Patrick Ryan Sosnay

Assistant Professor

20032019
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Fingerprint Dive into the research topics where Patrick Ryan Sosnay is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Cystic Fibrosis Medicine & Life Sciences
Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences
Mutation Medicine & Life Sciences
Sweat Medicine & Life Sciences
Phenotype Medicine & Life Sciences
Chlorides Medicine & Life Sciences
Newborn Infant Medicine & Life Sciences
Genotype Medicine & Life Sciences

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Research Output 2003 2019

Correlating cystic fibrosis transmembrane conductance regulator function with clinical features to inform precision treatment of cystic fibrosis

McCague, A. F., Raraigh, K. S., Pellicore, M. J., Davis-Marcisak, E. F., Evans, T. A., Han, S. T., Lu, Z., Joynt, A. T., Sharma, N., Castellani, C., Collaco, M., Corey, M., Lewis, M. H., Penland, C. M., Rommens, J. M., Stephenson, A. L., Sosnay, P. R. & Cutting, G. R., May 1 2019, In : American journal of respiratory and critical care medicine. 199, 9, p. 1116-1126 11 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Genotype
Sweat
Chlorides

Decreased mRNA and protein stability of W1282X limits response to modulator therapy

Aksit, M. A., Bowling, A. D., Evans, T. A., Joynt, A. T., Osorio, D., Patel, S., West, N. E., Merlo, C., Sosnay, P. R., Cutting, G. R. & Sharma, N., Jan 1 2019, In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Protein Stability
RNA Stability
Nose
Cystic Fibrosis Transmembrane Conductance Regulator
RNA

Capitalizing on the heterogeneous effects of CFTR nonsense and frameshift variants to inform therapeutic strategy for cystic fibrosis

Sharma, N., Evans, T. A., Pellicore, M. J., Davis, E., Aksit, M. A., McCague, A. F., Joynt, A. T., Lu, Z., Han, S. T., Anzmann, A. F., Lam, A. T. N., Thaxton, A., West, N. E., Merlo, C., Gottschalk, L. B., Raraigh, K. S., Sosnay, P. R., Cotton, C. U. & Cutting, G. R., Nov 1 2018, In : PLoS Genetics. 14, 11, e1007723.

Research output: Contribution to journalArticle

cystic fibrosis
Cystic Fibrosis
Nonsense Codon
therapeutics
protein

Functional Assays Are Essential for Interpretation of Missense Variants Associated with Variable Expressivity

Raraigh, K. S., Han, S. T., Davis, E., Evans, T. A., Pellicore, M. J., McCague, A. F., Joynt, A. T., Lu, Z., Atalar, M., Sharma, N., Sheridan, M., Sosnay, P. R. & Cutting, G. R., Jun 7 2018, In : American Journal of Human Genetics. 102, 6, p. 1062-1077 16 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Virulence
Molecular Pathology
Human Genome
Genomics

Sweat test for cystic fibrosis: Wearable sweat sensor vs. standard laboratory test

Choi, D. H., Thaxton, A., Jeong, I. C., Kim, K., Sosnay, P. R., Cutting, G. R. & Searson, P. C., Jan 1 2018, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Sweat
Cystic Fibrosis
Chlorides
Arm
Healthy Volunteers