Research Output 2003 2017

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2017

Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage

Chang, C. F., Wan, J., Li, Q., Renfroe, S. C., Heller, N. M. & Wang, J. Jul 1 2017 In : Neurobiology of Disease. 103, p. 54-69 16 p.

Research output: Research - peer-reviewArticle

Cerebral Hemorrhage
Microglia
Hematoma
Macrophages
Interleukin-10

Estrogen signaling contributes to sex differences in macrophage polarization during asthma aleksander keselman1

Fang, X., White, P. B. & Heller, N. M. Sep 1 2017 In : Journal of Immunology. 199, 5, p. 1573-1583 11 p.

Research output: Research - peer-reviewArticle

Sex Characteristics
Estrogens
Asthma
Macrophages
Interleukin-4
2016

Enhanced resolution of experimental ards through il-4-mediated lung macrophage reprogramming

D’Alessio, F. R., Craig, J. M., Singer, B. D., Files, D. C., Mock, J. R., Garibaldi, B. T., Fallica, J., Tripathi, A., Mandke, P., Gans, J. H., Limjunyawong, N., Sidhaye, V. K., Heller, N. M., Mitzner, W., King, L. S. & Aggarwal, N. R. Apr 15 2016 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 8, p. L733-L746

Research output: Research - peer-reviewArticle

Interleukin-4
Macrophages
Lung
Acute Lung Injury
Adult Respiratory Distress Syndrome
Pulmonary Hypertension
Hypoxia
Lung
Interleukin-6
Hypoxia-Inducible Factor 1
Insulin Receptor Substrate Proteins
Proteasome Endopeptidase Complex
Interleukin-4
Monocytes
Macrophages

The TORC1-activated proteins, p70S6K and GRB10, regulate IL-4 signaling and M2 macrophage polarization by modulating phosphorylation of insulin receptor substrate-2

Warren, K. J., Fang, X., Gowda, N. M., Thompson, J. J. & Heller, N. M. Nov 25 2016 In : Journal of Biological Chemistry. 291, 48, p. 24922-24930 9 p.

Research output: Research - peer-reviewArticle

70-kDa Ribosomal Protein S6 Kinases
Insulin Receptor Substrate Proteins
Phosphorylation
Macrophages
Interleukin-4
2015

Commentary: IL-4 and IL-13 receptors and signaling

McCormick, S. M. & Heller, N. M. Sep 1 2015 In : Cytokine. 75, 1, p. 38-50 13 p.

Research output: Research - peer-reviewArticle

Type II Interleukin-4 Receptors
Interleukin-13 Receptors
Interleukin-4
Therapeutics
Interleukin-13

Estrogen signaling modulates allergic inflammation and contributes to sex differences in asthma

Keselman, A. & Heller, N. 2015 In : Frontiers in Immunology. 6, NOV, 568

Research output: Research - peer-reviewArticle

Sex Characteristics
Estrogens
Asthma
Inflammation
Constriction

Regulation of macrophage, dendritic cell, and microglial phenotype and function by the SOCS proteins

McCormick, S. M. & Heller, N. M. 2015 In : Frontiers in Immunology. 6, OCT, 549

Research output: Research - peer-reviewArticle

Suppressor of Cytokine Signaling Proteins
Dendritic Cells
Macrophages
Phenotype
Cytokines

β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation

Berga-Bolaños, R., Sharma, A., Steinke, F. C., Pyaram, K., Kim, Y. H., Sultana, D. A., Fang, J. X., Chang, C. H., Xue, H. H., Heller, N. M. & Sen, J. M. Oct 19 2015 In : BMC Immunology. 16, 1, 62

Research output: Research - peer-reviewArticle

beta Catenin
Pneumonia
Natural Killer T-Cells
Thymus Gland
T-Lymphoid Precursor Cells
2012

IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro

Heller, N. M., Gwinn, W. M., Donnelly, R. P., Constant, S. L. & Keegan, A. D. Jun 28 2012 In : PLoS One. 7, 6, e39673

Research output: Research - peer-reviewArticle

Type I Interleukin-4 Receptors
Chemokine CCL11
Eosinophils
Interleukin-4
In Vitro Techniques

Regulation of inflammation by interleukin-4: A review of "alternatives"

Luzina, I. G., Keegan, A. D., Heller, N. M., Rook, G. A. W., Shea-Donohue, T. & Atamas, S. P. Oct 2012 In : Journal of Leukocyte Biology. 92, 4, p. 753-764 12 p.

Research output: Research - peer-reviewArticle

Interleukin-4
Inflammation
Macrophage Activation
Alternative Splicing
Exons
Interleukin-13 Receptors
Phosphorylation
Interleukin-13
Interleukin-4
Interleukins
2009

An atopy-associated polymorphism in the ectodomain of the IL-4Rα chain (V50) regulates the persistence of STAT6 phosphorylation

Ford, A. Q., Heller, N. M., Stephenson, L., Boothby, M. R. & Keegan, A. D. Aug 1 2009 In : Journal of Immunology. 183, 3, p. 1607-1616 10 p.

Research output: Research - peer-reviewArticle

Interleukin-4
Phosphorylation
Tyrosine
Complementary DNA
Cell Line
2008

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

LaPorte, S. L., Juo, Z. S., Vaclavikova, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D. & Garcia, K. C. Jan 25 2008 In : Cell. 132, 2, p. 259-272 14 p.

Research output: Research - peer-reviewArticle

Cytokine Receptors
Interleukin-13
Interleukin-4
Cytokines
Intracellular Membranes

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages

Heller, N. M., Qi, X., Junttila, I. S., Shirey, K. A., Vogel, S. N., Paul, W. E. & Keegan, A. D. Dec 23 2008 In : Science Signaling. 1, 51

Research output: Research - peer-reviewArticle

Insulin Receptor Substrate Proteins
Interleukin-13
Macrophages
Gene expression
Interleukin-4
2005

The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy

Fan, J., Heller, N. M., Gorospe, M., Atasoy, U. & Stellato, C. Nov 2005 In : European Respiratory Journal. 26, 5, p. 933-947 15 p.

Research output: Research - peer-reviewArticle

Chemokines
Hypersensitivity
Inflammation
Gene Expression
RNA Stability
2004

Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells

Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Stellato, C. & Schleimer, R. P. Nov 2004 In : Clinical and Experimental Allergy. 34, 11, p. 1690-1700 11 p.

Research output: Research - peer-reviewArticle

STAT6 Transcription Factor
Glucocorticoids
Epithelial Cells
Interleukin-4
Interleukin-13

Interferon-γ inhibits STAT6 signal transduction and gene expression in human airway epithelial cells

Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Rothman, P. B., Stellato, C. & Schleimer, R. P. Nov 2004 In : American Journal of Respiratory Cell and Molecular Biology. 31, 5, p. 573-582 10 p.

Research output: Research - peer-reviewArticle

STAT6 Transcription Factor
Interleukin-4
Interferon-gamma
Signal Transduction
Epithelial Cells

Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro

Gao, P. S., Heller, N. M., Walker, W., Chen, C. H., Moller, M., Plunkett, B., Roberts, M. H., Schleimer, R. P., Hopkin, J. M. & Huang, S. K. Jul 2004 In : Journal of Medical Genetics. 41, 7, p. 535-539 5 p.

Research output: Research - peer-reviewArticle

2003

Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry

Hubbard, W. C., Blum, A. E., Bickel, C. A., Heller, N. M. & Schleimer, R. P. Nov 15 2003 In : Analytical Biochemistry. 322, 2, p. 243-250 8 p.

Research output: Research - peer-reviewArticle

Triamcinolone Acetonide
Gas chromatography
Mass spectrometry
Negative ions
Fatty Acids

Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells

Kurosawa, S., Myers, A. C., Chen, L., Wang, S., Ni, J., Plitt, J. R., Heller, N. M., Bochner, B. S. & Schleimer, R. P. May 1 2003 In : American Journal of Respiratory Cell and Molecular Biology. 28, 5, p. 563-573 11 p.

Research output: Research - peer-reviewArticle

Inducible T-Cell Co-Stimulator Protein
B7 Antigens
Epithelial Cells
Ligands
Antigen Presentation