dehydrogenases
Long-Chain Acyl-CoA Dehydrogenase

Brain uptake and utilization of fatty acids, lipids & lipoproteins: Recommendations for future research

Katz, R., Hamilton, J. A., Pownall, H. J., Deckelbaum, R. J., Hillard, C. J., LeBoeuf, R. C. & Watkins, P. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 146-150 5 p.

Research output: Research - peer-reviewArticle

Unsaturated Fatty Acids
Lipoproteins
Fatty Acids
Lipids
Brain

Brain uptake and utilization of fatty acids, lipids and lipoproteins: Application to neurological disorders

Hamilton, J. A., Hillard, C. J., Spector, A. A. & Watkins, P. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 2-11 10 p.

Research output: Research - peer-reviewArticle

Nervous System Diseases
Lipoproteins
Fatty Acids
Lipids
Brain

Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Watkins, P. A., Maiguel, D., Jia, Z. & Pevsner, J. Dec 2007 In : Journal of Lipid Research. 48, 12, p. 2736-2750 15 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Human Genome
Genes
Proteins
Amino Acid Sequence

Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts

Jia, Z., Moulson, C. L., Pei, Z., Miner, J. H. & Watkins, P. A. Jul 13 2007 In : Journal of Biological Chemistry. 282, 28, p. 20573-20583 11 p.

Research output: Research - peer-reviewArticle

Fatty Acid Transport Proteins
Acyl Coenzyme A
Fibroblasts
Skin
long-chain-fatty-acid-CoA ligase

Peroxisomal diseases

Watkins, P. A., Schwarz, K. B. & Schwarz, K. B. Jan 1 2007 Liver Disease in Children, Third Edition. Cambridge University Press, p. 840-857 18 p.

Research output: ResearchChapter

Peroxisomes
Organelles
Enzymes
Microbodies
Urate Oxidase

Roundtable discussion of session 1: Mechanisms of lipid uptake and transport in the brain

Watkins, P. A. & Hamilton, J. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 45-50 6 p.

Research output: Research - peer-reviewArticle

Roundtable discussion of session 2: Lipoproteins and polyunsaturated fatty acids

Watkins, P. A. & Hamilton, J. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 74-79 6 p.

Research output: Research - peer-reviewArticle

Roundtable discussion of session 3: Eicosanoids in brain function

Watkins, P. A. & Hamilton, J. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 100-104 5 p.

Research output: Research - peer-reviewArticle

Roundtable discussion of session 4: Fatty acids and lipids in brain disorders

Watkins, P. A. & Hamilton, J. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 120-124 5 p.

Research output: Research - peer-reviewArticle

Posters
Nervous System Diseases
Lipoproteins
Fatty Acids
Lipids

The fatty acid transport protein (FATP) family: Very long chain acyl-CoA synthetases or solute carriers?

Jia, Z., Pei, Z., Maiguel, D., Toomer, C. J. & Watkins, P. A. Sep 2007 In : Journal of Molecular Neuroscience. 33, 1, p. 25-31 7 p.

Research output: Research - peer-reviewArticle

Fatty Acid Transport Proteins
Proteins
long-chain-fatty-acid-CoA ligase
Fatty Acids
Cell membranes

The role of peroxisomal ABC transporters in the mouse adrenal gland: The loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage

Lu, J. F., Barron-Casella, E., Deering, R., Heinzer, A. K., Moser, A. B., DeMesy Bentley, K. L., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., Pujol, A., Smith, K. D. & Powers, J. M. Mar 2007 In : Laboratory Investigation. 87, 3, p. 261-272 12 p.

Research output: Research - peer-reviewArticle

ATP-Binding Cassette Transporters
Adrenal Glands
Knockout Mice
Oxidative Stress
Hemizygote
2006

Bromocriptine reduces steatosis in obese rodent models

Davis, L. M., Pei, Z., Trush, M. A., Cheskin, L. J., Contoreggi, C., McCullough, K., Watkins, P. A. & Moran, T. H. Sep 2006 In : Journal of Hepatology. 45, 3, p. 439-444 6 p.

Research output: Research - peer-reviewArticle

Bromocriptine
Rodentia
Non-alcoholic Fatty Liver Disease
Obesity
Diet

Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4

Milger, K., Herrmann, T., Becker, C., Gotthardt, D., Zickwolf, J., Ehehalt, R., Watkins, P. A., Stremmel, W. & Füllekrug, J. Nov 15 2006 In : Journal of Cell Science. 119, 22, p. 4678-4688 11 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Fatty Acids
Cell Membrane
Esterification
Fatty Acid Transport Proteins

The second member of the human and murine "bubblegum" family is a testis- and brainstem-specific Acyl-CoA synthetase

Pei, Z., Jia, Z. & Watkins, P. A. Mar 10 2006 In : Journal of Biological Chemistry. 281, 10, p. 6632-6641 10 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Fatty Acids
Substrates
Brain Stem
Testis
2005

Adreno-leukodystrophy: Oxidative stress of mice and men

Powers, J. M., Pei, Z., Heinzer, A. K., Deering, R., Moser, A. B., Moser, H. W., Watkins, P. A. & Smith, K. D. Dec 2005 In : Journal of Neuropathology and Experimental Neurology. 64, 12, p. 1067-1079 13 p.

Research output: Research - peer-reviewArticle

Oxidative Stress
Adrenal Cortex
Knockout Mice
Phenotype
Demyelinating Diseases

Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast

DiRusso, C. C., Li, H., Darwis, D., Watkins, P. A., Berger, J. & Black, P. N. Apr 29 2005 In : Journal of Biological Chemistry. 280, 17, p. 16829-16837 9 p.

Research output: Research - peer-reviewArticle

Fatty Acid Transport Proteins
Yeast
Fatty Acids
Yeasts
Protein Isoforms
2004

Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells

Pei, Z., Fraisl, P., Berger, J., Jia, Z., Forss-Petter, S. & Watkins, P. A. Dec 24 2004 In : Journal of Biological Chemistry. 279, 52, p. 54454-54462 9 p.

Research output: Research - peer-reviewArticle

Fatty Acid Transport Proteins
Coenzyme A Ligases
Fatty Acids
Chemical activation
long-chain-fatty-acid-CoA ligase

Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family

Mashek, D. G., Bornfeldt, K. E., Coleman, R. A., Berger, J., Bernlohr, D. A., Black, P., DiRusso, C. C., Farber, S. A., Guo, W., Hashimoto, N., Khodiyar, V., Kuypers, F. A., Maltais, L. J., Nebert, D. W., Renieri, A., Schaffer, J. E., Stahl, A., Watkins, P. A., Vasiliou, V. & Yamamoto, T. T. Oct 2004 In : Journal of Lipid Research. 45, 10, p. 1958-1961 4 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Acyl Coenzyme A
Terminology
Genes
Human Genome

X-linked adrenoleukodystrophy: Role of very long-chain acyl-CoA synthetases

Jia, Z., Pei, Z., Li, Y., Wei, L., Smith, K. D. & Watkins, P. A. Sep 2004 In : Molecular Genetics and Metabolism. 83, 1-2, p. 117-127 11 p.

Research output: Research - peer-reviewArticle

Fatty Acids
long-chain-fatty-acid-CoA ligase
Adrenoleukodystrophy
Enzymes
Tissue
2003

A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy

Heinzer, A. K., Watkins, P. A., Lu, J. F., Kemp, S., Moser, A. B., Li, Y. Y., Mihalik, S., Powers, J. M. & Smith, K. D. May 15 2003 In : Human Molecular Genetics. 12, 10, p. 1145-1154 10 p.

Research output: Research - peer-reviewArticle

Adrenoleukodystrophy
long-chain-fatty-acid-CoA ligase
Knockout Mice
Fatty Acids
Peroxisomes

Cytokine network during NASH and possible treatment selection [1] (multiple letters)

Perrella, A., Tarantino, G., Borgia, G., Conca, P., Sorrentino, P., Ragucci, P., Vecchione, R., Perrella, O., Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., DeSimone, C., Song, X. Y. & Diehl, A. M. Aug 1 2003 In : Hepatology. 38, 2, p. 530-531 2 p.

Research output: Research - peer-reviewArticle

Mouse models and genetic modifiers in X-linked adrenoleukodystrophy

Heinzer, A. K., Mcguinness, M. C., Lu, J. F., Stine, O. C., Wei, H., Van Der Vlies, M., Dong, G., Powers, J., Watkins, P. A. & Smith, K. D. 2003 In : Advances in Experimental Medicine and Biology. 544, p. 75-93 19 p.

Research output: Research - peer-reviewArticle

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., DeSimone, C., Song, X. Y. & Diehl, A. M. Feb 1 2003 In : Hepatology. 37, 2, p. 343-350 8 p.

Research output: Research - peer-reviewArticle

Probiotics
Antibodies
Therapeutics
Non-alcoholic Fatty Liver Disease
Anti-Idiotypic Antibodies

Role of ALDP (ABCD1) and mitochondria in X-linked adrenoleukodystrophy

McGuinness, M. C., Lu, J. F., Zhang, H. P., Dong, G. X., Heinzer, A. K., Watkins, P. A., Powers, J. & Smith, K. D. Jan 2003 In : Molecular and Cellular Biology. 23, 2, p. 744-753 10 p.

Research output: Research - peer-reviewArticle

Adrenoleukodystrophy
Mitochondria
Fatty Acids
Fibroblasts
Peroxisomal Disorders

The Acyl-CoA synthetase "bubblegum" (lipidosin): Further characterization and role in neuronal fatty acid β-oxidation

Pei, Z., Oey, N. A., Zuidervaart, M. M., Jia, Z., Li, Y., Steinberg, S. J., Smith, K. D. & Watkins, P. A. Nov 21 2003 In : Journal of Biological Chemistry. 278, 47, p. 47070-47078 9 p.

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Fatty Acids
Oxidation
lipidosin
Enzymes
2002

Cerebral X-linked adrenoleukodystrophy in a girl with Xq27-Ter deletion

Hershkovitz, E., Narkis, G., Shorer, Z., Moser, A. B., Watkins, P. A., Moser, H. W. & Manor, E. 2002 In : Annals of Neurology. 52, 2, p. 234-237 4 p.

Research output: Research - peer-reviewArticle

Adrenoleukodystrophy
X Chromosome
Cytogenetics
Heterozygote
Adenosine Triphosphate