Patrick A Brown

Associate Professor

20042019

Research output per year

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Research Output

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Article
2010

Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric Acute Lymphocytic Leukemia (ALL): Review from an International Consensus Conference

Horton, T. M., Sposto, R., Brown, P. A., Reynolds, C. P., Hunger, S. P., Winick, N. J., Raetz, E. A., Carroll, W. L., Arceci, R. J., Borowitz, M. J., Gaynon, P. S., Gore, L., Jeha, S., Maurer, B. J., Siegel, S. E., Biondi, A., Kearns, P. R., Narendran, A., Silverman, L. B., Smith, M. A. & 2 others, Zwaan, C. M. & Whitlock, J. A., Jul 1 2010, In : Pediatric Blood and Cancer. 54, 7, p. 872-878 7 p.

Research output: Contribution to journalArticle

2009

50 Years Ago in The Journal of Pediatrics. Congenital Leukemia

Brown, P. A., Jul 2009, In : Journal of Pediatrics. 155, 1, p. 67 1 p.

Research output: Contribution to journalArticle

Adding WT1 to childhood AML alphabet soup

Brown, P. A., 2009, In : Blood. 113, 23, p. 5696-5697 2 p.

Research output: Contribution to journalArticle

Novel targeted drug therapies for the treatment of childhood acute leukemia

Brown, P. A., Hunger, S. P., Smith, F. O., Carroll, W. L. & Reaman, G. H., 2009, In : Expert Review of Hematology. 2, 2, p. 145-158 14 p.

Research output: Contribution to journalArticle

Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma

Hu, R., Mukhina, G. L., Lee, S. H., Jones, R. J., Englund, P. T., Brown, P. A., Sharkis, S. J., Buckley, J. T. & Brodsky, R. A., Apr 2009, In : Experimental Hematology. 37, 4

Research output: Contribution to journalArticle

2008

Molecularly targeted therapies for pediatric acute myeloid leukemia: Progress to date

Brown, P. A. & Smith, F. O., 2008, In : Pediatric Drugs. 10, 2, p. 85-92 8 p.

Research output: Contribution to journalArticle

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia

Falini, B., Mecucci, C., Saglio, G., Lo Coco, F., Diverio, D., Brown, P. A., Pane, F., Mancini, M., Martelli, M. P., Pileri, S., Haferlach, T., Haferlach, C. & Schnittger, S., Mar 2008, In : Haematologica. 93, 3, p. 439-442 4 p.

Research output: Contribution to journalArticle

Rapid method for detection of mutations in the nucleophosmin gene in acute myeloid leukemia

Laughlin, T. S., Becker, M. W., Liesveld, J. L., Mulford, D. A., Abboud, C. N., Brown, P. A. & Rothberg, P. G., Jul 2008, In : Journal of Molecular Diagnostics. 10, 4, p. 338-345 8 p.

Research output: Contribution to journalArticle

2007

Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways

Piloto, O., Wright, M., Brown, P. A., Kim, K. T., Levis, M. J. & Small, D., Feb 15 2007, In : Blood. 109, 4, p. 1643-1652 10 p.

Research output: Contribution to journalArticle

The incidence and clinical significance of nucleophosmin mutations in childhood AML

Brown, P. A., McIntyre, E., Rau, R., Meshinchi, S., Lacayo, N., Dahl, G., Alonzo, T. A., Chang, M., Arceci, R. J. & Small, D., Aug 1 2007, In : Blood. 110, 3, p. 979-985 7 p.

Research output: Contribution to journalArticle

2006

Answers to key questions about childhood leukemia - For the generalist

Brown, P. A., 2006, In : Contemporary Pediatrics. 23, 3, p. 81-98 18 p.

Research output: Contribution to journalArticle

IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples

Piloto, O., Nguyen, B., Huso, D., Kim, K. T., Li, Y., Witte, L., Hicklin, D. J., Brown, P. A. & Small, D., May 1 2006, In : Cancer Research. 66, 9, p. 4843-4851 9 p.

Research output: Contribution to journalArticle

Plasma inhibitory activity (PIA): A pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

Levis, M., Brown, P., Smith, B. D., Stine, A., Pham, R., Stone, R., DeAngelo, D., Galinsky, I., Giles, F., Estey, E., Kantarjian, H., Cohen, P., Wang, Y., Roesel, J., Karp, J. E. & Small, D., Nov 15 2006, In : Blood. 108, 10, p. 3477-3483 7 p.

Research output: Contribution to journalArticle

2005

FLT3/ITD mutation signaling includes suppression of SHP-1

Chen, P., Levis, M. J., Brown, P. A., Kim, K. T., Allebach, J. & Small, D., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5361-5369 9 p.

Research output: Contribution to journalArticle

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression

Brown, P. A., Levis, M. J., Shurtleff, S., Campana, D., Downing, J. & Small, D., Jan 15 2005, In : Blood. 105, 2, p. 812-820 9 p.

Research output: Contribution to journalArticle

2004

FLT3 Inhibitors: A paradigm for the development of targeted therapeutics for paediatric cancer

Brown, P. A. & Small, D., Mar 2004, In : European Journal of Cancer. 40, 5, p. 707-721 15 p.

Research output: Contribution to journalArticle

FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells

Zheng, R., Levis, M., Piloto, O., Brown, P., Baldwin, B. R., Gorin, N. C., Beran, M., Zhu, Z., Ludwig, D., Hicklin, D., Witte, L., Li, Y. & Small, D., Jan 1 2004, In : Blood. 103, 1, p. 267-274 8 p.

Research output: Contribution to journalArticle

Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

Brown, P. A., Meshinchi, S., Levis, M. J., Alonzo, T. A., Gerbing, R., Lange, B., Arceci, R. & Small, D., Sep 15 2004, In : Blood. 104, 6, p. 1841-1849 9 p.

Research output: Contribution to journalArticle