Nicholas Zachos

Associate Professor

20022019
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Research Output 2002 2019

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Article
2019

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf V600E -Induced Tumorigenesis

Tao, Y., Kang, B., Petkovich, D. A., Bhandari, Y. R., In, J., Stein-O'Brien, G., Kong, X., Xie, W., Zachos, N., Maegawa, S., Vaidya, H., Brown, S., Chiu Yen, R. W., Shao, X., Thakor, J., Lu, Z., Cai, Y., Zhang, Y., Mallona, I., Peinado, M. A. & 6 others, Zahnow, C. A., Ahuja, N., Fertig, E., Issa, J. P., Baylin, S. B. & Easwaran, H., Feb 11 2019, In : Cancer cell. 35, 2, p. 315-328.e6

Research output: Contribution to journalArticle

Epigenomics
Organoids
Colon
Carcinogenesis
Clustered Regularly Interspaced Short Palindromic Repeats

Evaluating shigella flexneri pathogenesis in the human enteroid model

Ranganathan, S., Doucet, M., Grassel, C. L., Delaine-Elias, B. O., Zachos, N. & Barry, E. M., Apr 1 2019, In : Infection and Immunity. 87, 4, e00740.

Research output: Contribution to journalArticle

Open Access
Shigella flexneri
Shigella
Transformed Cell Line
Animal Models
Intestines

Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections

Zou, W. Y., Blutt, S. E., Crawford, S. E., Ettayebi, K., Zeng, X. L., Saxena, K., Ramani, S., Karandikar, U. C., Zachos, N. & Estes, M. K., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1576, p. 229-247 19 p.

Research output: Contribution to journalArticle

Virus Diseases
Rotavirus
Norovirus
Viruses
Rotavirus Infections
2018

Enterohemorrhagic E. Coli (EHEC)—Secreted serine protease EspP stimulates electrogenic ion transport in human colonoid monolayers

Tse, C. M., In, J. G., Yin, J., Donowitz, M., Doucet, M., Foulke-Abel, J., Ruiz-Perez, F., Nataro, J. P., Zachos, N., Kaper, J. B. & Kovbasnjuk, O. N., Sep 1 2018, In : Toxins. 10, 9, 351.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Ion Transport
Serine Proteases
Escherichia coli
Monolayers

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C., Jun 13 2018, In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT4
G-Protein-Coupled Receptors
Gastrointestinal Transit
Fluids and Secretions
Tryptophan

The Function of ATPase Copper Transporter ATP7B in Intestine

Pierson, H., Muchenditsi, A., Kim, B. E., Ralle, M., Zachos, N., Huster, D. & Lutsenko, S., Jan 1 2018, In : Gastroenterology. 154, 1, p. 168-180.e5

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Intestines
Adenosine Triphosphatases
Copper
Enterocytes
2017

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

Saxena, K., Simon, L. M., Zeng, X. L., Blutt, S. E., Crawford, S. E., Sastri, N. P., Karandikar, U. C., Ajami, N. J., Zachos, N., Kovbasnjuk, O. N., Donowitz, M., Conner, M. E., Shaw, C. A. & Estes, M. K., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. E570-E579

Research output: Contribution to journalArticle

Enterovirus Infections
Interferons
Rotavirus
Rotavirus Infections
Enterovirus

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

Noel, G., Baetz, N. W., Staab, J. F., Donowitz, M., Kovbasnjuk, O. N., Pasetti, M. F. & Zachos, N., Mar 27 2017, In : Scientific Reports. 7, 45270.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Coculture Techniques
Macrophages
Intestinal Mucosa
Cytokines

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins

Cil, O., Phuan, P. W., Gillespie, A. M., Lee, S., Tradtrantip, L., Yin, J., Tse, C. M., Zachos, N., Lin, R., Donowitz, M. & Verkman, A. S., Feb 1 2017, In : FASEB Journal. 31, 2, p. 751-760 10 p.

Research output: Contribution to journalArticle

Oxazines
Cystic Fibrosis Transmembrane Conductance Regulator
Enterotoxins
Diarrhea
Cholera Toxin

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Vernetti, L., Gough, A., Baetz, N., Blutt, S., Broughman, J. R., Brown, J. A., Foulke-Abel, J., Hasan, N., In, J., Kelly, E., Kovbasnjuk, O. N., Repper, J., Senutovitch, N., Stabb, J., Yeung, C., Zachos, N., Donowitz, M., Estes, M., Himmelfarb, J., Truskey, G. & 2 others, Wikswo, J. P. & Taylor, D. L., Feb 8 2017, In : Scientific Reports. 7, 42296.

Research output: Contribution to journalArticle

Proximal Kidney Tubule
Blood-Brain Barrier
Intestines
Skeletal Muscle
Liver

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class i PDZ-binding motifs

Cha, B., Yang, J., Singh, V., Zachos, N., Sarker, R., Chen, T. E., Chakraborty, M., Tse, C. M. & Donowitz, M., May 19 2017, In : Journal of Biological Chemistry. 292, 20, p. 8279-8290 12 p.

Research output: Contribution to journalArticle

PDZ Domains
Cell membranes
Mutation
Cell Membrane
Proteins
2016

Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids

In, J., Foulke-Abel, J., Zachos, N., Hansen, A. M., Kaper, J. B., Bernstein, H. D., Halushka, M. K., Blutt, S., Estes, M. K., Donowitz, M. & Kovbasnjuk, O. N., Jan 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 1, p. 48-62.e3

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Mucus
Stem Cells
Microvilli
Mucin-2

Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology

Zachos, N. C., Kovbasnjuk, O., Foulke-Abel, J., In, J., Blutt, S. E., De Jonge, H. R., Estes, M. K. & Donowitz, M., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3759-3766 8 p.

Research output: Contribution to journalArticle

Organoids
Physiology
Stem cells
Stem Cells
Host-Pathogen Interactions

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

Foulke-Abel, J., In, J., Yin, J., Zachos, N., Kovbasnjuk, O. N., Estes, M. K., De Jonge, H. & Donowitz, M., Mar 1 2016, In : Gastroenterology. 150, 3, p. 638-649e8

Research output: Contribution to journalArticle

Ion Transport
Cystic Fibrosis Transmembrane Conductance Regulator
Sodium-Hydrogen Antiporter
Colforsin
Cyclic AMP

Human intestinal enteroids: A new model to study human rotavirus infection, host restriction, and pathophysiology

Saxena, K., Blutt, S. E., Ettayebi, K., Zeng, X. L., Broughman, J. R., Crawford, S. E., Karandikar, U. C., Sastri, N. P., Conner, M. E., Opekun, A. R., Graham, D. Y., Qureshi, W., Sherman, V., Foulke-Abel, J., In, J., Kovbasnjuk, O. N., Zachos, N., Donowitz, M. & Estes, M. K., 2016, In : Journal of Virology. 90, 1, p. 43-56 14 p.

Research output: Contribution to journalArticle

Rotavirus Infections
Rotavirus
pathophysiology
infection
Enteroendocrine Cells
Developmental Biology
Infection
Research
Small Intestine
Intercellular Signaling Peptides and Proteins

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

Cil, O., Phuan, P. W., Son, J. H., Zhu, J. S., Ku, C. K., Tabib, N. A., Teuthorn, A. P., Ferrera, L., Zachos, N., Lin, R., Galietta, L. J. V., Donowitz, M., Kurth, M. J. & Verkman, ALAN. L. A. N. S., Jun 14 2016, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Constipation
Intestinal Secretions
Fluids and Secretions
Fluids
2015

Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function

Grant, C. N., Mojica, S. G., Sala, F. G., Ryan Hill, J., Levin, D. E., Speer, A. L., Barthel, E. R., Shimada, H., Zachos, N. & Grikscheit, T. C., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 8, p. G664-G677

Research output: Contribution to journalArticle

Small Intestine
Microvilli
Short Bowel Syndrome
Stem Cells
Epithelium

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea

Janecke, A. R., Heinz-Erian, P., Yin, J., Petersen, B. S., Franke, A., Lechner, S., Fuchs, I., Melancon, S., Uhlig, H. H., Travis, S., Marinier, E., Perisic, V., Ristic, N., Gerner, P., Booth, I. W., Wedenoja, S., Baumgartner, N., Vodopiutz, J., Frechette-Duval, M. C., De Lafollie, J. & 13 others, Persad, R., Warner, N., Tse, C. M., Sud, K., Zachos, N., Sarker, R., Zhu, X., Muise, A. M., Zimmer, K. P., Witt, H., Zoller, H., Donowitz, M. & Müller, T., Dec 1 2015, In : Human Molecular Genetics. 24, 23, p. 6614-6623 10 p.

Research output: Contribution to journalArticle

Protons
Sodium
Missense Mutation
Mutation
Sodium-Hydrogen Antiporter
2014

Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42

Zachos, N., Alamelumangpuram, B., Lee, L. J., Wang, P. & Kovbasnjuk, O. N., 2014, In : Cellular Physiology and Biochemistry. 33, 3, p. 869-881 13 p.

Research output: Contribution to journalArticle

Clathrin
Carbachol
Endocytosis
Lipids
Caco-2 Cells

Human enteroids as an ex-vivo model of host–pathogen interactions in the gastrointestinal tract

Foulke-Abel, J., In, J., Kovbasnjuk, O. N., Zachos, N., Ettayebi, K., Blutt, S. E., Hyser, J. M., Zeng, X. L., Crawford, S. E., Broughman, J. R., Estes, M. K. & Donowitz, M., Sep 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

Gastrointestinal Tract
Stem cells
Pharmaceutical Preparations
Animals
Drug therapy

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids

Jin, B. J., Battula, S., Zachos, N., Kovbasnjuk, O. N., Fawlke-Abel, J., In, J., Donowitz, M. & Verkman, A. S., Mar 1 2014, In : Biomicrofluidics. 8, 2, 24106.

Research output: Contribution to journalArticle

Microfluidics
Cystic Fibrosis
platforms
Drug Evaluation
Cholera Toxin

NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol

Yang, J., Singh, V., Chen, T. E., Sarker, R., Xiong, L., Cha, B., Jin, S., Li, X., Tse, C. M., Zachos, N. & Donowitz, M., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20039-20053 15 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Carbachol
Dimerization
Proteins
Actinin
Diarrhea
Therapeutics
Electrolytes
Rehydration Solutions
Pharmaceutical Preparations
2013

Human enteroids: Preclinical models of non-inflammatory diarrhea

Kovbasnjuk, O. N., Zachos, N., In, J., Foulke-Abel, J., Ettayebi, K., Hyser, J. M., Broughman, J. R., Zeng, X. L., Middendorp, S., De Jonge, H. R., Estes, M. K. & Donowitz, M., Dec 20 2013, In : Stem Cell Research and Therapy. 4, SUPPL.1, S3.

Research output: Contribution to journalArticle

Diarrhea
Carrier Proteins
Drug therapy
Physiology
Escherichia coli

NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells

Yang, J., Singh, V., Cha, B., Chen, T. E., Sarker, R., Murtazina, R., Jin, S., Zachos, N., Patterson, G. H., Tse, C. M., Kovbasnjuk, O. N., Li, X. & Donowitz, M., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 16960-16974 15 p.

Research output: Contribution to journalArticle

Microvilli
Multiprotein Complexes
Proteins
Proximal Kidney Tubule
Calcium Ionophores
Sodium-Hydrogen Antiporter
Caco-2 Cells
Carbachol
src Homology Domains
Multiprotein Complexes
2012

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na +/H + exchanger 3 (NHE3) by a NHERF2 protein-dependent process

Zizak, M., Chen, T., Bartonicek, D., Sarker, R., Zachos, N., Cha, B., Kovbasnjuk, O. N., Korac, J., Mohan, S., Cole, R. N., Chen, Y., Tse, C. M. & Donowitz, M., Apr 13 2012, In : Journal of Biological Chemistry. 287, 16, p. 13442-13456 15 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinases
Sodium-Hydrogen Antiporter
Brushes
Microvilli
Calcium-Calmodulin-Dependent Protein Kinase Type 2
2011

Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles

Donowitz, M., Singh, S., Singh, P., Chakraborty, M., Chen, Y., Murtazina, R., Gucek, M., Cole, R. N., Zachos, N., Salahuddin, F. F., Kovbasnjuk, O. N., Broere, N., Smalley-Freed, W. G., Reynolds, A. B., Hubbard, A. L., Seidler, U., Weinman, E., De Jonge, H. R., Hogema, B. M. & Li, X., Jun 2011, In : Physiological Genomics. 43, 11, p. 674-684 11 p.

Research output: Contribution to journalArticle

Proteome
Microvilli
Knockout Mice
Membranes
Proteins

Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli

Zhu, X., Cha, B., Zachos, N., Sarker, R., Chakraborty, M., Chen, T. E., Kovbasnjuk, O. N. & Donowitz, M., Oct 7 2011, In : Journal of Biological Chemistry. 286, 40, p. 34486-34496 11 p.

Research output: Contribution to journalArticle

Opossums
Brushes
Microvilli
Calcium
Kidney

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity

Sarker, R., Valkhoff, V. E., Zachos, N., Lin, R., Cha, B., Chen, T. E., Guggino, S., Zizak, M., de Jonge, H., Hogema, B. & Donowitz, M., Apr 2011, In : American Journal of Physiology - Cell Physiology. 300, 4

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Small Interfering RNA
Lentivirus
Epidermal Growth Factor
Caco-2 Cells

NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum

Murtazina, R., Kovbasnjuk, O. N., Chen, T. E., Zachos, N., Chen, Y., Kocinsky, H. S., Hogema, B. M., Seidler, U., de Jonge, H. R. & Donowitz, M., Jul 2011, In : American Journal of Physiology - Cell Physiology. 301, 1

Research output: Contribution to journalArticle

Second Messenger Systems
Ileum
Uridine Triphosphate
Cyclic GMP-Dependent Protein Kinase Type II
Small Intestine
2010

Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles

Donowitz, M., Singh, S., Singh, P., Salahuddin, F. F., Chen, Y., Chakraborty, M., Murtazina, R., Gucek, M., Cole, R. N., Zachos, N., Kovbasnjuk, O. N., Broere, N., Smalley-Freed, W. G., Reynolds, A. B., Hubbard, A. L., Seidler, U., Weinman, E., De Jonge, H. R., Hogema, B. M. & Li, X., Nov 2010, In : Physiological Genomics. 42 A, 3, p. 200-210 11 p.

Research output: Contribution to journalArticle

Proteome
Microvilli
Knockout Mice
Membranes
Proteins

Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis

Alex, P., Ye, M., Zachos, N., Sipes, J., Nguyen, T., Suhodrev, M., Gonzales, L., Arora, Z., Zhang, T., Centola, M., Guggino, S. E. & Li, X., Apr 1 2010, In : Journal of Immunology. 184, 7, p. 3988-3996 9 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Knockout Mice
Ulcerative Colitis
Interleukin-6

Epac1 mediates protein kinase A-independent mechanism of forskolinactivated intestinal chloride secretion

Hoque, K. M., Woodward, O. M., Van Rossum, D. B., Zachos, N., Chen, L., Leung, G. P. H., Guggino, W. B., Guggino, S. E. & Tse, C. M., Jan 2010, In : Journal of General Physiology. 135, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

Intestinal Secretions
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Chlorides
Colforsin

Mutations in TTC37 Cause Trichohepatoenteric Syndrome (Phenotypic Diarrhea of Infancy)

Hartley, J. L., Zachos, N., Dawood, B., Donowitz, M., Forman, J., Pollitt, R. J., Morgan, N. V., Tee, L., Gissen, P., Kahr, W. H. A., Knisely, A. S., Watson, S., Chitayat, D., Booth, I. W., Protheroe, S., Murphy, S., de Vries, E., Kelly, D. A. & Maher, E. R., Jun 2010, In : Gastroenterology. 138, 7

Research output: Contribution to journalArticle

Diarrhea
Mutation
Proteins
Blood Platelets
H(+)-K(+)-Exchanging ATPase

NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region

Mohan, S., Tse, C. M., Gabelli, S. B., Sarker, R., Cha, B., Fahie, K., Nadella, M., Zachos, N., Tu-Sekine, B., Raben, D. M., Amzel, M. L. & Donowitz, M., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34566-34578 13 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Amino Acids
Mutation
Lipids
Sodium-Hydrogen Antiporter

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid

Cha, B., Zhu, X. C., Chen, W., Jones, M., Ryoo, S., Zachos, N., Chen, T. E., Lin, R., Sarker, R., Kenworthy, A. K., Tse, C. M., Kovbasnjuk, O. N. & Donowitz, M., Jul 15 2010, In : Journal of Cell Science. 123, 14, p. 2434-2443 10 p.

Research output: Contribution to journalArticle

Microvilli
Acids
1-Phosphatidylinositol 4-Kinase
Exocytosis
Actin Cytoskeleton
2009

Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis

Alex, P., Zachos, N., Nguyen, T., Gonzales, L., Chen, T. E., Conklin, L. S., Centola, M. & Li, X., 2009, In : Inflammatory Bowel Diseases. 15, 3, p. 341-352 12 p.

Research output: Contribution to journalArticle

Colitis
Cytokines
Interleukin-17
Inflammatory Bowel Diseases
Interleukin-6

Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: Potential contributors to IBD-associated diarrhea

Sullivan, S., Alex, P., Dassopoulos, T., Zachos, N., Iacobuzio-Donahue, C., Donowitz, M., Brant, S. R., Cuffari, C., Harris, M. L., Datta, L., Conklin, L., Chen, Y. & Li, X., 2009, In : Inflammatory Bowel Diseases. 15, 2, p. 261-274 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Colitis
Inflammatory Bowel Diseases
Diarrhea
Down-Regulation

NHE3 regulatory complexes

Donowitz, M., Mohan, S., Zhu, C. X., Chen, T. E., Lin, R., Cha, B., Zachos, N., Murtazina, R., Sarker, R. & Li, X., Jun 1 2009, In : Journal of Experimental Biology. 212, 11, p. 1638-1646 9 p.

Research output: Contribution to journalArticle

PDZ Domains
Proximal Kidney Tubule
Sodium-Hydrogen Antiporter
proximal tubules
second messengers

NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells

Zachos, N., Li, X., Kovbasnjuk, O. N., Hogema, B., Sarker, R., Lee, L. J., Li, M., de Jonge, H. & Donowitz, M., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23708-23718 11 p.

Research output: Contribution to journalArticle

Carbachol
Cell membranes
Small Interfering RNA
Calcium
Confocal microscopy

Phospholipase C-γ binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity

Zachos, N., van Rossum, D. B., Li, X., Caraveo, G., Sarker, R., Cha, B., Mohan, S., Desiderio, S., Patterson, R. L. & Donowitz, M., Jul 17 2009, In : Journal of Biological Chemistry. 284, 29, p. 19437-19444 8 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Type C Phospholipases
Programmable logic controllers
Calcium
Transient Receptor Potential Channels
2008

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism

Zachos, N., Hodson, C., Kovbasnjuk, O. N., Li, X., Thelin, W. R., Cha, B., Milgram, S. & Donowitz, M., 2008, In : Cellular Physiology and Biochemistry. 22, 5-6, p. 693-704 12 p.

Research output: Contribution to journalArticle

Calcium
PDZ Domains
Cell Membrane
Proteins
Density Gradient Centrifugation

Proteome of murine jejunal brush border membrane vesicles (Journal of Proteome Research (2007) 6, 10, (4068-4079))

Donowitz, M., Singh, S., Salahuddin, F. F., Hogema, B. M., Chen, Y., Gucek, M., Cole, R. N., Ham, A., Zachos, N., Kovbasnjuk, O. N., Lapierre, L. A., Broere, N., Goldenring, J., DeJonge, H. & Li, X., Jan 2008, In : Journal of Proteome Research. 7, 1, p. 456 1 p.

Research output: Contribution to journalArticle

Brushes
Proteome
Membranes

Regulation of expression of microvillus membrane proteins by estrogen in baboon fetal ovarian oocytes

Zachos, N., Burch, M. G., Billiar, R. B., Li, C., Albrecht, E. D. & Pepe, G. J., Dec 2008, In : Biology of Reproduction. 79, 6, p. 1160-1168 9 p.

Research output: Contribution to journalArticle

Papio
Microvilli
Oocytes
Estrogens
Membrane Proteins
2007

Proteome of murine jejunal brush border membrane vesicles

Donowitz, M., Singh, S., Salahuddin, F. F., Hogema, B. M., Chen, Y., Gucek, M., Cole, R. N., Zachos, N., Kovbasnjuk, O. N., Lapierre, L. A., Broere, N., Goldenring, J., Dejonge, H. & Li, X., Oct 2007, In : Journal of Proteome Research. 6, 10, p. 4068-4079 12 p.

Research output: Contribution to journalArticle

Brushes
Proteome
Microvilli
Cations
Symporters
Sodium-Hydrogen Antiporter
Ileum
Protons
Protein Isoforms
Sodium
2005

Molecular physiology of intestinal Na+/H+ exchange

Zachos, N., Tse, C. M. & Donowitz, M., 2005, In : Annual Review of Physiology. 67, p. 411-443 33 p.

Research output: Contribution to journalArticle

Sodium
Cell Membrane
Protein Isoforms
Proteins
Phosphorylation

NHERF family and NHE3 regulation

Donowitz, M., Cha, B., Zachos, N., Brett, C. L., Sharma, A., Tse, C. M. & Li, X., Aug 15 2005, In : Journal of Physiology. 567, 1, p. 3-11 9 p.

Research output: Contribution to journalArticle

Microvilli
Proteins
Proximal Kidney Tubule
Sodium-Hydrogen Antiporter
Names