Nicolas Arbez

Research Associate

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Research Output 2002 2017

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Lim, R. G. , Salazar, L. L. , Wilton, D. K. , King, A. R. , Stocksdale, J. T. , Sharifabad, D. , Lau, A. L. , Stevens, B. , Reidling, J. C. , Winokur, S. T. , Casale, M. S. , Thompson, L. M. , Pardo, M. , Díaz-Barriga, A. G. G. , Straccia, M. , Sanders, P. , Alberch, J. , Canals, J. M. , Kaye, J. A. , Dunlap, M. & 31 others Jo, L., May, H., Mount, E., Anderson-Bergman, C., Haston, K., Finkbeiner, S., Kedaigle, A. J., Gipson, T. A., Yildirim, F., Ng, C. W., Milani, P., Housman, D. E., Fraenkel, E., Allen, N. D., Kemp, P. J., Atwal, R. S., Biagioli, M., Gusella, J. F., MacDonald, M. E., Akimov, S. S., Arbez, N., Stewart, J., Ross, C. A., Mattis, V. B., Tom, C. M., Ornelas, L., Sahabian, A., Lenaeus, L., Mandefro, B., Sareen, D. & The HD iPSC Consortium May 1 2017 In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Histone Code

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C. , Daigle, J. G. , Arbez, N. , Cunningham, K. C. , Zhang, K. , Ochaba, J. , Geater, C. , Morozko, E. , Stocksdale, J. , Glatzer, J. C. , Pham, J. T. , Ahmed, I. , Peng, Q. , Wadhwa, H. , Pletnikova, O. , Troncoso, J. C. , Duan, W. , Snyder, S. H. , Ranum, L. P. W. , Thompson, L. M. & 3 others Lloyd, T. E., Ross, C. A. & Rothstein, J. D. Apr 5 2017 In : Neuron. 94, 1, p. 93-107.e6

Research output: Contribution to journalArticle

Nuclear Pore
Nuclear Pore Complex Proteins
Huntington Disease
Cell Nucleus Active Transport

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

Ratovitski, T., O'Meally, R. N., Jiang, M., Chaerkady, R., Chighladze, E., Stewart, J. C., Wang, X., Arbez, N., Roby, E., Alexandris, A., Duan, W., Vijayvargia, R., Seong, I. S., Lavery, D. J., Cole, R. N. & Ross, C. A. Aug 4 2017 In : Journal of Proteome Research. 16, 8, p. 2692-2708 17 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Mass spectrometry
Huntington Disease
Phospho-Specific Antibodies

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

Arbez, N., Ratovitski, T., Roby, E., Chighladze, E., Stewart, J. C., Ren, M., Wang, X., Lavery, D. J. & Ross, C. A. Jan 1 2017 In : Journal of Biological Chemistry. 292, 47, p. 19238-19254 17 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Cluster Analysis
Huntington Disease

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R. Dec 6 2017 In : Science Translational Medicine. 9, 419, eaal2332

Research output: Contribution to journalArticle

Huntington Disease
Quality Control
Energy Metabolism
Retinoid X Receptors