Nicolas Arbez

Research Associate

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Research Output 2002 2018

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Bowie, L. E., Maiuri, T., Alpaugh, M., Gabriel, M., Arbez, N., Galleguillos, D., Hung, C. L. K., Patel, S., Xia, J., Hertz, N. T., Ross, C. A., Litchfield, D. W., Sipione, S. & Truant, R., Jul 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. E7081-E7090

Research output: Contribution to journalArticle

Huntington Disease
Casein Kinase II
Adenine Phosphoribosyltransferase
DNA Damage

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, May 1 2017, In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Histone Code

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C. , Daigle, J. G. , Arbez, N. , Cunningham, K. C. , Zhang, K. , Ochaba, J. , Geater, C. , Morozko, E. , Stocksdale, J. , Glatzer, J. C. , Pham, J. T. , Ahmed, I. , Peng, Q. , Wadhwa, H. , Pletnikova, O. , Troncoso, J. C. , Duan, W. , Snyder, S. H. , Ranum, L. P. W. , Thompson, L. M. & 3 others Lloyd, T. E., Ross, C. A. & Rothstein, J. D., Apr 5 2017, In : Neuron. 94, 1, p. 93-107.e6

Research output: Contribution to journalArticle

Nuclear Pore
Nuclear Pore Complex Proteins
Huntington Disease
Cell Nucleus Active Transport

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

Ratovitski, T., O'Meally, R. N., Jiang, M., Chaerkady, R., Chighladze, E., Stewart, J. C., Wang, X., Arbez, N., Roby, E., Alexandris, A., Duan, W., Vijayvargia, R., Seong, I. S., Lavery, D. J., Cole, R. N. & Ross, C. A., Aug 4 2017, In : Journal of Proteome Research. 16, 8, p. 2692-2708 17 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Mass spectrometry
Huntington Disease
Phospho-Specific Antibodies

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

Arbez, N., Ratovitski, T., Roby, E., Chighladze, E., Stewart, J. C., Ren, M., Wang, X., Lavery, D. J. & Ross, C. A., Jan 1 2017, In : Journal of Biological Chemistry. 292, 47, p. 19238-19254 17 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Cluster Analysis
Huntington Disease