Nicholas Roberts

Assistant Professor

20112019
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Research Output 2011 2019

2019

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

Alzheimer’s Disease Neuroimaging Initiative, Aug 1 2019, In : PLoS genetics. 15, 8, p. e1008344

Research output: Contribution to journalArticle

Open Access
pancreatic neoplasms
Neoplasm Genes
adenocarcinoma
Pancreatic Neoplasms
sensitivity analysis

Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture

Matsushita, Y., Smith, B., Delannoy, M., Trujillo, M. A., Chianchiano, P., McMillan, R., Kamiyama, H., Liang, H., Thompson, E. D., Hruban, R. H., Matsui, W., Wood, L. D., Roberts, N. J. & Eshleman, J. R., Oct 1 2019, In : Pancreas. 48, 9, p. 1225-1231 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Organoids
Pancreatic Ducts
Microvilli

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N., London, N., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access
Deceleration
Cell Division
Incidence
Neoplasms
Stem Cells

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Hutchings, D., Jiang, Z., Skaro, M., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Zheng, L., Klimstra, D. S., Brand, R. E., Singhi, A. D., Goggins, M. S., Klein, A., Roberts, N. & Hruban, R. H., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Pancreatic Neoplasms
Colloids
Adenocarcinoma
Carcinoma

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., Springer, S., Dal Molin, M., Masica, D., Scharpf, R. B., Thompson, E. D., He, J., Wolfgang, C. L., Hruban, R. H., Roberts, N. J., Lennon, A. M. & 3 others, Jiao, Y., Karchin, R. & Wood, L. D., Oct 1 2019, In : Gastroenterology. 157, 4, p. 1123-1137.e22

Research output: Contribution to journalArticle

Clone Cells
Mutation
Neoplasms
Carcinogenesis
Pancreatic Neoplasms

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasms
Pancreatic Neoplasms
Mutation
Confidence Intervals

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E. D., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Roberts, N. J., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Neoplasms
Mutation
Genes
2018

Exome-Wide Association Study of Pancreatic Cancer Risk

Grant, R. C., Denroche, R. E., Borgida, A., Virtanen, C., Cook, N., Smith, A. L., Connor, A. A., Wilson, J. M., Peterson, G., Roberts, N., Klein, A., Grimmond, S. M., Biankin, A., Cleary, S., Moore, M., Lemire, M., Zogopoulos, G., Stein, L. & Gallinger, S., Feb 1 2018, In : Gastroenterology. 154, 3, p. 719-722.e3

Research output: Contribution to journalArticle

Exome
Pancreatic Neoplasms
Genes
Genetic Heterogeneity
Neoplasm Genes

Familial pancreatic cancer

Roberts, N. & Klein, A., Apr 11 2018, Pancreatic Cancer. Springer New York, p. 553-572 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
Mutation
Penetrance
Germ-Line Mutation
Early Detection of Cancer

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë, M., Rezaee, N., Asrani, K., Skaro, M., Groot, V. P., Wu, P. H., Olson, M. T., Hong, S. M., Kim, S. J., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Wirtz, D., Roberts, N., Offerhaus, G. J. A., Brosens, L. A. A., Wood, L. D. & Hruban, R. H., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1530-1535 6 p.

Research output: Contribution to journalArticle

Pancreas
Anatomy
Pathology
Pancreatic Neoplasms
Paraffin

IPMNs with co-occurring invasive cancers: Neighbours but not always relatives

Felsenstein, M., Noë, M., Masica, D. L., Hosoda, W., Chianchiano, P., Fischer, C. G., Lionheart, G., Brosens, L. A. A., Pea, A., Yu, J., Gemenetzis, G., Groot, V. P., Makary, M. A., He, J., Weiss, M. J., Cameron, J. L., Wolfgang, C., Hruban, R. H., Roberts, N., Karchin, R. & 2 others, Goggins, M. S. & Wood, L. D., Mar 2 2018, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Neoplasms
Adenocarcinoma
Mucinous Adenocarcinoma
Carcinoma
Carcinoma, Intraductal, Noninfiltrating

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., MacGregor-Das, A., Borges, M., Wolfgang, C., Weiss, M. J., He, J., Canto, M., Petersen, G. M., Gallinger, S., Syngal, S., Brand, R. E., Rustgi, A., Olson, S. H., Stoffel, E., Cote, M. L. & 13 others, Zogopoulos, G., Potash, J. B., Goes, F. S., McCombie, R. W., Zandi, P. P., Pirooznia, M., Kramer, M., Parla, J., Eshleman, J., Roberts, N., Hruban, R. H., Klein, A. & Goggins, M. S., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4767-4772 6 p.

Research output: Contribution to journalArticle

Carboxypeptidases A
Pancreatic Neoplasms
Endoplasmic Reticulum Stress
Mutation
Enzymes

Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1

Noë, M., Pea, A., Luchini, C., Felsenstein, M., Barbi, S., Bhaijee, F., Yonescu, R., Ning, Y., Adsay, N. V., Zamboni, G., Lawlor, R. T., Scarpa, A., Offerhaus, G. J. A., Brosens, L. A. A., Hruban, R. H., Roberts, N. & Wood, L. D., May 30 2018, (Accepted/In press) In : Modern Pathology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Exome
Neurofibromatosis 1
Neuroendocrine Tumors
Chromosomes, Human, Pair 22
Neoplasms
2017

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Cho, C., Macgregor-Das, A., Siddiqui, A., Witmer, P. D., Tamura, K., Song, T. J., Almario, J. A. N., Brant, A., Borges, M., Ford, M., Barkley, T., He, J., Weiss, M. J., Wolfgang, C., Roberts, N., Hruban, R. H. & 2 others, Klein, A. & Goggins, M. S., Oct 20 2017, In : Journal of Clinical Oncology. 35, 30, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms

Inherited pancreatic cancer

Chen, F., Roberts, N. & Klein, A., Dec 1 2017, In : Chinese Clinical Oncology. 6, 6, 58.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Penetrance
Neoplasm Genes
Ovarian Neoplasms
Cluster Analysis
2016

Aristolochic acid in the etiology of renal cell carcinoma

Hoang, M. L., Chen, C. H., Chen, P. C., Roberts, N., Dickman, K. G., Yun, B. H., Turesky, R. J., Pu, Y. S., Vogelstein, B., Papadopoulos, N., Grollman, A. P., Kinzler, K. W. & Rosenquist, T. A., Dec 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 12, p. 1600-1608 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Aristolochia
Exome
Taiwan
aristolochic acid I

Clostridium novyi-NT in cancer therapy

Staedtke, V., Roberts, N., Bai, R. & Zhou, S., Jun 1 2016, In : Genes and Diseases. 3, 2, p. 144-152 9 p.

Research output: Contribution to journalReview article

Clostridium
Genetic engineering
Neoplasms
Recombinant DNA
Anaerobic Bacteria

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers

Robles, A. I., Traverso, G., Zhang, M., Roberts, N., Khan, M. A., Joseph, C., Lauwers, G. Y., Selaru, F., Popoli, M., Pittman, M. E., Ke, X., Hruban, R. H., Meltzer, S., Kinzler, K. W., Vogelstein, B., Harris, C. C. & Papadopoulos, N., Apr 1 2016, In : Gastroenterology. 150, 4, p. 931-943 13 p.

Research output: Contribution to journalArticle

Exome
Inflammatory Bowel Diseases
Colorectal Neoplasms
Mutation
Neoplasms

Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer

Roberts, N., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., Stoffel, E., Syngal, S., Zogopoulos, G., Ali, S. Z., Axilbund, J., Chaffee, K. G., Chen, Y. C., Cote, M. L., Childs, E. J., Douville, C. & 25 others, Goes, F. S., Herman, J. M., Iacobuzio-Donahue, C., Kramer, M., Makohon-Moore, A., McCombie, R. W., McMahon, K. W., Niknafs, N., Parla, J., Pirooznia, M., Potash, J. B., Rhim, A. D., Smith, A. L., Wang, Y., Wolfgang, C., Wood, L. D., Zandi, P. P., Goggins, M. S., Karchin, R., Eshleman, J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Hruban, R. H. & Klein, A., Feb 1 2016, In : Cancer Discovery. 6, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Genome
Exome
Inborn Genetic Diseases
2015

A histomorphologic comparison of familial and sporadic pancreatic cancers

Singhi, A. D., Ishida, H., Ali, S. Z., Goggins, M. S., Canto, M., Wolfgang, C., Meriden, Z., Roberts, N., Klein, A. & Hruban, R. H., Jul 1 2015, In : Pancreatology. 15, 4, p. 387-391 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Dysplastic Nevus Syndrome
Peutz-Jeghers Syndrome
Neoplasms

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: A PACGENE study

Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. S., Hruban, R. H., Cote, M. L., McWilliams, R. R., Roberts, N., Cannon-Albright, L. A., Li, D., Moyes, K., Wenstrup, R. J., Hartman, A. R., Seminara, D., Klein, A. & Petersen, G. M., Jul 2 2015, In : Genetics in Medicine. 17, 7, p. 569-577 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genetic Testing
Genes
Viverridae
2014

Familial and sporadic pancreatic cancer share the same molecular pathogenesis

Norris, A. L., Roberts, N., Jones, S., Wheelan, S., Papadopoulos, N., Vogelstein, B., Kinzler, K. W., Hruban, R. H., Klein, A. & Eshleman, J., Sep 21 2014, In : Familial Cancer. 14, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Age of Onset
Genes
RNA Sequence Analysis

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

Roberts, N., Zhang, L., Janku, F., Collins, A., Bai, R., Staedtke, V., Rusk, A. W., Tung, D., Miller, M., Roix, J., Khanna, K. V., Murthy, R., Benjamin, R. S., Helgason, T., Szvalb, A. D., Bird, J. E., Roy-Chowdhuri, S., Zhang, H. H., Qiao, Y., Karim, B. & 18 others, McDaniel, J., Elpiner, A., Sahora, A., Lachowicz, J., Phillips, B., Turner, A., Klein, M. K., Post, G., Diaz, L. A., Riggins, G. J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Bettegowda, C., Huso, D. L., Varterasian, M., Saha, S. & Zhou, S., Aug 13 2014, In : Science Translational Medicine. 6, 249, 249ra111.

Research output: Contribution to journalArticle

Clostridium
Spores
Injections
Neoplasms
Canidae
2013

Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS

Agrawal, N., Jiao, Y., Sausen, M., Leary, R., Bettegowda, C., Roberts, N., Bhan, S., Ho, A. S., Khan, Z., Bishop, J., Westra, W. H., Wood, L. D., Hruban, R. H., Tufano, R. P., Robinson, B., Dralle, H., Toledo, S. P. A., Toledo, R. A., Morris, L. G. T., Ghossein, R. A. & 8 others, Fagin, J. A., Chan, T. A., Velculescu, V. E., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Nelkin, B. D. & Ball, D. W., Feb 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 2

Research output: Contribution to journalArticle

Genes
Tumors
Mutation
Exons
Exome
Hereditary Neoplastic Syndromes
Pancreatic Neoplasms
Genome
Human Genome
Technology
2012

ATM mutations in patients with hereditary pancreatic cancer

Roberts, N., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., Axilbund, J., Schulick, R., Ali, S. Z., Eshleman, J., Velculescu, V. E., Goggins, M. S., Vogelstein, B., Papadopoulos, N., Hruban, R. H., Kinzler, K. W. & 1 others, Klein, A., Jan 2012, In : Cancer Discovery. 2, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Pancreatic Neoplasms
Mutation
Genes
Adenocarcinoma

Response to comments on "The predictive capacity of personal genome sequencing"

Vogelstein, B., Roberts, N., Vogelstein, J. T., Parmigiani, G., Kinzler, K. W. & Velculescu, V. E., May 23 2012, In : Science Translational Medicine. 4, 135, 135lr3.

Research output: Contribution to journalArticle

Public Health
Genome
Power (Psychology)

The predictive capacity of personal genome sequencing

Roberts, N., Vogelstein, J. T., Parmigiani, G., Kinzler, K. W., Vogelstein, B. & Velculescu, V. E., May 9 2012, In : Science Translational Medicine. 4, 133, 133ra58.

Research output: Contribution to journalArticle

Genome
Population
Monozygotic Twins
Genetic Testing
Health Insurance
2011
Hydromorphone
Opioid Analgesics
Analgesics
Pain
Breakthrough Pain

Systemic use of tumor necrosis factor alpha as an anticancer agent

Roberts, N., Zhou, S., Diaz, L. A. & Holdhoff, M., Oct 2011, In : Oncotarget. 2, 10, p. 739-751 13 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Tumor Necrosis Factor-alpha
Extremities
Perfusion
Drug Therapy