Nicholas Zachos

Associate Professor

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Research Output 2002 2018

Enterohemorrhagic E. Coli (EHEC)—Secreted serine protease EspP stimulates electrogenic ion transport in human colonoid monolayers

Tse, C. M., In, J. G., Yin, J., Donowitz, M., Doucet, M., Foulke-Abel, J., Ruiz-Perez, F., Nataro, J. P., Zachos, N. C., Kaper, J. B. & Kovbasnjuk, O., Sep 1 2018, In : Toxins. 10, 9, 351

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Ion Transport
Serine Proteases
Cystic Fibrosis Transmembrane Conductance Regulator
Escherichia coli

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C., Jun 13 2018, In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Gastrointestinal Transit
Fluids and Secretions

The Function of ATPase Copper Transporter ATP7B in Intestine

Pierson, H., Muchenditsi, A., Kim, B. E., Ralle, M., Zachos, N., Huster, D. & Lutsenko, S., Jan 1 2018, In : Gastroenterology. 154, 1, p. 168-180.e5

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Apolipoproteins B
Adenosine Triphosphatases

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

Saxena, K., Simon, L. M., Zeng, X. L., Blutt, S. E., Crawford, S. E., Sastri, N. P., Karandikar, U. C., Ajami, N. J., Zachos, N. C., Kovbasnjuk, O., Donowitz, M., Conner, M. E., Shaw, C. A. & Estes, M. K., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. E570-E579

Research output: Contribution to journalArticle

Enterovirus Infections
Rotavirus Infections

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

Noel, G., Baetz, N. W., Staab, J. F., Donowitz, M., Kovbasnjuk, O., Pasetti, M. F. & Zachos, N. C., Mar 27 2017, In : Scientific Reports. 7, 45270

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Coculture Techniques
Intestinal Mucosa