Paul A Bottomley

Professor

1976 …2019
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Research Output 1976 2019

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Article
2009

Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses

El-Sharkawy, A. M., Schar, M., Ouwerkerk, R., Weiss, R. G. & Bottomley, P. A., Apr 2009, In : Magnetic Resonance in Medicine. 61, 4, p. 785-795 11 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Magnetic Resonance Spectroscopy
Phosphocreatine
Phosphorus
Adenosine Triphosphate
MB Form Creatine Kinase
Creatine Kinase
Phosphorus
Phosphocreatine
Magnetic Resonance Spectroscopy
2008

Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy

Gabr, R. E., Weiss, R. G. & Bottomley, P. A., Apr 2008, In : Journal of Magnetic Resonance. 191, 2, p. 248-258 11 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
magnetic resonance spectroscopy
Creatine Kinase
Reaction rates
reaction kinetics

Optimized quadrature surface coil designs

Kumar, A. & Bottomley, P. A., Mar 2008, In : Magma (New York, N.Y.). 21, 1-2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Butterflies
Signal-To-Noise Ratio
Electromagnetic Phenomena

The performance of interventional loopless MRI antennae at higher magnetic field strengths

El-Sharkawy, A. M. M., Qian, D. & Bottomley, P. A., 2008, In : Medical Physics. 35, 5, p. 1995-2006 12 p.

Research output: Contribution to journalArticle

Interventional Magnetic Resonance Imaging
Signal-To-Noise Ratio
Magnetic Fields
Electromagnetic Phenomena
Heating

Tissue sodium concentration in myocardial infarction in humans: A quantitative 23Na MR imaging study

Ouwerkerk, R., Bottomley, P. A., Solaiyappan, M., Spooner, A. E., Tomaselli, G. F., Wu, K. C-C. & Weiss, R. G., Jul 2008, In : Radiology. 248, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

Sodium
Myocardial Infarction
Magnetic Resonance Imaging
Ventricular Tachycardia
Weights and Measures

Turning Up the Heat on MRI

Bottomley, P. A., 2008, In : Journal of the American College of Radiology. 5, 7, p. 853-855 3 p.

Research output: Contribution to journalArticle

Hot Temperature
2007

A prototype RF dosimeter for independent measurement of the average specific absorption rate (SAR) during MRI

Stralka, J. P. & Bottomley, P. A., Nov 2007, In : Journal of Magnetic Resonance Imaging. 26, 5, p. 1296-1302 7 p.

Research output: Contribution to journalArticle

Transducers
Radio
Head
Torso
Calibration

Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI

Ouwerkerk, R., Jacobs, M., Macura, K., Wolff, A. C., Stearns, V., Mezban, S. D., Khouri, N. F., Bluemke, D. A. & Bottomley, P. A., Dec 2007, In : Breast Cancer Research and Treatment. 106, 2, p. 151-160 10 p.

Research output: Contribution to journalArticle

Breast
Sodium
Magnetic Resonance Imaging
Radio
Protons

Local planar gradients with order-of-magnitude strength and speed advantage

Aksel, B., Marinelli, L., Collick, B. D., Von Morze, C., Bottomley, P. A. & Hardy, C. J., Jul 2007, In : Magnetic Resonance in Medicine. 58, 1, p. 134-143 10 p.

Research output: Contribution to journalArticle

Imaging Phantoms
Torque
Heating
2006

Absolute temperature monitoring using RF radiometry in the MRI scanner

El-Sharkawy, A. M. M., Sotiriadis, P. P., Bottomley, P. A. & Atalar, E., Nov 2006, In : IEEE Transactions on Circuits and Systems I: Regular Papers. 53, 11, p. 2396-2404 9 p.

Research output: Contribution to journalArticle

Radiometry
Radiometers
Magnetic resonance
Imaging techniques
Monitoring

Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium

Smith, C. S., Bottomley, P. A., Schulman, S. P., Gerstenblith, G. & Weiss, R. G., Sep 2006, In : Circulation. 114, 11, p. 1151-1158 8 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Creatine Kinase
Myocardium
Adenosine Triphosphate
Heart Failure

Deconvolution-interpolation gridding (DING): Accurate reconstruction for arbitrary k-space trajectories

Gabr, R. E., Aksit, P., Bottomley, P. A., Youssef, A. B. M. & Kadah, Y. M., Dec 2006, In : Magnetic Resonance in Medicine. 56, 6, p. 1182-1191 10 p.

Research output: Contribution to journalArticle

Compensation and Redress
Computer Simulation
Costs and Cost Analysis

Monitoring and correcting spatio-temporal variations of the MR scanner's static magnetic field

El-Sharkawy, A. M., Schar, M., Bottomley, P. A. & Atalar, E., Nov 2006, In : Magma (New York, N.Y.). 19, 5, p. 223-236 14 p.

Research output: Contribution to journalArticle

Magnetic Fields
Thermometry
Magnetic Resonance Spectroscopy
Magnets
Heating

On restoring motion-induced signal loss in single-voxel magnetic resonance spectra

Gabr, R. E., Sathyanarayana, S., Schar, M., Weiss, R. G. & Bottomley, P. A., Oct 2006, In : Magnetic Resonance in Medicine. 56, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Magnetic Resonance Spectroscopy
Spectrum Analysis
Torso
Artifacts

Optimizing the intrinsic signal-to-noise ratio of MRI strip detectors

Kumar, A. & Bottomley, P. A., Jul 2006, In : Magnetic Resonance in Medicine. 56, 1, p. 157-166 10 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Electromagnetic Phenomena

Quantifying in vivo MR spectra with circles

Gabr, R. E., Ouwerkerk, R. & Bottomley, P. A., Mar 2006, In : Journal of Magnetic Resonance. 179, 1, p. 152-163 12 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Artifacts
artifacts
2005
Creatine Kinase
Adenosine Triphosphate
Heart Failure
Magnetic Resonance Spectroscopy
MB Form Creatine Kinase
Coronary Artery Disease
Hemoglobins
Ischemia
Oxygen
Myocardial Ischemia
Sodium
Pulse
Adipose Tissue
Autopsy
Healthy Volunteers
2004

Large field-of-view real-time MRI with a 32-channel system

Hardy, C. J., Darrow, R. D., Saranathan, M., Giaquinto, R. O., Zhu, Y., Dumoulin, C. L. & Bottomley, P. A., Oct 2004, In : Magnetic Resonance in Medicine. 52, 4, p. 878-884 7 p.

Research output: Contribution to journalArticle

Torso
Software
Surveys and Questionnaires

Lumped-Element Planar Strip Array (LPSA) for Parallel MRI

Lee, R. F., Hardy, C. J., Sodickson, D. K. & Bottomley, P. A., Jan 2004, In : Magnetic Resonance in Medicine. 51, 1, p. 172-183 12 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Electromagnetic Fields
Artifacts
Magnetic Resonance Imaging
Breast Neoplasms
Magnetic Resonance Spectroscopy
Breast
Sodium
Choline
Protons
Magnetic Resonance Imaging
Breast Neoplasms
Signal-To-Noise Ratio
2003

The effect of orientation on quantification of muscle creatine by 1H MR spectroscopy

Gao, F., Bottomley, P. A., Arnold, C. & Weiss, R. G., Jun 2003, In : Magnetic Resonance Imaging. 21, 5, p. 561-566 6 p.

Research output: Contribution to journalArticle

creatine
Creatine
muscles
Muscle
Magnetic Resonance Spectroscopy

Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging

Ouwerkerk, R., Bleich, K., Gillen, J. S., Pomper, M. G. & Bottomley, P. A., May 1 2003, In : Radiology. 227, 2, p. 529-537 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Sodium
Magnetic Resonance Imaging
Cerebrospinal Fluid
Vitreous Body
2002

Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo

Bottomley, P. A., Ouwerkerk, R., Lee, R. F. & Weiss, R. G., 2002, In : Magnetic Resonance in Medicine. 47, 5, p. 850-863 14 p.

Research output: Contribution to journalArticle

Creatine Kinase
Phosphocreatine
Magnetic Resonance Spectroscopy
Signal-To-Noise Ratio
Phosphorus
2001

Attenuated myocardial vasodilator response in patients with hypertensive hypertrophy revealed by oxygenation-dependent magnetic resonance imaging

Beache, G. M., Herzka, D., Boxerman, J. L., Post, W. S., Gupta, S. N., Faranesh, A. Z., Solaiyappan, M., Bottomley, P. A., Weiss, J. L., Shapiro, E. & Hill, M., Sep 11 2001, In : Circulation. 104, 11, p. 1214-1217 4 p.

Research output: Contribution to journalArticle

Vasodilator Agents
Hypertrophy
Magnetic Resonance Imaging
Ventricular Dysfunction
Dipyridamole
Creatine Kinase
Phosphocreatine
Creatine
Canidae
Myocardium

Noninvasive quantification of total sodium concentrations in acute reperfused myocardial infarction using 23Na MRI

Constantinides, C. D., Kraitchman, D., O'Brien, K. O., Boada, F. E., Gillen, J. S. & Bottomley, P. A., 2001, In : Magnetic Resonance in Medicine. 46, 6, p. 1144-1151 8 p.

Research output: Contribution to journalArticle

Sodium
Myocardial Infarction
Atomic Spectrophotometry
Dogs
Sodium-Potassium-Exchanging ATPase

On neglecting chemical exchange effects when correcting in Vivo 31P MRS data for partial saturation

Ouwerkerk, R. & Bottomley, P. A., 2001, In : Journal of Magnetic Resonance. 148, 2, p. 425-435 11 p.

Research output: Contribution to journalArticle

Phosphocreatine
Metabolites
Signal-To-Noise Ratio
Chemical Models
saturation
Phosphocreatine
metabolites
Signal-To-Noise Ratio
Metabolites
Phosphates

Planar strip array (PSA) for MRI

Lee, R. F., Westgate, C. R., Weiss, R. G., Newman, D. C. & Bottomley, P. A., 2001, In : Magnetic Resonance in Medicine. 45, 4, p. 673-683 11 p.

Research output: Contribution to journalArticle

Electromagnetic Radiation
Electromagnetic Phenomena
Signal-To-Noise Ratio

Superparamagnetic iron oxide MION as a contrast agent for sodium MRI in myocardial infarction

Constantinides, C. D., Rogers, J., Herzka, D., Boada, F. E., Bolar, D., Kraitchman, D., Gillen, J. S. & Bottomley, P. A., 2001, In : Magnetic Resonance in Medicine. 46, 6, p. 1164-1168 5 p.

Research output: Contribution to journalArticle

Contrast Media
Sodium
Myocardial Infarction
Canidae
Noise
2000

A broadband phased-array system for direct phosphorus and sodium metabolic MRI on a clinical scanner

Lee, R. F., Giaquinto, R., Constantinides, C., Souza, S., Weiss, R. G. & Bottomley, P. A., 2000, In : Magnetic Resonance in Medicine. 43, 2, p. 269-277 9 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Phosphorus
Sodium
Protons
Magnetic Resonance Spectroscopy

An analytical SMASH procedure (ASP) for sensitivity-encoded MRI

Lee, R. F., Westgate, C. R., Weiss, R. G. & Bottomley, P. A., 2000, In : Magnetic Resonance in Medicine. 43, 5, p. 716-725 10 p.

Research output: Contribution to journalArticle

Computer-Assisted Image Processing
Fourier Analysis
Magnetic Resonance Imaging

Cardiovascular MRI probes for the outside in and for the inside out

Bottomley, P. A., Atalar, E., Lee, R. F., Shunk, K. A. & Lardo, A., 2000, In : Magma (New York, N.Y.). 11, 1-2, p. 49-51 3 p.

Research output: Contribution to journalArticle

Imaging Phantoms
Cardiovascular System
Magnetic Resonance Imaging

Categorical Course - The Bleeding Edge of Medical Innovation: Tools for the 21st Century

Antonuk, L., Naughton, G. K., Bottomley, P. A., Aralar, E., Halperin, H. R., Lardo, A., Foo, T., Yang, X., Johnson, M. S. & Warren, W. L., Feb 2000, In : Journal of Vascular and Interventional Radiology. 11, 2 II, p. 347-351 5 p.

Research output: Contribution to journalArticle

Human skeletal muscle: Sodium MR imaging and quantification - Potential applications in exercise and disease

Constantinides, C. D., Gillen, J. S., Boada, F. E., Pomper, M. G. & Bottomley, P. A., Aug 2000, In : Radiology. 216, 2, p. 559-568 10 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Sodium
Magnetic Resonance Imaging
Exercise
Muscles

Quantification and imaging of myocardial sodium and creatine kinase metabolites

Bottomley, P. A., Lee, R. F., Constantinides, C. D., Ouwerkerk, R. & Weiss, R. G., 2000, In : Magma (New York, N.Y.). 11, 1-2, p. 39-41 3 p.

Research output: Contribution to journalArticle

MB Form Creatine Kinase
Phosphocreatine
Creatine Kinase
Phosphorus
Myocardial Ischemia

Restoration of low resolution metabolic images with a priori anatomic information: 23Na MRI in myocardial infarction

Constantinidesa, C. D., Weiss, R. G., Lee, R., Bolar, D. & Bottomley, P. A., May 2000, In : Magnetic Resonance Imaging. 18, 4, p. 461-471 11 p.

Research output: Contribution to journalArticle

myocardial infarction
Magnetic resonance
restoration
Restoration
magnetic resonance
1998

Human cardiac spectroscopy

Bottomley, P. A. & Weiss, R. G., Sep 1998, In : Magma (New York, N.Y.). 6, 2-3, p. 157-160 4 p.

Research output: Contribution to journalArticle

Biomolecular Nuclear Magnetic Resonance
Phosphocreatine
Creatine
Creatine Kinase
Spectrum Analysis

Mitral regurgitation: Impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans

Conway, M. A., Bottomley, P. A., Ouwerkerk, R., Radda, G. K., Rajagopalan, B. & Cooper, R., May 5 1998, In : Circulation. 97, 17, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

Phosphocreatine
Mitral Valve Insufficiency
Hypertrophy
Magnetic Resonance Spectroscopy
Adenosine Triphosphate

Non-invasive magnetic-resonance detection of creatine depletion in non-viable infarcted myocardium

Bottomley, P. A. & Weiss, R. G., Mar 7 1998, In : The Lancet. 351, 9104, p. 714-718 5 p.

Research output: Contribution to journalArticle

Creatine
Myocardium
Magnetic Resonance Spectroscopy
MB Form Creatine Kinase
Infarction
1997

The rise of human in vivo NMR spectroscopy

Bottomley, P. A., Nov 1997, In : Solid State Nuclear Magnetic Resonance. 9, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance spectroscopy
Spectroscopy
nuclear magnetic resonance
spectroscopy
Imaging systems

Total creatine in muscle: Imaging and quantification with proton MR spectroscopy

Bottomley, P. A., Lee, Y. H. & Weiss, R. G., Aug 1997, In : Radiology. 204, 2, p. 403-410 8 p.

Research output: Contribution to journalArticle

Creatine
Muscles
Water
Proton Magnetic Resonance Spectroscopy
Magnetic Resonance Spectroscopy

What is the optimum phased array coil design for cardiac and torso magnetic resonance?

Bottomley, P. A., Lugo Olivieri, C. H. & Giaquinto, R., Apr 1997, In : Magnetic Resonance in Medicine. 37, 4, p. 591-599 9 p.

Research output: Contribution to journalArticle

Torso
Signal-To-Noise Ratio
Magnetic Resonance Spectroscopy
Myocardium
Healthy Volunteers
1996

High resolution intravascular MRI and MRS by using a catheter receiver coil

Atalar, E., Bottomley, P. A., Ocali, O., Correia, L. C. L., Kelemen, M. D., Lima, J. A. C. & Zerhouni, E. A., Oct 1996, In : Magnetic Resonance in Medicine. 36, 4, p. 596-605 10 p.

Research output: Contribution to journalArticle

Aorta
Catheters
Coronary Vessels
Signal-To-Noise Ratio
Renal Artery

Human cardiac high-energy phosphate metabolite concentrations by 1D-resolved NMR spectroscopy

Bottomley, P. A., Atalar, E. & Weiss, R. G., May 1996, In : Magnetic Resonance in Medicine. 35, 5, p. 664-670 7 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Phosphates
Phosphocreatine
Phosphorus
Protons
1995

Advances in physiological chemistry by in vivo NMR: A workshop sponsored by the society of magnetic resonance held in Woods Hole, Massachusetts

Balaban, R., Bottomley, P. A., Brown, T. R., Gadian, D., Mountford, C., Radda, G. K., Ross, B. D., Shulman, R. G., Springer, C. & Ugurbil, K., 1995, In : Magnetic Resonance in Medicine. 34, 3, p. 289-292 4 p.

Research output: Contribution to journalArticle