Nyall London

Assistant Professor

20082020
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Research Output 2008 2020

Airborne particulate matter induces nonallergic eosinophilic sinonasal inflammation in mice

Ramanathan, M., London, N., Tharakan, A., Surya, N., Sussan, T. E., Rao, X., Lin, S. Y., Toskala, E., Rajagopalan, S. & Biswal, S., Jul 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 57, 1, p. 59-65 7 p.

Research output: Contribution to journalReview article

Particulate Matter
Inflammation
Chemokine CCL11
Nasal Lavage Fluid
Claudin-1

Anatomical Variants of the Infraorbital Canal: Implications for the Prelacrimal Approach to the Orbital Floor

Li, L., London, N. R., Prevedello, D. M. & Carrau, R. L., Jan 1 2019, (Accepted/In press) In : American Journal of Rhinology and Allergy.

Research output: Contribution to journalArticle

Pterygopalatine Fossa
Anatomic Variation
Anatomy
Arteries
Incidence

Anatomy based corridors to the infratemporal fossa: Implications for endoscopic approaches

Li, L., London, N. R., Prevedello, D. M. & Carrau, R. L., Jan 1 2019, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

Open Access
Pterygoid Muscles
Anatomy
Muscles
Foramen Ovale
Eustachian Tube

Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever

Gowen, B. B., Julander, J. G., London, N., Wong, M. H., Larson, D., Morrey, J. D., Li, D. Y. & Bray, M., Sep 20 2010, In : Virology Journal. 7, 240.

Research output: Contribution to journalArticle

Open Access
Viral Hemorrhagic Fevers
Capillary Permeability
Cricetinae
Blood Vessels
Evans Blue

Bactericidal antibiotics promote oxidative damage and programmed cell death in sinonasal epithelial cells

Kohanski, M. A., Tharakan, A., London, N., Lane, A. P. & Ramanathan, M., Apr 1 2017, In : International Forum of Allergy and Rhinology. 7, 4, p. 359-364 6 p.

Research output: Contribution to journalArticle

Levofloxacin
Cell Death
Epithelial Cells
Reactive Oxygen Species
Anti-Bacterial Agents

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N., London, N., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access
Deceleration
Cell Division
Incidence
Neoplasms
Stem Cells

Characterization of a novel, papain-inducible murine model of eosinophilic rhinosinusitis

Tharakan, A., Dobzanski, A., London, N., Khalil, S. M., Surya, N., Lane, A. P. & Ramanathan, M., Jan 1 2018, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Papain
Nasal Lavage Fluid
Cytokines
Goblet Cells
Cysteine Proteases

Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability (Nature Medicine (2008) 14, (448-453))

Jones, C. A., London, N., Chen, H., Park, K. W., Sauvaget, D., Stockton, R. A., Wythe, J. D., Suh, W., Larrieu-Lahargue, F., Mukouyama, Y. S., Lindblom, P., Seth, P., Frias, A., Nishiya, N., Ginsberg, M. H., Gerhardt, H., Zhang, K. & Li, D. Y., May 1 2008, In : Nature medicine. 14, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Pathologic Neovascularization
Blood Vessels
Medicine
corrigendum

Deletion of Nrf2 enhances susceptibility to eosinophilic sinonasal inflammation in a murine model of rhinosinusitis

London, N., Tharakan, A., Mendiola, M., Sussan, T. E., Chen, M., Dobzanski, A., Lane, A. P., Sidhaye, V., Biswal, S. & Ramanathan, M., Jan 1 2018, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Inflammation
Ovalbumin
Nasal Lavage Fluid
Cytokines
Goblet Cells

Development and implementation of an inpatient otolaryngology consultation service at an academic medical center

Huddle, M. G., London, N. & Stewart, C. M., Feb 1 2018, In : Southern Medical Journal. 111, 2, p. 118-122 5 p.

Research output: Contribution to journalArticle

Otolaryngology
Inpatients
Referral and Consultation
Hospitalists
Physician Assistants

Differential Diagnosis of Chronic Rhinosinusitis with Nasal Polyps

London, N. & Reh, D. D., 2016, In : Advances in Oto-Rhino-Laryngology. 79, p. 1-12 12 p.

Research output: Contribution to journalArticle

Nasal Polyps
Differential Diagnosis
Olfactory Esthesioneuroblastoma
Angiofibroma
Encephalocele

Emerging mechanisms of vascular stabilization

London, N., Smith, M. C. P. & Li, D. Y., Aug 4 2009, In : Journal of Thrombosis and Haemostasis. 7, SUPPL. 1, p. 57-60 4 p.

Research output: Contribution to journalReview article

Open Access
Blood Vessels
Cues
Axons
Central Nervous System Cavernous Hemangioma
Neurobiology

Endogenous endothelial cell signaling systems maintain vascular stability

London, N., Whitehead, K. J. & Li, D. Y., Jun 1 2009, In : Angiogenesis. 12, 2, p. 149-158 10 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Cell signaling
Endothelial cells
Blood Vessels
Endothelial Cells

Endoscopic prelacrimal approach to lateral recess of sphenoid sinus: feasibility study

Li, L., London, N. R., Prevedello, D. M. & Carrau, R. L., Jan 1 2019, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Sphenoid Sinus
Feasibility Studies
Parasympathetic Ganglia
Pterygopalatine Fossa
Endoscopes

Erratum: The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases (Nature Medicine (2009) 15 (177-184))

Whitehead, K. J., Chan, A. C., Navankasattusas, S., Koh, W., London, N., Ling, J., Mayo, A. H., Drakos, S. G., Jones, C. A., Zhu, W., Marchuk, D. A., Davis, G. E. & Li, D. Y., Apr 1 2009, In : Nature medicine. 15, 4, 1 p.

Research output: Contribution to journalComment/debate

rho GTP-Binding Proteins
Medicine

Erratum: Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice (Journal of Clinical Investigation (2010) 120, 7(2395-2405) DOI: 10.1172/JCI42011)

De Domenico, I., Zhang, T. Y., Koening, C. L., Branch, R. W., London, N., Lo, E., Daynes, R. A., Kushner, J. P., Li, D., Ward, D. M. & Kaplan, J., Jun 1 2012, In : Journal of Clinical Investigation. 122, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Hepcidins
Cytokines

Expression of Programmed Cell Death Ligand 1 and Associated Lymphocyte Infiltration in Olfactory Neuroblastoma

London, N. R., Rooper, L. M., Bishop, J. A., Xu, H., Bernhardt, L. J., Ishii, M., Hann, C. L., Taube, J. M., Izumchenko, E., Gaykalova, D. A. & Gallia, G. L., Jan 1 2020, (Accepted/In press) In : World neurosurgery.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
Cell Death
Lymphocytes
Ligands
CD274 Antigen

Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration

Yang, Z., Tong, Z., Chen, Y., Zeng, J., Lu, F., Sun, X., Zhao, C., Wang, K., Davey, L., Chen, H., London, N., Muramatsu, D., Salasar, F., Carmona, R., Kasuga, D., Wang, X., Bedell, M., Dixie, M., Zhao, P., Yang, R. & 13 others, Gibbs, D., Liu, X., Li, Y., Li, C., Li, Y., Campochiaro, B., Constantine, R., Zack, D. J., Campochiaro, P. A., Fu, Y., Li, D. Y., Katsanis, N. & Zhang, K., Feb 2010, In : PLoS Genetics. 6, 2, e1000836.

Research output: Contribution to journalArticle

dissection
Macular Degeneration
Haplotypes
Dissection
haplotypes

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

De Domenico, I., Zhang, T. Y., Koening, C. L., Branch, R. W., London, N., Lo, E., Daynes, R. A., Kushner, J. P., Li, D., Ward, D. M. & Kaplan, J., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2395-2405 11 p.

Research output: Contribution to journalArticle

Open Access
Hepcidins
Cytokines
Iron
Homeostasis
Macrophages

Immune profiles in primary squamous cell carcinoma of the head and neck

Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I., Zhavoronkov, A., Sidransky, D., Bedi, A., Hoque, M. O., Koeppen, H., Keck, M. K., Khattri, A., London, N., Kotlov, N., Fatima, A., Vougiouklakis, T., Nakamura, Y., Lingen, M., Agrawal, N. & 5 others, Savage, P. A., Kron, S., Kline, J., Kowanetz, M. & Seiwert, T. Y., Sep 1 2019, In : Oral Oncology. 96, p. 77-88 12 p.

Research output: Contribution to journalArticle

Neoplasms
Regulatory T-Lymphocytes
Mutation
Macrophages
Carcinoma, squamous cell of head and neck

Impact of high- versus low-risk genotype on sinonasal radiographic disease in cystic fibrosis

Halderman, A. A., Lee, S., London, N., Day, A., Jain, R., Moore, J. A. & Lin, S. Y., Jan 1 2018, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Cystic Fibrosis
Genotype
Cystic Fibrosis Transmembrane Conductance Regulator
Paranasal Sinus Diseases
Laryngoscopes

Impact of posterior septum resection on nasal airflow pattern and warming function

Li, L., London, N. R., Zang, H. & Han, D., Jan 1 2019, (Accepted/In press) In : Acta Oto-Laryngologica.

Research output: Contribution to journalArticle

Nose
Nasal Cavity
Nose Diseases
Temperature
Hydrodynamics

Impact of Varying Types of Nasal Septal Deviation on Nasal Airflow Pattern and Warming Function: A Computational Fluid Dynamics Analysis

Li, L., Zang, H., Han, D. & London, N. R., Jan 1 2019, (Accepted/In press) In : Ear, Nose and Throat Journal.

Research output: Contribution to journalArticle

Open Access
Hydrodynamics
Nose
Temperature

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

Makarev, E., Schubert, A. D., Kanherkar, R. R., London, N., Teka, M., Ozerov, I., Lezhnina, K., Bedi, A., Ravi, R., Mehra, R., Hoque, M. O., Sloma, I., Gaykalova, D. A., Csoka, A. B., Sidransky, D., Zhavoronkov, A. & Izumchenko, E., Dec 4 2017, In : Cell Death Discovery. 3, 1, 17022.

Research output: Contribution to journalArticle

Open Access
Oral Leukoplakia
Activation Analysis
Computer Simulation
Squamous Cell Carcinoma
Leukoplakia

Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability

Zhu, W., London, N., Gibson, C. C., Davis, C. T., Tong, Z., Sorensen, L. K., Shi, D. S., Guo, J., Smith, M. C. P., Grossmann, A. H., Thomas, K. R. & Li, D. Y., Dec 13 2012, In : Nature. 492, 7428, p. 252-255 4 p.

Research output: Contribution to journalArticle

Myeloid Differentiation Factor 88
Interleukin Receptors
Interleukin-1
Blood Vessels
Endothelial Cells

Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation

London, N., Tharakan, A., Mendiola, M., Chen, M., Dobzanski, A., Sussan, T. E., Zaykaner, M., Han, A. H., Lane, A. P., Sidhaye, V., Biswal, S. & Ramanathan, M., Jan 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalLetter

Ovum
Inflammation
sulforafan
Pyroglyphidae
Epithelial Cells
Electric Impedance
Zonula Occludens-1 Protein
Permeability

Paraganglioma of the recurrent laryngeal nerve

London, N. R., Hopkins, M., Best, S. R., Rooper, L. M. & Fakhry, C., Jan 1 2019, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Recurrent Laryngeal Nerve
Paraganglioma
Neck
Head
Glossopharyngeal Nerve

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment

di Tomaso, E., London, N., Fuja, D., Logie, J., Tyrrell, J. A., Kamoun, W., Munn, L. L. & Jain, R. K., Apr 8 2009, In : PloS one. 4, 4, e5123.

Research output: Contribution to journalArticle

Open Access
platelet-derived growth factor
Blood vessels
Glioblastoma
blood vessels
Vascular Endothelial Growth Factor A

Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications

Tong, Z., Yang, Z., Patel, S., Chen, H., Gibbs, D., Yang, X., Hau, V. S., Kaminoh, Y., Harmon, J., Pearson, E., Buehler, J., Chen, Y., Yu, B., Tinkham, N. H., Zabriskie, N. A., Zeng, J., Luo, L., Sun, J. K., Prakash, M., Hamam, R. N. & 25 others, Tonna, S., Constantine, R., Ronquillo, C. C., Sadda, S. V., Avery, R. L., Brand, J. M., London, N., Anduze, A. L., King, G. L., Bernstein, P. S., Watkins, S., Ma, X., Joshua-Cameron, D., Rabena, M., Goldfarb-Rumyantzev, A., Banerjee, N., Hilary-Keenan, Mamalis, N., Perez, C., Katz, B. J., Jorde, L. B., Li, D. Y., Aiello, L. P., Pollak, M. R. & Zhang, K., May 13 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 19, p. 6998-7003 6 p.

Research output: Contribution to journalArticle

Open Access
Diabetic Retinopathy
Erythropoietin
Chronic Kidney Failure
Kidney
Alleles

Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm

London, N. & Li, D. Y., May 1 2011, In : Current opinion in hematology. 18, 3, p. 186-190 5 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Cytokines
Blood Vessels
Paxillin
Influenza in Birds

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

Jones, C. A., London, N., Chen, H., Park, K. W., Sauvaget, D., Stockton, R. A., Wythe, J. D., Suh, W., Larrieu-Lahargue, F., Mukouyama, Y. S., Lindblom, P., Seth, P., Frias, A., Nishiya, N., Ginsberg, M. H., Gerhardt, H., Zhang, K. & Li, D. Y., Apr 1 2008, In : Nature medicine. 14, 4, p. 448-453 6 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Blood Vessels
Chemical activation
src-Family Kinases
Neurology

Role of secondary intention healing

Ward, P. D., London, N. & Collar, R., Sep 24 2013, In : Facial Plastic Surgery. 29, 5, p. 346-350 5 p.

Research output: Contribution to journalArticle

Wound Healing
Wounds and Injuries
Ectropion
Nasal Obstruction
Alopecia

Sinuses and Common Rhinologic Conditions

London, N. & Ramanathan, M., Jan 1 2018, (Accepted/In press) In : Medical Clinics of North America.

Research output: Contribution to journalArticle

Primary Health Care
Epistaxis
Hemostasis
Differential Diagnosis
Allergic Rhinitis

Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity

Jones, C. A., Nishiya, N., London, N., Zhu, W., Sorensen, L. K., Chan, A. C., Lim, C. J., Chen, H., Zhang, Q., Schultz, P. G., Hayallah, A. M., Thomas, K. R., Famulok, M., Zhang, K., Ginsberg, M. H. & Li, D. Y., Oct 26 2009, In : Nature cell biology. 11, 11, p. 1325-1331 7 p.

Research output: Contribution to journalArticle

Paxillin
Blood Vessels
Vascular Diseases
ADP-Ribosylation Factors
Pathologic Neovascularization

Slit-robo signaling in ocular angiogenesis

Chen, H., Zhang, M., Tang, S., London, N., Li, D. Y. & Zhang, K., Dec 1 2010, Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations. Anderson, R., Mandal, N., Hollyfield, J. & LaVail, M. (eds.). p. 457-463 7 p. (Advances in Experimental Medicine and Biology; vol. 664).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Endothelial Cells
Endothelial cells
Vascular Endothelial Growth Factor A
Biological Phenomena
Choroidal Neovascularization

Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma

Schubert, A. D., Channah Broner, E., Agrawal, N., London, N., Pearson, A., Gupta, A., Wali, N., Seiwert, T. Y., Wheelan, S., Lingen, M., Macleod, K., Allen, H., Chatterjee, A., Vassiliki, S., Gaykalova, D., Hoque, M. O., Sidransky, D., Suresh, K. & Izumchenko, E., Feb 28 2020, In : Cancer Letters. 471, p. 49-60 12 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Mitochondrial Genome
Mitochondrial DNA
Mutation
Neoplasms

Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza

London, N., Zhu, W., Bozza, F. A., Smith, M. C. P., Greif, D. M., Sorensen, L. K., Chen, L., Kaminoh, Y., Chan, A. C., Passi, S. F., Day, C. W., Barnard, D. L., Zimmerman, G. A., Krasnow, M. A. & Li, D. Y., Jun 7 2010, In : Science translational medicine. 2, 23

Research output: Contribution to journalArticle

Human Influenza
Sepsis
Cytokines
Blood Vessels
Immune System
Free Tissue Flaps
Posterior Cranial Fossa
Skull Base
Nasopharynx
Maxillary Sinus

Techniques and challenges of the expanded endoscopic endonasal access to the ventrolateral skull base during the “far-medial” and “extreme medial” approaches

Silveira-Bertazzo, G., Manjila, S., London, N. R. & Prevedello, D. M., Jan 1 2020, (Accepted/In press) In : Acta Neurochirurgica.

Research output: Contribution to journalArticle

Chondrosarcoma
Skull Base
Cranial Nerve Injuries
Morbidity
Posterior Cranial Fossa

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

Whitehead, K. J., Chan, A. C., Navankasattusas, S., Koh, W., London, N., Ling, J., Mayo, A. H., Drakos, S. G., Marchuk, D. A., Davis, G. E. & Li, D. Y., Feb 1 2009, In : Nature medicine. 15, 2, p. 177-184 8 p.

Research output: Contribution to journalArticle

Central Nervous System Cavernous Hemangioma
rho GTP-Binding Proteins
Blood Vessels
Simvastatin
GTP Phosphohydrolases

The Role of Innate Immunity and Aeroallergens in Chronic Rhinosinusitis

London, N., Tharakan, A. & Ramanathan, M., 2016, In : Advances in Oto-Rhino-Laryngology. 79, p. 69-77 9 p.

Research output: Contribution to journalArticle

Innate Immunity
Pyroglyphidae
Epithelial Cells
Cytokines
Pattern Recognition Receptors

The Role of the Sinonasal Epithelium in Allergic Rhinitis

London, N. & Ramanathan, M., 2017, (Accepted/In press) In : Otolaryngologic Clinics of North America.

Research output: Contribution to journalArticle

Epithelium
Tight Junction Proteins
Adherens Junctions
Antigens
Tight Junctions

The role of vascular endothelial growth factor and vascular stability in diseases of the ear

London, N. & Gurgel, R. K., Jan 1 2014, In : Laryngoscope. 124, 8

Research output: Contribution to journalReview article

Ear Diseases
Vascular Endothelial Growth Factor A
Blood Vessels
Otitis Media with Effusion
Hearing

Transnasal prelacrimal approach to the inferior intraconal space: a feasibility study

Li, L., London, N., Silva, S., Prevedello, D. & Carrau, R. L., Sep 1 2019, In : International Forum of Allergy and Rhinology. 9, 9, p. 1063-1068 6 p.

Research output: Contribution to journalArticle

Feasibility Studies
Muscles
Optic Nerve
Oculomotor Nerve
Ophthalmic Artery

Tympanoplasty with intact canal wall mastoidectomy for cholesteatoma: Long-term hearing outcomes

Wilson, K. F., London, N. & Shelton, C., Dec 1 2013, In : Laryngoscope. 123, 12, p. 3168-3171 4 p.

Research output: Contribution to journalReview article

Tympanoplasty
Cholesteatoma
Hearing
Stapes
Air

When a Meningioma Isn't: Endoscopic Endonasal Orbital Decompression and Biopsy of Skull Base Rosai-Dorfman Disease Treated Previously with Empiric Radiation Therapy

Shah, V., Mohyeldin, A., London, N. R., Fritz, J., Prevedello, D. M., Carrau, R. L. & Hardesty, D. A., Mar 2020, In : World neurosurgery. 135, p. 141-145 5 p.

Research output: Contribution to journalArticle

Sinus Histiocytosis
Skull Base
Meningioma
Decompression
Radiotherapy