Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 11 Similar Profiles
Huntington Disease Medicine & Life Sciences
Neurons Medicine & Life Sciences
Proteins Chemical Compounds
Poisons Medicine & Life Sciences
Toxicity Chemical Compounds
Genes Medicine & Life Sciences
Mutation Medicine & Life Sciences
Brain Medicine & Life Sciences

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Research Output 2002 2017

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Lim, R. G. , Salazar, L. L. , Wilton, D. K. , King, A. R. , Stocksdale, J. T. , Sharifabad, D. , Lau, A. L. , Stevens, B. , Reidling, J. C. , Winokur, S. T. , Casale, M. S. , Thompson, L. M. , Pardo, M. , Díaz-Barriga, A. G. G. , Straccia, M. , Sanders, P. , Alberch, J. , Canals, J. M. , Kaye, J. A. , Dunlap, M. & 32 others Jo, L., May, H., Mount, E., Anderson-Bergman, C., Haston, K., Finkbeiner, S., Kedaigle, A. J., Gipson, T. A., Yildirim, F., Ng, C. W., Milani, P., Housman, D. E., Fraenkel, E., Allen, N. D., Kemp, P. J., Atwal, R. S., Biagioli, M., Gusella, J. F., MacDonald, M. E., Akimov, S. S., Arbez, N., Stewart, J., Ross, C. A., Mattis, V. B., Tom, C. M., Ornelas, L., Sahabian, A., Lenaeus, L., Mandefro, B., Sareen, D., Svendsen, C. N. & The HD iPSC Consortium May 1 2017 In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Research - peer-reviewArticle

Huntington Disease
Pharmacology
Genes
polyglutamine
Histone Code

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C. , Daigle, J. G. , Arbez, N. , Cunningham, K. C. , Zhang, K. , Ochaba, J. , Geater, C. , Morozko, E. , Stocksdale, J. , Glatzer, J. C. , Pham, J. T. , Ahmed, I. , Peng, Q. , Wadhwa, H. , Pletnikova, O. , Troncoso, J. C. , Duan, W. , Snyder, S. H. , Ranum, L. P. W. , Thompson, L. M. & 3 others Lloyd, T. E., Ross, C. A. & Rothstein, J. D. Apr 5 2017 In : Neuron. 94, 1, p. 93-107.e6

Research output: Research - peer-reviewArticle

Nuclear Pore
Huntington Disease
Nuclear Pore Complex Proteins
Cell Nucleus Active Transport
Neurons

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

Ratovitski, T., O'Meally, R. N., Jiang, M., Chaerkady, R., Chighladze, E., Stewart, J. C., Wang, X., Arbez, N., Roby, E., Alexandris, A., Duan, W., Vijayvargia, R., Seong, I. S., Lavery, D. J., Cole, R. N. & Ross, C. A. Aug 4 2017 In : Journal of Proteome Research. 16, 8, p. 2692-2708 17 p.

Research output: Research - peer-reviewArticle

Post Translational Protein Processing
Mass spectrometry
Proteins
Brain
Huntington Disease

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

Arbez, N., Ratovitski, T., Roby, E., Chighladze, E., Stewart, J. C., Ren, M., Wang, X., Lavery, D. J. & Ross, C. A. Jan 1 2017 In : Journal of Biological Chemistry. 292, 47, p. 19238-19254 17 p.

Research output: Research - peer-reviewArticle

Toxicity
Post Translational Protein Processing
Cluster Analysis
Proteins
Serine

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R. Dec 6 2017 In : Science Translational Medicine. 9, 419, eaal2332

Research output: Research - peer-reviewArticle

Huntington Disease
Quality Control
Energy Metabolism
Homeostasis
bexarotene