Patrick A Brown

Associate Professor

20042019
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Research Output 2004 2019

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2019

Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group

Horton, T. M., Whitlock, J. A., Lu, X., O'Brien, M. M., Borowitz, M. J., Devidas, M., Raetz, E. A., Brown, P. A., Carroll, W. L. & Hunger, S. P., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Drug Therapy
Residual Neoplasm
Survival

Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2019

Brown, P. A., Wieduwilt, M., Logan, A., DeAngelo, D. J., Wang, E. S., Fathi, A., Cassaday, R. D., Litzow, M., Advani, A., Aoun, P., Bhatnagar, B., Boyer, M. W., Bryan, T., Burke, P. W., Coccia, P. F., Coutre, S. E., Jain, N., Kirby, S., Liu, A., Massaro, S. & 9 others, Mattison, R. J., Oluwole, O., Papadantonakis, N., Park, J., Rubnitz, J. E., Uy, G. L., Gregory, K. M., Ogba, N. & Shah, B., May 1 2019, In : Journal of the National Comprehensive Cancer Network : JNCCN. 17, 5, p. 414-423 10 p.

Research output: Contribution to journalArticle

Open Access
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Guidelines
Residual Neoplasm
Therapeutics
Comorbidity

Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children's Oncology Group

Esiashvili, N., Lu, X., Ulin, K., Laurie, F., Kessel, S., Kalapurakal, J. A., Merchant, T. E., Followill, D. S., Sathiaseelan, V., Schmitter, M. K., Devidas, M., Chen, Y., Wall, D. A., Brown, P. A., Hunger, S. P., Grupp, S. A. & Pulsipher, M. A., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

transplantation
leukemias
stem cells
Whole-Body Irradiation
Hematopoietic Stem Cell Transplantation

How I treat infant leukemia

Brown, P., Pieters, R. & Biondi, A., Jan 17 2019, In : Blood. 133, 3, p. 205-214 10 p.

Research output: Contribution to journalArticle

Open Access
Molecular biology
Leukemia
Genes
Modulation
Gene Rearrangement

Universal premedication and therapeutic drug monitoring for asparaginase-based therapy prevents infusion-associated acute adverse events and drug substitutions

Cooper, S., Young, D. J., Bowen, C. J., Arwood, N. M., Poggi, S. G. & Brown, P. A., Jan 1 2019, In : Pediatric Blood and Cancer. e27797.

Research output: Contribution to journalArticle

Drug Substitution
Asparaginase
Premedication
Drug Monitoring
Pectobacterium chrysanthemi
2018

Chimeric antigen receptor T-cell therapy

Ogba, N., Arwood, N. M., Bartlett, N. L., Bloom, M., Brown, P. A., Brown, C., Budde, E. L., Carlson, R., Farnia, S., Fry, T. J., Garber, M., Gardner, R. A., Gurschick, L., Kropf, P., Reitan, J. J., Sauter, C., Shah, B., Shpall, E. J. & Rosen, S. T., Sep 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 9, p. 1093-1106 14 p.

Research output: Contribution to journalArticle

Antigen Receptors
Cell- and Tissue-Based Therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Advisory Committees
Health Policy

Emerging treatment options for acute lymphoblastic leukemia: Focus on CAR T-cell therapy

Brown, P. A. & Shah, B., May 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 5S, p. 651-655 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
Cell- and Tissue-Based Therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bispecific Antibodies
Recurrence

Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group (COG)

Gupta, S., Devidas, M., Loh, M. L., Raetz, E. A., Chen, S., Wang, C., Brown, P. A., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Dunsmore, K. P., Larsen, E. C., Maloney, K. W., Mattano, L. A., Winter, S. S., Winick, N. J., Carroll, W. L., Hunger, S. P., Borowitz, M. J. & Wood, B. L., Feb 23 2018, (Accepted/In press) In : Leukemia. p. 1-10 10 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Flow Cytometry
Disease-Free Survival

Knock-In of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice

Annesley, C. E., Rabik, C., Duffield, A. S., Rau, R. E., Magoon, D., Li, L., Huff, V., Small, D., Loeb, D. M. & Brown, P. A., Oct 1 2018, In : Oncotarget. 9, 82, p. 35313-35326 14 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Wilms Tumor
Mutation
Neoplasms
Karyotype
2017

A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study (POE 10-03)

Cooper, T. M., Sison, E. A. R., Baker, S. D., Li, L., Ahmed, A., Trippett, T., Gore, L., Macy, M. E., Narendran, A., August, K., Absalon, M. J., Boklan, J., Pollard, J., Magoon, D. & Brown, P. A., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Cytarabine
Etoposide
Leukemia
Research Personnel

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B., Williams, A. B., Young, D. J., Ma, H., Li, L., Levis, M. J., Brown, P. A. & Small, D., 2017, In : Oncotarget. 8, 7, p. 10931-10944 14 p.

Research output: Contribution to journalArticle

fms-Like Tyrosine Kinase 3
Protein-Tyrosine Kinases
Mutation
Acute Myeloid Leukemia
Cell Proliferation

NCCN Guidelines® insights acute lymphoblastic Leukemia, Version 1.2017 featured updates to the NCCN guidelines

Brown, P. A., Shah, B., Fathi, A., Wieduwilt, M., Advani, A., Aoun, P., Barta, S. K., Boyer, M. W., Bryan, T., Burke, P. W., Cassaday, R., Coccia, P. F., Coutre, S. E., Damon, L. E., DeAngelo, D. J., Frankfurt, O., Greer, J. P., Kantarjian, H. M., Klisovic, R. B., Kupfer, G. & 10 others, Litzow, M., Liu, A., Mattison, R., Park, J., Rubnitz, J., Saad, A., Uy, G. L., Wang, E. S., Gregory, K. M. & Ogba, N., Sep 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 9, p. 1091-1102 12 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Guidelines
Hematinics
Cell Transplantation
Protein-Tyrosine Kinases
2016

Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia

Vrooman, L. M., Kirov, I. I., Dreyer, Z. A. E., Kelly, M., Hijiya, N., Brown, P. A., Drachtman, R. A., Messinger, Y. H., Ritchey, A. K., Hale, G. A., Maloney, K., Lu, Y., Plourde, P. V. & Silverman, L. B., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 228-233 6 p.

Research output: Contribution to journalArticle

Erwinia
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypersensitivity
Escherichia coli

A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) study

Cooper, T. M., Cassar, J., Eckroth, E., Malvar, J., Sposto, R., Gaynon, P., Chang, B. H., Gore, L., August, K., Pollard, J. A., DuBois, S. G., Silverman, L. B., Oesterheld, J., Gammon, G., Magoon, D., Annesley, C. & Brown, P. A., Aug 15 2016, In : Clinical Cancer Research. 22, 16, p. 4014-4022 9 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Drug Therapy
Therapeutics
Blood Platelets

A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia

Hale, V., Hale, G. A., Brown, P. A. & Amankwah, E., Nov 2 2016, (Accepted/In press) In : Oncology.

Research output: Contribution to journalArticle

DNA Methylation
MicroRNAs
Leukemia
Pediatrics
Epigenomics

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Fox, J. M., Moynihan, J. R., Mott, B. T., Mazzone, J. R., Anders, N., Brown, P. A., Rudek-Renaut, M., Liu, J., Boger, R., Posner, G. H., Civin, C. I. & Chen, X., 2016, In : Oncotarget. 7, 6, p. 7268-7279 12 p.

Research output: Contribution to journalArticle

Leukemia
Pharmaceutical Preparations
SCID Mice
Antimalarials
Artemisinins
Bone Marrow Transplantation
Cyclophosphamide
Transplantation
Tissue Donors
Neoplasms
2015

Acute lymphoblastic leukemia, version 2.2015: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Barta, S. K., Borate, U., Boyer, M. W., Burke, P. W., Cassaday, R., Castro, J. E., Coccia, P. F., Coutre, S. E., Damon, L. E., De Angelo, D. J., Douer, D., Frankfurt, O., Greer, J. P., Johnson, R. A., Kantarjian, H. M., Klisovic, R. B. & 10 others, Kupfer, G., Litzow, M., Liu, A., Rao, A. V., Shah, B., Uy, G. L., Wang, E. S., Zelenetz, A. D., Gregory, K. & Smith, C., Oct 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 10, p. 1240-1279 40 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Practice Guidelines
Residual Neoplasm
Therapeutics
Guidelines

A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011)

Loh, M. L., Tasian, S. K., Rabin, K. R., Brown, P. A., Magoon, D., Reid, J. M., Chen, X., Ahern, C. H., Weigel, B. J. & Blaney, S. M., Oct 1 2015, In : Pediatric Blood and Cancer. 62, 10, p. 1717-1724 8 p.

Research output: Contribution to journalArticle

Leukemia
Neoplasms
Pharmacokinetics
Hematologic Neoplasms
S 6

Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis

Amankwah, E., Saenz, A. M., Hale, G. A. & Brown, P. A., Sep 4 2015, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.

Research output: Contribution to journalArticle

Meta-Analysis
Leukemia
Body Mass Index
Pediatrics
Recurrence

Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: A report from the children's oncology group

Salzer, W. L., Jones, T. L., Devidas, M., Dreyer, Z. E., Gore, L., Winick, N. J., Sung, L., Raetz, E., Loh, M. L., Wang, C. Y., De Lorenzo, P., Valsecchi, M. G., Pieters, R., Carroll, W. L., Hunger, S. P., Hilden, J. M. & Brown, P. A., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Morbidity
Mortality
Recurrence
Therapeutics

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

Li, Z., Younger, K., Gartenhaus, R., Joseph, A. M., Hu, F., Baer, M. R., Brown, P. A. & Davila, E., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1081-1097 17 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Drug Therapy
Leukemia
TNF Receptor-Associated Factor 6

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Romagnoli, B., Douglas, G. J., Tuffin, G., Zimmermann, J. & Brown, P. A., 2015, In : Oncotarget. 6, 31, p. 30902-30918 17 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
Drug Therapy
Cytarabine
Hematopoietic Stem Cells
G2 Phase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Apoptosis
Phosphotransferases
Neoplasms

The genomic landscape of juvenile myelomonocytic leukemia

Stieglitz, E., Taylor-Weiner, A. N., Chang, T. Y., Gelston, L. C., Wang, Y. D., Mazor, T., Esquivel, E., Yu, A., Seepo, S., Olsen, S. R., Rosenberg, M., Archambeault, S. L., Abusin, G., Beckman, K., Brown, P. A., Briones, M., Carcamo, B., Cooper, T., Dahl, G. V., Emanuel, P. D. & 27 others, Fluchel, M. N., Goyal, R. K., Hayashi, R. J., Hitzler, J., Hugge, C., Liu, Y. L., Messinger, Y. H., Mahoney, D. H., Monteleone, P., Nemecek, E. R., Roehrs, P. A., Schore, R. J., Stine, K. C., Takemoto, C. M., Toretsky, J. A., Costello, J. F., Olshen, A. B., Stewart, C., Li, Y., Ma, J., Gerbing, R. B., Alonzo, T. A., Getz, G., Gruber, T. A., Golub, T. R., Stegmaier, K. & Loh, M. L., Nov 1 2015, In : Nature Genetics. 47, 11, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Polycomb Repressive Complex 2
Mutation
Investigational Therapies
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Death
Growth
Pharmaceutical Preparations
G2 Phase Cell Cycle Checkpoints

Treatment of pediatric acute lymphoblastic leukemia

Cooper, S. & Brown, P. A., Feb 1 2015, In : Pediatric Clinics of North America. 62, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
Therapeutics
Remission Induction
Poisons
2014

A phase i study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium

Raetz, E. A., Morrison, D., Romanos-Sirakis, E., Gaynon, P., Sposto, R., Bhojwani, D., Bostrom, B. C., Brown, P. A., Eckroth, E., Cassar, J., Malvar, J., Buchbinder, A. & Carroll, W. L., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 6, p. 458-463 6 p.

Research output: Contribution to journalArticle

Combination Drug Therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphoma
Leukemia
RNA

FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia

Ma, H. S., Nguyen, B., Duffield, A. S., Li, L., Galanis, A., Williams, A. B., Brown, P. A., Levis, M. J., Leahy, D. J. & Small, D., Jul 24 2014, In : Cancer Research. 74, 18, p. 5206-5217 12 p.

Research output: Contribution to journalArticle

Drug Resistance
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Phosphotransferases
Mutation

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Rau, R., Magoon, D., Greenblatt, S., Li, L., Annesley, C., Duffield, A. S., Huso, D., McIntyre, E., Clohessy, J. G., Reschke, M., Pandolfi, P. P., Small, D. & Brown, P. A., Feb 2014, In : Experimental Hematology. 42, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Leukemia
Mutation
Acute Myeloid Leukemia
Myeloid Leukemia

Open-label bendamustine monotherapy for pediatric patients with relapsed or refractory acute leukemia: Efficacy and tolerability

Fraser, C., Brown, P. A., Megason, G., Ahn, H. S., Cho, B., Kirov, I., Frankel, L., Aplenc, R., Bensen-Kennedy, D., Munteanu, M., Weaver, J. & Harker-Murray, P., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 4

Research output: Contribution to journalArticle

Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
Acute Myeloid Leukemia
Bendamustine Hydrochloride

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: Efficacy and potential mechanisms of resistance to CXCR4 inhibition

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Rau, R. E., Small, D. & Brown, P. A., 2014, In : Oncotarget. 5, 19, p. 8947-8958 12 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
Drug Therapy
Therapeutics
Bone Marrow

The biology and targeting of FLT3 in pediatric leukemia

Annesley, C. E. & Brown, P. A., 2014, In : Frontiers in Oncology. 4, SEP, Article 263.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Leukemia
Pediatrics
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
2013
Hematopoietic Stem Cell Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Therapeutics

Dynamic chemotherapy-induced upregulation of CXCR4 expression: A mechanism of therapeutic resistance in pediatric AML

Sison, E. A. R., McIntyre, E., Magoon, D. & Brown, P. A., Sep 2013, In : Molecular Cancer Research. 11, 9, p. 1004-1016 13 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Up-Regulation
Pediatrics
Drug Therapy
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Communication
Stem Cells
Bone Marrow
Survival

Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, A. B., Nguyen, B., Li, L., Brown, P. A., Levis, M. J., Leahy, D. & Small, D., Jan 2013, In : Leukemia. 27, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Mutation
Hematopoietic Stem Cells
Mutagenesis

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

Matheny, C. J., Wei, M. C., Bassik, M. C., Donnelly, A. J., Kampmann, M., Iwasaki, M., Piloto, O., Solow-Cordero, D. E., Bouley, D. M., Rau, R., Brown, P. A., McManus, M. T., Weissman, J. S. & Cleary, M. L., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1352-1363 12 p.

Research output: Contribution to journalArticle

Niacinamide
Transferases
Small Interfering RNA
Biochemical Phenomena
Throughput
Leukemia
Therapeutics
Gene Rearrangement
Epigenomics
Molecular Biology
2012

Acute lymphoblastic leukemia: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Bellam, N., Blum, W., Boyer, M. W., Carraway, H. E., Coccia, P. F., Coutre, S. E., Cultrera, J., Damon, L. E., DeAngelo, D. J., Douer, D., Frangoul, H., Frankfurt, O., Goorha, S., Millenson, M. M., O'Brien, S., Petersdorf, S. H. & 7 others, Rao, A. V., Terezakis, S. A., Uy, G., Wetzler, M., Zelenetz, A. D., Naganuma, M. & Gregory, K. M., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 858-914 57 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Practice Guidelines
Guidelines
Philadelphia Chromosome
Residual Neoplasm

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P. A. & Carroll, W. L., Jun 5 2012, In : Blood. 119, 22, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

decitabine
Chemotherapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcriptome
Epigenomics

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

Williams, A. B., Li, L., Nguyen, B., Brown, P. A., Levis, M. J. & Small, D., Oct 11 2012, In : Blood. 120, 15, p. 3069-3079 11 p.

Research output: Contribution to journalArticle

fluvastatin
Glycosylation
Cell Survival
Leukemia
Protein-Tyrosine Kinases

Reaping the benefits of recent advances for adults with acute lymphoblastic leukemia

Brown, P. A. & Alvarnas, J. C., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 800-801 2 p.

Research output: Contribution to journalArticle

bcr-abl Fusion Proteins
Protein Kinase Inhibitors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antineoplastic Agents
Young Adult

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Dave, H., Anver, M. R., Butcher, D. O., Brown, P. A., Khan, J., Wayne, A. S., Baskar, S. & Rader, C., Dec 20 2012, In : PLoS One. 7, 12, e52655.

Research output: Contribution to journalArticle

Receptor Tyrosine Kinase-like Orphan Receptors
lymphocytic leukemia
Pediatrics
Receptor Protein-Tyrosine Kinases
Cell Surface Receptors
2011

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P. A., Valent, P., Bradner, J. E., Lowe, S. W. & Vakoc, C. R., Oct 27 2011, In : Nature. 478, 7370, p. 524-528 5 p.

Research output: Contribution to journalArticle

RNA Interference
Acute Myeloid Leukemia
Epigenomics
Chromatin
Small Interfering RNA

TEL-AML1 in cord blood: 1% or 0.01%?

Brown, P. A., Jan 6 2011, In : Blood. 117, 1, p. 2-4 3 p.

Research output: Contribution to journalArticle

Fetal Blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Screening
Blood

The bone marrow microenvironment and leukemia: Biology and therapeutic targeting

Sison, E. A. R. & Brown, P. A., Jun 2011, In : Expert Review of Hematology. 4, 3, p. 271-283 13 p.

Research output: Contribution to journalArticle

Leukemia
Bone Marrow
Therapeutics
Cell Surface Receptors
Chemotaxis
2010

High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias

Morisot, S., Wayne, A. S., Bohana-Kashtan, O., Kaplan, I. M., Gocke, C., Hildreth, R., Stetler-Stevenson, M., Walker, R. L., Davis, S., Meltzer, P. S., Wheelan, S., Brown, P. A., Jones, R. J., Shultz, L. D. & Civin, C. I., Nov 23 2010, In : Leukemia. 24, 11, p. 1859-1866 8 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Stem Cells
Gene Rearrangement
Transcriptome

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: Biology and therapeutic targeting

Schafer, E., Irizarry, R., Negi, S., McIntyre, E., Small, D., Figueroa, M. E., Melnick, A. & Brown, P. A., Jun 10 2010, In : Blood. 115, 23, p. 4798-4809 12 p.

Research output: Contribution to journalArticle

Methylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymerase chain reaction
Genes
decitabine

Self-renewal of acute lymphocytic leukemia cells is limited by the hedgehog pathway inhibitors cyclopamine and IPI-926

Lin, T. L., Wang, Q. H., Brown, P. A., Peacock, C., Merchant, A. A., Brennan, S., Jones, E., McGovern, K., Neil Watkins, D., Sakamoto, K. M. & Matsui, W., 2010, In : PLoS One. 5, 12, e15262.

Research output: Contribution to journalArticle

B-Cell Leukemia
lymphocytic leukemia
Erinaceidae
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-lymphocytes