Research Output 2003 2018

2018

IL-4 and IL-13 receptor signaling from 4PS to insulin receptor substrate 2: There and back again, a historical view

Keegan, A. D., Zamorano, J., Keselman, A. & Heller, N. M. May 15 2018 In : Frontiers in Immunology. 9, MAY, 1037

Research output: Contribution to journalReview article

Interleukin-13 Receptors
Insulin Receptor Substrate Proteins
Insulin Receptor
Interleukin-4
Interleukin-4 Receptors
2017

Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage

Chang, C. F., Wan, J., Li, Q., Renfroe, S. C., Heller, N. M. & Wang, J. Jul 1 2017 In : Neurobiology of Disease. 103, p. 54-69 16 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Microglia
Hematoma
Macrophages
Interleukin-10

Estrogen signaling contributes to sex differences in macrophage polarization during asthma aleksander keselman1

Fang, X., White, P. B. & Heller, N. M. Sep 1 2017 In : Journal of Immunology. 199, 5, p. 1573-1583 11 p.

Research output: Contribution to journalArticle

Sex Characteristics
Estrogens
Asthma
Macrophages
Interleukin-4

New perspectives on the regulation of type II inflammation in asthma

Becerra-Díaz, M., Wills-Karp, M. & Heller, N. M. 2017 In : F1000Research. 6, 1014

Research output: Contribution to journalReview article

Asthma
Inflammation
Interleukin-13 Receptors
Interleukin-13
Interleukin-5
2016

Enhanced resolution of experimental ards through il-4-mediated lung macrophage reprogramming

D’Alessio, F. R., Craig, J. M., Singer, B. D., Files, D. C., Mock, J. R., Garibaldi, B. T., Fallica, J., Tripathi, A., Mandke, P., Gans, J. H., Limjunyawong, N., Sidhaye, V. K., Heller, N. M., Mitzner, W., King, L. S. & Aggarwal, N. R. Apr 15 2016 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 8, p. L733-L746

Research output: Contribution to journalArticle

Interleukin-4
Acute Lung Injury
Macrophages
Lung
Adult Respiratory Distress Syndrome
Pulmonary Hypertension
Interleukin-6
Lung
Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
Insulin Receptor Substrate Proteins
Phosphorylation
Macrophages
Proteasome Endopeptidase Complex
Interleukin-4

The TORC1-activated proteins, p70S6K and GRB10, regulate IL-4 signaling and M2 macrophage polarization by modulating phosphorylation of insulin receptor substrate-2

Warren, K. J., Fang, X., Gowda, N. M., Thompson, J. J. & Heller, N. M. Nov 25 2016 In : Journal of Biological Chemistry. 291, 48, p. 24922-24930 9 p.

Research output: Contribution to journalArticle

GRB10 Adaptor Protein
70-kDa Ribosomal Protein S6 Kinases
Insulin Receptor Substrate Proteins
Phosphorylation
Macrophages
2015

Commentary: IL-4 and IL-13 receptors and signaling

McCormick, S. M. & Heller, N. M. Sep 1 2015 In : Cytokine. 75, 1, p. 38-50 13 p.

Research output: Contribution to journalArticle

Type II Interleukin-4 Receptors
Interleukin-13 Receptors
Interleukin-4
Interleukin-13
Allergies

Estrogen signaling modulates allergic inflammation and contributes to sex differences in asthma

Keselman, A. & Heller, N. 2015 In : Frontiers in Immunology. 6, NOV, 568

Research output: Contribution to journalArticle

Sex Characteristics
Estrogens
Asthma
Inflammation
Constriction

Regulation of macrophage, dendritic cell, and microglial phenotype and function by the SOCS proteins

McCormick, S. M. & Heller, N. M. 2015 In : Frontiers in Immunology. 6, OCT, 549

Research output: Contribution to journalArticle

Suppressor of Cytokine Signaling Proteins
Dendritic Cells
Macrophages
Phenotype
Cytokines

β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation

Berga-Bolaños, R., Sharma, A., Steinke, F. C., Pyaram, K., Kim, Y. H., Sultana, D. A., Fang, J. X., Chang, C. H., Xue, H. H., Heller, N. M. & Sen, J. M. Oct 19 2015 In : BMC Immunology. 16, 1, 62

Research output: Contribution to journalArticle

beta Catenin
Natural Killer T-Cells
Pneumonia
T-Lymphoid Precursor Cells
Thymus Gland
2012

IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro

Heller, N. M., Gwinn, W. M., Donnelly, R. P., Constant, S. L. & Keegan, A. D. Jun 28 2012 In : PLoS One. 7, 6, e39673

Research output: Contribution to journalArticle

Type I Interleukin-4 Receptors
Chemokine CCL11
interleukin-4
eosinophils
Eosinophils

Regulation of inflammation by interleukin-4: A review of "alternatives"

Luzina, I. G., Keegan, A. D., Heller, N. M., Rook, G. A. W., Shea-Donohue, T. & Atamas, S. P. Oct 2012 In : Journal of Leukocyte Biology. 92, 4, p. 753-764 12 p.

Research output: Contribution to journalArticle

Interleukin-4
Inflammation
Macrophage Activation
Alternative Splicing
Exons
Interleukin-13 Receptors
Phosphorylation
Interleukin-13
Interleukin-4
Interleukins
2009

An atopy-associated polymorphism in the ectodomain of the IL-4Rα chain (V50) regulates the persistence of STAT6 phosphorylation

Ford, A. Q., Heller, N. M., Stephenson, L., Boothby, M. R. & Keegan, A. D. Aug 1 2009 In : Journal of Immunology. 183, 3, p. 1607-1616 10 p.

Research output: Contribution to journalArticle

Interleukin-4
Phosphorylation
Tyrosine
Complementary DNA
Cell Line
2008

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

LaPorte, S. L., Juo, Z. S., Vaclavikova, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D. & Garcia, K. C. Jan 25 2008 In : Cell. 132, 2, p. 259-272 14 p.

Research output: Contribution to journalArticle

Cytokine Receptors
Interleukin-13
Interleukin-4
Cytokines
Allergies

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages

Heller, N. M., Qi, X., Junttila, I. S., Shirey, K. A., Vogel, S. N., Paul, W. E. & Keegan, A. D. Dec 23 2008 In : Science Signaling. 1, 51

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Interleukin-13
Macrophages
Gene expression
Interleukin-4
2005

The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy

Fan, J., Heller, N. M., Gorospe, M., Atasoy, U. & Stellato, C. Nov 2005 In : European Respiratory Journal. 26, 5, p. 933-947 15 p.

Research output: Contribution to journalArticle

Chemokines
Hypersensitivity
Inflammation
Gene Expression
RNA Stability
2004

Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells

Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Stellato, C. & Schleimer, R. P. Nov 2004 In : Clinical and Experimental Allergy. 34, 11, p. 1690-1700 11 p.

Research output: Contribution to journalArticle

STAT6 Transcription Factor
Glucocorticoids
Epithelial Cells
Interleukin-4
Interleukin-13

Interferon-γ inhibits STAT6 signal transduction and gene expression in human airway epithelial cells

Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Rothman, P. B., Stellato, C. & Schleimer, R. P. Nov 2004 In : American Journal of Respiratory Cell and Molecular Biology. 31, 5, p. 573-582 10 p.

Research output: Contribution to journalArticle

STAT6 Transcription Factor
Signal transduction
Gene expression
Interleukin-4
Interferon-gamma

Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro

Gao, P. S., Heller, N. M., Walker, W., Chen, C. H., Moller, M., Plunkett, B., Roberts, M. H., Schleimer, R. P., Hopkin, J. M. & Huang, S. K. Jul 2004 In : Journal of Medical Genetics. 41, 7, p. 535-539 5 p.

Research output: Contribution to journalArticle

2003

Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry

Hubbard, W. C., Blum, A. E., Bickel, C. A., Heller, N. M. & Schleimer, R. P. Nov 15 2003 In : Analytical Biochemistry. 322, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

Triamcinolone Acetonide
Gas chromatography
Gas Chromatography
Mass spectrometry
Mass Spectrometry

Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells

Kurosawa, S., Myers, A. C., Chen, L., Wang, S., Ni, J., Plitt, J. R., Heller, N. M., Bochner, B. S. & Schleimer, R. P. May 1 2003 In : American Journal of Respiratory Cell and Molecular Biology. 28, 5, p. 563-573 11 p.

Research output: Contribution to journalArticle

Inducible T-Cell Co-Stimulator Protein
B7 Antigens
Epithelial Cells
Ligands
Antigen Presentation