Nazareno Paolocci

Assistant Professor

19942019

Research output per year

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Research Output

2019

Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2

Cannavo, A., Marzano, F., Elia, A., Liccardo, D., Bencivenga, L., Gambino, G., Perna, C., Rapacciuolo, A., Cittadini, A., Ferrara, N., Paolocci, N., Koch, W. & Rengo, G., Jan 1 2019, In : Frontiers in Pharmacology. 10, JULY, 888.

Research output: Contribution to journalArticle

Open Access

Anesthetic Agents Isoflurane and Propofol Decrease Maximal Ca2+-Activated Force and Thus Contractility in the Failing Myocardium

Meng, T., Ren, X., Chen, X., Yu, J., Agrimi, J., Paolocci, N. & Gao, W. D., Dec 1 2019, In : The Journal of pharmacology and experimental therapeutics. 371, 3, p. 615-623 9 p.

Research output: Contribution to journalArticle

Empagliflozin and HFrEF: Known and Possible Benefits of NHE1 Inhibition

Jun, S., Aon, M. A. & Paolocci, N., Nov 2019, In : JACC: Basic to Translational Science. 4, 7, p. 841-844 4 p.

Research output: Contribution to journalEditorial

Open Access

Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice

Cortassa, S., Caceres, V., Tocchetti, C. G., Bernier, M., de Cabo, R., Paolocci, N., Sollott, S. J. & Aon, M. A., Jan 1 2019, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function

Keceli, G., Majumdar, A., Thorpe, C. N., Jun, S., Tocchetti, C. G., Lee, D., Mahaney, J. E., Paolocci, N. & Toscano, J. P., Jun 3 2019, In : The Journal of general physiology. 151, 6, p. 758-770 13 p.

Research output: Contribution to journalArticle

Open Access

Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion

Agrimi, J., Spalletti, C., Baroni, C., Keceli, G., Zhu, G., Caragnano, A., Matteucci, M., Chelko, S., Ramirez-Correa, G. A., Bedja, D., Casieri, V., Di Lascio, N., Scalco, A., Beltrami, A. P., Paolocci, N., Caleo, M. & Lionetti, V., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
2018

Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology

Cannavo, A., Bencivenga, L., Liccardo, D., Elia, A., Marzano, F., Gambino, G., D'Amico, M. L., Perna, C., Ferrara, N., Rengo, G. & Paolocci, N., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1 p.

Research output: Contribution to journalReview article

Circulating biomarkers for cardiovascular diseases: The beats never stop editorial

Xi, L., Kouvelos, G. & Paolocci, N., Jul 1 2018, In : Acta Pharmacologica Sinica. 39, 7, p. 1065-1067 3 p.

Research output: Contribution to journalEditorial

Death of an antioxidant brings heart failure with preserved ejection fraction to life: 5-oxoproline and post-ischaemic cardio-renal dysfunction

Sourdon, J., Keceli, G., Lindsey, M. L. & Paolocci, N., Dec 1 2018, In : Cardiovascular Research. 114, 14, p. 1819-1821 3 p.

Research output: Contribution to journalArticle

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

Rainer, P. P., Dong, P., Sorge, M., Fert-Bober, J., Holewinski, R. J., Wang, Y., Foss, C. A., An, S. S., Baracca, A., Solaini, G., Glabe, C. G., Pomper, M. G., Van Eyk, J. E., Tomaselli, G. F., Paolocci, N. & Agnetti, G., May 11 2018, In : Circulation research. 122, 10, p. e75-e83

Research output: Contribution to journalArticle

Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes

Deshwal, S., Forkink, M., Hu, C. H., Buonincontri, G., Antonucci, S., Di Sante, M., Murphy, M. P., Paolocci, N., Mochly-Rosen, D., Krieg, T., Di Lisa, F. & Kaludercic, N., Feb 19 2018, (Accepted/In press) In : Cell Death and Differentiation. p. 1-15 15 p.

Research output: Contribution to journalArticle

2017

Burning Redoxstats in the Brainstem Lack of Nrf2 and the Rise of Hypertension

Paolocci, N., Cannavo, A., Chelko, S. & Montano, N., Jun 1 2017, In : Hypertension. 69, 6, p. 1019-1021 3 p.

Research output: Contribution to journalComment/debate

Contribution of autonomic reflexes to the hyperadrenergic state in heart failure

Toschi-Dias, E., Rondon, M. U. P. B., Cogliati, C., Paolocci, N., Tobaldini, E. & Montano, N., Mar 30 2017, In : Frontiers in Neuroscience. 11, MAR, 162.

Research output: Contribution to journalReview article

GRK2 Regulates α2-Adrenergic Receptor–Dependent Catecholamine Release in Human Adrenal Chromaffin Cells

Department of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy, Mar 21 2017, In : Journal of the American College of Cardiology. 69, 11, p. 1515-1517 3 p.

Research output: Contribution to journalLetter

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo

Li, Y., Zhu, G., Paolocci, N., Zhang, P., Takahashi, C., Okumus, N., Heravi, A., Keceli, G., Ramirez-Correa, G., Kass, D. A. & Murphy, A. M., Sep 1 2017, In : Circulation. Heart failure. 10, 9

Research output: Contribution to journalArticle

Sphingosine kinases and sphingosine 1-phosphate receptors: Signaling and actions in the cardiovascular system

Cannavo, A., Liccardo, D., Komici, K., Corbi, M., de Lucia, C., Femminella, G. D., Elia, A., Bencivenga, L., Ferrara, N., Koch, W. J., Paolocci, N. & Rengo, G., Aug 23 2017, In : Frontiers in Pharmacology. 8, AUG, 556.

Research output: Contribution to journalReview article

β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling

Cannavo, A., Rengo, G., Liccardo, D., Pun, A., Gao, E., George, A. J., Gambino, G., Rapacciuolo, A., Leosco, D., Ibanez, B., Ferrara, N., Paolocci, N. & Koch, W. J., Jul 11 2017, In : Journal of the American College of Cardiology. 70, 2, p. 182-192 11 p.

Research output: Contribution to journalArticle

2016

Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways

Sysa-Shah, P., Tocchetti, C. G., Gupta, M., Rainer, P. P., Shen, X., Kang, B. H., Belmonte, F., Li, J., Xu, Y., Guo, X., Bedja, D., Gao, W. D., Paolocci, N., Rath, R., Sawyer, D. B., Naga Prasad, S. V. & Gabrielson, K. L., Mar 1 2016, In : Cardiovascular Research. 109, 3, p. 358-373 16 p.

Research output: Contribution to journalArticle

From Heaven to Heart: Nitroxyl (HNO) in the Cardiovascular System and Beyond

Paolocci, N., Keceli, G., Wink, D. A. & Kass, D. A., Sep 1 2016, The Chemistry and Biology of Nitroxyl (HNO). Elsevier Inc., p. 353-387 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Cofilin-2 phosphorylation and sequestration in myocardial aggregates: Novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy

Subramanian, K., Gianni, D., Balla, C., Assenza, G. E., Joshi, M., Semigran, M. J., Macgillivray, T. E., Van Eyk, J. E., Agnetti, G., Paolocci, N., Bamburg, J. R., Agrawal, P. B. & Del Monte, F., Mar 31 2015, In : Journal of the American College of Cardiology. 65, 12, p. 1199-1214 16 p.

Research output: Contribution to journalArticle

ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity

Belmonte, F., Das, S., Sysa-Shah, P., Sivakumaran, V., Stanley, B., Guo, X., Paolocci, N., Aon, M. A., Nagane, M., Kuppusamy, P., Steenbergen, C. J. & Gabrielson, K. L., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 8, p. H1271-H1280

Research output: Contribution to journalArticle

Erratum: Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation (Proc Natl Acad Sci USA (2015) 112 (1880-1885) DOI: 10.1073/pnas.1504270112)

Feng, N., Huke, S., Zhu, G., Tocchetti, C. G., Shi, S., Aiba, T., Kaludercic, N., Hoover, D. B., Beck, S., Mankowski, J. L., Tomaselli, G. F., Bers, D. M., Kass, D. A. & Paolocci, N., Mar 31 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 13, p. E1691

Research output: Contribution to journalArticle

From metabolomics to fluxomics: A computational procedure to translate metabolite profiles into metabolic fluxes

Cortassa, S., Caceres, V., Bell, L. N., O'Rourke, B., Paolocci, N. & Aon, M. A., Jan 6 2015, In : Biophysical Journal. 108, 1, p. 163-172 10 p.

Research output: Contribution to journalArticle

Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Tocchetti, C. G., Stanley, B. A., Sivakumaran, V., Bedja, D., O'Rourke, B., Paolocci, N., Cortassa, S. & Aon, M. A., 2015, In : Clinical Science. 129, 7, p. 561-574 14 p.

Research output: Contribution to journalArticle

Protective Mechanisms of Mitochondria and Heart Function in Diabetes

Aon, M. A., Tocchetti, C. G., Bhatt, N., Paolocci, N. & Cortassa, S., Jun 10 2015, In : Antioxidants and Redox Signaling. 22, 17, p. 1563-1586 24 p.

Research output: Contribution to journalArticle

Removal of abnormal myofilament O-GlcNAcylation restores Ca2+ sensitivity in diabetic cardiac muscle

Ramirez-Correa, G. A., Ma, J., Slawson, C., Zeidan, Q., Lugo-Fagundo, N. S., Xu, M., Shen, X., Gao, W. D., Caceres, V., Chakir, K., DeVine, L., Cole, R. N., Marchionni, L., Paolocci, N., Hart, G. W. & Murphy, A. M., Oct 1 2015, In : Diabetes. 64, 10, p. 3573-3587 15 p.

Research output: Contribution to journalArticle

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse

Zhu, G., Groneberg, D., Sikka, G., Hori, D., Ranek, M., Nakamura, T., Takimoto, E., Paolocci, N., Berkowitz, D. E., Friebe, A. & Kass, D. A., Feb 21 2015, In : Hypertension. 65, 2, p. 385-392 8 p.

Research output: Contribution to journalArticle

2014

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

Kelly, K. M., Tocchetti, C. G., Lyashkov, A., Tarwater, P. M., Bedja, D., Graham, D. R., Beck, S. E., Metcalf Pate, K. A., Queen, S. E., Adams, R. J., Paolocci, N. & Mankowski, J. L., 2014, In : Journal of the American Heart Association. 3, 2

Research output: Contribution to journalArticle

Erratum: H2S increases survival during sepsis: Protective effect of CHOP inhibition (Journal of Immunology (2014) 192 (1806-1814))

Ferlito, M., Wang, Q., Fulton, W. B., Colombani, P., Marchionni, L., Fox-Talbot, K., Paolocci, N. & Steenbergen, C. J., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3991 1 p.

Research output: Contribution to journalArticle

H2S increases survival during sepsis: Protective effect of CHOP inhibition

Ferlito, M., Wang, Q., Fulton, W. B., Colombani, P., Marchionni, L., Fox-Talbot, K., Paolocci, N. & Steenbergen, C. J., Feb 15 2014, In : Journal of Immunology. 192, 4, p. 1806-1814 9 p.

Research output: Contribution to journalArticle

Monoamine Oxidase b prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts

Kaludercic, N., Carpi, A., Nagayama, T., Sivakumaran, V., Zhu, G., Lai, E. W., Bedja, D., De Mario, A., Chen, K., Gabrielson, K. L., Lindsey, M. L., Pacak, K., Takimoto, E., Shih, J. C., Kass, D. A., Di Lisa, F. & Paolocci, N., 2014, In : Antioxidants and Redox Signaling. 20, 2, p. 267-280 14 p.

Research output: Contribution to journalArticle

Monoamine oxidases as sources of oxidants in the heart

Kaludercic, N., Mialet-Perez, J., Paolocci, N., Parini, A. & Di Lisa, F., 2014, In : Journal of Molecular and Cellular Cardiology. 73, p. 34-42 9 p.

Research output: Contribution to journalArticle

New redox-related arrows in the arsenal of cardiac disease treatment

Kirk, J. A. & Paolocci, N., Nov 10 2014, In : Antioxidants and Redox Signaling. 21, 14, p. 1945-1948 4 p.

Research output: Contribution to journalArticle

2013

A novel approach for the acute treatment of heart failure

Sabbah, H. N., Tocchetti, C. G., Wang, M., Daya, S., Gupta, R. C., Tunin, R. S., Mazhari, R., Takimoto, E., Paolocci, N., Cowart, D., Colucci, W. S. & Kass, D. A., 2013, In : Circulation: Heart Failure. 6, 6, p. 1250-1258 9 p.

Research output: Contribution to journalArticle

Endocardial endothelium is a key determinant of force-frequency relationship in rat ventricular myocardium

Shen, X., Tan, Z., Zhong, X., Tian, Y., Wang, X., Yu, B., Ramirez-Correa, G., Murphy, A. M., Gabrielson, K. L., Paolocci, N. & Gao, W. D., Aug 1 2013, In : Journal of Applied Physiology. 115, 3, p. 383-393 11 p.

Research output: Contribution to journalArticle

Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs

Xie, C., Biary, N., Tocchetti, C. G., Aon, M. A., Paolocci, N., Kauffman, J. & Akar, F. G., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 7

Research output: Contribution to journalArticle

HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization

Sivakumaran, V., Stanley, B. A., Tocchetti, C. G., Ballin, J. D., Caceres, V., Zhou, L., Keceli, G., Rainer, P. P., Lee, D., Huke, S., Ziolo, M. T., Kranias, E. G., Toscano, J. P., Wilson, G. M., O'Rourke, B., Kass, D. A., Mahaney, J. E. & Paolocci, N., Oct 10 2013, In : Antioxidants and Redox Signaling. 19, 11, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives

Basudhar, D., Bharadwaj, G., Cheng, R. Y., Jain, S., Shi, S., Heinecke, J. L., Holland, R. J., Ridnour, L. A., Caceres, V. M., Spadari-Bratfisch, R. C., Paolocci, N., Velázquez-Martínez, C. A., Wink, D. A. & Miranda, K. M., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 7804-7820 17 p.

Research output: Contribution to journalArticle

2012

Acyloxy nitroso compounds inhibit lif signaling in endothelial cells and cardiac myocytes: Evidence that STAT3 signaling is redox-sensitive

Zgheib, C., Kurdi, M., Zouein, F. A., Gunter, B. W., Stanley, B. A., Zgheib, J., Romero, D. G., King, S. B., Paolocci, N. & Booz, G. W., Aug 15 2012, In : PLoS One. 7, 8, e43313.

Research output: Contribution to journalArticle

Cardioprotective effect of beta-3 adrenergic receptor agonism: Role of neuronal nitric oxide synthase

Niu, X., Watts, V. L., Cingolani, O., Sivakumaran, V., Leyton-Mange, J. S., Ellis, C. L., Miller, K. L., Vandegaer, K., Bedja, D., Gabrielson, K. L., Paolocci, N., Kass, D. A. & Barouch, L., May 29 2012, In : Journal of the American College of Cardiology. 59, 22, p. 1979-1987 9 p.

Research output: Contribution to journalArticle

Cobalt-protoporphyrin improves heart function by blunting oxidative stress and restoring NO synthase equilibrium in an animal model of experimental diabetes

Cao, J., Vecoli, C., Neglia, D., Tavazzi, B., Lazzarino, G., Novelli, M., Masiello, P., Wang, Y. T., Puri, N., Paolocci, N., L'Abbate, A. & Abraham, N. G., 2012, In : Frontiers in Physiology. 3 JUN, Article 160.

Research output: Contribution to journalArticle

Creatine kinase - Mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved

Gupta, A., Akki, A., Wang, Y., Leppo, M. K., Chacko, V. P., Foster, D. B., Caceres, V., Shi, S., Kirk, J. A., Su, J., Lai, S., Paolocci, N., Steenbergen, C. J., Gerstenblith, G. & Weiss, R. G., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 291-302 12 p.

Research output: Contribution to journalArticle

Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes

Kurdi, M., Sivakumaran, V., Duhé, R. J., Aon, M. A., Paolocci, N. & Booz, G. W., Dec 2012, In : International Journal of Biochemistry and Cell Biology. 44, 12, p. 2106-2115 10 p.

Research output: Contribution to journalArticle

Erratum: Cardioprotective effect of beta-3 adrenergic receptor agonism: Role of neuronal nitric oxide synthase (Journal of the American College of Cardiology (2012) 59 (1979-1987))

Niu, X., Watts, V. L., Cingolani, O., Sivakumaran, V., Leyton-Mange, J. S., Ellis, C. L., Miller, K. L., Vandegaer, K., Bedja, D., Gabrielson, K. L., Paolocci, N., Kass, D. A. & Barouch, L., Jul 31 2012, In : Journal of the American College of Cardiology. 60, 5, p. 481 1 p.

Research output: Contribution to journalArticle

Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study

Aon, M. A., Stanley, B. A., Sivakumaran, V., Kembro, J. M., O'Rourke, B., Paolocci, N. & Cortassa, S., Jun 2012, In : Journal of General Physiology. 139, 6, p. 479-491 13 p.

Research output: Contribution to journalArticle

GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice

Tocchetti, C. G., Caceres, V., Stanley, B. A., Xie, C., Shi, S., Watson, W. H., O'Rourke, B., Spadari-Bratfisch, R. C., Cortassa, S., Akar, F. G., Paolocci, N. & Aon, M. A., Dec 2012, In : Diabetes. 61, 12, p. 3094-3105 12 p.

Research output: Contribution to journalArticle

Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function

Gao, W. D., Murray, C. I., Tian, Y., Zhong, X., Dumond, J. F., Shen, X., Stanley, B. A., Foster, D. B., Wink, D. A., Bruce King, S., Van Eyk, J. E. & Paolocci, N., Sep 2012, In : Circulation Research. 111, 8, p. 1002-1011 10 p.

Research output: Contribution to journalArticle

Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: Insights from a mouse cell model applied to human tumor tissue

Fliedner, S. M. J., Kaludercic, N., Jiang, X. S., Hansikova, H., Hajkova, Z., Sladkova, J., Limpuangthip, A., Backlund, P. S., Wesley, R., Martiniova, L., Jochmanova, I., Lendvai, N. K., Breza, J., Yergey, A. L., Paolocci, N., Tischler, A. S., Zeman, J., Porter, F. D., Lehnert, H. & Pacak, K., Jul 31 2012, In : PLoS One. 7, 7, e40949.

Research output: Contribution to journalArticle

2011

Apolipoprotein A-I mimetic peptide L-4F prevents myocardial and coronary dysfunction in diabetic mice

Vecoli, C., Cao, J., Neglia, D., Inoue, K., Sodhi, K., Vanella, L., Gabrielson, K. L., Bedja, D., Paolocci, N., L'Abbate, A. & Abraham, N. G., Sep 2011, In : Journal of Cellular Biochemistry. 112, 9, p. 2616-2626 11 p.

Research output: Contribution to journalArticle

Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury

Kaludercic, N., Carpi, A., Menabò, R., Di Lisa, F. & Paolocci, N., Jul 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 7, p. 1323-1332 10 p.

Research output: Contribution to journalArticle