Patrick A Brown

Associate Professor

20042019

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50 Years Ago in The Journal of Pediatrics. Congenital Leukemia

Brown, P. A., Jul 2009, In : Journal of Pediatrics. 155, 1, p. 67 1 p.

Research output: Contribution to journalArticle

Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia

Vrooman, L. M., Kirov, I. I., Dreyer, Z. A. E., Kelly, M., Hijiya, N., Brown, P. A., Drachtman, R. A., Messinger, Y. H., Ritchey, A. K., Hale, G. A., Maloney, K., Lu, Y., Plourde, P. V. & Silverman, L. B., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 228-233 6 p.

Research output: Contribution to journalArticle

Acute lymphoblastic leukemia: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Bellam, N., Blum, W., Boyer, M. W., Carraway, H. E., Coccia, P. F., Coutre, S. E., Cultrera, J., Damon, L. E., DeAngelo, D. J., Douer, D., Frangoul, H., Frankfurt, O., Goorha, S., Millenson, M. M., O'Brien, S., Petersdorf, S. H. & 7 others, Rao, A. V., Terezakis, S. A., Uy, G., Wetzler, M., Zelenetz, A. D., Naganuma, M. & Gregory, K. M., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 858-914 57 p.

Research output: Contribution to journalArticle

Acute lymphoblastic leukemia, version 2.2015: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Barta, S. K., Borate, U., Boyer, M. W., Burke, P. W., Cassaday, R., Castro, J. E., Coccia, P. F., Coutre, S. E., Damon, L. E., De Angelo, D. J., Douer, D., Frankfurt, O., Greer, J. P., Johnson, R. A., Kantarjian, H. M., Klisovic, R. B. & 10 others, Kupfer, G., Litzow, M., Liu, A., Rao, A. V., Shah, B., Uy, G. L., Wang, E. S., Zelenetz, A. D., Gregory, K. & Smith, C., Oct 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 10, p. 1240-1279 40 p.

Research output: Contribution to journalArticle

Adding WT1 to childhood AML alphabet soup

Brown, P. A., 2009, In : Blood. 113, 23, p. 5696-5697 2 p.

Research output: Contribution to journalArticle

Answers to key questions about childhood leukemia - For the generalist

Brown, P. A., 2006, In : Contemporary Pediatrics. 23, 3, p. 81-98 18 p.

Research output: Contribution to journalArticle

A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011)

Loh, M. L., Tasian, S. K., Rabin, K. R., Brown, P. A., Magoon, D., Reid, J. M., Chen, X., Ahern, C. H., Weigel, B. J. & Blaney, S. M., Oct 1 2015, In : Pediatric Blood and Cancer. 62, 10, p. 1717-1724 8 p.

Research output: Contribution to journalArticle

A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study (POE 10-03)

Cooper, T. M., Sison, E. A. R., Baker, S. D., Li, L., Ahmed, A., Trippett, T., Gore, L., Macy, M. E., Narendran, A., August, K., Absalon, M. J., Boklan, J., Pollard, J., Magoon, D. & Brown, P. A., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

A phase i study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium

Raetz, E. A., Morrison, D., Romanos-Sirakis, E., Gaynon, P., Sposto, R., Bhojwani, D., Bostrom, B. C., Brown, P. A., Eckroth, E., Cassar, J., Malvar, J., Buchbinder, A. & Carroll, W. L., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 6, p. 458-463 6 p.

Research output: Contribution to journalArticle

A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) study

Cooper, T. M., Cassar, J., Eckroth, E., Malvar, J., Sposto, R., Gaynon, P., Chang, B. H., Gore, L., August, K., Pollard, J. A., DuBois, S. G., Silverman, L. B., Oesterheld, J., Gammon, G., Magoon, D., Annesley, C. & Brown, P. A., Aug 15 2016, In : Clinical Cancer Research. 22, 16, p. 4014-4022 9 p.

Research output: Contribution to journalArticle

A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia

Hale, V., Hale, G. A., Brown, P. A. & Amankwah, E., Nov 2 2016, (Accepted/In press) In : Oncology.

Research output: Contribution to journalArticle

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Fox, J. M., Moynihan, J. R., Mott, B. T., Mazzone, J. R., Anders, N., Brown, P. A., Rudek-Renaut, M., Liu, J., Boger, R., Posner, G. H., Civin, C. I. & Chen, X., 2016, In : Oncotarget. 7, 6, p. 7268-7279 12 p.

Research output: Contribution to journalArticle

Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis

Amankwah, E., Saenz, A. M., Hale, G. A. & Brown, P. A., Sep 4 2015, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.

Research output: Contribution to journalArticle

Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group

Horton, T. M., Whitlock, J. A., Lu, X., O'Brien, M. M., Borowitz, M. J., Devidas, M., Raetz, E. A., Brown, P. A., Carroll, W. L. & Hunger, S. P., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

Chimeric antigen receptor T-cell therapy

Ogba, N., Arwood, N. M., Bartlett, N. L., Bloom, M., Brown, P. A., Brown, C., Budde, E. L., Carlson, R., Farnia, S., Fry, T. J., Garber, M., Gardner, R. A., Gurschick, L., Kropf, P., Reitan, J. J., Sauter, C., Shah, B., Shpall, E. J. & Rosen, S. T., Sep 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 9, p. 1093-1106 14 p.

Research output: Contribution to journalArticle

Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: A report from the children's oncology group

Salzer, W. L., Jones, T. L., Devidas, M., Dreyer, Z. E., Gore, L., Winick, N. J., Sung, L., Raetz, E., Loh, M. L., Wang, C. Y., De Lorenzo, P., Valsecchi, M. G., Pieters, R., Carroll, W. L., Hunger, S. P., Hilden, J. M. & Brown, P. A., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Dynamic chemotherapy-induced upregulation of CXCR4 expression: A mechanism of therapeutic resistance in pediatric AML

Sison, E. A. R., McIntyre, E., Magoon, D. & Brown, P. A., Sep 2013, In : Molecular Cancer Research. 11, 9, p. 1004-1016 13 p.

Research output: Contribution to journalArticle

Emerging treatment options for acute lymphoblastic leukemia: Focus on CAR T-cell therapy

Brown, P. A. & Shah, B., May 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 5S, p. 651-655 5 p.

Research output: Contribution to journalArticle

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P. A. & Carroll, W. L., Jun 5 2012, In : Blood. 119, 22, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group (COG)

Gupta, S., Devidas, M., Loh, M. L., Raetz, E. A., Chen, S., Wang, C., Brown, P. A., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Dunsmore, K. P., Larsen, E. C., Maloney, K. W., Mattano, L. A., Winter, S. S., Winick, N. J., Carroll, W. L., Hunger, S. P., Borowitz, M. J. & Wood, B. L., Feb 23 2018, (Accepted/In press) In : Leukemia. p. 1-10 10 p.

Research output: Contribution to journalArticle

FLT3/ITD mutation signaling includes suppression of SHP-1

Chen, P., Levis, M. J., Brown, P. A., Kim, K. T., Allebach, J. & Small, D., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5361-5369 9 p.

Research output: Contribution to journalArticle

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B., Williams, A. B., Young, D. J., Ma, H., Li, L., Levis, M. J., Brown, P. A. & Small, D., 2017, In : Oncotarget. 8, 7, p. 10931-10944 14 p.

Research output: Contribution to journalArticle

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression

Brown, P. A., Levis, M. J., Shurtleff, S., Campana, D., Downing, J. & Small, D., Jan 15 2005, In : Blood. 105, 2, p. 812-820 9 p.

Research output: Contribution to journalArticle

FLT3 Inhibitors: A paradigm for the development of targeted therapeutics for paediatric cancer

Brown, P. A. & Small, D., Mar 2004, In : European Journal of Cancer. 40, 5, p. 707-721 15 p.

Research output: Contribution to journalArticle

FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia

Ma, H. S., Nguyen, B., Duffield, A. S., Li, L., Galanis, A., Williams, A. B., Brown, P. A., Levis, M. J., Leahy, D. J. & Small, D., Jul 24 2014, In : Cancer Research. 74, 18, p. 5206-5217 12 p.

Research output: Contribution to journalArticle

FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells

Zheng, R., Levis, M., Piloto, O., Brown, P., Baldwin, B. R., Gorin, N. C., Beran, M., Zhu, Z., Ludwig, D., Hicklin, D., Witte, L., Li, Y. & Small, D., Jan 1 2004, In : Blood. 103, 1, p. 267-274 8 p.

Research output: Contribution to journalArticle

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

Williams, A. B., Li, L., Nguyen, B., Brown, P. A., Levis, M. J. & Small, D., Oct 11 2012, In : Blood. 120, 15, p. 3069-3079 11 p.

Research output: Contribution to journalArticle

Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2019

Brown, P. A., Wieduwilt, M., Logan, A., DeAngelo, D. J., Wang, E. S., Fathi, A., Cassaday, R. D., Litzow, M., Advani, A., Aoun, P., Bhatnagar, B., Boyer, M. W., Bryan, T., Burke, P. W., Coccia, P. F., Coutre, S. E., Jain, N., Kirby, S., Liu, A., Massaro, S. & 9 others, Mattison, R. J., Oluwole, O., Papadantonakis, N., Park, J., Rubnitz, J. E., Uy, G. L., Gregory, K. M., Ogba, N. & Shah, B., May 1 2019, In : Journal of the National Comprehensive Cancer Network : JNCCN. 17, 5, p. 414-423 10 p.

Research output: Contribution to journalArticle

Open Access

Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children's Oncology Group

Esiashvili, N., Lu, X., Ulin, K., Laurie, F., Kessel, S., Kalapurakal, J. A., Merchant, T. E., Followill, D. S., Sathiaseelan, V., Schmitter, M. K., Devidas, M., Chen, Y., Wall, D. A., Brown, P. A., Hunger, S. P., Grupp, S. A. & Pulsipher, M. A., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias

Morisot, S., Wayne, A. S., Bohana-Kashtan, O., Kaplan, I. M., Gocke, C., Hildreth, R., Stetler-Stevenson, M., Walker, R. L., Davis, S., Meltzer, P. S., Wheelan, S., Brown, P. A., Jones, R. J., Shultz, L. D. & Civin, C. I., Nov 23 2010, In : Leukemia. 24, 11, p. 1859-1866 8 p.

Research output: Contribution to journalArticle

How I treat infant leukemia

Brown, P., Pieters, R. & Biondi, A., Jan 17 2019, In : Blood. 133, 3, p. 205-214 10 p.

Research output: Contribution to journalArticle

Open Access

IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples

Piloto, O., Nguyen, B., Huso, D., Kim, K. T., Li, Y., Witte, L., Hicklin, D. J., Brown, P. A. & Small, D., May 1 2006, In : Cancer Research. 66, 9, p. 4843-4851 9 p.

Research output: Contribution to journalArticle

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

Li, Z., Younger, K., Gartenhaus, R., Joseph, A. M., Hu, F., Baer, M. R., Brown, P. A. & Davila, E., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1081-1097 17 p.

Research output: Contribution to journalArticle

Knock-In of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice

Annesley, C. E., Rabik, C., Duffield, A. S., Rau, R. E., Magoon, D., Li, L., Huff, V., Small, D., Loeb, D. M. & Brown, P. A., Oct 1 2018, In : Oncotarget. 9, 82, p. 35313-35326 14 p.

Research output: Contribution to journalArticle

Molecularly targeted therapies for pediatric acute myeloid leukemia: Progress to date

Brown, P. A. & Smith, F. O., 2008, In : Pediatric Drugs. 10, 2, p. 85-92 8 p.

Research output: Contribution to journalArticle

Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, A. B., Nguyen, B., Li, L., Brown, P. A., Levis, M. J., Leahy, D. & Small, D., Jan 2013, In : Leukemia. 27, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

NCCN Guidelines® insights acute lymphoblastic Leukemia, Version 1.2017 featured updates to the NCCN guidelines

Brown, P. A., Shah, B., Fathi, A., Wieduwilt, M., Advani, A., Aoun, P., Barta, S. K., Boyer, M. W., Bryan, T., Burke, P. W., Cassaday, R., Coccia, P. F., Coutre, S. E., Damon, L. E., DeAngelo, D. J., Frankfurt, O., Greer, J. P., Kantarjian, H. M., Klisovic, R. B., Kupfer, G. & 10 others, Litzow, M., Liu, A., Mattison, R., Park, J., Rubnitz, J., Saad, A., Uy, G. L., Wang, E. S., Gregory, K. M. & Ogba, N., Sep 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 9, p. 1091-1102 12 p.

Research output: Contribution to journalArticle

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

Matheny, C. J., Wei, M. C., Bassik, M. C., Donnelly, A. J., Kampmann, M., Iwasaki, M., Piloto, O., Solow-Cordero, D. E., Bouley, D. M., Rau, R., Brown, P. A., McManus, M. T., Weissman, J. S. & Cleary, M. L., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1352-1363 12 p.

Research output: Contribution to journalArticle

Novel targeted drug therapies for the treatment of childhood acute leukemia

Brown, P. A., Hunger, S. P., Smith, F. O., Carroll, W. L. & Reaman, G. H., 2009, In : Expert Review of Hematology. 2, 2, p. 145-158 14 p.

Research output: Contribution to journalArticle

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia

Falini, B., Mecucci, C., Saglio, G., Lo Coco, F., Diverio, D., Brown, P. A., Pane, F., Mancini, M., Martelli, M. P., Pileri, S., Haferlach, T., Haferlach, C. & Schnittger, S., Mar 2008, In : Haematologica. 93, 3, p. 439-442 4 p.

Research output: Contribution to journalArticle

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Rau, R., Magoon, D., Greenblatt, S., Li, L., Annesley, C., Duffield, A. S., Huso, D., McIntyre, E., Clohessy, J. G., Reschke, M., Pandolfi, P. P., Small, D. & Brown, P. A., Feb 2014, In : Experimental Hematology. 42, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

Open-label bendamustine monotherapy for pediatric patients with relapsed or refractory acute leukemia: Efficacy and tolerability

Fraser, C., Brown, P. A., Megason, G., Ahn, H. S., Cho, B., Kirov, I., Frankel, L., Aplenc, R., Bensen-Kennedy, D., Munteanu, M., Weaver, J. & Harker-Murray, P., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 4

Research output: Contribution to journalArticle

Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

Brown, P. A., Meshinchi, S., Levis, M. J., Alonzo, T. A., Gerbing, R., Lange, B., Arceci, R. & Small, D., Sep 15 2004, In : Blood. 104, 6, p. 1841-1849 9 p.

Research output: Contribution to journalArticle

Plasma inhibitory activity (PIA): A pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

Levis, M., Brown, P., Smith, B. D., Stine, A., Pham, R., Stone, R., DeAngelo, D., Galinsky, I., Giles, F., Estey, E., Kantarjian, H., Cohen, P., Wang, Y., Roesel, J., Karp, J. E. & Small, D., Nov 15 2006, In : Blood. 108, 10, p. 3477-3483 7 p.

Research output: Contribution to journalArticle

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: Efficacy and potential mechanisms of resistance to CXCR4 inhibition

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Rau, R. E., Small, D. & Brown, P. A., 2014, In : Oncotarget. 5, 19, p. 8947-8958 12 p.

Research output: Contribution to journalArticle