Patrick A Brown

Associate Professor

20042019

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2004

FLT3 Inhibitors: A paradigm for the development of targeted therapeutics for paediatric cancer

Brown, P. A. & Small, D., Mar 2004, In : European Journal of Cancer. 40, 5, p. 707-721 15 p.

Research output: Contribution to journalArticle

FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells

Zheng, R., Levis, M., Piloto, O., Brown, P., Baldwin, B. R., Gorin, N. C., Beran, M., Zhu, Z., Ludwig, D., Hicklin, D., Witte, L., Li, Y. & Small, D., Jan 1 2004, In : Blood. 103, 1, p. 267-274 8 p.

Research output: Contribution to journalArticle

Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

Brown, P. A., Meshinchi, S., Levis, M. J., Alonzo, T. A., Gerbing, R., Lange, B., Arceci, R. & Small, D., Sep 15 2004, In : Blood. 104, 6, p. 1841-1849 9 p.

Research output: Contribution to journalArticle

2005

FLT3/ITD mutation signaling includes suppression of SHP-1

Chen, P., Levis, M. J., Brown, P. A., Kim, K. T., Allebach, J. & Small, D., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5361-5369 9 p.

Research output: Contribution to journalArticle

2006

Answers to key questions about childhood leukemia - For the generalist

Brown, P. A., 2006, In : Contemporary Pediatrics. 23, 3, p. 81-98 18 p.

Research output: Contribution to journalArticle

2007

The incidence and clinical significance of nucleophosmin mutations in childhood AML

Brown, P. A., McIntyre, E., Rau, R., Meshinchi, S., Lacayo, N., Dahl, G., Alonzo, T. A., Chang, M., Arceci, R. J. & Small, D., Aug 1 2007, In : Blood. 110, 3, p. 979-985 7 p.

Research output: Contribution to journalArticle

2008

Molecularly targeted therapies for pediatric acute myeloid leukemia: Progress to date

Brown, P. A. & Smith, F. O., 2008, In : Pediatric Drugs. 10, 2, p. 85-92 8 p.

Research output: Contribution to journalArticle

Rapid method for detection of mutations in the nucleophosmin gene in acute myeloid leukemia

Laughlin, T. S., Becker, M. W., Liesveld, J. L., Mulford, D. A., Abboud, C. N., Brown, P. A. & Rothberg, P. G., Jul 2008, In : Journal of Molecular Diagnostics. 10, 4, p. 338-345 8 p.

Research output: Contribution to journalArticle

2009

50 Years Ago in The Journal of Pediatrics. Congenital Leukemia

Brown, P. A., Jul 2009, In : Journal of Pediatrics. 155, 1, p. 67 1 p.

Research output: Contribution to journalArticle

Adding WT1 to childhood AML alphabet soup

Brown, P. A., 2009, In : Blood. 113, 23, p. 5696-5697 2 p.

Research output: Contribution to journalArticle

Novel targeted drug therapies for the treatment of childhood acute leukemia

Brown, P. A., Hunger, S. P., Smith, F. O., Carroll, W. L. & Reaman, G. H., 2009, In : Expert Review of Hematology. 2, 2, p. 145-158 14 p.

Research output: Contribution to journalArticle

2010

Self-renewal of acute lymphocytic leukemia cells is limited by the hedgehog pathway inhibitors cyclopamine and IPI-926

Lin, T. L., Wang, Q. H., Brown, P. A., Peacock, C., Merchant, A. A., Brennan, S., Jones, E., McGovern, K., Neil Watkins, D., Sakamoto, K. M. & Matsui, W., 2010, In : PLoS One. 5, 12, e15262.

Research output: Contribution to journalArticle

Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric Acute Lymphocytic Leukemia (ALL): Review from an International Consensus Conference

Horton, T. M., Sposto, R., Brown, P. A., Reynolds, C. P., Hunger, S. P., Winick, N. J., Raetz, E. A., Carroll, W. L., Arceci, R. J., Borowitz, M. J., Gaynon, P. S., Gore, L., Jeha, S., Maurer, B. J., Siegel, S. E., Biondi, A., Kearns, P. R., Narendran, A., Silverman, L. B., Smith, M. A. & 2 others, Zwaan, C. M. & Whitlock, J. A., Jul 1 2010, In : Pediatric Blood and Cancer. 54, 7, p. 872-878 7 p.

Research output: Contribution to journalArticle

2011

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P. A., Valent, P., Bradner, J. E., Lowe, S. W. & Vakoc, C. R., Oct 27 2011, In : Nature. 478, 7370, p. 524-528 5 p.

Research output: Contribution to journalArticle

The bone marrow microenvironment and leukemia: Biology and therapeutic targeting

Sison, E. A. R. & Brown, P. A., Jun 2011, In : Expert Review of Hematology. 4, 3, p. 271-283 13 p.

Research output: Contribution to journalArticle

2012

Acute lymphoblastic leukemia: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Bellam, N., Blum, W., Boyer, M. W., Carraway, H. E., Coccia, P. F., Coutre, S. E., Cultrera, J., Damon, L. E., DeAngelo, D. J., Douer, D., Frangoul, H., Frankfurt, O., Goorha, S., Millenson, M. M., O'Brien, S., Petersdorf, S. H. & 7 others, Rao, A. V., Terezakis, S. A., Uy, G., Wetzler, M., Zelenetz, A. D., Naganuma, M. & Gregory, K. M., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 858-914 57 p.

Research output: Contribution to journalArticle

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P. A. & Carroll, W. L., Jun 5 2012, In : Blood. 119, 22, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

Williams, A. B., Li, L., Nguyen, B., Brown, P. A., Levis, M. J. & Small, D., Oct 11 2012, In : Blood. 120, 15, p. 3069-3079 11 p.

Research output: Contribution to journalArticle

Reaping the benefits of recent advances for adults with acute lymphoblastic leukemia

Brown, P. A. & Alvarnas, J. C., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 800-801 2 p.

Research output: Contribution to journalArticle

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Dave, H., Anver, M. R., Butcher, D. O., Brown, P. A., Khan, J., Wayne, A. S., Baskar, S. & Rader, C., Dec 20 2012, In : PLoS One. 7, 12, e52655.

Research output: Contribution to journalArticle

2013

Dynamic chemotherapy-induced upregulation of CXCR4 expression: A mechanism of therapeutic resistance in pediatric AML

Sison, E. A. R., McIntyre, E., Magoon, D. & Brown, P. A., Sep 2013, In : Molecular Cancer Research. 11, 9, p. 1004-1016 13 p.

Research output: Contribution to journalArticle

Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, A. B., Nguyen, B., Li, L., Brown, P. A., Levis, M. J., Leahy, D. & Small, D., Jan 2013, In : Leukemia. 27, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

2014

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Rau, R., Magoon, D., Greenblatt, S., Li, L., Annesley, C., Duffield, A. S., Huso, D., McIntyre, E., Clohessy, J. G., Reschke, M., Pandolfi, P. P., Small, D. & Brown, P. A., Feb 2014, In : Experimental Hematology. 42, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: Efficacy and potential mechanisms of resistance to CXCR4 inhibition

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Rau, R. E., Small, D. & Brown, P. A., 2014, In : Oncotarget. 5, 19, p. 8947-8958 12 p.

Research output: Contribution to journalArticle

The biology and targeting of FLT3 in pediatric leukemia

Annesley, C. E. & Brown, P. A., 2014, In : Frontiers in Oncology. 4, SEP, Article 263.

Research output: Contribution to journalArticle

2015

Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis

Amankwah, E., Saenz, A. M., Hale, G. A. & Brown, P. A., Sep 4 2015, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.

Research output: Contribution to journalArticle

Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: A report from the children's oncology group

Salzer, W. L., Jones, T. L., Devidas, M., Dreyer, Z. E., Gore, L., Winick, N. J., Sung, L., Raetz, E., Loh, M. L., Wang, C. Y., De Lorenzo, P., Valsecchi, M. G., Pieters, R., Carroll, W. L., Hunger, S. P., Hilden, J. M. & Brown, P. A., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

Li, Z., Younger, K., Gartenhaus, R., Joseph, A. M., Hu, F., Baer, M. R., Brown, P. A. & Davila, E., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1081-1097 17 p.

Research output: Contribution to journalArticle

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Romagnoli, B., Douglas, G. J., Tuffin, G., Zimmermann, J. & Brown, P. A., 2015, In : Oncotarget. 6, 31, p. 30902-30918 17 p.

Research output: Contribution to journalArticle