Nicholas Zachos

Associate Professor

20022018
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Research Output 2002 2018

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C. Jun 13 2018 In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Gastrointestinal Transit
Fluids and Secretions
Tryptophan
Epithelium

The Function of ATPase Copper Transporter ATP7B in Intestine

Pierson, H., Muchenditsi, A., Kim, B. E., Ralle, M., Zachos, N., Huster, D. & Lutsenko, S. Jan 1 2018 In : Gastroenterology. 154, 1, p. 168-180.e5

Research output: Contribution to journalArticle

Chylomicrons
Hepatolenticular Degeneration
Apolipoproteins B
Intestines
Adenosine Triphosphatases

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

Saxena, K., Simon, L. M., Zeng, X. L., Blutt, S. E., Crawford, S. E., Sastri, N. P., Karandikar, U. C., Ajami, N. J., Zachos, N. C., Kovbasnjuk, O., Donowitz, M., Conner, M. E., Shaw, C. A. & Estes, M. K. Jan 24 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. E570-E579

Research output: Contribution to journalArticle

Enterovirus Infections
Interferons
Rotavirus
Rotavirus Infections
Enterovirus

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

Noel, G., Baetz, N. W., Staab, J. F., Donowitz, M., Kovbasnjuk, O., Pasetti, M. F. & Zachos, N. C. Mar 27 2017 In : Scientific Reports. 7, 45270

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Coculture Techniques
Macrophages
Intestinal Mucosa
Cytokines

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins

Cil, O., Phuan, P. W., Gillespie, A. M., Lee, S., Tradtrantip, L., Yin, J., Tse, M., Zachos, N. C., Lin, R., Donowitz, M. & Verkman, A. S. Feb 1 2017 In : FASEB Journal. 31, 2, p. 751-760 10 p.

Research output: Contribution to journalArticle

Oxazines
Cystic Fibrosis Transmembrane Conductance Regulator
Enterotoxins
Diarrhea
Cholera Toxin