Patrick A Brown

Associate Professor

20042020

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2019

Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines

Brown, P. A., Wieduwilt, M., Logan, A., DeAngelo, D. J., Wang, E. S., Fathi, A., Cassaday, R. D., Litzow, M., Advani, A., Aoun, P., Bhatnagar, B., Boyer, M. W., Bryan, T., Burke, P. W., Coccia, P. F., Coutre, S. E., Jain, N., Kirby, S., Liu, A., Massaro, S. & 9 others, Mattison, R. J., Oluwole, O., Papadantonakis, N., Park, J., Rubnitz, J. E., Uy, G. L., Gregory, K. M., Ogba, N. & Shah, B., Jan 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 5, p. 414-423 10 p.

Research output: Contribution to journalArticle

Open Access

Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group

Horton, T. M., Whitlock, J. A., Lu, X., O'Brien, M. M., Borowitz, M. J., Devidas, M., Raetz, E. A., Brown, P. A., Carroll, W. L. & Hunger, S. P., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children's Oncology Group

Esiashvili, N., Lu, X., Ulin, K., Laurie, F., Kessel, S., Kalapurakal, J. A., Merchant, T. E., Followill, D. S., Sathiaseelan, V., Schmitter, M. K., Devidas, M., Chen, Y., Wall, D. A., Brown, P. A., Hunger, S. P., Grupp, S. A. & Pulsipher, M. A., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

How I treat infant leukemia

Brown, P., Pieters, R. & Biondi, A., Jan 17 2019, In : Blood. 133, 3, p. 205-214 10 p.

Research output: Contribution to journalArticle

Open Access

Universal premedication and therapeutic drug monitoring for asparaginase-based therapy prevents infusion-associated acute adverse events and drug substitutions

Cooper, S., Young, D. J., Bowen, C. J., Arwood, N. M., Poggi, S. G. & Brown, P. A., Jan 1 2019, In : Pediatric Blood and Cancer. e27797.

Research output: Contribution to journalArticle

2018

Chimeric antigen receptor T-cell therapy

Ogba, N., Arwood, N. M., Bartlett, N. L., Bloom, M., Brown, P., Brown, C., Budde, E. L., Carlson, R., Farnia, S., Fry, T. J., Garber, M., Gardner, R. A., Gurschick, L., Kropf, P., Reitan, J. J., Sauter, C., Shah, B., Shpall, E. J. & Rosen, S. T., Sep 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 9, p. 1093-1106 14 p.

Research output: Contribution to journalArticle

Emerging treatment options for acute lymphoblastic leukemia: Focus on CAR T-cell therapy

Brown, P. A. & Shah, B., May 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 5S, p. 651-655 5 p.

Research output: Contribution to journalArticle

Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group (COG)

Gupta, S., Devidas, M., Loh, M. L., Raetz, E. A., Chen, S., Wang, C., Brown, P., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Dunsmore, K. P., Larsen, E. C., Maloney, K. W., Mattano, L. A., Winter, S. S., Winick, N. J., Carroll, W. L., Hunger, S. P., Borowitz, M. J. & Wood, B. L., Jun 1 2018, In : Leukemia. 32, 6, p. 1370-1379 10 p.

Research output: Contribution to journalArticle

Knock-In of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice

Annesley, C. E., Rabik, C., Duffield, A. S., Rau, R. E., Magoon, D., Li, L., Huff, V., Small, D., Loeb, D. M. & Brown, P., Oct 1 2018, In : Oncotarget. 9, 82, p. 35313-35326 14 p.

Research output: Contribution to journalArticle

2017

A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study (POE 10-03)

Cooper, T. M., Sison, E. A. R., Baker, S. D., Li, L., Ahmed, A., Trippett, T., Gore, L., Macy, M. E., Narendran, A., August, K., Absalon, M. J., Boklan, J., Pollard, J., Magoon, D. & Brown, P. A., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B., Williams, A. B., Young, D. J., Ma, H., Li, L., Levis, M., Brown, P. & Small, D., Jan 1 2017, In : Oncotarget. 8, 7, p. 10931-10944 14 p.

Research output: Contribution to journalArticle

NCCN Guidelines® insights acute lymphoblastic Leukemia, Version 1.2017 featured updates to the NCCN guidelines

Brown, P. A., Shah, B., Fathi, A., Wieduwilt, M., Advani, A., Aoun, P., Barta, S. K., Boyer, M. W., Bryan, T., Burke, P. W., Cassaday, R., Coccia, P. F., Coutre, S. E., Damon, L. E., DeAngelo, D. J., Frankfurt, O., Greer, J. P., Kantarjian, H. M., Klisovic, R. B., Kupfer, G. & 10 others, Litzow, M., Liu, A., Mattison, R., Park, J., Rubnitz, J., Saad, A., Uy, G. L., Wang, E. S., Gregory, K. M. & Ogba, N., Sep 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 9, p. 1091-1102 12 p.

Research output: Contribution to journalArticle

2016

Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia

Vrooman, L. M., Kirov, I. I., Dreyer, Z. A. E., Kelly, M., Hijiya, N., Brown, P., Drachtman, R. A., Messinger, Y. H., Ritchey, A. K., Hale, G. A., Maloney, K., Lu, Y., Plourde, P. V. & Silverman, L. B., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 228-233 6 p.

Research output: Contribution to journalArticle

A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) study

Cooper, T. M., Cassar, J., Eckroth, E., Malvar, J., Sposto, R., Gaynon, P., Chang, B. H., Gore, L., August, K., Pollard, J. A., DuBois, S. G., Silverman, L. B., Oesterheld, J., Gammon, G., Magoon, D., Annesley, C. & Brown, P. A., Aug 15 2016, In : Clinical Cancer Research. 22, 16, p. 4014-4022 9 p.

Research output: Contribution to journalArticle

A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia

Hale, V., Hale, G. A., Brown, P. A. & Amankwah, E., Nov 2 2016, (Accepted/In press) In : Oncology.

Research output: Contribution to journalArticle

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Fox, J. M., Moynihan, J. R., Mott, B. T., Mazzone, J. R., Anders, N. M., Brown, P. A., Rudek, M. A., Liu, J. O., Arav-Boger, R., Posner, G. H., Civin, C. I. & Chen, X., Jan 1 2016, In : Oncotarget. 7, 6, p. 7268-7279 12 p.

Research output: Contribution to journalArticle

2015

A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011)

Loh, M. L., Tasian, S. K., Rabin, K. R., Brown, P., Magoon, D., Reid, J. M., Chen, X., Ahern, C. H., Weigel, B. J. & Blaney, S. M., Oct 1 2015, In : Pediatric Blood and Cancer. 62, 10, p. 1717-1724 8 p.

Research output: Contribution to journalArticle

Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: A report from the children's oncology group

Salzer, W. L., Jones, T. L., Devidas, M., Dreyer, Z. E., Gore, L., Winick, N. J., Sung, L., Raetz, E., Loh, M. L., Wang, C. Y., De Lorenzo, P., Valsecchi, M. G., Pieters, R., Carroll, W. L., Hunger, S. P., Hilden, J. M. & Brown, P., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

Li, Z., Younger, K., Gartenhaus, R., Joseph, A. M., Hu, F., Baer, M. R., Brown, P. & Davila, E., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1081-1097 17 p.

Research output: Contribution to journalArticle

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Romagnoli, B., Douglas, G. J., Tuffin, G., Zimmermann, J. & Brown, P., Jan 1 2015, In : Oncotarget. 6, 31, p. 30902-30918 17 p.

Research output: Contribution to journalArticle

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis

Negi, S. S. & Brown, P., Jan 1 2015, In : Oncotarget. 6, 20, p. 18094-18104 11 p.

Research output: Contribution to journalArticle

Open Access

The genomic landscape of juvenile myelomonocytic leukemia

Stieglitz, E., Taylor-Weiner, A. N., Chang, T. Y., Gelston, L. C., Wang, Y. D., Mazor, T., Esquivel, E., Yu, A., Seepo, S., Olsen, S. R., Rosenberg, M., Archambeault, S. L., Abusin, G., Beckman, K., Brown, P. A., Briones, M., Carcamo, B., Cooper, T., Dahl, G. V., Emanuel, P. D. & 27 others, Fluchel, M. N., Goyal, R. K., Hayashi, R. J., Hitzler, J., Hugge, C., Liu, Y. L., Messinger, Y. H., Mahoney, D. H., Monteleone, P., Nemecek, E. R., Roehrs, P. A., Schore, R. J., Stine, K. C., Takemoto, C. M., Toretsky, J. A., Costello, J. F., Olshen, A. B., Stewart, C., Li, Y., Ma, J., Gerbing, R. B., Alonzo, T. A., Getz, G., Gruber, T. A., Golub, T. R., Stegmaier, K. & Loh, M. L., Nov 1 2015, In : Nature genetics. 47, 11, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells

Negi, S. S. & Brown, P., Jan 1 2015, In : Oncotarget. 6, 33, p. 34846-34858 13 p.

Research output: Contribution to journalArticle

2014

A phase i study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium

Raetz, E. A., Morrison, D., Romanos-Sirakis, E., Gaynon, P., Sposto, R., Bhojwani, D., Bostrom, B. C., Brown, P., Eckroth, E., Cassar, J., Malvar, J., Buchbinder, A. & Carroll, W. L., Aug 2014, In : Journal of Pediatric Hematology/Oncology. 36, 6, p. 458-463 6 p.

Research output: Contribution to journalArticle

FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia

Ma, H. S., Nguyen, B., Duffield, A. S., Li, L., Galanis, A., Williams, A. B., Brown, P. A., Levis, M. J., Leahy, D. J. & Small, D., Jul 24 2014, In : Cancer Research. 74, 18, p. 5206-5217 12 p.

Research output: Contribution to journalArticle

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Rau, R., Magoon, D., Greenblatt, S., Li, L., Annesley, C., Duffield, A. S., Huso, D., McIntyre, E., Clohessy, J. G., Reschke, M., Pandolfi, P. P., Small, D. & Brown, P., Feb 2014, In : Experimental Hematology. 42, 2, p. 101-113.e5

Research output: Contribution to journalArticle

Open-label bendamustine monotherapy for pediatric patients with relapsed or refractory acute leukemia: Efficacy and tolerability

Fraser, C., Brown, P., Megason, G., Ahn, H. S., Cho, B., Kirov, I., Frankel, L., Aplenc, R., Bensen-Kennedy, D., Munteanu, M., Weaver, J. & Harker-Murray, P., May 2014, In : Journal of Pediatric Hematology/Oncology. 36, 4, p. e212-e218

Research output: Contribution to journalArticle

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: Efficacy and potential mechanisms of resistance to CXCR4 inhibition

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Rau, R. E., Small, D. & Brown, P., Jan 1 2014, In : Oncotarget. 5, 19, p. 8947-8958 12 p.

Research output: Contribution to journalArticle

Open Access
2013

Dynamic chemotherapy-induced upregulation of CXCR4 expression: A mechanism of therapeutic resistance in pediatric AML

Sison, E. A. R., McIntyre, E., Magoon, D. & Brown, P., Sep 1 2013, In : Molecular Cancer Research. 11, 9, p. 1004-1016 13 p.

Research output: Contribution to journalArticle

Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, A. B., Nguyen, B., Li, L., Brown, P., Levis, M., Leahy, D. & Small, D., Jan 1 2013, In : Leukemia. 27, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

Matheny, C. J., Wei, M. C., Bassik, M. C., Donnelly, A. J., Kampmann, M., Iwasaki, M., Piloto, O., Solow-Cordero, D. E., Bouley, D. M., Rau, R., Brown, P., McManus, M. T., Weissman, J. S. & Cleary, M. L., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1352-1363 12 p.

Research output: Contribution to journalArticle

2012

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P. & Carroll, W. L., Jun 5 2012, In : Blood. 119, 22, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

Williams, A. B., Li, L., Nguyen, B., Brown, P., Levis, M. & Small, D., Oct 11 2012, In : Blood. 120, 15, p. 3069-3079 11 p.

Research output: Contribution to journalArticle

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Dave, H., Anver, M. R., Butcher, D. O., Brown, P., Khan, J., Wayne, A. S., Baskar, S. & Rader, C., Dec 20 2012, In : PloS one. 7, 12, e52655.

Research output: Contribution to journalArticle

2011

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P., Valent, P., Bradner, J. E., Lowe, S. W. & Vakoc, C. R., Oct 27 2011, In : Nature. 478, 7370, p. 524-528 5 p.

Research output: Contribution to journalArticle

2010

High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias

Morisot, S., Wayne, A. S., Bohana-Kashtan, O., Kaplan, I. M., Gocke, C. D., Hildreth, R., Stetler-Stevenson, M., Walker, R. L., Davis, S., Meltzer, P. S., Wheelan, S. J., Brown, P., Jones, R. J., Shultz, L. D. & Civin, C. I., Nov 23 2010, In : Leukemia. 24, 11, p. 1859-1866 8 p.

Research output: Contribution to journalArticle

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: Biology and therapeutic targeting

Schafer, E., Irizarry, R., Negi, S., McIntyre, E., Small, D., Figueroa, M. E., Melnick, A. & Brown, P., Jun 10 2010, In : Blood. 115, 23, p. 4798-4809 12 p.

Research output: Contribution to journalArticle

Self-renewal of acute lymphocytic leukemia cells is limited by the hedgehog pathway inhibitors cyclopamine and IPI-926

Lin, T. L., Wang, Q. H., Brown, P., Peacock, C., Merchant, A. A., Brennan, S., Jones, E., McGovern, K., Neil Watkins, D., Sakamoto, K. M. & Matsui, W., Dec 1 2010, In : PloS one. 5, 12, e15262.

Research output: Contribution to journalArticle

2009

50 Years Ago in The Journal of Pediatrics. Congenital Leukemia

Brown, P., Jul 1 2009, In : Journal of Pediatrics. 155, 1, 1 p.

Research output: Contribution to journalArticle

Discordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin

Chuk, M. K., McIntyre, E., Small, D. & Brown, P., Nov 19 2009, In : Blood. 113, 26, p. 6691-6694 4 p.

Research output: Contribution to journalArticle

Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma

Hu, R., Mukhina, G. L., Lee, S. H., Jones, R. J., Englund, P. T., Brown, P., Sharkis, S. J., Buckley, J. T. & Brodsky, R. A., Apr 2009, In : Experimental Hematology. 37, 4, p. 423-434.e2

Research output: Contribution to journalArticle

2008

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia

Falini, B., Mecucci, C., Saglio, G., Lo Coco, F., Diverio, D., Brown, P., Pane, F., Mancini, M., Martelli, M. P., Pileri, S., Haferlach, T., Haferlach, C. & Schnittger, S., Mar 1 2008, In : Haematologica. 93, 3, p. 439-442 4 p.

Research output: Contribution to journalArticle

Rapid method for detection of mutations in the nucleophosmin gene in acute myeloid leukemia

Laughlin, T. S., Becker, M. W., Liesveld, J. L., Mulford, D. A., Abboud, C. N., Brown, P. & Rothberg, P. G., Jul 2008, In : Journal of Molecular Diagnostics. 10, 4, p. 338-345 8 p.

Research output: Contribution to journalArticle

2007

Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways

Piloto, O., Wright, M., Brown, P., Kim, K. T., Levis, M. & Small, D., Feb 15 2007, In : Blood. 109, 4, p. 1643-1652 10 p.

Research output: Contribution to journalArticle

The incidence and clinical significance of nucleophosmin mutations in childhood AML

Brown, P., McIntyre, E., Rau, R., Meshinchi, S., Lacayo, N., Dahl, G., Alonzo, T. A., Chang, M., Arceci, R. J. & Small, D., Aug 1 2007, In : Blood. 110, 3, p. 979-985 7 p.

Research output: Contribution to journalArticle

2006

IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples

Piloto, O., Nguyen, B., Huso, D., Kim, K. T., Li, Y., Witte, L., Hicklin, D. J., Brown, P. & Small, D., May 1 2006, In : Cancer Research. 66, 9, p. 4843-4851 9 p.

Research output: Contribution to journalArticle

Plasma inhibitory activity (PIA): A pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

Levis, M., Brown, P., Smith, B. D., Stine, A., Pham, R., Stone, R., DeAngelo, D., Galinsky, I., Giles, F., Estey, E., Kantarjian, H., Cohen, P., Wang, Y., Roesel, J., Karp, J. E. & Small, D., Nov 15 2006, In : Blood. 108, 10, p. 3477-3483 7 p.

Research output: Contribution to journalArticle