Paul A Bottomley

Professor

1976 …2019
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Research Output 1976 2019

2019
Artifacts
Brain Neoplasms
Healthy Volunteers
Amides
Protons

High-resolution intravascular MRI-guided perivascular ultrasound ablation

Liu, X., Ellens, N., Williams, E., Burdette, E. C., Karmarkar, P. P., Weiss, C., Kraitchman, D. & Bottomley, P. A., Jan 1 2019, (Accepted/In press) In : Magnetic resonance in medicine.

Research output: Contribution to journalArticle

Hot Temperature
Thermometry
High-Intensity Focused Ultrasound Ablation
Swine
Catheters
Open Access
Creatine Kinase
Energy Metabolism
Heart Diseases
Magnetic Resonance Spectroscopy
Heart Failure
2018
Creatine Kinase
Magnetic Resonance Spectroscopy
Heart Failure
Adenosine Triphosphate
Healthy Volunteers
2017

Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure

Weiss, K., Schar, M., Panjrath, G. S., Zhang, Y., Sharma, K., Bottomley, P. A., Golozar, A., Steinberg, A., Gerstenblith, G., Russell, S. D. & Weiss, R. G., Jul 1 2017, In : Circulation: Heart Failure. 10, 7, e004129.

Research output: Contribution to journalArticle

Skeletal Muscle
Heart Failure
Exercise
Phosphates
Fatigue
Protons
Magnetic Resonance Imaging
R388
Atherosclerosis
ROC Curve

Sir Peter Mansfield, PhD

Bottomley, P. A. & Maudsley, A. A., Jul 1 2017, In : Radiology. 284, 1, p. 305-306 2 p.

Research output: Contribution to journalArticle

Ultrafast compartmentalized relaxation time mapping with linear algebraic modeling

Zhang, Y., Liu, X., Zhou, J. & Bottomley, P. A., 2017, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Brain Neoplasms
Abdomen
Volunteers
Brain
Datasets
2016

Chemical exchange saturation transfer (CEST) imaging with fast variably-accelerated sensitivity encoding (vSENSE)

Zhang, Y., Heo, H. Y., Lee, D. H., Jiang, S., Zhao, X., Bottomley, P. A. & Zhou, J., 2016, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Amides
Brain Neoplasms
Artifacts
Protons
Healthy Volunteers

Highly accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling

Zhang, Y., Heo, H. Y., Jiang, S., Lee, D. H., Bottomley, P. A. & Zhou, J., Jul 1 2016, In : Magnetic Resonance in Medicine. 76, 1, p. 136-144 9 p.

Research output: Contribution to journalArticle

Fourier Analysis
Brain Neoplasms
R Factors
Signal-To-Noise Ratio

Measuring biochemical reaction rates in vivo with magnetization transfer

Bottomley, P. A., 2016, In : eMagRes. 5, 1, p. 843-858 16 p.

Research output: Contribution to journalArticle

Reaction rates
Magnetization
Nuclear magnetic resonance
Animals
Adenosine Triphosphate

MRS in the failing heart: From mice to humans

Weiss, R. G., Gupta, A. & Bottomley, P. A., 2016, In : eMagRes. 5, 2, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Creatine Kinase
Magnetic Resonance Spectroscopy
Heart Failure
Adenosine Triphosphate

MRS studies of creatine kinase metabolism in human heart

Bottomley, P. A., 2016, In : eMagRes. 5, 2, p. 1183-1202 20 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Creatine Kinase
Metabolism
Phosphocreatine
Magnetic Resonance Spectroscopy

Radiofrequency ablation, MR thermometry, and high-spatial-resolution MR parametric imaging with a single, minimally invasive device

Ertürk, M. A., Hegde, S. S. & Bottomley, P. A., Dec 1 2016, In : Radiology. 281, 3, p. 927-932 6 p.

Research output: Contribution to journalArticle

Thermometry
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Equipment and Supplies
Hot Temperature

Sodium MRI in human heart: A review

Bottomley, P. A., Feb 1 2016, In : NMR in Biomedicine. 29, 2, p. 187-196 10 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Sodium
Tissue
Poisons
Signal-To-Noise Ratio
2015

Accelerated spatially encoded spectroscopy of arbitrarily shaped compartments using prior knowledge and linear

Modeling, A., Bottomley, P. A. & Zhang, Y., 2015, In : eMagRes. 4, 1, p. 89-104 16 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Spectrum Analysis
Signal to noise ratio
Spectroscopy
Magnetic Resonance Imaging

Acceleration and motion-correction techniques for high-resolution intravascular MRI

Hegde, S. S., Zhang, Y. & Bottomley, P. A., Aug 1 2015, In : Magnetic Resonance in Medicine. 74, 2, p. 452-461 10 p.

Research output: Contribution to journalArticle

Artifacts
Compensation and Redress
Costs and Cost Analysis
Signal-To-Noise Ratio
Endoscopy

Minimizing lipid signal bleed in brain 1H chemical shift imaging by post-acquisition grid shifting

Zhang, Y., Zhou, J. & Bottomley, P. A., Aug 1 2015, In : Magnetic Resonance in Medicine. 74, 2, p. 320-329 10 p.

Research output: Contribution to journalArticle

Scalp
Magnetic Resonance Imaging
Lipids
Artifacts
Brain

Monitoring local heating around an interventional MRI antenna with RF radiometry

Ertürk, M. A., El-Sharkawy, A. M. M. & Bottomley, P. A., Mar 1 2015, In : Medical Physics. 42, 3, p. 1411-1423 13 p.

Research output: Contribution to journalArticle

Interventional Magnetic Resonance Imaging
Radiometry
Heating
Magnetic Resonance Imaging
Temperature
Creatine Kinase
Reaction kinetics
Phosphates
Adenosine Triphosphate
Fluxes

Quantifying metabolite ratios and concentrations by Non-1H MRS

Bottomley, P. A., 2015, In : eMagRes. 4, 3, p. 611-625 15 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Metabolites
Magnetic Resonance Spectroscopy
Brain
Nuclear magnetic resonance

The basics

Bottomley, P. A., 2015, In : eMagRes. 4, 2, p. 505-524 20 p.

Research output: Contribution to journalArticle

Radio
Nuclear magnetic resonance
Noise
Signal-To-Noise Ratio
Magnetic resonance spectroscopy
Creatine Kinase
Phosphocreatine
Adenosine Triphosphate
Heart Failure
Healthy Volunteers
2014

7 Tesla MRI with a transmit/receive loopless antenna and B 1-insensitive selective excitation

Erturk, M. A., El-Sharkawy, A. M. M., Moore, J. & Bottomley, P. A., 2014, In : Magnetic Resonance in Medicine. 72, 1, p. 220-226 7 p.

Research output: Contribution to journalArticle

Interventional Magnetic Resonance Imaging
Aorta
Rabbits
Signal-To-Noise Ratio
Heating

Evaluation of epidural and peripheral nerve catheter heating during magnetic resonance imaging

Owens, S., Erturk, M., Ouanes, J-P., Murphy, J., Wu, C. & Bottomley, P. A., Dec 12 2014, In : Regional Anesthesia and Pain Medicine. 39, 6, p. 534-539 6 p.

Research output: Contribution to journalArticle

Peripheral Nerves
Heating
Catheters
Magnetic Resonance Imaging
Temperature

In memoriam: William A. Edelstein, 1944-2014

Bottomley, P. A., Aug 1 2014, In : Magnetic Resonance in Medicine. 72, 2, p. 301-303 3 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Radiology
England
Magnetic Resonance Spectroscopy

Minimum acquisition methods for simultaneously imaging T1, T2, and proton density with B1 correction and no spin-echoes

Wang, G., El-Sharkawy, A. M. M. & Bottomley, P. A., 2014, In : Journal of Magnetic Resonance. 242, p. 243-255 13 p.

Research output: Contribution to journalArticle

Protons
acquisition
echoes
Imaging techniques
Magnetic resonance imaging
2013

An RF dosimeter for independent SAR measurement in MRI scanners

Qian, D., El-Sharkawy, A. M. M., Bottomley, P. A. & Edelstein, W. A., Dec 2013, In : Medical Physics. 40, 12, 122303.

Research output: Contribution to journalArticle

Radio
Magnetic Resonance Imaging
Transducers
Torso
Safety

Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy

Abraham, M. R., Bottomley, P. A., Dimaano, V. L., Pinheiro, A., Steinberg, A., Traill, T. A., Abraham, T. P. & Weiss, R. G., Sep 15 2013, In : The American Journal of Cardiology. 112, 6, p. 861-866 6 p.

Research output: Contribution to journalArticle

Phosphocreatine
Hypertrophic Cardiomyopathy
Creatine Kinase
Adenosine Triphosphate
Mutation

Denoising MRI using spectral subtraction

Arcan Erturk, M., Bottomley, P. A. & El-Sharkawy, A. M. M., 2013, In : IEEE Transactions on Biomedical Engineering. 60, 6, p. 1556-1562 7 p., 6409421.

Research output: Contribution to journalArticle

Magnetic resonance
Signal to noise ratio
Imaging techniques
Image resolution
Statistics
chemical equilibrium
Spectrum Analysis
coding
Magnetic Resonance Imaging
Spectroscopy

Metabolic rates of ATP transfer through creatine kinase (CK flux) predict clinical heart failure events and death

Bottomley, P. A., Panjrath, G. S., Lai, S., Hirsch, G. A., Wu, K. C-C., Najjar, S. S., Steinberg, A., Gerstenblith, G. & Weiss, R. G., Dec 11 2013, In : Science Translational Medicine. 5, 215, 215re3.

Research output: Contribution to journalArticle

Creatine Kinase
Heart Failure
Adenosine Triphosphate
Stroke Volume
MB Form Creatine Kinase

Quantification of human high-energy phosphate metabolite concentrations at 3T with partial volume and sensitivity corrections

El-Sharkawy, A. M. M., Gabr, R. E., Schar, M., Weiss, R. G. & Bottomley, P. A., Nov 2013, In : NMR in Biomedicine. 26, 11, p. 1363-1371 9 p.

Research output: Contribution to journalArticle

Phosphocreatine
Metabolites
Adenosine Triphosphate
Phosphates
Tissue
2012
Allopurinol
Adenosine
Creatine Kinase
Adenosine Triphosphate
Xanthine Oxidase

A multichannel, real-time MRI RF power monitor for independent SAR determination

El-Sharkawy, A. M. M., Qian, D., Bottomley, P. A. & Edelstein, W. A., May 2012, In : Medical Physics. 39, 5, p. 2334-2341 8 p.

Research output: Contribution to journalArticle

Safety
Equipment and Supplies
Compliance
Volunteers
Magnetic Resonance Imaging
magnetic resonance spectroscopy
magnetic resonance
reaction kinetics
Magnetic Resonance Spectroscopy
saturation
Atherosclerotic Plaques
Magnetic Resonance Spectroscopy
Histology
Investigational Therapies
Iliac Artery

Interventional loopless antenna at 7 T

Ertürk, M. A., El-Sharkawy, A. M. M. & Bottomley, P. A., Sep 2012, In : Magnetic Resonance in Medicine. 68, 3, p. 980-988 9 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Magnetic Resonance Imaging
Electromagnetic Phenomena
Needles
Microscopy

Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity

Zhang, Y., Gabr, R. E., Schar, M., Weiss, R. G. & Bottomley, P. A., May 2012, In : Journal of Magnetic Resonance. 218, p. 66-76 11 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
magnetic resonance spectroscopy
Signal-To-Noise Ratio
Spectrum Analysis
Signal to noise ratio

Measuring T 2 and T 1, and imaging T 2 without spin echoes

Wang, G., El-Sharkawy, A. M., Edelstein, W. A., Schar, M. & Bottomley, P. A., Jan 2012, In : Journal of Magnetic Resonance. 214, p. 273-280 8 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
echoes
Imaging techniques
Imaging Phantoms
pulses

Spectral subtraction de-noising of MRI

Erturk, M. A., Bottomley, P. A. & El-Sharkawy, A. M. M., 2012, 2012 Cairo International Biomedical Engineering Conference, CIBEC 2012. p. 138-141 4 p. 6473325

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Magnetic resonance
Magnetic resonance imaging
Signal to noise ratio
Image denoising
Imaging techniques
2011

Fluorine (19F) MRS and MRI in biomedicine

Ruiz-Cabello, J., Barnett, B. P., Bottomley, P. A. & Bulte, J. W., Feb 2011, In : NMR in Biomedicine. 24, 2, p. 114-129 16 p.

Research output: Contribution to journalArticle

Fluorine
Magnetic resonance imaging
Contrast Media
Cell Tracking
Molecular Imaging

High-energy phosphate transfer in human muscle: Diffusion of phosphocreatine

Gabr, R. E., El-Sharkawy, A. M. M., Schar, M., Weiss, R. G. & Bottomley, P. A., Jul 2011, In : American Journal of Physiology - Cell Physiology. 301, 1

Research output: Contribution to journalArticle

Phosphocreatine
Energy Transfer
Phosphates
Muscles
Myofibrils
2010

Designing passive MRI-safe implantable conducting leads with electrodes

Bottomley, P. A., Kumar, A., Edelstein, W. A., Allen, J. M. & Karmarkar, P. P., Jul 2010, In : Medical Physics. 37, 7, p. 3828-3843 16 p.

Research output: Contribution to journalArticle

Electrodes
Radio
Magnetic Resonance Imaging
Heating
Hot Temperature

Interventional MRI: Tapering improves the distal sensitivity of the loopless antenna

Qian, D., El-Sharkawy, A. M. M., Atalar, E. & Bottomley, P. A., Mar 2010, In : Magnetic Resonance in Medicine. 63, 3, p. 797-802 6 p.

Research output: Contribution to journalArticle

Interventional Magnetic Resonance Imaging
Signal-To-Noise Ratio
Electromagnetic Phenomena
Aorta

Towards real-time intravascular endoscopic magnetic resonance imaging

Sathyanarayana, S., Schr, M., Kraitchman, D. & Bottomley, P. A., Nov 2010, In : JACC: Cardiovascular Imaging. 3, 11, p. 1158-1165 8 p.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Endoscopy
Blood Vessels
Atherosclerosis
Iliac Artery
Creatine Kinase
Spectrum Analysis
Signal-To-Noise Ratio
Magnetic Fields
Phosphorus
2009

MRI dynamic range and its compatibility with signal transmission media

Gabr, R. E., Schar, M., Edelstein, A. D., Kraitchman, D., Bottomley, P. A. & Edelstein, W. A., Jun 2009, In : Journal of Magnetic Resonance. 198, 2, p. 137-145 9 p.

Research output: Contribution to journalArticle

signal transmission
Electromagnetic Phenomena
Magnetic resonance imaging
compatibility
dynamic range

MRI endoscopy using intrinsically localized probes

Sathyanarayana, S. & Bottomley, P. A., 2009, In : Medical Physics. 36, 3, p. 908-919 12 p.

Research output: Contribution to journalArticle

Endoscopy
Magnetic Resonance Imaging
Endoscopes
Equipment and Supplies
Magnetic Fields

Noise figure limits for circular loop MR coils

Kumar, A., Edelstein, W. A. & Bottomley, P. A., May 2009, In : Magnetic Resonance in Medicine. 61, 5, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

Signal-To-Noise Ratio
Noise
Electromagnetic Radiation
Joints