Paul A Watkins

Fac- Prof- Dir

1977 …2017
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Research Output 1977 2017

2017

Antioxidant capacity and superoxide dismutase activity in adrenoleukodystrophy

Turk, B. R., Theisen, B. E., Nemeth, C. L., Marx, J. S., Shi, X., Rosen, M., Jones, R. O., Moser, A. B., Watkins, P. A., Raymond, G. V., Tiffany, C. & Fatemi, A., May 1 2017, In : JAMA Neurology. 74, 5, p. 519-524 6 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Superoxide Dismutase
Antioxidants
Heterozygote
Proteins
2016

Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)

Recuero-Checa, M. A., Sharma, M., Lau, C., Watkins, P. A., Gaydos, C. A. & Dean, D., Mar 18 2016, In : Scientific Reports. 6, 23148

Research output: Contribution to journalArticle

Coenzyme A Ligases
Acyl Coenzyme A
Chlamydia trachomatis
Growth and Development
Fatty Acids

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

Bowman, C. E., Rodriguez, S., Selen Alpergin, E. S., Acoba, M. G., Zhao, L., Hartung, T., Claypool, S. M., Watkins, P. A. & Wolfgang, M. J., Nov 10 2016, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Malonyl Coenzyme A
Mitochondrial Proteins
Metabolism
Detoxification
Metabolites
2014

Effects of hematopoietic stem cell transplantation on acyl-CoA oxidase deficiency: a sibling comparison study

Wang, R. Y., Monuki, E. S., Powers, J., Schwartz, P. H., Watkins, P. A., Shi, Y., Moser, A., Shrier, D. A., Waterham, H. R., Nugent, D. J. & Abdenur, J. E., Sep 1 2014, In : Journal of Inherited Metabolic Disease. 37, 5, p. 791-799 9 p.

Research output: Contribution to journalArticle

Acyl-CoA Oxidase
Hematopoietic Stem Cell Transplantation
Siblings
Fatty Acids
Demyelinating Diseases

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Sun, P., Xia, S., Lal, B., Shi, X., Yang, K. S., Watkins, P. A. & Laterra, J., Jun 4 2014, In : BMC Cancer. 14, 1, 401

Research output: Contribution to journalArticle

Coenzyme A Ligases
Glioblastoma
Lipid Metabolism
Stem Cells
Maintenance

The Pex1-G844D mouse: A model for mild human Zellweger spectrum disorder

Hiebler, S., Masuda, T., Hacia, J. G., Moser, A. B., Faust, P. L., Liu, A., Chowdhury, N., Huang, N., Lauer, A., Bennett, J., Watkins, P. A., Zack, D. J., Braverman, N. E., Raymond, G. V. & Steinberg, S. J., 2014, In : Molecular Genetics and Metabolism. 111, 4, p. 522-532 11 p.

Research output: Contribution to journalArticle

Zellweger Syndrome
Liver
Alleles
Electrophysiology
Histology
2013

Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles

Nchoutmboube, J. A., Viktorova, E. G., Scott, A. J., Ford, L. A., Pei, Z., Watkins, P. A., Ernst, R. K. & Belov, G. A., Jun 2013, In : PLoS Pathogens. 9, 6, e1003401

Research output: Contribution to journalArticle

Picornaviridae
Fatty Acid Synthases
Organelles
Fatty Acids
Membranes

Very Long-Chain Acyl-CoA Synthetase 3: Overexpression and Growth Dependence in Lung Cancer

Pei, Z., Fraisl, P., Shi, X., Gabrielson, E., Forss-Petter, S., Berger, J. & Watkins, P. A., Jul 23 2013, In : PLoS One. 8, 7, e69392

Research output: Contribution to journalArticle

long-chain-fatty-acid-CoA ligase
lung neoplasms
Lung Neoplasms
Cells
Tumors
2012

Cell proliferation and oxidative stress pathways are modified in fibroblasts from Sturge-Weber syndrome patients

Kadam, S. D., Cole, R. N., Gucek, M., Watkins, P. A. & Comi, A. M., Apr 2012, In : Archives of Dermatological Research. 304, 3, p. 229-235 7 p.

Research output: Contribution to journalArticle

Sturge-Weber Syndrome
Oxidative Stress
Fibroblasts
Cell Proliferation
Proteins

Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase

Montgomery, C., Pei, Z., Watkins, P. A. & Miziorko, H. M., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33227-33236 10 p.

Research output: Contribution to journalArticle

Lyases
Proteins
Plasmids
Escherichia coli
3-hydroxy-3-methylglutaryl-coenzyme A

Peroxisomal acyl-CoA synthetases

Watkins, P. A. & Ellis, J. M., Sep 2012, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822, 9, p. 1411-1420 10 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Peroxisomes
Metabolic Networks and Pathways
Lipid Metabolism
Lipids
2011

Human and great ape red blood cells differ in plasmalogen levels and composition

Moser, A. B., Steinberg, S. J., Watkins, P. A., Moser, H. W., Ramaswamy, K., Siegmund, K. D., Lee, D. R., Ely, J. J., Ryder, O. A. & Hacia, J. G., 2011, In : Lipids in Health and Disease. 10, 101

Research output: Contribution to journalArticle

Plasmalogens
Hominidae
Blood
Erythrocytes
Cells

Human fatty acid transport protein 2a/very long chain Acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol

Melton, E. M., Cerny, R. L., Watkins, P. A., DiRusso, C. C. & Black, P. N., Sep 2 2011, In : Journal of Biological Chemistry. 286, 35, p. 30670-30679 10 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Omega-3 Fatty Acids
Phosphatidylinositols
Fatty Acids
Chemical activation

Identification and characterization of new long chain Acyl-CoA dehydrogenases

He, M., Pei, Z., Mohsen, A. W., Watkins, P., Murdoch, G., Van Veldhoven, P. P., Ensenauer, R. & Vockley, J., Apr 2011, In : Molecular Genetics and Metabolism. 102, 4, p. 418-429 12 p.

Research output: Contribution to journalArticle

Acyl-CoA Dehydrogenases
Long-Chain Acyl-CoA Dehydrogenase
Fatty Acids
Cerebellum
Brain

Peroxisomal diseases

Watkins, P. A. & Schwarz, K. B. Jan 1 2011 Liver Disease in Children, Fourth Edition. Cambridge University Press, p. 649-663 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Microbodies
Urate Oxidase
Organelles
Enzymes

X-linked adrenoleukodystrophy: ABCD1 de novo mutations and mosaicism

Wang, Y., Busin, R., Reeves, C., Bezman, L., Raymond, G., Toomer, C. J., Watkins, P. A., Snowden, A., Moser, A., Naidu, S., Bibat, G., Hewson, S., Tam, K., Clarke, J. T. R., Charnas, L., Stetten, G., Karczeski, B., Cutting, G. & Steinberg, S., Sep 2011, In : Molecular Genetics and Metabolism. 104, 1-2, p. 160-166 7 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Mosaicism
Fatty Acids
Genes
Plasmas
2010

Fatty acids | Metabolism

Watkins, P. A. 2010 Encyclopedia of Human Nutrition. Elsevier Ltd, p. 186-198 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

fatty acid metabolism
Fatty Acids

Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions

Watkins, P. A., Moser, A. B., Toomer, C. B., Steinberg, S. J., Moser, H. W., Karaman, M. W., Ramaswamy, K., Siegmund, K. D., Lee, D. R., Ely, J. J., Ryder, O. A. & Hacia, J. G., 2010, In : BMC Physiology. 10, 1, 19

Research output: Contribution to journalArticle

Phytanic Acid
Hominidae
Transcriptome
Lipid Metabolism
Sex Characteristics
2009

Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity

Pei, Z., Sun, P., Huang, P., Lal, B., Laterra, J. & Watkins, P. A., Dec 15 2009, In : Cancer Research. 69, 24, p. 9175-9182 8 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Glioma
Cell Proliferation
Heterografts
Growth

A PEX10 defect in a patient with no detectable defect in peroxisome assembly or metabolism in cultured fibroblasts

Steinberg, S. J., Snowden, A., Braverman, N. E., Chen, L., Watkins, P. A., Clayton, P. T., Setchell, K. D. R., Heubi, J. E., Raymond, G. V., Moser, A. B. & Moser, H. W., 2009, In : Journal of Inherited Metabolic Disease. 32, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Zellweger Syndrome
Fibroblasts
Genes
Bile Acids and Salts

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K., Feb 2009, In : Neuroendocrinology. 89, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

Zucker Rats
Leptin Receptors
Hyperphagia
Dopamine Plasma Membrane Transport Proteins
Bromocriptine
2008

Very-long-chain acyl-CoA synthetases

Watkins, P. A., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 1773-1777 5 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Coenzyme A Ligases
Species Specificity
Organ Specificity
Organelles
2007

A new genetic disorder in mitochondrial fatty acid β-oxidation: ACAD9 deficiency

He, M., Rutledge, S. L., Kelly, D. R., Palmer, C. A., Murdoch, G., Majumder, N., Nicholls, R. D., Pei, Z., Watkins, P. A. & Vockley, J., Jul 2007, In : American Journal of Human Genetics. 81, 1, p. 87-103 17 p.

Research output: Contribution to journalArticle

Acyl-CoA Dehydrogenase
Inborn Genetic Diseases
Fatty Acids
Acyl-CoA Dehydrogenases
Long-Chain Acyl-CoA Dehydrogenase

Brain uptake and utilization of fatty acids, lipids & lipoproteins: Recommendations for future research

Katz, R., Hamilton, J. A., Pownall, H. J., Deckelbaum, R. J., Hillard, C. J., LeBoeuf, R. C. & Watkins, P. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 146-150 5 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Lipoproteins
Brain
Fatty Acids
Lipids

Brain uptake and utilization of fatty acids, lipids and lipoproteins: Application to neurological disorders

Hamilton, J. A., Hillard, C. J., Spector, A. A. & Watkins, P. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 2-11 10 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Lipoproteins
Brain
Fatty Acids
Lipids

Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Watkins, P. A., Maiguel, D., Jia, Z. & Pevsner, J., Dec 2007, In : Journal of Lipid Research. 48, 12, p. 2736-2750 15 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Human Genome
Genes
Amino Acid Sequence
Amino Acid Motifs

Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts

Jia, Z., Moulson, C. L., Pei, Z., Miner, J. H. & Watkins, P. A., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20573-20583 11 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Coenzyme A Ligases
Acyl Coenzyme A
Fibroblasts
Skin

Peroxisomal diseases

Watkins, P. A., Schwarz, K. B. & Schwarz, K. B., Jan 1 2007, Liver Disease in Children, Third Edition. Cambridge University Press, p. 840-857 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Microbodies
Urate Oxidase
Organelles
Enzymes

Roundtable discussion of session 1: Mechanisms of lipid uptake and transport in the brain

Watkins, P. A. & Hamilton, J. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 45-50 6 p.

Research output: Contribution to journalArticle

Biological Transport
Coenzyme A Ligases
Water recycling
Membrane Microdomains
Fatty Acid-Binding Proteins

Roundtable discussion of session 2: Lipoproteins and polyunsaturated fatty acids

Watkins, P. A. & Hamilton, J. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

Inert gas welding
Docosahexaenoic Acids
Unsaturated Fatty Acids
Lipoproteins
Signal Transduction

Roundtable discussion of session 3: Eicosanoids in brain function

Watkins, P. A. & Hamilton, J. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 100-104 5 p.

Research output: Contribution to journalArticle

Eicosanoids
Fatty Acids
Diet
Brain

Roundtable discussion of session 4: Fatty acids and lipids in brain disorders

Watkins, P. A. & Hamilton, J. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 120-124 5 p.

Research output: Contribution to journalArticle

Posters
Nervous System Diseases
Lipoproteins
Brain
Fatty Acids

The fatty acid transport protein (FATP) family: Very long chain acyl-CoA synthetases or solute carriers?

Jia, Z., Pei, Z., Maiguel, D., Toomer, C. J. & Watkins, P. A., Sep 2007, In : Journal of Molecular Neuroscience. 33, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Fatty Acids
Cell membranes
Proteins
Cell Membrane

The role of peroxisomal ABC transporters in the mouse adrenal gland: The loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage

Lu, J. F., Barron-Casella, E., Deering, R., Heinzer, A. K., Moser, A. B., DeMesy Bentley, K. L., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., Pujol, A., Smith, K. D. & Powers, J. M., Mar 2007, In : Laboratory Investigation. 87, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Adrenal Glands
Knockout Mice
Oxidative Stress
Hemizygote
2006

Bromocriptine reduces steatosis in obese rodent models

Davis, L. M., Pei, Z., Trush, M. A., Cheskin, L. J., Contoreggi, C., McCullough, K., Watkins, P. A. & Moran, T. H., Sep 2006, In : Journal of Hepatology. 45, 3, p. 439-444 6 p.

Research output: Contribution to journalArticle

Bromocriptine
Rodentia
Zucker Rats
Obesity
Diet

Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4

Milger, K., Herrmann, T., Becker, C., Gotthardt, D., Zickwolf, J., Ehehalt, R., Watkins, P. A., Stremmel, W. & Füllekrug, J., Nov 15 2006, In : Journal of Cell Science. 119, 22, p. 4678-4688 11 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Fatty Acids
Esterification
Cell Membrane
Fatty Acid Transport Proteins

The second member of the human and murine "bubblegum" family is a testis- and brainstem-specific Acyl-CoA synthetase

Pei, Z., Jia, Z. & Watkins, P. A., Mar 10 2006, In : Journal of Biological Chemistry. 281, 10, p. 6632-6641 10 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Brain Stem
Testis
Fatty Acids
Pathology
2005

Adreno-leukodystrophy: Oxidative stress of mice and men

Powers, J. M., Pei, Z., Heinzer, A. K., Deering, R., Moser, A. B., Moser, H. W., Watkins, P. A. & Smith, K. D., Dec 2005, In : Journal of Neuropathology and Experimental Neurology. 64, 12, p. 1067-1079 13 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Oxidative Stress
Knockout Mice
Demyelinating Diseases
Phenotype

Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast

DiRusso, C. C., Li, H., Darwis, D., Watkins, P. A., Berger, J. & Black, P. N., Apr 29 2005, In : Journal of Biological Chemistry. 280, 17, p. 16829-16837 9 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Yeast
Fatty Acids
Yeasts
Coenzyme A Ligases
2004

Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells

Pei, Z., Fraisl, P., Berger, J., Jia, Z., Forss-Petter, S. & Watkins, P. A., Dec 24 2004, In : Journal of Biological Chemistry. 279, 52, p. 54454-54462 9 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Coenzyme A Ligases
Fatty Acids
Chemical activation
Brain

Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family

Mashek, D. G., Bornfeldt, K. E., Coleman, R. A., Berger, J., Bernlohr, D. A., Black, P., DiRusso, C. C., Farber, S. A., Guo, W., Hashimoto, N., Khodiyar, V., Kuypers, F. A., Maltais, L. J., Nebert, D. W., Renieri, A., Schaffer, J. E., Stahl, A., Watkins, P. A., Vasiliou, V. & Yamamoto, T. T., Oct 2004, In : Journal of Lipid Research. 45, 10, p. 1958-1961 4 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Acyl Coenzyme A
Terminology
Genes
Human Genome

X-linked adrenoleukodystrophy: Role of very long-chain acyl-CoA synthetases

Jia, Z., Pei, Z., Li, Y., Wei, L., Smith, K. D. & Watkins, P. A., Sep 2004, In : Molecular Genetics and Metabolism. 83, 1-2, p. 117-127 11 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Fatty Acids
Cholesterol Esters
Pathology
Enzymes
2003

A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy

Heinzer, A. K., Watkins, P. A., Lu, J. F., Kemp, S., Moser, A. B., Li, Y. Y., Mihalik, S., Powers, J. M. & Smith, K. D., May 15 2003, In : Human Molecular Genetics. 12, 10, p. 1145-1154 10 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Knockout Mice
Fatty Acids
Peroxisomes
long-chain-fatty-acid-CoA ligase

Cytokine network during NASH and possible treatment selection [1] (multiple letters)

Perrella, A., Tarantino, G., Borgia, G., Conca, P., Sorrentino, P., Ragucci, P., Vecchione, R., Perrella, O., Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., DeSimone, C., Song, X. Y. & Diehl, A. M., Aug 1 2003, In : Hepatology. 38, 2, p. 530-531 2 p.

Research output: Contribution to journalArticle

Fatty Liver
Cytokines

Mouse models and genetic modifiers in X-linked adrenoleukodystrophy

Heinzer, A. K., Mcguinness, M. C., Lu, J. F., Stine, O. C., Wei, H., Van Der Vlies, M., Dong, G., Powers, J., Watkins, P. A. & Smith, K. D., 2003, In : Advances in Experimental Medicine and Biology. 544, p. 75-93 19 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Animal Disease Models
ATP-Binding Cassette Transporters
Genetic Models
Pedigree

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., DeSimone, C., Song, X. Y. & Diehl, A. M., Feb 1 2003, In : Hepatology. 37, 2, p. 343-350 8 p.

Research output: Contribution to journalArticle

Probiotics
Alcoholic Fatty Liver
Anti-Idiotypic Antibodies
Alcoholic Liver Diseases
Insulin Resistance

Role of ALDP (ABCD1) and mitochondria in X-linked adrenoleukodystrophy

McGuinness, M. C., Lu, J. F., Zhang, H. P., Dong, G. X., Heinzer, A. K., Watkins, P. A., Powers, J. & Smith, K. D., Jan 2003, In : Molecular and Cellular Biology. 23, 2, p. 744-753 10 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Mitochondria
Fatty Acids
Fibroblasts
Peroxisomal Disorders

The Acyl-CoA synthetase "bubblegum" (lipidosin): Further characterization and role in neuronal fatty acid β-oxidation

Pei, Z., Oey, N. A., Zuidervaart, M. M., Jia, Z., Li, Y., Steinberg, S. J., Smith, K. D. & Watkins, P. A., Nov 21 2003, In : Journal of Biological Chemistry. 278, 47, p. 47070-47078 9 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Fatty Acids
Oxidation
Mitochondria
Metabolism
2002

Cerebral X-linked adrenoleukodystrophy in a girl with Xq27-Ter deletion

Hershkovitz, E., Narkis, G., Shorer, Z., Moser, A. B., Watkins, P. A., Moser, H. W. & Manor, E., 2002, In : Annals of Neurology. 52, 2, p. 234-237 4 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
X Chromosome
Cytogenetics
Heterozygote
Adenosine Triphosphate