Patrick A Brown

Associate Professor

20042019

Research output per year

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Research Output

2019

Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group

Horton, T. M., Whitlock, J. A., Lu, X., O'Brien, M. M., Borowitz, M. J., Devidas, M., Raetz, E. A., Brown, P. A., Carroll, W. L. & Hunger, S. P., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

Day 15 bone marrow minimal residual disease predicts response to blinatumomab in relapsed/refractory paediatric B-ALL

Brown, P., Zugmaier, G., Gore, L., Tuglus, C. A. & von Stackelberg, A., Jan 1 2019, (Accepted/In press) In : British journal of haematology.

Research output: Contribution to journalLetter

Open Access

Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2019

Brown, P. A., Wieduwilt, M., Logan, A., DeAngelo, D. J., Wang, E. S., Fathi, A., Cassaday, R. D., Litzow, M., Advani, A., Aoun, P., Bhatnagar, B., Boyer, M. W., Bryan, T., Burke, P. W., Coccia, P. F., Coutre, S. E., Jain, N., Kirby, S., Liu, A., Massaro, S. & 9 others, Mattison, R. J., Oluwole, O., Papadantonakis, N., Park, J., Rubnitz, J. E., Uy, G. L., Gregory, K. M., Ogba, N. & Shah, B., May 1 2019, In : Journal of the National Comprehensive Cancer Network : JNCCN. 17, 5, p. 414-423 10 p.

Research output: Contribution to journalArticle

Open Access

Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children's Oncology Group

Esiashvili, N., Lu, X., Ulin, K., Laurie, F., Kessel, S., Kalapurakal, J. A., Merchant, T. E., Followill, D. S., Sathiaseelan, V., Schmitter, M. K., Devidas, M., Chen, Y., Wall, D. A., Brown, P. A., Hunger, S. P., Grupp, S. A. & Pulsipher, M. A., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

How I treat infant leukemia

Brown, P., Pieters, R. & Biondi, A., Jan 17 2019, In : Blood. 133, 3, p. 205-214 10 p.

Research output: Contribution to journalArticle

Open Access

Universal premedication and therapeutic drug monitoring for asparaginase-based therapy prevents infusion-associated acute adverse events and drug substitutions

Cooper, S., Young, D. J., Bowen, C. J., Arwood, N. M., Poggi, S. G. & Brown, P. A., Jan 1 2019, In : Pediatric Blood and Cancer. e27797.

Research output: Contribution to journalArticle

2018

Blinatumomab for MRD1 B-all: The evidence strengthens

Brown, P. A., Apr 5 2018, In : Blood. 131, 14, p. 1497-1498 2 p.

Research output: Contribution to journalReview article

Chimeric antigen receptor T-cell therapy

Ogba, N., Arwood, N. M., Bartlett, N. L., Bloom, M., Brown, P. A., Brown, C., Budde, E. L., Carlson, R., Farnia, S., Fry, T. J., Garber, M., Gardner, R. A., Gurschick, L., Kropf, P., Reitan, J. J., Sauter, C., Shah, B., Shpall, E. J. & Rosen, S. T., Sep 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 9, p. 1093-1106 14 p.

Research output: Contribution to journalArticle

Emerging treatment options for acute lymphoblastic leukemia: Focus on CAR T-cell therapy

Brown, P. A. & Shah, B., May 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 5S, p. 651-655 5 p.

Research output: Contribution to journalArticle

Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group (COG)

Gupta, S., Devidas, M., Loh, M. L., Raetz, E. A., Chen, S., Wang, C., Brown, P. A., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Dunsmore, K. P., Larsen, E. C., Maloney, K. W., Mattano, L. A., Winter, S. S., Winick, N. J., Carroll, W. L., Hunger, S. P., Borowitz, M. J. & Wood, B. L., Feb 23 2018, (Accepted/In press) In : Leukemia. p. 1-10 10 p.

Research output: Contribution to journalArticle

Knock-In of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice

Annesley, C. E., Rabik, C., Duffield, A. S., Rau, R. E., Magoon, D., Li, L., Huff, V., Small, D., Loeb, D. M. & Brown, P. A., Oct 1 2018, In : Oncotarget. 9, 82, p. 35313-35326 14 p.

Research output: Contribution to journalArticle

2017

A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study (POE 10-03)

Cooper, T. M., Sison, E. A. R., Baker, S. D., Li, L., Ahmed, A., Trippett, T., Gore, L., Macy, M. E., Narendran, A., August, K., Absalon, M. J., Boklan, J., Pollard, J., Magoon, D. & Brown, P. A., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B., Williams, A. B., Young, D. J., Ma, H., Li, L., Levis, M. J., Brown, P. A. & Small, D., 2017, In : Oncotarget. 8, 7, p. 10931-10944 14 p.

Research output: Contribution to journalArticle

NCCN Guidelines® insights acute lymphoblastic Leukemia, Version 1.2017 featured updates to the NCCN guidelines

Brown, P. A., Shah, B., Fathi, A., Wieduwilt, M., Advani, A., Aoun, P., Barta, S. K., Boyer, M. W., Bryan, T., Burke, P. W., Cassaday, R., Coccia, P. F., Coutre, S. E., Damon, L. E., DeAngelo, D. J., Frankfurt, O., Greer, J. P., Kantarjian, H. M., Klisovic, R. B., Kupfer, G. & 10 others, Litzow, M., Liu, A., Mattison, R., Park, J., Rubnitz, J., Saad, A., Uy, G. L., Wang, E. S., Gregory, K. M. & Ogba, N., Sep 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 9, p. 1091-1102 12 p.

Research output: Contribution to journalArticle

2016

Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia

Vrooman, L. M., Kirov, I. I., Dreyer, Z. A. E., Kelly, M., Hijiya, N., Brown, P. A., Drachtman, R. A., Messinger, Y. H., Ritchey, A. K., Hale, G. A., Maloney, K., Lu, Y., Plourde, P. V. & Silverman, L. B., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 228-233 6 p.

Research output: Contribution to journalArticle

A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) study

Cooper, T. M., Cassar, J., Eckroth, E., Malvar, J., Sposto, R., Gaynon, P., Chang, B. H., Gore, L., August, K., Pollard, J. A., DuBois, S. G., Silverman, L. B., Oesterheld, J., Gammon, G., Magoon, D., Annesley, C. & Brown, P. A., Aug 15 2016, In : Clinical Cancer Research. 22, 16, p. 4014-4022 9 p.

Research output: Contribution to journalArticle

A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia

Hale, V., Hale, G. A., Brown, P. A. & Amankwah, E., Nov 2 2016, (Accepted/In press) In : Oncology.

Research output: Contribution to journalArticle

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Fox, J. M., Moynihan, J. R., Mott, B. T., Mazzone, J. R., Anders, N., Brown, P. A., Rudek-Renaut, M., Liu, J., Boger, R., Posner, G. H., Civin, C. I. & Chen, X., 2016, In : Oncotarget. 7, 6, p. 7268-7279 12 p.

Research output: Contribution to journalArticle

2015

Acute lymphoblastic leukemia, version 2.2015: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Barta, S. K., Borate, U., Boyer, M. W., Burke, P. W., Cassaday, R., Castro, J. E., Coccia, P. F., Coutre, S. E., Damon, L. E., De Angelo, D. J., Douer, D., Frankfurt, O., Greer, J. P., Johnson, R. A., Kantarjian, H. M., Klisovic, R. B. & 10 others, Kupfer, G., Litzow, M., Liu, A., Rao, A. V., Shah, B., Uy, G. L., Wang, E. S., Zelenetz, A. D., Gregory, K. & Smith, C., Oct 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 10, p. 1240-1279 40 p.

Research output: Contribution to journalArticle

A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011)

Loh, M. L., Tasian, S. K., Rabin, K. R., Brown, P. A., Magoon, D., Reid, J. M., Chen, X., Ahern, C. H., Weigel, B. J. & Blaney, S. M., Oct 1 2015, In : Pediatric Blood and Cancer. 62, 10, p. 1717-1724 8 p.

Research output: Contribution to journalArticle

Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis

Amankwah, E., Saenz, A. M., Hale, G. A. & Brown, P. A., Sep 4 2015, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.

Research output: Contribution to journalArticle

Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: A report from the children's oncology group

Salzer, W. L., Jones, T. L., Devidas, M., Dreyer, Z. E., Gore, L., Winick, N. J., Sung, L., Raetz, E., Loh, M. L., Wang, C. Y., De Lorenzo, P., Valsecchi, M. G., Pieters, R., Carroll, W. L., Hunger, S. P., Hilden, J. M. & Brown, P. A., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Erratum: The genomic landscape of juvenile myelomonocytic leukemia (Nature Genetics (2015) 47 (1326-1333))

Stieglitz, E., Taylor-Weiner, A. N., Chang, T. Y., Gelston, L. C., Wang, Y. D., Mazor, T., Esquivel, E., Yu, A., Seepo, S., Olsen, S. R., Rosenberg, M., Archambeault, S. L., Abusin, G., Beckman, K., Brown, P. A., Briones, M., Carcamo, B., Cooper, T., Dahl, G. V., Emanuel, P. D. & 27 others, Fluchel, M. N., Goyal, R. K., Hayashi, R. J., Hitzler, J., Hugge, C., Liu, Y. L., Messinger, Y. H., Mahoney, D. H., Monteleone, P., Nemecek, E. R., Roehrs, P. A., Schore, R. J., Stine, K. C., Takemoto, C. M., Toretsky, J. A., Costello, J. F., Olshen, A. B., Stewart, C., Li, Y., Ma, J., Gerbing, R. B., Alonzo, T. A., Getz, G., Gruber, T. A., Golub, T. R., Stegmaier, K. & Loh, M. L., Dec 29 2015, In : Nature Genetics. 48, 1, p. 101 1 p.

Research output: Contribution to journalComment/debate

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

Li, Z., Younger, K., Gartenhaus, R., Joseph, A. M., Hu, F., Baer, M. R., Brown, P. A. & Davila, E., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1081-1097 17 p.

Research output: Contribution to journalArticle

Novel agents for the treatment of childhood acute leukemia

Annesley, C. E. & Brown, P. A., 2015, In : Therapeutic Advances in Hematology. 6, 2, p. 61-79 19 p.

Research output: Contribution to journalReview article

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Romagnoli, B., Douglas, G. J., Tuffin, G., Zimmermann, J. & Brown, P. A., 2015, In : Oncotarget. 6, 31, p. 30902-30918 17 p.

Research output: Contribution to journalArticle

The genomic landscape of juvenile myelomonocytic leukemia

Stieglitz, E., Taylor-Weiner, A. N., Chang, T. Y., Gelston, L. C., Wang, Y. D., Mazor, T., Esquivel, E., Yu, A., Seepo, S., Olsen, S. R., Rosenberg, M., Archambeault, S. L., Abusin, G., Beckman, K., Brown, P. A., Briones, M., Carcamo, B., Cooper, T., Dahl, G. V., Emanuel, P. D. & 27 others, Fluchel, M. N., Goyal, R. K., Hayashi, R. J., Hitzler, J., Hugge, C., Liu, Y. L., Messinger, Y. H., Mahoney, D. H., Monteleone, P., Nemecek, E. R., Roehrs, P. A., Schore, R. J., Stine, K. C., Takemoto, C. M., Toretsky, J. A., Costello, J. F., Olshen, A. B., Stewart, C., Li, Y., Ma, J., Gerbing, R. B., Alonzo, T. A., Getz, G., Gruber, T. A., Golub, T. R., Stegmaier, K. & Loh, M. L., Nov 1 2015, In : Nature Genetics. 47, 11, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Treatment of pediatric acute lymphoblastic leukemia

Cooper, S. & Brown, P. A., Feb 1 2015, In : Pediatric Clinics of North America. 62, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

2014

A phase i study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium

Raetz, E. A., Morrison, D., Romanos-Sirakis, E., Gaynon, P., Sposto, R., Bhojwani, D., Bostrom, B. C., Brown, P. A., Eckroth, E., Cassar, J., Malvar, J., Buchbinder, A. & Carroll, W. L., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 6, p. 458-463 6 p.

Research output: Contribution to journalArticle

FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia

Ma, H. S., Nguyen, B., Duffield, A. S., Li, L., Galanis, A., Williams, A. B., Brown, P. A., Levis, M. J., Leahy, D. J. & Small, D., Jul 24 2014, In : Cancer Research. 74, 18, p. 5206-5217 12 p.

Research output: Contribution to journalArticle

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Rau, R., Magoon, D., Greenblatt, S., Li, L., Annesley, C., Duffield, A. S., Huso, D., McIntyre, E., Clohessy, J. G., Reschke, M., Pandolfi, P. P., Small, D. & Brown, P. A., Feb 2014, In : Experimental Hematology. 42, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

Open-label bendamustine monotherapy for pediatric patients with relapsed or refractory acute leukemia: Efficacy and tolerability

Fraser, C., Brown, P. A., Megason, G., Ahn, H. S., Cho, B., Kirov, I., Frankel, L., Aplenc, R., Bensen-Kennedy, D., Munteanu, M., Weaver, J. & Harker-Murray, P., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 4

Research output: Contribution to journalArticle

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: Efficacy and potential mechanisms of resistance to CXCR4 inhibition

Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Rau, R. E., Small, D. & Brown, P. A., 2014, In : Oncotarget. 5, 19, p. 8947-8958 12 p.

Research output: Contribution to journalArticle

The biology and targeting of FLT3 in pediatric leukemia

Annesley, C. E. & Brown, P. A., 2014, In : Frontiers in Oncology. 4, SEP, Article 263.

Research output: Contribution to journalArticle

2013

Dynamic chemotherapy-induced upregulation of CXCR4 expression: A mechanism of therapeutic resistance in pediatric AML

Sison, E. A. R., McIntyre, E., Magoon, D. & Brown, P. A., Sep 2013, In : Molecular Cancer Research. 11, 9, p. 1004-1016 13 p.

Research output: Contribution to journalArticle

Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, A. B., Nguyen, B., Li, L., Brown, P. A., Levis, M. J., Leahy, D. & Small, D., Jan 2013, In : Leukemia. 27, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

Matheny, C. J., Wei, M. C., Bassik, M. C., Donnelly, A. J., Kampmann, M., Iwasaki, M., Piloto, O., Solow-Cordero, D. E., Bouley, D. M., Rau, R., Brown, P. A., McManus, M. T., Weissman, J. S. & Cleary, M. L., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1352-1363 12 p.

Research output: Contribution to journalArticle

2012

Acute lymphoblastic leukemia: Clinical practice guidelines in oncology

Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Bellam, N., Blum, W., Boyer, M. W., Carraway, H. E., Coccia, P. F., Coutre, S. E., Cultrera, J., Damon, L. E., DeAngelo, D. J., Douer, D., Frangoul, H., Frankfurt, O., Goorha, S., Millenson, M. M., O'Brien, S., Petersdorf, S. H. & 7 others, Rao, A. V., Terezakis, S. A., Uy, G., Wetzler, M., Zelenetz, A. D., Naganuma, M. & Gregory, K. M., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 858-914 57 p.

Research output: Contribution to journalArticle

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P. A. & Carroll, W. L., Jun 5 2012, In : Blood. 119, 22, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

Williams, A. B., Li, L., Nguyen, B., Brown, P. A., Levis, M. J. & Small, D., Oct 11 2012, In : Blood. 120, 15, p. 3069-3079 11 p.

Research output: Contribution to journalArticle

Reaping the benefits of recent advances for adults with acute lymphoblastic leukemia

Brown, P. A. & Alvarnas, J. C., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 800-801 2 p.

Research output: Contribution to journalArticle

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Dave, H., Anver, M. R., Butcher, D. O., Brown, P. A., Khan, J., Wayne, A. S., Baskar, S. & Rader, C., Dec 20 2012, In : PLoS One. 7, 12, e52655.

Research output: Contribution to journalArticle

2011

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P. A., Valent, P., Bradner, J. E., Lowe, S. W. & Vakoc, C. R., Oct 27 2011, In : Nature. 478, 7370, p. 524-528 5 p.

Research output: Contribution to journalArticle