Paul A Bottomley

Professor

1976 …2019
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Research Output 1976 2019

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1995

Display of cross sectional anatomy by nuclear magnetic resonance imaging. 1978.

Hinshaw, W. S., Andrew, E. R., Bottomley, P. A., Holland, G. N. & Moore, W. S., Dec 1995, In : British Journal of Radiology. 68, 816

Research output: Contribution to journalArticle

Cross-Sectional Anatomy
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Hydrogen
Anatomy

Practice effects with the NIMH AIDS abbreviated neuropsychological battery

McCaffrey, R. J., Cousins, J. P., Westervelt, H. J., Martynowicz, M., Remick, S. C., Szebenyi, S., Wagle, W. A., Bottomley, P. A., Hardy, C. J. & Haase, R. F., 1995, In : Archives of Clinical Neuropsychology. 10, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

National Institute of Mental Health (U.S.)
Acquired Immunodeficiency Syndrome
Verbal Learning
HIV Infections
Volunteers
1994

MR spectroscopy of the human heart: The status and the challenges

Bottomley, P. A., Jun 1994, In : Radiology. 191, 3, p. 593-612 20 p.

Research output: Contribution to journalArticle

Phosphocreatine
Magnetic Resonance Spectroscopy
Adenosine Triphosphate
Ischemia
Myocardial Infarction

Optimum flip-angles for exciting NMR with uncertain T1 values

Bottomley, P. A. & Ouwerkerk, R., 1994, In : Magnetic Resonance in Medicine. 32, 1, p. 137-141 5 p.

Research output: Contribution to journalArticle

Confidence Intervals
Brain
Calibration
Uncertainty
Pulse

The Dual-Angle Method for Fast, Sensitive T1 Measurement in Vivo with Low-Angle Adiabatic Pulses

Bottomley, P. A. & Ouwerkerk, R., Jun 1994, In : Journal of Magnetic Resonance, Series B. 104, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

Muscle
Recovery
Liver
Signal to noise ratio
Nuclear magnetic resonance

Whither human cardiac spectroscopy?

Bottomley, P. A., Oct 1994, In : Magma (New York, N.Y.). 2, 3, p. 169-176 8 p.

Research output: Contribution to journalArticle

Phosphocreatine
Spectrum Analysis
Heart Failure
Adenosine Triphosphate
Myocardial Infarction
1993

An In Vivo Study of Phosphorus and Glucose Metabolism in Alzheimer's Disease using Magnetic Resonance Spectroscopy and PET

Murphy, D. G. M., Bottomley, P. A., Salerno, J. A., DeCarli, C., Mentis, M. J., Grady, C. L., Teichberg, D., Giacometti, K. R., Rosenberg, J. M., Hardy, C. J., Schapiro, M. B., Rapoport, S. I., Alger, J. R. & Horwitz, B., 1993, In : Archives of General Psychiatry. 50, 5, p. 341-349 9 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Emission-Computed Tomography
Phosphorus
Alzheimer Disease
Magnetic Resonance Spectroscopy

BIRP, an Improved Implementation of Low-Angle Adiabatic (BIR-4) Excitation Pulses

Bottomley, P. A. & Ouwerkerk, R., Jun 15 1993, In : Journal of Magnetic Resonance, Series A. 103, 2, p. 242-244 3 p.

Research output: Contribution to journalArticle

NMR imaging of root water distribution in intact Vicia faba L plants in elevated atmospheric CO2

Bottomley, P. A., ROGERS, H. H. & PRIOR, S. A., 1993, In : Plant, Cell and Environment. 16, 3, p. 335-338 4 p.

Research output: Contribution to journalArticle

Vicia faba
water distribution
magnetic resonance imaging
nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
1992

Alzheimer dementia: Quantification of energy metabolism and mobile phosphoesters with P-31 NMR spectroscopy

Bottomley, P. A., Cousins, J. P., Pendrey, D. L., Wagle, W. A., Hardy, C. J., Eames, F. A., McCaffrey, R. J. & Thompson, D. A., Jun 1992, In : Radiology. 183, 3, p. 695-699 5 p.

Research output: Contribution to journalArticle

Energy Metabolism
Alzheimer Disease
Magnetic Resonance Spectroscopy
Phosphates
Atrophy

An NMR phased array for human cardiac 31P spectroscopy

Hardy, C. J., Bottomley, P. A., Rohling, K. W. & Roemer, P. B., 1992, In : Magnetic Resonance in Medicine. 28, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Spectrum Analysis
Myocardium
Radio Waves
Anatomic Models
Mathematics
Body Temperature
Magnetic Resonance Spectroscopy

Proton MR spectroscopy for diagnosing hepatic encephalopathy?

Bottomley, P. A., 1992, In : Radiology. 182, 1, p. 6-7 2 p.

Research output: Contribution to journalArticle

Glutamates
Hepatic Encephalopathy
Brain Diseases
Glutamine
Liver Cirrhosis

Proton overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5 T

Bottomley, P. A. & Hardy, C. J., 1992, In : Magnetic Resonance in Medicine. 24, 2, p. 384-390 7 p.

Research output: Contribution to journalArticle

Phosphorus
Protons
Magnetic Resonance Spectroscopy
Adenosine Triphosphate
Phosphocreatine

The trouble with spectroscopy papers.

Bottomley, P. A., Jan 1992, In : Journal of Magnetic Resonance Imaging. 2, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Art
Research
1991

31P spectroscopic localization using pinwheel NMR excitation pulses

Hardy, C. J. & Bottomley, P. A., 1991, In : Magnetic Resonance in Medicine. 17, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

Pulse
Phosphorus

Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy

Hardy, C. J., Weiss, R. G., Bottomley, P. A. & Gerstenblith, G., 1991, In : American Heart Journal. 122, 3 PART 1, p. 795-801 7 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Phosphates
Adenosine Triphosphate
Phosphocreatine
Healthy Volunteers
Creatine
Adenosine Triphosphate
Thorax
Myocardium
Muscles

Myocardial high-energy phosphate metabolism and allograft rejection in patients with heart transplants

Bottomley, P. A., Weiss, R. G., Hardy, C. J. & Baumgartner, W. A., Oct 1991, In : Radiology. 181, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Phosphocreatine
Energy Metabolism
Allografts
Phosphates
Transplants

Regional myocardial metabolism of high-energy phosphates in patients with coronary artery disease [4]

Achterberg, P. W., Bottomley, P. A., Gerstenblith, G. & Hardy, C. J., 1991, In : New England Journal of Medicine. 324, 17, p. 1218-1219 2 p.

Research output: Contribution to journalArticle

Hypoxanthine
Phosphocreatine
Medical Societies
Succinic Acid
Energy Metabolism

The trouble with spectroscopy papers

Bottomley, P. A., Nov 1991, In : Radiology. 181, 2, p. 344-350 7 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Art
Research
1990

AIDS dementia complex: Brain high-energy phosphate metabolite deficits

Bottomley, P. A., Hardy, C. J., Cousins, J. P., Armstrong, M. & Wagle, W. A., Aug 1990, In : Radiology. 176, 2, p. 407-411 5 p.

Research output: Contribution to journalArticle

AIDS Dementia Complex
Magnetic Resonance Spectroscopy
Phosphates
Phosphocreatine
Brain

Correcting for nonuniform k-space sampling in two-dimensional NMR selective excitation

Hardy, C. J., Cline, H. E. & Bottomley, P. A., 1990, In : Journal of Magnetic Resonance (1969). 87, 3, p. 639-645 7 p.

Research output: Contribution to journalArticle

Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance

Bottomley, P. A., Hardy, C. J. & Roemer, P. B., 1990, In : Magnetic Resonance in Medicine. 14, 3, p. 425-434 10 p.

Research output: Contribution to journalArticle

Myocardium
Magnetic Resonance Spectroscopy
Thorax
Phosphates
2,3-Diphosphoglycerate
Phosphocreatine
Energy Metabolism
Coronary Artery Disease
Phosphates
Hand Strength
1989

Human in vivo NMR spectroscopy in diagnostic medicine: Clinical tool or research probe?

Bottomley, P. A., 1989, In : Radiology. 170, 1 I, p. 1-15 15 p.

Research output: Contribution to journalArticle

Clinical Medicine
Magnetic Resonance Spectroscopy
Spectrum Analysis
Citric Acid Cycle
Research
Spectrum Analysis
Magnetic Resonance Imaging
Spectroscopy
Artifacts
Tissue

Proton-decoupled, Overhauser-enhanced, Spatially localized carbon-13 spectroscopy in humans

Bottomley, P. A., Hardy, C. J., Roemer, P. B. & Mueller, O. M., 1989, In : Magnetic Resonance in Medicine. 12, 3, p. 348-363 16 p.

Research output: Contribution to journalArticle

Protons
Spectrum Analysis
Carbon
Citric Acid Cycle
Electromagnetic Phenomena

Rapid, reliable in vivo assays of human phosphate metabolites by nuclear magnetic resonance

Bottomley, P. A. & Hardy, C. J., 1989, In : Clinical Chemistry. 35, 3, p. 392-395 4 p.

Research output: Contribution to journalArticle

Metabolites
Assays
Magnetic Resonance Spectroscopy
Phosphates
Nuclear magnetic resonance
1988

Human in vivo phosphate metabolite imaging with 31P NMR

Bottomley, P. A., Charles, H. C., Roemer, P. B., Flamig, D., Engeseth, H., Edelstein, W. A. & Mueller, O. M., 1988, In : Magnetic Resonance in Medicine. 7, 3, p. 319-336 18 p.

Research output: Contribution to journalArticle

Phosphates
Magnetic Fields
Noise
Brain
Adenosine Triphosphate

Off-axis spatial localization with frequency modulated nuclear magnetic resonance rotating (ρ) pulses

Hardy, C. J., Bottomley, P. A. & Roemer, P. B., 1988, In : Journal of Applied Physics. 63, 9, p. 4741-4743 3 p.

Research output: Contribution to journalArticle

nuclear magnetic resonance
pulses
relocation
frequency modulation
excitation

Optimization of two-dimensional spatially selective NMR pulses by simulated annealing

Hardy, C. J., Bottomley, P. A., O'Donnell, M. & Roemer, P., 1988, In : Journal of Magnetic Resonance (1969). 77, 2, p. 233-250 18 p.

Research output: Contribution to journalArticle

simulated annealing
nuclear magnetic resonance
optimization
pulses
gradients

Rapid 31P spectroscopy on a 4-T whole-body system

Hardy, C. J., Bottomley, P. A., Roemer, P. B. & Redington, R. W., 1988, In : Magnetic Resonance in Medicine. 8, 1, p. 104-109 6 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Head
Liver
1987

Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy

Bottomley, P. A., Herfkens, R. J., Smith, L. S. & Bashore, T. M., 1987, In : Radiology. 165, 3, p. 703-707 5 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Phosphates
Myocardial Infarction
Healthy Volunteers
2,3-Diphosphoglycerate

A review of 1H nuclear magnetic resonance relaxation in pathology: Are T1 and T2 diagnostic?

Bottomley, P. A., Hardy, C. J., Argersinger, R. E. & Allen-Moore, G., 1987, In : Medical Physics. 14, 1, p. 1-37 37 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Pathology
Neoplasms
Liver
Temperature

Reply to comments of Akber

Bottomley, P. A. & Hardy, C. J., 1987, In : Medical Physics. 14, 6, p. 1091 1 p.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Oxygen

Spatial localization in NMR spectroscopy in vivo

Bottomley, P. A., 1987, In : Annals of the New York Academy of Sciences. 508, p. 333-348 16 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance spectroscopy
Spectrum Analysis
Magnetic Resonance Spectroscopy
Magnetic Fields
Spectroscopy

The fate of inorganic phosphate and pH in regional myocardial ischemia and infarction: a noninvasive 31P NMR study.

Bottomley, P. A., Smith, L. S., Brazzamano, S., Hedlund, L. W., Redington, R. W. & Herfkens, R. J., Aug 1987, In : Magnetic Resonance in Medicine. 5, 2, p. 129-142 14 p.

Research output: Contribution to journalArticle

Phosphocreatine
Infarction
Myocardial Ischemia
Phosphates
Myocardial Infarction
echoes
inversions
nuclear magnetic resonance
pulses
gradients
1986

Chronic adult cerebral infarction studied by phosphorus NMR spectroscopy

Bottomley, P. A., Drayer, B. P. & Smith, L. S., 1986, In : Radiology. 160, 3, p. 763-766 4 p.

Research output: Contribution to journalArticle

Cerebral Infarction
Phosphorus
Magnetic Resonance Spectroscopy
Phosphates
Brain Infarction
1985

Cerebral NMR: diagnostic evaluation of brain tumors by partial saturation technique with resistive NMR

Zimmerman, R. A., Bilaniuk, L. T., Grossman, R. I., Goldberg, H. I., Edelstein, W., Bottomley, P. A. & Redington, R. W., Jan 1985, In : Neuroradiology. 27, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Edema
Neoplasms
Protons
Magnetic Resonance Imaging

Estimating radiofrequency power deposition in body NMR imaging

Bottomley, P. A., Redington, R. W., Edelstein, W. A. & Schenck, J. F., 1985, In : Magnetic Resonance in Medicine. 2, 4, p. 336-349 14 p.

Research output: Contribution to journalArticle

Torso
Magnetic Resonance Imaging
Body Image
Artifacts
Hydrogen

High-field surface-coil MR imaging of localized anatomy

Schenck, J. F., Foster, T. H., Henkes, J. L., Adams, W. J., Hayes, C., Hart, H. R., Edelstein, W. A., Bottomley, P. A. & Wehrli, F. W., 1985, In : American Journal of Neuroradiology. 6, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

Improved MR imaging of the orbit at 1.5 T with surface coils

Schenck, J. F., Hart, H. R., Foster, T. H., Edelstein, W. A., Bottomley, P. A., Redington, R. W., Hardy, C. J., Zimmerman, R. A. & Bilaniuk, L. T., 1985, In : American Journal of Roentgenology. 144, 5, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

Orbit
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Signal-To-Noise Ratio
Noise

In vivo solvent-suppressed localized hydrogen nuclear magnetic resonance spectroscopy: A window to metabolism?

Bottomley, P. A., Edelstein, W. A., Foster, T. H. & Adams, W. A., 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 7, p. 2148-2152 5 p.

Research output: Contribution to journalArticle

Hydrogen
Spectrum Analysis
Magnetic Resonance Spectroscopy
Brain
Magnetic Fields

Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy

Bottomley, P. A., Herfkens, R. J., Smith, L. S., Brazzamano, S., Blinder, R., Hedlund, L. W., Swain, J. L. & Redington, R. W., 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 24, p. 8747-8751 5 p.

Research output: Contribution to journalArticle

Myocardial Ischemia
Magnetic Resonance Spectroscopy
Phosphocreatine
Adenosine Triphosphate
Process Assessment (Health Care)

Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy

Bottomley, P. A., 1985, In : Science. 229, 4715, p. 769-772 4 p.

Research output: Contribution to journalArticle

Energy Metabolism
Magnetic Resonance Spectroscopy
Phosphates
Phosphorus
Magnetic Fields

Orbital magnetic resonance imaging

Zimmerman, R. A., Bilaniuk, L. T., Yanoff, M., Schenck, J. F., Hart, H. R., Foster, T. H., Edelstein, W. A., Bottomley, P. A., Redinglon, R. W. & Hardy, C. J., 1985, In : American Journal of Ophthalmology. 100, 2, p. 312-317 6 p.

Research output: Contribution to journalArticle

Orbit
Magnetic Resonance Spectroscopy
Tomography
Magnetic Resonance Imaging