Nickolas Papadopoulos

Professor

1993 …2020

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2020

Assessing aneuploidy with repetitive element sequencing

Douville, C., Cohen, J. D., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Schoen, R. E., Tie, J., Gibbs, P., Goggins, M., Wolfgang, C. L., Wang, T. L., Shih, I. M., Karchin, R., Lennon, A. M., Hruban, R. H., Tomasetti, C., Bettegowda, C., Kinzler, K. W. & 2 others, Papadopoulos, N. & Vogelstein, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4858-4863 6 p.

Research output: Contribution to journalArticle

Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology

Rodriguez Pena, M. D. C., Springer, S. U., Taheri, D., Li, L., Tregnago, A. C., Eich, M. L., Eltoum, I. E. A., VandenBussche, C. J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Mar 1 2020, In : Virchows Archiv. 476, 3, p. 423-429 7 p.

Research output: Contribution to journalArticle

2019

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Miller, M. S., Douglass, J., Hwang, M. S., Skora, A. D., Murphy, M., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Zhou, S. & Gabelli, S. B., Dec 13 2019, In : Journal of Biological Chemistry. 294, 50, p. 19322-19334 13 p.

Research output: Contribution to journalArticle

Open Access

Applications of liquid biopsies for cancer

Mattox, A. K., Bettegowda, C., Zhou, S., Papadopoulos, N., Kinzler, K. W. & Vogelstein, B., Aug 28 2019, In : Science translational medicine. 11, 507, aay1984.

Research output: Contribution to journalArticle

Open Access

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

Tie, J., Cohen, J. D., Wang, Y., Christie, M., Simons, K., Lee, M., Wong, R., Kosmider, S., Ananda, S., McKendrick, J., Lee, B., Cho, J. H., Faragher, I., Jones, I. T., Ptak, J., Schaeffer, M. J., Silliman, N., Dobbyn, L., Li, L., Tomasetti, C. & 4 others, Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2019, (Accepted/In press) In : JAMA Oncology.

Research output: Contribution to journalArticle

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer

Lee, B., Lipton, L., Cohen, J., Tie, J., Javed, A. A., Li, L., Goldstein, D., Burge, M., Cooray, P., Nagrial, A., Tebbutt, N. C., Thomson, B., Nikfarjam, M., Harris, M., Haydon, A., Lawrence, B., Tai, D. W. M., Simons, K., Lennon, A. M., Wolfgang, C. L. & 5 others, Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Sep 1 2019, In : Annals of Oncology. 30, 9, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

Direct detection and quantification of neoantigens

Wang, Q., Douglass, J., Hwang, M. S., Hsiue, E. H. C., Mog, B. J., Zhang, M., Papadopoulos, N., Kinzler, K. W., Zhou, S. & Vogelstein, B., Jan 1 2019, In : Cancer Immunology Research. 7, 11, p. 1748-1754 7 p.

Research output: Contribution to journalArticle

Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma

Eich, M. L., Rodriguez Pena, M. D. C., Springer, S. U., Taheri, D., Tregnago, A. C., Salles, D. C., Bezerra, S. M., Cunha, I. W., Fujita, K., Ertoy, D., Bivalacqua, T. J., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Oct 1 2019, In : Modern Pathology. 32, 10, p. 1544-1550 7 p.

Research output: Contribution to journalArticle

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access

Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer

Wang, Y., Li, L., Cohen, J. D., Kinde, I., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tie, J., Gibbs, P., Tomasetti, C., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Olsson, L., Aug 2019, In : JAMA Oncology. 5, 8, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: A prospective biomarker study

Tie, J., Cohen, J. D., Wang, Y., Li, L., Christie, M., Simons, K., Elsaleh, H., Kosmider, S., Wong, R., Yip, D., Lee, M., Tran, B., Rangiah, D., Burge, M., Goldstein, D., Singh, M., Skinner, I., Faragher, I., Croxford, M., Bampton, C. & 14 others, Haydon, A., Jones, I. T., S Karapetis, C., Price, T., Schaefer, M. J., Ptak, J., Dobbyn, L., Silliman, N., Kinde, I., Tomasetti, C., Papadopoulos, N., Kinzler, K., Volgestein, B. & Gibbs, P., Apr 1 2019, In : Gut. 68, 4, p. 663-671 9 p.

Research output: Contribution to journalArticle

Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations

Palsgrove, D. N., Taheri, D., Springer, S. U., Cowan, M., Guner, G., Mendoza Rodriguez, M. A., Rodriguez Pena, M. D. C., Wang, Y., Kinde, I., Ricardo, B. F. P., Cunha, I., Fujita, K., Ertoy, D., Kinzler, K. W., Bivalacqua, T., Papadopoulos, N., Vogelstein, B. & Netto, G. J., Mar 1 2019, In : Human Pathology. 85, p. 1-9 9 p.

Research output: Contribution to journalArticle

The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations

Wong, R., Tie, J., Lee, M., Cohen, J., Wang, Y., Li, L., Ma, S., Christie, M., Kosmider, S., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

2018

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T. L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Fader, A. N., Gilbert, L. & Papadopoulos, N., Mar 21 2018, In : Science translational medicine. 10, 433, 8793.

Research output: Contribution to journalArticle

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L. V., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Precancerous neoplastic cells can move through the pancreatic ductal system

Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., Hruban, R. H., Klimstra, D. S., Papadopoulos, N., Nowak, M. A., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Sep 13 2018, In : Nature. 561, 7722, p. 201-205 5 p.

Research output: Contribution to journalArticle

2017

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Masica, D. L., Molin, M. D., Wolfgang, C., Tomita, T., Ostovaneh, M. R., Blackford, A., Moran, R. A., Law, J. K., Barkley, T., Goggins, M. S., Canto, M., Pittman, M., Eshleman, J., Ali, S. Z., Fishman, E. K., Kamel, I. R., Raman, S. P., Zaheer, A., Ahuja, N., Makary, M. A. & 16 others, Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & O'Broin-Lennon, A. M., 2017, In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Cancer-associated mutations in endometriosis without cancer

Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R. C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F. & 20 others, Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T. L., Vogelstein, B., Yong, P. J., Huntsman, D. G. & Shih, I. M., May 11 2017, In : New England Journal of Medicine. 376, 19, p. 1835-1848 14 p.

Research output: Contribution to journalArticle

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., Hong, J., Attiyeh, M., Javier, B., Wood, L. D., Hruban, R. H., Nowak, M. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Jan 16 2017, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N. S., Rucki, A. A., Laheru, D., Donehower, R., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F. & 26 others, Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K. M., Fader, A. N., Taube, J., Housseau, F., Spetzler, D., Xiao, N., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J. R., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Selected reaction monitoring approach for validating peptide biomarkers

Wang, Q., Zhang, M., Tomita, T., Vogelstein, J. T., Zhou, S., Papadopoulos, N., Kinzler, K. W. & Vogelstein, B., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13519-13524 6 p.

Research output: Contribution to journalArticle

Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder

Rodriguez Pena, M. D. C., Tregnago, A. C., Eich, M. L., Springer, S., Wang, Y., Taheri, D., Ertoy, D., Fujita, K., Bezerra, S. M., Cunha, I. W., Raspollini, M. R., Yu, L., Bivalacqua, T., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Jun 8 2017, (Accepted/In press) In : Virchows Archiv. p. 1-7 7 p.

Research output: Contribution to journalArticle

2016

Aristolochic acid in the etiology of renal cell carcinoma

Hoang, M. L., Chen, C. H., Chen, P. C., Roberts, N., Dickman, K. G., Yun, B. H., Turesky, R. J., Pu, Y. S., Vogelstein, B., Papadopoulos, N., Grollman, A. P., Kinzler, K. W. & Rosenquist, T. A., Dec 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 12, p. 1600-1608 9 p.

Research output: Contribution to journalArticle

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Tie, J., Wang, Y., Tomasetti, C., Li, L., Springer, S., Kinde, I., Silliman, N., Tacey, M., Wong, H. L., Christie, M., Kosmider, S., Skinner, I., Wong, R., Steel, M., Tran, B., Desai, J., Jones, I., Haydon, A., Hayes, T., Price, T. J. & 6 others, Strausberg, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jul 6 2016, In : Science Translational Medicine. 8, 346, 346ra92.

Research output: Contribution to journalArticle

Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder

Cowan, M. L., Springer, S., Nguyen, D., Taheri, D., Guner, G., Mendoza Rodriguez, M. A., Wang, Y., Kinde, I., Del Carmen Rodriguez Pena, M., VandenBussche, C., Olson, M. T., Cunha, I., Fujita, K., Ertoy, D., Kinzler, K. W., Bivalacqua, T., Papadopoulos, N., Vogelstein, B. & Netto, G. J., Jul 1 2016, In : Human Pathology. 53, p. 8-13 6 p.

Research output: Contribution to journalArticle

Diagnostic potential of tumor DNA from ovarian cyst fluid

Wang, Y., Sundfeldt, K., Mateoiu, C., Shih, I. M., Kurman, R. J., Schaefer, J., Silliman, N., Kinde, I., Springer, S., Foote, M., Kristjansdottir, B., James, N., Kinzler, K. W., Papadopoulos, N., Diaz, L. A. & Vogelstein, B., Jul 15 2016, In : eLife. 5, 2016JULY, e15175.

Research output: Contribution to journalArticle

Evaluating the evaluation of cancer driver genes

Tokheim, C. J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Karchin, R., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14330-14335 6 p.

Research output: Contribution to journalArticle

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing

Hoang, M. L., Kinde, I., Tomasetti, C., McMahon, K. W., Rosenquist, T. A., Grollman, A. P., Kinzler, K. W., Vogelstein, B. & Papadopoulos, N., Aug 30 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 35, p. 9846-9851 6 p.

Research output: Contribution to journalArticle

High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma

Nguyen, D., Taheri, D., Springer, S., Cowan, M., Guner, G., Rodriguez, M. A. M., Wang, Y., Kinde, I., VandenBussche, C., Olson, M. T., Ricardo, B. F. P., Cunha, I., Fujita, K., Ertoy, D., Kinzler, K. W., Bivalacqua, T., Papadopoulos, N., Vogelstein, B. & Netto, G. J., Aug 12 2016, (Accepted/In press) In : Virchows Archiv. p. 1-8 8 p.

Research output: Contribution to journalArticle

High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

Cowan, M., Springer, S., Nguyen, D., Taheri, D., Guner, G., Rodriguez, M. A. M., Wang, Y., Kinde, I., VandenBussche, C. J., Olson, M. T., Cunha, I., Fujita, K., Ertoy, D., Bivalacqua, T. J., Kinzler, K., Vogelstein, B., Netto, G. J. & Papadopoulos, N., May 1 2016, In : Modern Pathology. 29, 5, p. 511-515 5 p.

Research output: Contribution to journalArticle

Identification of novel noncoding transcripts in telomerase-negative yeast using RNA-seq

Niederer, R. O., Papadopoulos, N. & Zappulla, D. C., Jan 20 2016, In : Scientific reports. 6, 19376.

Research output: Contribution to journalArticle

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers

Robles, A. I., Traverso, G., Zhang, M., Roberts, N., Khan, M. A., Joseph, C., Lauwers, G. Y., Selaru, F., Popoli, M., Pittman, M. E., Ke, X., Hruban, R. H., Meltzer, S., Kinzler, K. W., Vogelstein, B., Harris, C. C. & Papadopoulos, N., Apr 1 2016, In : Gastroenterology. 150, 4, p. 931-943 13 p.

Research output: Contribution to journalArticle

Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer

Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., Stoffel, E., Syngal, S., Zogopoulos, G., Ali, S. Z., Axilbund, J., Chaffee, K. G., Chen, Y. C., Cote, M. L., Childs, E. J., Douville, C. & 25 others, Goes, F. S., Herman, J. M., Iacobuzio-Donahue, C., Kramer, M., Makohon-Moore, A., McCombie, R. W., Wyatt Mcmahon, K., Niknafs, N., Parla, J., Pirooznia, M., Potash, J. B., Rhim, A. D., Smith, A. L., Wang, Y., Wolfgang, C. L., Wood, L. D., Zandi, P. P., Goggins, M., Karchin, R., Eshleman, J. R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Hruban, R. H. & Klein, A. P., Feb 2016, In : Cancer discovery. 6, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

Whole-genome sequencing of salivary gland adenoid cystic carcinoma

Rettig, E. M., Talbot, C. C., Sausen, M., Jones, S., Bishop, J. A., Wood, L. D., Tokheim, C., Niknafs, N., Karchin, R., Fertig, E., Wheelan, S., Marchionni, L., Considine, M., Fakhry, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Ha, P. K. & Agrawal, N., Apr 1 2016, In : Cancer Prevention Research. 9, 4, p. 265-274 10 p.

Research output: Contribution to journalArticle

2015

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

Springer, S., Wang, Y., Dal Molin, M., Masica, D. L., Jiao, Y., Kinde, I., Blackford, A., Raman, S. P., Wolfgang, C. L., Tomita, T., Niknafs, N., Douville, C., Ptak, J., Dobbyn, L., Allen, P. J., Klimstra, D. S., Schattner, M. A., Schmidt, C. M., Yip-Schneider, M., Cummings, O. W. & 47 others, Brand, R. E., Zeh, H. J., Singhi, A. D., Scarpa, A., Salvia, R., Malleo, G., Zamboni, G., Falconi, M., Jang, J. Y., Kim, S. W., Kwon, W., Hong, S. M., Song, K. B., Kim, S. C., Swan, N., Murphy, J., Geoghegan, J., Brugge, W., Fernandez-Del Castillo, C., Mino-Kenudson, M., Schulick, R., Edil, B. H., Adsay, V., Paulino, J., Van Hooft, J., Yachida, S., Nara, S., Hiraoka, N., Yamao, K., Hijioka, S., Van Der Merwe, S., Goggins, M., Canto, M. I., Ahuja, N., Hirose, K., Makary, M., Weiss, M. J., Cameron, J., Pittman, M., Eshleman, J. R., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Karchin, R., Hruban, R. H., Vogelstein, B. & Lennon, A. M., Nov 2015, In : Gastroenterology. 149, 6, p. 1501-1510 10 p.

Research output: Contribution to journalArticle

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

Tie, J., Kinde, I., Wang, Y., Wong, H. L., Roebert, J., Christie, M., Tacey, M., Wong, R., Singh, M., Karapetis, C. S., Desai, J., Tran, B., Strausberg, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2015, In : Annals of Oncology. 26, 8, p. 1715-1722 8 p.

Research output: Contribution to journalArticle

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke

Li, R., Faden, D. L., Fakhry, C., Langelier, C., Jiao, Y., Wang, Y., Wilkerson, M. D., Pedamallu, C. S., Old, M., Lang, J., Loyo, M., Ahn, S. M., Tan, M., Gooi, Z., Chan, J., Richmon, J., Wood, L. D., Hruban, R. H., Bishop, J., Westra, W. H. & 11 others, Chung, C. H., Califano, J., Gourin, C. G., Bettegowda, C., Meyerson, M., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Derisi, J. L., Koch, W. M. & Agrawal, N., Nov 2015, In : Head and Neck. 37, 11, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

Wang, Y., Springer, S., Mulvey, C. L., Silliman, N., Schaefer, J., Sausen, M., James, N., Rettig, E. M., Guo, T., Pickering, C. R., Bishop, J. A., Chung, C. H., Califano, J. A., Eisele, D. W., Fakhry, C., Gourin, C. G., Ha, P. K., Kang, H., Kiess, A., Koch, W. M. & 12 others, Myers, J. N., Quon, H., Richmon, J. D., Sidransky, D., Tufano, R. P., Westra, W. H., Bettegowda, C., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Agrawal, N., Jun 24 2015, In : Science translational medicine. 7, 293, 293ra104.

Research output: Contribution to journalArticle

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

Wang, Y., Springer, S., Zhang, M., McMahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Groves, M. L., Jallo, G. I., Lim, M., Olivi, A., Quinones-Hinojosa, A., Rigamonti, D., Riggins, G. J., Sciubba, D. M., Weingart, J. D. & 11 others, Wolinsky, J. P., Ye, X., Oba-Shinjo, S. M., Marie, S. K. N., Holdhoff, M., Agrawal, N., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Bettegowda, C., Aug 4 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 31, p. 9704-9709 6 p.

Research output: Contribution to journalArticle

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes

Skora, A. D., Douglass, J., Hwang, M. S., Tam, A. J., Blosser, R. L., Gabelli, S. B., Cao, J., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Zhou, S., Aug 11 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 32, p. 9967-9972 6 p.

Research output: Contribution to journalArticle

Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation

Jiao, Y., Lumpkins, K., Terhune, J., Hruban, R. H., Klein, A., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Strauch, E., Mar 1 2015, In : Pancreatology. 15, 2, p. 194-196 3 p.

Research output: Contribution to journalArticle

Lavage of the uterine cavity for molecular detection of Müllerian duct carcinomas: A proof-of-concept study

Maritschnegg, E., Wang, Y., Pecha, N., Horvat, R., Van Nieuwenhuysen, E., Vergote, I., Heitz, F., Sehouli, J., Kinde, I., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Speiser, P. & Zeillinger, R., Dec 20 2015, In : Journal of Clinical Oncology. 33, 36, p. 4293-4300 8 p.

Research output: Contribution to journalArticle

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers

Stern, J. L., Theodorescu, D., Vogelstein, B., Papadopoulos, N. & Cech, T. R., Nov 1 2015, In : Genes and Development. 29, 21, p. 2219-2224 6 p.

Research output: Contribution to journalArticle