1961 …2016
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Research Output 1961 2016

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2016

National Cancer Institute Workshop on the Possible Roles of Metallothionein in Carcinogenesis

Cherian, M. G., Huang, P. C., Klaassen, C. D., Longfellow, D. G., Waalkes, M. P. & Waulkes, M. P., 2016, In : Cancer Research. 53, 4, p. 922-925 4 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Metallothionein
National Institutes of Health (U.S.)
Cadmium
Drug Resistance
2000

The integrative nature of biochemistry: Challenges of biochemical education in the USA

Huang, P. C., Mar 1 2000, In : Biochemical Education. 28, 2, p. 64-70 7 p.

Research output: Contribution to journalArticle

Biochemistry
Education
Curriculum
Curricula
Art
1999

Function and sequence analyses of tumor suppressor gene p53 of CHO.K1 cells

Tzang, B. S., Lai, Y. C., Hsu, M., Chang, H. W., Chang, C. C., Huang, P. C. & Liu, Y. C., Apr 1999, In : DNA and Cell Biology. 18, 4, p. 315-321 7 p.

Research output: Contribution to journalArticle

Cricetulus
Tumor Suppressor Genes
Sequence Analysis
Ovary
p53 Genes

Why reversing the sequence of the α domain of human metallothionein-2 does not change its metal-binding and folding characteristics

Pan, P. K. Y., Zheng, Z. F., Lyu, P. C. & Huang, P. C., Nov 15 1999, In : European Journal of Biochemistry. 266, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Metallothionein
Metals
Titration
Dithionitrobenzoic Acid
Sulfhydryl Reagents
1998

Cysteine contributions to metal binding preference for Zn/Cd in the β-domain of metallothionein

Chang, C. C., Liao, W. F. & Huang, P. C., Jan 1998, In : Protein Engineering. 11, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Metallothionein
X ray crystallography
Binding sites
Metal ions
Cysteine

Multiple isoforms of metallothionein are expressed in the porcine liver

Huang, M. C., Pan, P. K., Zheng, Z. F., Chen, N. C., Peng, J. Y. & Huang, P. C., Apr 28 1998, In : Gene. 211, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Metallothionein
Protein Isoforms
Swine
Liver
Cysteine

Promoter structure and activity of type 1 rice metallothionein-like gene

Hsieh, H. M. & Huang, P. C., 1998, In : Mitochondrial DNA. 9, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Metallothionein
Genes
TATA Box
Glucuronidase
Nucleic Acid Repetitive Sequences

Type 2 rice metallothionein-like gene has two introns

Che, W. M., Hsieh, H. M. & Huang, P. C., 1998, In : Mitochondrial DNA. 8, 4, p. 223-228 6 p.

Research output: Contribution to journalArticle

Metallothionein
Introns
Genes
Polymerase Chain Reaction
Base Pairing
1996

RNA expression patterns of a type 2 metallothionein-like gene from rice

Hsieh, H. M., Liu, W. K., Chang, A. & Huang, P. C., Nov 1996, In : Plant Molecular Biology. 32, 3, p. 525-529 5 p.

Research output: Contribution to journalArticle

Metallothionein
metallothionein
Genes
RNA
rice

Semi-empirical simulation of Zn/Cd binding site preference in the metal binding domains of mammalian metallothionein

Chang, C. C. & Huang, P. C., 1996, In : Protein Engineering. 9, 12, p. 1165-1172 8 p.

Research output: Contribution to journalArticle

Metallothionein
Binding sites
Metals
Binding Sites
X ray crystallography
1995

A novel stress-inducible metallothionein-like gene from rice

Hsieh, H. M., Liu, W. K. & Huang, P. C., Jun 1995, In : Plant Molecular Biology. 28, 3, p. 381-389 9 p.

Research output: Contribution to journalArticle

Metallothionein
metallothionein
Genes
rice
genomics

Transcripts of metallothionein genes in arabidopsis thaliana

Yeh, S. C., Hsieh, H. M. & Huang, P. C., 1995, In : Mitochondrial DNA. 5, 3, p. 141-144 4 p.

Research output: Contribution to journalArticle

Metallothionein
Arabidopsis
Cysteine
Genes
Gene Library
1994

Replacement of All α-Domain Lysines with Glutamates Reduces Metallothionein Detoxification Function

Cody, C. W. & Huang, P. C., Jul 29 1994, In : Biochemical and Biophysical Research Communications. 202, 2, p. 954-959 6 p.

Research output: Contribution to journalArticle

Glutamates
Detoxification
Metallothionein
Lysine
Yeast
Glutamates
Metallothionein
Lysine
Substitution reactions
Metals
1993
Detoxification
Metallothionein
Hinges
Glutamine
Lysine
1992

The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: Conservation and variations among vertebrates

Tzeng, C. S., Hui, C. F., Shen, S. C. & Huang, P. C., Sep 25 1992, In : Nucleic Acids Research. 20, 18, p. 4853-4858 6 p.

Research output: Contribution to journalArticle

Mitochondrial Genome
Nucleotides
Vertebrates
Conservation
Genome
1991
Metallothionein
Serine
Cysteine
Cadmium
Yeasts

Effect of cysteine replacements at positions 13 and 50 on metallothionein structure

Cismowski, M. J. & Huang, P. C., 1991, In : Biochemistry®. 30, 26, p. 6626-6632 7 p.

Research output: Contribution to journalArticle

Metallothionein
Cadmium
Cysteine
Mutant Proteins
Yeast

Glial immunoreactivity for metallothionein in the rat brain

Young, J. K., Garvey, J. S. & Huang, P. C., 1991, In : GLIA. 4, 6, p. 602-610 9 p.

Research output: Contribution to journalArticle

Metallothionein
Neuroglia
Astrocytes
Hypothalamus
Brain

Molecular cloning of Chinese hamster metallothionein II gene and its 5' flanking region

Hung, S. H., Yu, C. W., Chou, T. M., Huang, P. C. & Lin, L. Y., 1991, In : BBA - Gene Structure and Expression. 1090, 2, p. 255-258 4 p.

Research output: Contribution to journalArticle

Metallothionein
5' Flanking Region
Cloning
Molecular Cloning
Cricetulus

Mutation of invariant cysteines of mammalian metallothionein alters metal binding capacity, cadmium resistance, and 113Cd NMR spectrum

Cismowski, M. J., Narula, S. S., Armitage, I. M., Chernaik, M. L. & Huang, P. C., Dec 25 1991, In : Journal of Biological Chemistry. 266, 36, p. 24390-24397 8 p.

Research output: Contribution to journalArticle

Metallothionein
Cadmium
Cysteine
Metals
Nuclear magnetic resonance

Purification of mammalian metallothionein from recombinant systems

Cismowski, M. J. & Huang, P. C., 1991, In : Methods in Enzymology. 205, p. 312-319 8 p.

Research output: Contribution to journalArticle

Metallothionein
1990

Assignment of the Nance-Horan syndrome to the distal short arm of the X chromosome

Zhu, D., Alcorn, D. M., Antonarakis, S. E., Levin, L. S., Huang, P. C., Mitchell, T. N., Warren, A. C. & Maumenee, I. H., 1990, In : Human Genetics. 86, 1, p. 54-58 5 p.

Research output: Contribution to journalArticle

X Chromosome
Genetic Markers
Microphthalmos
Pedigree
Heterozygote

Complete homology in metallothionein from two genera of ducks and their hybrids

Lin, L. Y. & Huang, P. C., Apr 16 1990, In : Biochemical and Biophysical Research Communications. 168, 1, p. 182-187 6 p.

Research output: Contribution to journalArticle

Ducks
Metallothionein
Sulfhydryl Compounds
Vertebrates
Amino Acid Sequence

Maternal transmission of mitochondrial DNA in ducks

Lin, L. Y., Cheng, I. P., Tzeng, C. S. & Huang, P. C., Apr 16 1990, In : Biochemical and Biophysical Research Communications. 168, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

Ducks
Mitochondrial DNA
Mothers
Mammals
Mitochondrial Genome

Metallothioniens with interdomain hinges expanded by insertion mutagenesis

Rhee, I. K., Lee, K. S. & Huang, P. C., Jan 1990, In : Protein Engineering, Design and Selection. 3, 3, p. 205-213 9 p.

Research output: Contribution to journalArticle

Mutagenesis
Metallothionein
Hinges
Yeast
lysyllysine
1989

Chronic cadmium intake results in dose-related excretion of metallothionein in urine

Shaikh, Z. A., Harnett, K. M., Perlin, S. A. & Huang, P. C., Feb 1989, In : Experientia. 45, 2, p. 146-148 3 p.

Research output: Contribution to journalArticle

Metallothionein
Cadmium
Urine
Drinking Water
Radioimmunoassay
Metallothionein
Zinc
Messenger RNA
Cadmium
CHO Cells

Metallothionein accumulation in CHO Cdr cells in response to lead treatment

Rhee, S. J. & Huang, P. C., 1989, In : Chemico-Biological Interactions. 72, 3, p. 347-361 15 p.

Research output: Contribution to journalArticle

CHO Cells
Metallothionein
Zinc
Cell death
Thymidine
1987

Ontogenic variation in acute lethality of cadmium in C57BL/6J mice

Thomas, D. J., Winchurch, R. A. & Huang, P. C., Dec 14 1987, In : Toxicology. 47, 3, p. 317-323 7 p.

Research output: Contribution to journalArticle

Cadmium
Inbred C57BL Mouse
Carrier Proteins
Metals
Metallothionein

Role of metallothionein in detoxification and tolerance to transition metals.

Huang, P. C., Morris, S., Dinman, J., Pine, R. & Smith, B., 1987, In : Experientia. Supplementum. 52, p. 439-446 8 p.

Research output: Contribution to journalArticle

Metallothionein
Metals
Cadmium
Inbred Strains Mice
CHO Cells

Transient response of amplified metallothionein genes in CHO cells to induction by alpha interferon

Morris, S. & Huang, P. C., 1987, In : Molecular and Cellular Biology. 7, 2, p. 600-605 6 p.

Research output: Contribution to journalArticle

Genetic Transcription
Interferon Type I
CHO Cells
Metallothionein
Gene Amplification
1986

Transition metal-binding proteins from three Chesapeake Bay fish species

Andersen, R., Frazier, J. & Huang, P. C., 1986, In : Environmental Health Perspectives. VOL. 65, p. 149-156 8 p.

Research output: Contribution to journalArticle

metal binding
transition element
Bass
Cadmium
Fish
1985

Construction and characterization of a library of metallothionein coding sequence mutants

Pine, R., Cismowski, M., Suo Win Liu, W. L. & Huang, P. C., 1985, In : DNA. 4, 2, p. 115-126 12 p.

Research output: Contribution to journalArticle

Metallothionein
Codon
Libraries
Cysteine
Antisense DNA
1984

Characterization of recognition sites on bacteriophage HP1c1 DNA which interact with the DNA uptake system of Haemophilus influenzae Rd

Fitzmaurice, W. P., Benjamin, R. C., Huang, P. C. & Scocca, J. J., 1984, In : Gene. 31, 1-3, p. 187-196 10 p.

Research output: Contribution to journalArticle

Haemophilus influenzae
Bacteriophages
DNA
Haemophilus
Genome

Nucleotide sequence and properties of the cohesive DNA termini from bacteriophage HP1c1 of Haemophilus influenzae Rd

Fitzmaurice, W. P., Waldman, A. S., Benjamin, R. C., Huang, P. C. & Scocca, J. J., 1984, In : Gene. 31, 1-3, p. 197-203 7 p.

Research output: Contribution to journalArticle

Haemophilus influenzae
Bacteriophages
Pyrimidines
Purines
DNA

Nucleotide sequence of cloned DNA segments of the Haemophilus influenzae bacteriophage HP1c1

Benjamin, R. C., Fitzmaurice, W. P., Huang, P. C. & Scocca, J. J., 1984, In : Gene. 31, 1-3, p. 173-185 13 p.

Research output: Contribution to journalArticle

Haemophilus influenzae
Bacteriophages
Open Reading Frames
DNA
Genome
1983

Cadmium and zinc flux in wild-type and cadmium-resistant CHO cells

Corrigan, A. J. & Huang, P. C., Feb 1983, In : Biological Trace Element Research. 5, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

CHO Cells
Cadmium
Zinc
Fluxes
Dactinomycin
1982

A BASIC microcomputer program for plotting the secondary structure of proteins

Corrigan, A. J. & Huang, P. C., 1982, In : Computer Programs in Biomedicine. 15, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
X ray crystallography
X Ray Crystallography
Microcomputers
Amino acids

Cloning of a family of genes inducible by cadmium

Ohi, S. & Huang, P. C., 1982, In : Journal of Cell Biology. 95, 2 II

Research output: Contribution to journalArticle

Cadmium
Organism Cloning
Genes

Immunochemical detection of metallothionein in specific epithelial cells of rat organs

Danielson, K. G., Ohi, S. & Huang, P. C., 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 7 I, p. 2301-2304 4 p.

Research output: Contribution to journalArticle

Metallothionein
Epithelial Cells

Immunochemical localization of metallothionein in rat liver and kidney

Danielson, K. G., Ohi, S. & Huang, P. C., 1982, In : Journal of Histochemistry and Cytochemistry. 30, 10, p. 1033-1039 7 p.

Research output: Contribution to journalArticle

Metallothionein
Kidney
Liver
Cadmium
Hepatocytes
1981

Cadmium-induced accumulation of metallothionein messenger RNA in rat liver.

Ohi, S., Cardenosa, G., Pine, R. & Huang, P. C., Mar 10 1981, In : Journal of Biological Chemistry. 256, 5, p. 2180-2184 5 p.

Research output: Contribution to journalArticle

Metallothionein
Cadmium
Liver
Rats
Messenger RNA

Cellular uptake of cadmium and zinc

Corrigan, A. J. & Huang, P. C., Sep 1981, In : Biological Trace Element Research. 3, 3, p. 197-216 20 p.

Research output: Contribution to journalArticle

Cadmium
Zinc
Metals
Poisons
Kinetics

Genetic and biochemical studies with ataxia telangiectasia - A review

Huang, P. C. & Sheridan, R. B., Nov 1981, In : Human Genetics. 59, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Sugar Phosphates
Ataxia Telangiectasia
Ionizing Radiation
Cytogenetics
DNA Repair
1980

Effect of zinc on cadmium influx and toxicity in cultured CHO cells

Huang, P. C., Smith, B., Bohdan, P. & Corrigan, A., Sep 1980, In : Biological Trace Element Research. 2, 3, p. 211-220 10 p.

Research output: Contribution to journalArticle

CHO Cells
Cadmium
Toxicity
Zinc
Cultured Cells

Unscheduled DNA synthesis in cultured ataxia telangiectasia fibroblast-like cells

Vincent, R. A., Fink, A. J. & Huang, P. C., Jan 1 1980, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 72, 2, p. 245-249 5 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Fibroblasts
DNA
1979
Ataxia Telangiectasia
Ataxia
Single-Stranded DNA Breaks
Enzyme Assays
Ionizing Radiation
Ataxia Telangiectasia
Cell Extracts
Fibroblasts
DNA
DNA-(Apurinic or Apyrimidinic Site) Lyase
Ataxia Telangiectasia
Cell Extracts
Catalase
Superoxide Dismutase
Fibroblasts