Research Output per year
Research Output
2019
Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group
Horton, T. M., Whitlock, J. A., Lu, X., O'Brien, M. M., Borowitz, M. J., Devidas, M., Raetz, E. A., Brown, P. A., Carroll, W. L. & Hunger, S. P., Jan 1 2019, In : British journal of haematology.Research output: Contribution to journal › Article
Day 15 bone marrow minimal residual disease predicts response to blinatumomab in relapsed/refractory paediatric B-ALL
Brown, P., Zugmaier, G., Gore, L., Tuglus, C. A. & von Stackelberg, A., Jan 1 2019, (Accepted/In press) In : British journal of haematology.Research output: Contribution to journal › Letter
Open Access
Guidelines Insights: Acute Lymphoblastic Leukemia, Version 1.2019
Brown, P. A., Wieduwilt, M., Logan, A., DeAngelo, D. J., Wang, E. S., Fathi, A., Cassaday, R. D., Litzow, M., Advani, A., Aoun, P., Bhatnagar, B., Boyer, M. W., Bryan, T., Burke, P. W., Coccia, P. F., Coutre, S. E., Jain, N., Kirby, S., Liu, A., Massaro, S. & 9 others, , May 1 2019, In : Journal of the National Comprehensive Cancer Network : JNCCN. 17, 5, p. 414-423 10 p.Research output: Contribution to journal › Article
Open Access
Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children's Oncology Group
Esiashvili, N., Lu, X., Ulin, K., Laurie, F., Kessel, S., Kalapurakal, J. A., Merchant, T. E., Followill, D. S., Sathiaseelan, V., Schmitter, M. K., Devidas, M., Chen, Y., Wall, D. A., Brown, P. A., Hunger, S. P., Grupp, S. A. & Pulsipher, M. A., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics.Research output: Contribution to journal › Article
How I treat infant leukemia
Brown, P., Pieters, R. & Biondi, A., Jan 17 2019, In : Blood. 133, 3, p. 205-214 10 p.Research output: Contribution to journal › Article
Open Access
Universal premedication and therapeutic drug monitoring for asparaginase-based therapy prevents infusion-associated acute adverse events and drug substitutions
Cooper, S., Young, D. J., Bowen, C. J., Arwood, N. M., Poggi, S. G. & Brown, P. A., Jan 1 2019, In : Pediatric Blood and Cancer. e27797.Research output: Contribution to journal › Article
2018
Blinatumomab for MRD1 B-all: The evidence strengthens
Brown, P. A., Apr 5 2018, In : Blood. 131, 14, p. 1497-1498 2 p.Research output: Contribution to journal › Review article
Chimeric antigen receptor T-cell therapy
Ogba, N., Arwood, N. M., Bartlett, N. L., Bloom, M., Brown, P. A., Brown, C., Budde, E. L., Carlson, R., Farnia, S., Fry, T. J., Garber, M., Gardner, R. A., Gurschick, L., Kropf, P., Reitan, J. J., Sauter, C., Shah, B., Shpall, E. J. & Rosen, S. T., Sep 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 9, p. 1093-1106 14 p.Research output: Contribution to journal › Article
Emerging treatment options for acute lymphoblastic leukemia: Focus on CAR T-cell therapy
Brown, P. A. & Shah, B., May 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 5S, p. 651-655 5 p.Research output: Contribution to journal › Article
Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group (COG)
Gupta, S., Devidas, M., Loh, M. L., Raetz, E. A., Chen, S., Wang, C., Brown, P. A., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Dunsmore, K. P., Larsen, E. C., Maloney, K. W., Mattano, L. A., Winter, S. S., Winick, N. J., Carroll, W. L., Hunger, S. P., Borowitz, M. J. & Wood, B. L., Feb 23 2018, (Accepted/In press) In : Leukemia. p. 1-10 10 p.Research output: Contribution to journal › Article
Knock-In of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice
Annesley, C. E., Rabik, C., Duffield, A. S., Rau, R. E., Magoon, D., Li, L., Huff, V., Small, D., Loeb, D. M. & Brown, P. A., Oct 1 2018, In : Oncotarget. 9, 82, p. 35313-35326 14 p.Research output: Contribution to journal › Article
2017
A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study (POE 10-03)
Cooper, T. M., Sison, E. A. R., Baker, S. D., Li, L., Ahmed, A., Trippett, T., Gore, L., Macy, M. E., Narendran, A., August, K., Absalon, M. J., Boklan, J., Pollard, J., Magoon, D. & Brown, P. A., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.Research output: Contribution to journal › Article
FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
Nguyen, B., Williams, A. B., Young, D. J., Ma, H., Li, L., Levis, M. J., Brown, P. A. & Small, D., 2017, In : Oncotarget. 8, 7, p. 10931-10944 14 p.Research output: Contribution to journal › Article
NCCN Guidelines® insights acute lymphoblastic Leukemia, Version 1.2017 featured updates to the NCCN guidelines
Brown, P. A., Shah, B., Fathi, A., Wieduwilt, M., Advani, A., Aoun, P., Barta, S. K., Boyer, M. W., Bryan, T., Burke, P. W., Cassaday, R., Coccia, P. F., Coutre, S. E., Damon, L. E., DeAngelo, D. J., Frankfurt, O., Greer, J. P., Kantarjian, H. M., Klisovic, R. B., Kupfer, G. & 10 others, , Sep 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 9, p. 1091-1102 12 p.Research output: Contribution to journal › Article
2016
Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia
Vrooman, L. M., Kirov, I. I., Dreyer, Z. A. E., Kelly, M., Hijiya, N., Brown, P. A., Drachtman, R. A., Messinger, Y. H., Ritchey, A. K., Hale, G. A., Maloney, K., Lu, Y., Plourde, P. V. & Silverman, L. B., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 228-233 6 p.Research output: Contribution to journal › Article
Advances in the care of adult patients with acute lymphoblastic leukemia: Optimism tempered by reality
Alvarnas, J. C. & Brown, P. A., Jul 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 7, p. 815-817 3 p.Research output: Contribution to journal › Editorial
A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) study
Cooper, T. M., Cassar, J., Eckroth, E., Malvar, J., Sposto, R., Gaynon, P., Chang, B. H., Gore, L., August, K., Pollard, J. A., DuBois, S. G., Silverman, L. B., Oesterheld, J., Gammon, G., Magoon, D., Annesley, C. & Brown, P. A., Aug 15 2016, In : Clinical Cancer Research. 22, 16, p. 4014-4022 9 p.Research output: Contribution to journal › Article
A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia
Hale, V., Hale, G. A., Brown, P. A. & Amankwah, E., Nov 2 2016, (Accepted/In press) In : Oncology.Research output: Contribution to journal › Article
Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs
Fox, J. M., Moynihan, J. R., Mott, B. T., Mazzone, J. R., Anders, N., Brown, P. A., Rudek-Renaut, M., Liu, J., Boger, R., Posner, G. H., Civin, C. I. & Chen, X., 2016, In : Oncotarget. 7, 6, p. 7268-7279 12 p.Research output: Contribution to journal › Article
Post-Transplantation Cyclophosphamide after Bone Marrow Transplantation Is Not Associated with an Increased Risk of Donor-Derived Malignancy
Majzner, R. G., Mogri, H., Varadhan, R., Brown, P. A., Cooke, K. R., Bolanos Meade, F. J., Swinnen, L., Kanakry, J., Luznik, L., Jones, R. J., Fuchs, E. J., Ambinder, R. F., Kasamon, Y. & Symons, H., Nov 8 2016, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.Research output: Contribution to journal › Article
2015
Acute lymphoblastic leukemia, version 2.2015: Clinical practice guidelines in oncology
Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Barta, S. K., Borate, U., Boyer, M. W., Burke, P. W., Cassaday, R., Castro, J. E., Coccia, P. F., Coutre, S. E., Damon, L. E., De Angelo, D. J., Douer, D., Frankfurt, O., Greer, J. P., Johnson, R. A., Kantarjian, H. M., Klisovic, R. B. & 10 others, , Oct 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 10, p. 1240-1279 40 p.Research output: Contribution to journal › Article
A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011)
Loh, M. L., Tasian, S. K., Rabin, K. R., Brown, P. A., Magoon, D., Reid, J. M., Chen, X., Ahern, C. H., Weigel, B. J. & Blaney, S. M., Oct 1 2015, In : Pediatric Blood and Cancer. 62, 10, p. 1717-1724 8 p.Research output: Contribution to journal › Article
Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis
Amankwah, E., Saenz, A. M., Hale, G. A. & Brown, P. A., Sep 4 2015, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.Research output: Contribution to journal › Article
Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: A report from the children's oncology group
Salzer, W. L., Jones, T. L., Devidas, M., Dreyer, Z. E., Gore, L., Winick, N. J., Sung, L., Raetz, E., Loh, M. L., Wang, C. Y., De Lorenzo, P., Valsecchi, M. G., Pieters, R., Carroll, W. L., Hunger, S. P., Hilden, J. M. & Brown, P. A., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 414-418 5 p.Research output: Contribution to journal › Article
Erratum: The genomic landscape of juvenile myelomonocytic leukemia (Nature Genetics (2015) 47 (1326-1333))
Stieglitz, E., Taylor-Weiner, A. N., Chang, T. Y., Gelston, L. C., Wang, Y. D., Mazor, T., Esquivel, E., Yu, A., Seepo, S., Olsen, S. R., Rosenberg, M., Archambeault, S. L., Abusin, G., Beckman, K., Brown, P. A., Briones, M., Carcamo, B., Cooper, T., Dahl, G. V., Emanuel, P. D. & 27 others, , Dec 29 2015, In : Nature Genetics. 48, 1, p. 101 1 p.Research output: Contribution to journal › Comment/debate
Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies
Li, Z., Younger, K., Gartenhaus, R., Joseph, A. M., Hu, F., Baer, M. R., Brown, P. A. & Davila, E., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1081-1097 17 p.Research output: Contribution to journal › Article
Novel agents for the treatment of childhood acute leukemia
Annesley, C. E. & Brown, P. A., 2015, In : Therapeutic Advances in Hematology. 6, 2, p. 61-79 19 p.Research output: Contribution to journal › Review article
POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL
Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Romagnoli, B., Douglas, G. J., Tuffin, G., Zimmermann, J. & Brown, P. A., 2015, In : Oncotarget. 6, 31, p. 30902-30918 17 p.Research output: Contribution to journal › Article
rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis
Negi, S. S. & Brown, P. A., 2015, In : Oncotarget. 6, 20, p. 18094-18104 11 p.Research output: Contribution to journal › Article
The genomic landscape of juvenile myelomonocytic leukemia
Stieglitz, E., Taylor-Weiner, A. N., Chang, T. Y., Gelston, L. C., Wang, Y. D., Mazor, T., Esquivel, E., Yu, A., Seepo, S., Olsen, S. R., Rosenberg, M., Archambeault, S. L., Abusin, G., Beckman, K., Brown, P. A., Briones, M., Carcamo, B., Cooper, T., Dahl, G. V., Emanuel, P. D. & 27 others, , Nov 1 2015, In : Nature Genetics. 47, 11, p. 1326-1333 8 p.Research output: Contribution to journal › Article
Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells
Negi, S. S. & Brown, P. A., 2015, In : Oncotarget. 6, 33, p. 34846-34858 13 p.Research output: Contribution to journal › Article
Treatment of pediatric acute lymphoblastic leukemia
Cooper, S. & Brown, P. A., Feb 1 2015, In : Pediatric Clinics of North America. 62, 1, p. 61-73 13 p.Research output: Contribution to journal › Article
2014
A phase i study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium
Raetz, E. A., Morrison, D., Romanos-Sirakis, E., Gaynon, P., Sposto, R., Bhojwani, D., Bostrom, B. C., Brown, P. A., Eckroth, E., Cassar, J., Malvar, J., Buchbinder, A. & Carroll, W. L., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 6, p. 458-463 6 p.Research output: Contribution to journal › Article
FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia
Ma, H. S., Nguyen, B., Duffield, A. S., Li, L., Galanis, A., Williams, A. B., Brown, P. A., Levis, M. J., Leahy, D. J. & Small, D., Jul 24 2014, In : Cancer Research. 74, 18, p. 5206-5217 12 p.Research output: Contribution to journal › Article
NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease
Rau, R., Magoon, D., Greenblatt, S., Li, L., Annesley, C., Duffield, A. S., Huso, D., McIntyre, E., Clohessy, J. G., Reschke, M., Pandolfi, P. P., Small, D. & Brown, P. A., Feb 2014, In : Experimental Hematology. 42, 2, p. 101-113 13 p.Research output: Contribution to journal › Article
Open-label bendamustine monotherapy for pediatric patients with relapsed or refractory acute leukemia: Efficacy and tolerability
Fraser, C., Brown, P. A., Megason, G., Ahn, H. S., Cho, B., Kirov, I., Frankel, L., Aplenc, R., Bensen-Kennedy, D., Munteanu, M., Weaver, J. & Harker-Murray, P., 2014, In : Journal of Pediatric Hematology/Oncology. 36, 4Research output: Contribution to journal › Article
Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: Efficacy and potential mechanisms of resistance to CXCR4 inhibition
Sison, E. A. R., Magoon, D., Li, L., Annesley, C. E., Rau, R. E., Small, D. & Brown, P. A., 2014, In : Oncotarget. 5, 19, p. 8947-8958 12 p.Research output: Contribution to journal › Article
The biology and targeting of FLT3 in pediatric leukemia
Annesley, C. E. & Brown, P. A., 2014, In : Frontiers in Oncology. 4, SEP, Article 263.Research output: Contribution to journal › Article
2013
Does hematopoietic stem cell transplantation benefit infants with acute leukemia?
Sison, E. A. R. & Brown, P. A., 2013, In : Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2013, p. 601-604 4 p.Research output: Contribution to journal › Article
Dynamic chemotherapy-induced upregulation of CXCR4 expression: A mechanism of therapeutic resistance in pediatric AML
Sison, E. A. R., McIntyre, E., Magoon, D. & Brown, P. A., Sep 2013, In : Molecular Cancer Research. 11, 9, p. 1004-1016 13 p.Research output: Contribution to journal › Article
MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism
Sison, E. A. R., Rau, R. E., Mcintyre, E., Li, L., Small, D. & Brown, P. A., Mar 2013, In : British Journal of Haematology. 160, 6, p. 785-797 13 p.Research output: Contribution to journal › Article
Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
Williams, A. B., Nguyen, B., Li, L., Brown, P. A., Levis, M. J., Leahy, D. & Small, D., Jan 2013, In : Leukemia. 27, 1, p. 48-55 8 p.Research output: Contribution to journal › Article
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens
Matheny, C. J., Wei, M. C., Bassik, M. C., Donnelly, A. J., Kampmann, M., Iwasaki, M., Piloto, O., Solow-Cordero, D. E., Bouley, D. M., Rau, R., Brown, P. A., McManus, M. T., Weissman, J. S. & Cleary, M. L., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1352-1363 12 p.Research output: Contribution to journal › Article
Treatment of infant leukemias: challenge and promise.
Brown, P. A., 2013, In : Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2013, p. 596-600 5 p.Research output: Contribution to journal › Article
2012
Acute lymphoblastic leukemia: Clinical practice guidelines in oncology
Alvarnas, J. C., Brown, P. A., Aoun, P., Ballen, K. K., Bellam, N., Blum, W., Boyer, M. W., Carraway, H. E., Coccia, P. F., Coutre, S. E., Cultrera, J., Damon, L. E., DeAngelo, D. J., Douer, D., Frangoul, H., Frankfurt, O., Goorha, S., Millenson, M. M., O'Brien, S., Petersdorf, S. H. & 7 others, , Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 858-914 57 p.Research output: Contribution to journal › Article
Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia
Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P. A. & Carroll, W. L., Jun 5 2012, In : Blood. 119, 22, p. 5201-5210 10 p.Research output: Contribution to journal › Article
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia
Williams, A. B., Li, L., Nguyen, B., Brown, P. A., Levis, M. J. & Small, D., Oct 11 2012, In : Blood. 120, 15, p. 3069-3079 11 p.Research output: Contribution to journal › Article
Reaping the benefits of recent advances for adults with acute lymphoblastic leukemia
Brown, P. A. & Alvarnas, J. C., Jul 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 7, p. 800-801 2 p.Research output: Contribution to journal › Article
Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies
Dave, H., Anver, M. R., Butcher, D. O., Brown, P. A., Khan, J., Wayne, A. S., Baskar, S. & Rader, C., Dec 20 2012, In : PLoS One. 7, 12, e52655.Research output: Contribution to journal › Article
2011
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P. A., Valent, P., Bradner, J. E., Lowe, S. W. & Vakoc, C. R., Oct 27 2011, In : Nature. 478, 7370, p. 524-528 5 p.Research output: Contribution to journal › Article