Nauder Faraday

Professor

19932018
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Research Output 1993 2018

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Article
2018

Diabetes and Platelet Response to Low-Dose Aspirin

Al-Sofiani, M. E., Yanek, L., Faraday, N., Kral, B. G., Mathias, R., Becker, L., Becker, D. M., Vaidya, D. & Kalyani, R. R., Dec 1 2018, In : The Journal of clinical endocrinology and metabolism. 103, 12, p. 4599-4608 10 p.

Research output: Contribution to journalArticle

Medical problems
Platelets
Aspirin
Blood Platelets
Platelet Activation

Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI

Chen, L., Xu, X., Zeng, H., Chan, K. W. Y., Yadav, N., Cai, S., Schunke, K. J., Faraday, N., Van Zijl, P. C. & Xu, J., Jan 1 2018, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Protons
Brain
Bovine Serum Albumin
Hair
Glutamic Acid

Targeted deep sequencing of the PEAR1 locus for platelet aggregation in European and African American families

Keramati, A. R., Yanek, L., Iyer, K., Taub, M. A., Ruczinski, I., Becker, D. M., Becker, L., Faraday, N. & Mathias, R., Mar 18 2018, (Accepted/In press) In : Platelets. p. 1-7 7 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Platelet Aggregation
African Americans
Aspirin
Genome-Wide Association Study
2017

Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation

Chen, M. H., Yanek, L., Backman, J. D., Eicher, J. D., Huffman, J. E., Ben-Shlomo, Y., Beswick, A. D., Yerges-Armstrong, L. M., Shuldiner, A. R., O’Connell, J. R., Mathias, R., Becker, D. M., Becker, L., Lewis, J. P., Johnson, A. D. & Faraday, N., Nov 30 2017, (Accepted/In press) In : Platelets. p. 1-10 10 p.

Research output: Contribution to journalArticle

Exome
Platelet Aggregation
Meta-Analysis
Blood Platelets
Adenosine Diphosphate
megakaryocytes
Induced Pluripotent Stem Cells
Megakaryocytes
Stem cells
transcriptomics

Whole exome sequencing in the Framingham heart study identifies rare variation in HYAL2 that influences platelet aggregation

Eicher, J. D., Chen, M. H., Pitsillides, A. N., Lin, H., Veeraraghavan, N., Brody, J. A., Metcalf, G. A., Muzny, D. M., Gibbs, R. A., Becker, D. M., Becker, L., Faraday, N., Mathias, R., Yanek, L., Boerwinkle, E., Adrienne Cupples, L. & Johnson, A. D., 2017, In : Thrombosis and Haemostasis. 117, 6, p. 1083-1092 10 p.

Research output: Contribution to journalArticle

Exome
Platelet Aggregation
Blood Platelets
Adenosine Diphosphate
Epinephrine
2016

Association of Selective Serotonin Reuptake Inhibitors with Transfusion in Surgical Patients

Sajan, F., Conte, J. V., Tamargo, R. J., Riley, L. H., Rock, P. & Faraday, N., May 6 2016, (Accepted/In press) In : Anesthesia and Analgesia.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Hemostatics
Odds Ratio
Confidence Intervals
Propensity Score

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

Chami, N., Chen, M. H., Slater, A. J., Eicher, J. D., Evangelou, E., Tajuddin, S. M., Love-Gregory, L., Kacprowski, T., Schick, U. M., Nomura, A., Giri, A., Lessard, S., Brody, J. A., Schurmann, C., Pankratz, N., Yanek, L., Manichaikul, A., Pazoki, R., Mihailov, E., Hill, W. D. & 93 others, Raffield, L. M., Burt, A., Bartz, T. M., Becker, D. M., Becker, L., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., O'Donoghue, M. L., Crosslin, D. R., de Denus, S., Dubé, M. P., Elliott, P., Engström, G., Evans, M. K., Floyd, J. S., Fornage, M., Gao, H., Greinacher, A., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hernesniemi, J., Highland, H. M., Hirschhorn, J. N., Hofman, A., Irvin, M. R., Kähönen, M., Lange, E., Launer, L. J., Lehtimäki, T., Li, J., Liewald, D. C. M., Linneberg, A., Liu, Y., Lu, Y., Lyytikäinen, L. P., Mägi, R., Mathias, R., Melander, O., Metspalu, A., Mononen, N., Nalls, M. A., Nickerson, D. A., Nikus, K., O'Donnell, C. J., Orho-Melander, M., Pedersen, O., Petersmann, A., Polfus, L., Psaty, B. M., Raitakari, O. T., Raitoharju, E., Richard, M., Rice, K. M., Rivadeneira, F., Rotter, J. I., Schmidt, F., Smith, A. V., Starr, J. M., Taylor, K. D., Teumer, A., Thuesen, B. H., Torstenson, E. S., Tracy, R. P., Tzoulaki, I., Zakai, N. A., Vacchi-Suzzi, C., van Duijn, C. M., van Rooij, F. J. A., Cushman, M., Deary, I. J., Velez Edwards, D. R., Vergnaud, A. C., Wallentin, L., Waterworth, D. M., White, H. D., Wilson, J. G., Zonderman, A. B., Kathiresan, S., Grarup, N., Esko, T., Loos, R. J. F., Lange, L. A., Faraday, N., Abumrad, N. A., Edwards, T. L., Ganesh, S. K., Auer, P. L., Johnson, A. D., Reiner, A. P. & Lettre, G., Jul 7 2016, In : American Journal of Human Genetics. 99, 1, p. 8-21 14 p.

Research output: Contribution to journalArticle

Exome
Gene Frequency
Erythrocytes
Erythrocyte Indices
Hemoglobins

Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases

Tajuddin, S. M., Schick, U. M., Eicher, J. D., Chami, N., Giri, A., Brody, J. A., Hill, W. D., Kacprowski, T., Li, J., Lyytikäinen, L. P., Manichaikul, A., Mihailov, E., O'Donoghue, M. L., Pankratz, N., Pazoki, R., Polfus, L. M., Smith, A. V., Schurmann, C., Vacchi-Suzzi, C., Waterworth, D. M. & 77 others, Evangelou, E., Yanek, L., Burt, A., Chen, M. H., van Rooij, F. J. A., Floyd, J. S., Greinacher, A., Harris, T. B., Highland, H. M., Lange, L. A., Liu, Y., Mägi, R., Nalls, M. A., Mathias, R., Nickerson, D. A., Nikus, K., Starr, J. M., Tardif, J. C., Tzoulaki, I., Velez Edwards, D. R., Wallentin, L., Bartz, T. M., Becker, L., Denny, J. C., Raffield, L. M., Rioux, J. D., Friedrich, N., Fornage, M., Gao, H., Hirschhorn, J. N., Liewald, D. C. M., Rich, S. S., Uitterlinden, A., Bastarache, L., Becker, D. M., Boerwinkle, E., de Denus, S., Bottinger, E. P., Hayward, C., Hofman, A., Homuth, G., Lange, E., Launer, L. J., Lehtimäki, T., Lu, Y., Metspalu, A., O'Donnell, C. J., Quarells, R. C., Richard, M., Torstenson, E. S., Taylor, K. D., Vergnaud, A. C., Zonderman, A. B., Crosslin, D. R., Deary, I. J., Dörr, M., Elliott, P., Evans, M. K., Gudnason, V., Kähönen, M., Psaty, B. M., Rotter, J. I., Slater, A. J., Dehghan, A., White, H. D., Ganesh, S. K., Loos, R. J. F., Esko, T., Faraday, N., Wilson, J. G., Cushman, M., Johnson, A. D., Edwards, T. L., Zakai, N. A., Lettre, G., Reiner, A. P. & Auer, P. L., Jul 7 2016, In : American Journal of Human Genetics. 99, 1, p. 22-39 18 p.

Research output: Contribution to journalArticle

Exome
Immune System Diseases
Leukocyte Count
Autoimmune Diseases
Leukocytes

Platelet glycoproteins associated with aspirin-treatment upon platelet activation

Shah, P., Yang, W., Sun, S., Pasay, J., Faraday, N. & Zhang, H., 2016, (Accepted/In press) In : Proteomics.

Research output: Contribution to journalArticle

Platelet Membrane Glycoproteins
Platelet Activation
Platelets
Aspirin
Blood Platelets

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

Eicher, J. D., Chami, N., Kacprowski, T., Nomura, A., Chen, M. H., Yanek, L., Tajuddin, S. M., Schick, U. M., Slater, A. J., Pankratz, N., Polfus, L., Schurmann, C., Giri, A., Brody, J. A., Lange, L. A., Manichaikul, A., Hill, W. D., Pazoki, R., Elliot, P., Evangelou, E. & 93 others, Tzoulaki, I., Gao, H., Vergnaud, A. C., Mathias, R., Becker, D. M., Becker, L., Burt, A., Crosslin, D. R., Lyytikäinen, L. P., Nikus, K., Hernesniemi, J., Kähönen, M., Raitoharju, E., Mononen, N., Raitakari, O. T., Lehtimäki, T., Cushman, M., Zakai, N. A., Nickerson, D. A., Raffield, L. M., Quarells, R., Willer, C. J., Peloso, G. M., Abecasis, G. R., Liu, D. J., Deloukas, P., Samani, N. J., Schunkert, H., Erdmann, J., Fornage, M., Richard, M., Tardif, J. C., Rioux, J. D., Dube, M. P., de Denus, S., Lu, Y., Bottinger, E. P., Loos, R. J. F., Smith, A. V., Harris, T. B., Launer, L. J., Gudnason, V., Velez Edwards, D. R., Torstenson, E. S., Liu, Y., Tracy, R. P., Rotter, J. I., Rich, S. S., Highland, H. M., Boerwinkle, E., Li, J., Lange, E., Wilson, J. G., Mihailov, E., Mägi, R., Hirschhorn, J., Metspalu, A., Esko, T., Vacchi-Suzzi, C., Nalls, M. A., Zonderman, A. B., Evans, M. K., Engström, G., Orho-Melander, M., Melander, O., O'Donoghue, M. L., Waterworth, D. M., Wallentin, L., White, H. D., Floyd, J. S., Bartz, T. M., Rice, K. M., Psaty, B. M., Starr, J. M., Liewald, D. C. M., Hayward, C., Deary, I. J., Greinacher, A., Völker, U., Thiele, T., Völzke, H., van Rooij, F. J. A., Uitterlinden, A. G., Franco, O. H., Dehghan, A., Edwards, T. L., Ganesh, S. K., Kathiresan, S., Faraday, N., Auer, P. L., Reiner, A. P., Lettre, G. & Johnson, A. D., Jul 7 2016, In : American Journal of Human Genetics. 99, 1, p. 40-55 16 p.

Research output: Contribution to journalArticle

Mean Platelet Volume
Platelet Count
Meta-Analysis
Blood Platelets
Blood Cells
Cardiac Surgical Procedures
Tranexamic Acid
Aminocaproic Acid
Antifibrinolytic Agents
Intraoperative Complications
2015

A novel atherothrombotic model of ischemic stroke induced by injection of collagen into the cerebral vasculature

Schunke, K. J., Toung, T. J., Zhang, J., Pathak, A., Xu, J., Zhang, J., Koehler, R. C. & Faraday, N., Jan 5 2015, In : Journal of Neuroscience Methods. 239, p. 65-74 10 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Collagen
Stroke
Injections
Intracranial Thrombosis

Genome-wide association study of platelet aggregation in African Americans

Qayyum, R., Becker, L., Becker, D. M., Faraday, N., Yanek, L., Leal, S. M., Shaw, C., Mathias, R., Suktitipat, B. & Bray, P. F., May 30 2015, In : BMC Genetics. 16, 1, 58.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Platelet Aggregation
African Americans
Adenosine Diphosphate
Single Nucleotide Polymorphism
Cyclooxygenase 1
Acute Coronary Syndrome
Platelets
Platelet Aggregation
Collagen

Protocol adherence when managing massive bleeding following complex cardiac surgery: A study design pilot

Greilich, P. E., Edson, E., Rutland, L., Jessen, M. E., Key, N. S., Levy, J. H., Faraday, N. & Steiner, M. E., Apr 1 2015, In : Journal of Cardiothoracic and Vascular Anesthesia. 29, 2, p. 303-310 8 p.

Research output: Contribution to journalArticle

Thoracic Surgery
Hemorrhage
Hemostatics
Hemostasis
Therapeutics
2014

Use of hemodynamic algorithm after gastrointestinal surgery

Latif, A. & Faraday, N., Oct 8 2014, In : Journal of the American Medical Association. 312, 14, p. 1470 1 p.

Research output: Contribution to journalArticle

Digestive System Surgical Procedures
Fluid Therapy
Cardiac Output
Hemodynamics
2013

Balancing thrombotic and bleeding risks related to antiplatelet therapy in coronary bypass surgery

Faraday, N., Jun 2013, In : JAMA Surgery. 148, 6, p. 548 1 p.

Research output: Contribution to journalArticle

Surgical Blood Loss
Tranexamic Acid
Ticlopidine
Antifibrinolytic Agents
Platelet Aggregation Inhibitors

Cathepsin G-Dependent Modulation of Platelet Thrombus Formation In Vivo by Blood Neutrophils

Faraday, N., Schunke, K., Saleem, S., Fu, J., Wang, B., Zhang, J., Morrell, C. & Dore, S., Aug 5 2013, In : PLoS One. 8, 8, e71447.

Research output: Contribution to journalArticle

cathepsin G
Cathepsin G
Platelets
neutrophils
Neutrophils

Fibrinogen concentrate and allogeneic blood transfusion in high-risk surgery

Faraday, N., Jan 2013, In : Anesthesiology. 118, 1, p. 7-9 3 p.

Research output: Contribution to journalArticle

Intraoperative Care
Postoperative Hemorrhage
Hemostatics
Blood Transfusion
Fibrinogen

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes

Lewis, J. P., Ryan, K., O'Connell, J. R., Horenstein, R. B., Damcott, C. M., Gibson, Q., Pollin, T. I., Mitchell, B. D., Beitelshees, A. L., Pakzy, R., Tanner, K., Parsa, A., Tantry, U. S., Bliden, K. P., Post, W. S., Faraday, N., Herzog, W. R., Gong, Y., Pepine, C. J., Johnson, J. A. & 2 others, Gurbel, P. A. & Shuldiner, A. R., Apr 2013, In : Circulation: Cardiovascular Genetics. 6, 2, p. 184-192 9 p.

Research output: Contribution to journalArticle

clopidogrel
Platelet Aggregation
Aspirin
trandolapril
Genome-Wide Association Study

Past history of skin infection and risk of surgical site infection after elective surgery

Faraday, N., Rock, P., Lin, E. E., Perl, T. M., Carroll, K. C., Smith Stierer, T., Robarts, P., McFillin, A., Ross, T., Shah, A. S., Riley, L. H., Tamargo, R. J., Black, J. H., Blasco-Colmenares, E. & Guallar, E., Jan 2013, In : Annals of Surgery. 257, 1, p. 150-154 5 p.

Research output: Contribution to journalArticle

Surgical Wound Infection
Skin
Infection Control
Infection
Confidence Intervals

Targeted Deep Resequencing Identifies Coding Variants in the PEAR1 Gene That Play a Role in Platelet Aggregation

Kim, Y., Suktitipat, B., Yanek, L., Faraday, N., Wilson, A. F., Becker, D. M., Becker, L. & Mathias, R., May 21 2013, In : PLoS One. 8, 5, e64179.

Research output: Contribution to journalArticle

platelet aggregation
Platelets
Platelet Aggregation
Agglomeration
Genes
2011

Emergency cardiac surgery in patients with acute coronary syndromes: A review of the evidence and perioperative implications of medical and mechanical therapeutics

Brown, C., Joshi, B., Faraday, N., Shah, A., Yuh, D., Rade, J. J. & Hogue, C. W., Apr 2011, In : Anesthesia and Analgesia. 112, 4, p. 777-799 23 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Thoracic Surgery
Emergencies
Hemorrhage
Therapeutics

Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression

Faraday, N., Yanek, L., Yang, X. P., Mathias, R., Herrera-Galeano, J. E., Suktitipat, B., Qayyum, R., Johnson, A. D., Chen, M. H., Tofler, G. H., Ruczinski, I., Friedman, A. D., Gylfason, A., Thorsteinsdottir, U., Bray, P. F., O'Donnell, C. J., Becker, D. M. & Becker, L., Sep 22 2011, In : Blood. 118, 12, p. 3367-3375 9 p.

Research output: Contribution to journalArticle

Platelets
Platelet Aggregation
Blood Platelets
Agglomeration
Genes
2010
African Americans
Coronary Artery Disease
Blood Platelets
Single Nucleotide Polymorphism
Genome

A common variant in the Von Willebrand factor gene is associated with multiple functional consequences

Vaidya, D., Yanek, L., Herrera-Galeano, J. E., Mathias, R., Moy, T. F., Faraday, N., Becker, L. & Becker, D. M., Dec 2010, In : American Journal of Hematology. 85, 12, p. 971-973 3 p.

Research output: Contribution to journalArticle

Nonsense Codon
Genome-Wide Association Study
von Willebrand Factor
Platelet Aggregation
African Americans

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: A potential mechanism for increased vascular disease

Musunuru, K., Post, W. S., Herzog, W. R., Shen, H., O'Connell, J. R., McArdle, P. F., Ryan, K. A., Gibson, Q., Cheng, Y. C., Clearfield, E., Johnson, A. D., Tofler, G., Yang, Q., O'Donnell, C. J., Becker, D. M., Yanek, L., Becker, L., Faraday, N., Bielak, L. F., Peyser, P. A. & 2 others, Shuldiner, A. R. & Mitchell, B. D., Oct 2010, In : Circulation: Cardiovascular Genetics. 3, 5, p. 445-453 9 p.

Research output: Contribution to journalArticle

Vascular Diseases
Single Nucleotide Polymorphism
Blood Platelets
Chromosomes
Coronary Vessels

Effect of obesity on platelet reactivity and response to low-dose aspirin

Bordeaux, B. C., Qayyum, R., Yanek, L., Vaidya, D., Becker, L., Faraday, N. & Becker, D. M., Mar 2010, In : Preventive Cardiology. 13, 2, p. 56-62 7 p.

Research output: Contribution to journalArticle

Aspirin
Blood Platelets
Obesity
Adenosine Diphosphate
Collagen

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

Johnson, A. D., Yanek, L., Chen, M. H., Faraday, N., Larson, M. G., Tofler, G., Lin, S. J., Kraja, A. T., Province, M. A., Yang, Q., Becker, D. M., O'Donnell, C. J. & Becker, L., Jul 2010, In : Nature Genetics. 42, 7, p. 608-613 6 p.

Research output: Contribution to journalArticle

Platelet Aggregation
Meta-Analysis
Genome
Atherosclerosis
African Americans

Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

Assimes, T. L., Hlm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., Voight, B. F., Erdmann, J., Willenborg, C., Vaidya, D., Xie, C., Patterson, C. C., Morgan, T. M., Burnett, M. S., Li, M., Hlatky, M. A., Knowles, J. W., Thompson, J. R., Absher, D., Iribarren, C., Go, A. & 111 others, Fortmann, S. P., Sidney, S., Risch, N., Tang, H., Myers, R. M., Berger, K., Stoll, M., Shah, S. H., Thorgeirsson, G., Andersen, K., Havulinna, A. S., Herrera, J. E., Faraday, N., Kim, Y., Kral, B. G., Mathias, R., Ruczinski, I., Suktitipat, B., Wilson, A. F., Yanek, L., Becker, L., Linsel-Nitschke, P., Lieb, W., Knig, I. R., Hengstenberg, C., Fischer, M., Stark, K., Reinhard, W., Winogradow, J., Grassl, M., Grosshennig, A., Preuss, M., Schreiber, S., Wichmann, H. E., Meisinger, C., Yee, J., Friedlander, Y., Do, R., Meigs, J. B., Williams, G., Nathan, D. M., MacRae, C. A., Qu, L., Wilensky, R. L., Matthai, W. H., Qasim, A. N., Hakonarson, H., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Knouff, C. W., Waterworth, D. M., Walker, M. C., Mooser, V. E., Marrugat, J., Lucas, G., Subirana, I., Sala, J., Ramos, R., Martinelli, N., Olivieri, O., Trabetti, E., Malerba, G., Pignatti, P. F., Guiducci, C., Mirel, D., Parkin, M., Hirschhorn, J. N., Asselta, R., Duga, S., Musunuru, K., Daly, M. J., Purcell, S., Eifert, S., Braund, P. S., Wright, B. J., Balmforth, A. J., Ball, S. G., Ouwehand, W. H., Deloukas, P., Scholz, M., Cambien, F., Huge, A., Scheffold, T., Salomaa, V., Girelli, D., Granger, C. B., Peltonen, L., McKeown, P. P., Altshuler, D., Melander, O., Devaney, J. M., Epstein, S. E., Rader, D. J., Elosua, R., Engert, J. C., Anand, S. S., Hall, A. S., Ziegler, A., O'Donnell, C. J., Spertus, J. A., Siscovick, D., Schwartz, S. M., Becker, D. M., Thorsteinsdottir, U., Stefansson, K., Schunkert, H., Samani, N. J. & Quertermous, T., Nov 2 2010, In : Journal of the American College of Cardiology. 56, 19, p. 1552-1563 12 p.

Research output: Contribution to journalArticle

Kinesin
Case-Control Studies
Coronary Artery Disease
Proteins
Alleles
2009

Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery

Blasco-Colmenares, E., Perl, T. M., Guallar, E., Baumgartner, W. A., Conte, J. V., Alejo, D., Pastor-Barriuso, R., Sharrett, A. R. & Faraday, N., Apr 27 2009, In : Archives of Internal Medicine. 169, 8, p. 788-796 9 p.

Research output: Contribution to journalArticle

clopidogrel
Coronary Artery Bypass
Aspirin
Infection
Confidence Intervals

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

Shuldiner, A. R., O'Connell, J. R., Bliden, K. P., Gandhi, A., Ryan, K., Horenstein, R. B., Damcott, C. M., Pakyz, R., Tantry, U. S., Gibson, Q., Pollin, T. I., Post, W. S., Parsa, A., Mitchell, B. D., Faraday, N., Herzog, W. R. & Gurbel, P. A., Aug 26 2009, In : Journal of the American Medical Association. 302, 8, p. 849-858 10 p.

Research output: Contribution to journalArticle

clopidogrel
Cytochrome P-450 Enzyme System
Genotype
Blood Platelets
Platelet Aggregation
Leukocyte Count
Aspirin
Coronary Artery Disease
Blood Platelets
C-Reactive Protein
Platelet Aggregation
Aspirin
Coronary Artery Disease
Platelet Activation
Arachidonic Acid

Perioperative platelet activation and the inhibitory effect of milrinone

Faraday, N., Dec 2009, In : Anesthesiology. 111, 6, p. 1185-1186 2 p.

Research output: Contribution to journalArticle

Milrinone
Perioperative Care
Phosphodiesterase Inhibitors
Platelet Aggregation Inhibitors
Platelet Activation

Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation

Sun, H., Swaim, A. M., Herrera, J. E., Becker, D. M., Becker, L., Srivastava, K., Thompson, L. E., Shero, M. R., Perez-Tamayo, A., Suktitipat, B., Mathias, R., Contractor, A., Faraday, N. & Morrell, C. N., 2009, In : Circulation Research. 105, 6, p. 595-603 9 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Platelet Activation
Prostaglandin-Endoperoxide Synthases
Thrombosis
Blood Platelets
2008

A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability

Enrique Herrera-Galeano, J., Becker, D. M., Wilson, A. F., Yanek, L., Bray, P., Vaidya, D., Faraday, N. & Becker, L., Aug 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 8, p. 1484-1490 7 p.

Research output: Contribution to journalArticle

Platelet Aggregation
Blood Platelets
Genes
Single Nucleotide Polymorphism
Alleles

Glutamate mediates platelet activation through the AMPA receptor

Morrell, C. N., Sun, H., Ikeda, M., Beique, J. C., Swaim, A. M., Mason, E., Martin, T. V., Thompson, L. E., Gozen, O., Ampagoomian, D., Sprengel, R., Rothstein, J. D., Faraday, N., Huganir, R. L. & Lowenstein, C. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

AMPA Receptors
Platelet Activation
Glutamic Acid
Blood Platelets
Hemostasis
Aspirin
Cardiovascular Diseases
Blood Platelets
Platelet Aggregation
Platelet-Rich Plasma
2007

Casual chocolate consumption and inhibition of platelet function.

Bordeaux, B., Yanek, L., Moy, T. F., White, L. W., Becker, L., Faraday, N. & Becker, D. M., Sep 2007, In : Preventive Cardiology. 10, 4, p. 175-180 6 p.

Research output: Contribution to journalArticle

Blood Platelets
Chocolate
Observational Studies
Creatinine
Food

Heritability of platelet function in families with premature coronary artery disease

Bray, P. F., Mathias, R., Faraday, N., Yanek, L., Fallin, D. D., Wilson, A. F., Becker, L. & Becker, D. M., Aug 2007, In : Journal of Thrombosis and Haemostasis. 5, 8, p. 1617-1623 7 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Blood Platelets
African Americans
Platelet Aggregation
Epinephrine

Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1

Faraday, N., Yanek, L., Mathias, R., Herrera-Galeano, J. E., Vaidya, D., Moy, T. F., Fallin, D. D., Wilson, A. F., Bray, P. F., Becker, L. & Becker, D. M., May 2007, In : Circulation. 115, 19, p. 2490-2496 7 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Aspirin
Blood Platelets
Myocardial Infarction
Phenotype

Pharmacogenomics of platelet responsiveness to aspirin

Faraday, N., Becker, D. M. & Becker, L., Oct 2007, In : Pharmacogenomics. 8, 10, p. 1413-1425 13 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Aspirin
Blood Platelets
Cyclooxygenase 1
Phenotype
2006

Nitric oxide inhibits exocystosis of cytolytic granules from lymphokine-activated killer cells

Ferlito, M., Irani, K., Faraday, N. & Lowenstein, C. J., Aug 1 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 31, p. 11689-11694 6 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Exocytosis
Granzymes
Nitric Oxide
Lymphocytes
Platelet Count
Postoperative Period
Coronary Artery Bypass
Thrombocytopenia
Anticoagulants

Relation Between Atherosclerosis Risk Factors and Aspirin Resistance in a Primary Prevention Population

Faraday, N., Becker, D. M., Yanek, L., Herrera-Galeano, J. E., Segal, J., Moy, T. F., Bray, P. F. & Becker, L., Sep 8 2006, In : The American Journal of Cardiology. 98, 6, p. 774-779 6 p.

Research output: Contribution to journalArticle

Primary Prevention
Aspirin
Atherosclerosis
Population
Blood Platelets

Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis

Njoku, D. B., Mellerson, J. L., Talor, M. V., Kerr, D. R., Faraday, N., Outschoorn, I. & Rose, N. R., Feb 2006, In : Clinical and Vaccine Immunology. 13, 2, p. 258-265 8 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Cytochrome P-450 CYP2E1
Anesthetics
Immunoglobulins
Autoantibodies

Sex differences in platelet reactivity and response to low-dose aspirin therapy

Becker, D. M., Segal, J., Vaidya, D., Yanek, L., Herrera-Galeano, J. E., Bray, P. F., Moy, T. F., Becker, L. & Faraday, N., Mar 22 2006, In : Journal of the American Medical Association. 295, 12, p. 1420-1427 8 p.

Research output: Contribution to journalArticle

Sex Characteristics
Aspirin
Blood Platelets
Cyclooxygenase 1
Platelet Aggregation
2005

Regulation of platelet granule exocytosis by S-nitrosylation

Morrell, C. N., Matsushita, K., Chiles, K., Scharpf, R. B., Yamakuchi, M., Mason, R. J. A., Bergmeier, W., Mankowski, J. L., Baldwin, W. M., Faraday, N. & Lowenstein, C. J., Mar 8 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 10, p. 3782-3787 6 p.

Research output: Contribution to journalArticle

Exocytosis
N-Ethylmaleimide-Sensitive Proteins
Blood Platelets
Nitric Oxide
Platelet Activation