Namandje N Bumpus

Associate Professor

20042020

Research output per year

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Research Output

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Article
2020

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

Swift, R. P., Rajaram, K., Liu, H. B., Dziedzic, A., Jedlicka, A. E., Roberts, A. D., Matthews, K. A., Jhun, H., Bumpus, N. N., Tewari, S. G., Wallqvist, A. & Prigge, S. T., 2020, In : PLoS pathogens. 16, 2, e1008316.

Research output: Contribution to journalArticle

Open Access
2019

Drug concentration asymmetry in tissues and plasma for small molecule-related therapeutic modalities

Zhang, D., Hop, C. E. C. A., Patilea-Vrana, G., Gampa, G., Seneviratne, H. K., Unadkat, J. D., Kenny, J. R., Nagapudi, K., Di, L., Zhou, L., Zak, M., Wright, M. R., Bumpus, N. N., Zang, R., Liu, X., Lai, Y. & Cyrus Khojasteh, S., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 10, p. 1122-1135 14 p.

Research output: Contribution to journalArticle

Open Access

Efavirenz and efavirenz-like compounds activate human, murine, and macaque hepatic IRE1a-XBP1

Heck, C. J. S., Hamlin, A. N. & Bumpus, N. N., Feb 1 2019, In : Molecular Pharmacology. 95, 2, p. 185-195 11 p.

Research output: Contribution to journalArticle

Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir

Hamlin, A. N., Tillotson, J. & Bumpus, N. N., Jan 2019, In : Pharmacogenomics. 20, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

Open Access
2018

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

Figueroa, D. B., Tillotson, J., Li, M., Piwowar-Manning, E., Hendrix, C. W., Holtz, T. H., Bokoch, K., Bekker, L. G., van Griensven, F., Mannheimer, S., Hughes, J. P., Grant, R. M. & Bumpus, N. N., Apr 2018, In : PloS one. 13, 4, e0195764.

Research output: Contribution to journalArticle

Genetic Variation of the Kinases That Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells

Figueroa, D. B., Madeen, E. P., Tillotson, J., Richardson, P., Cottle, L., McCauley, M., Landovitz, R. J., Andrade, A., Hendrix, C. W., Mayer, K. H., Wilkin, T., Gulick, R. M. & Bumpus, N. N., May 2018, In : AIDS research and human retroviruses. 34, 5, p. 421-429 9 p.

Research output: Contribution to journalArticle

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial

Lee, S. A., Elliott, J. H., McMahon, J., Hartogenesis, W., Bumpus, N. N., Lifson, J. D., Gorelick, R. J., Bacchetti, P., Deeks, S. G., Lewin, S. R. & Savic, R. M., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Probing Ligand Structure–Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation

Narayanan, B., Lade, J. M., Heck, C. J. S., Dietz, K. D., Wade, H. & Bumpus, N. N., Apr 6 2018, In : ChemMedChem. 13, 7, p. 736-747 12 p.

Research output: Contribution to journalArticle

Utility of Different Adherence Measures for PrEP: Patterns and Incremental Value

Abaasa, A., Hendrix, C., Gandhi, M., Anderson, P., Kamali, A., Kibengo, F., Sanders, E. J., Mutua, G., Bumpus, N. N., Priddy, F. & Haberer, J. E., Apr 1 2018, In : AIDS and behavior. 22, 4, p. 1165-1173 9 p.

Research output: Contribution to journalArticle

2016

Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole

Shim, J. S., Li, R. J., Bumpus, N. N., Head, S. A., Pasunooti, K. K., Yang, E. J., Lv, J., Shi, W. & Liu, J. O., Jun 1 2016, In : Clinical Cancer Research. 22, 11, p. 2709-2720 12 p.

Research output: Contribution to journalArticle

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Hendrix, C. W., Andrade, A., Bumpus, N. N., Kashuba, A. D., Marzinke, M. A., Moore, A., Anderson, P. L., Bushman, L. R., Fuchs, E. J., Wiggins, I., Radebaugh, C., Prince, H. A., Bakshi, R. P., Wang, R., Richardson, P., Shieh, E., McKinstry, L., Li, X., Donnell, D., Elharrar, V. & 2 others, Mayer, K. H. & Patterson, K. B., Jan 1 2016, In : AIDS research and human retroviruses. 32, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle

Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6

Cox, P. M. & Bumpus, N. N., 2016, In : ChemMedChem. 11, 23, p. 2630-2637 8 p.

Research output: Contribution to journalArticle

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

Seamon, K. J., Bumpus, N. N. & Stivers, J., Nov 8 2016, In : Biochemistry. 55, 44, p. 6087-6099 13 p.

Research output: Contribution to journalArticle

2015

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner

Lade, J. M., To, E. E., Hendrix, C. W. & Bumpus, N. N., Sep 1 2015, In : EBioMedicine. 2, 9, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

Elliott, J. H., McMahon, J. H., Chang, C. C., Lee, S. A., Hartogensis, W., Bumpus, N. N., Savic, R., Roney, J., Hoh, R., Solomon, A., Piatak, M., Gorelick, R. J., Lifson, J., Bacchetti, P., Deeks, S. G. & Lewin, S. R., Dec 1 2015, In : The lancet. HIV. 2, 12, p. e520-e529

Research output: Contribution to journalArticle

2014

A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarate

Yang, K. H., Hendrix, C., Bumpus, N., Elliott, J., Tanner, K., Mauck, C., Cranston, R., McGowan, I., Richardson-Harman, N., Anton, P. A. & Kashuba, A. D. M., Oct 28 2014, In : PloS one. 9, 10, e106196.

Research output: Contribution to journalArticle

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

Spivak, A. M., Andrade, A., Eisele, E., Hoh, R., Bacchetti, P., Bumpus, N. N., Emad, F., Buckheit, R., Ccance-Katz, E. F., Lai, J., Kennedy, M., Chander, G., Siliciano, R. F., Siliciano, J. D. & Deeks, S. G., Mar 2014, In : Clinical Infectious Diseases. 58, 6, p. 883-890 8 p.

Research output: Contribution to journalArticle

A targeted proteomics approach for profiling Murine Cytochrome P450 expressions

Hersman, E. M. & Bumpus, N. N., May 2014, In : Journal of Pharmacology and Experimental Therapeutics. 349, 2, p. 221-228 8 p.

Research output: Contribution to journalArticle

Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study

Richardson-Harman, N., Hendrix, C. W., Bumpus, N. N., Mauck, C., Cranston, R. D., Yang, K., Elliott, J., Tanner, K., McGowan, I., Kashuba, A. & Anton, P. A., Oct 28 2014, In : PloS one. 9, 10, e111507.

Research output: Contribution to journalArticle

CYP3A5 genotype impacts Maraviroc concentrations in healthy volunteers

Lu, Y., Fuchs, E. J., Hendrix, C. W. & Bumpus, N. N., Nov 1 2014, In : Drug Metabolism and Disposition. 42, 11, p. 1796-1802 7 p.

Research output: Contribution to journalArticle

HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention

Donnell, D., Baeten, J. M., Bumpus, N. N., Brantley, J., Bangsberg, D. R., Haberer, J. E., Mujugira, A., Mugo, N., Ndase, P., Hendrix, C. & Celum, C., Jul 1 2014, In : Journal of acquired immune deficiency syndromes. 66, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization

Seamon, K. J., Hansen, E. C., Kadina, A. P., Kashemirov, B. A., McKenna, C. E., Bumpus, N. N. & Stivers, J. T., Jul 16 2014, In : Journal of the American Chemical Society. 136, 28, p. 9822-9825 4 p.

Research output: Contribution to journalArticle

Structure-activity studies reveal the oxazinone ring is a determinant of cytochrome P450 2B6 activity toward efavirenz

Cox, P. M. & Bumpus, N. N., Oct 9 2014, In : ACS Medicinal Chemistry Letters. 5, 10, p. 1156-1161 6 p.

Research output: Contribution to journalArticle

2013

Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid

Avery, L. B., VanAusdal, J. L., Hendrix, C. W. & Bumpus, N. N., Feb 2013, In : Drug Metabolism and Disposition. 41, 2, p. 422-429 8 p.

Research output: Contribution to journalArticle

Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison

Lade, J. M., Avery, L. B. & Bumpus, N. N., Oct 1 2013, In : Antimicrobial agents and chemotherapy. 57, 10, p. 5067-5079 13 p.

Research output: Contribution to journalArticle

MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

Hendrix, C. W., Chen, B. A., Guddera, V., Hoesley, C., Justman, J., Nakabiito, C., Salata, R., Soto-Torres, L., Patterson, K., Minnis, A. M., Gandham, S., Gomez, K., Richardson, B. A. & Bumpus, N. N., Jan 30 2013, In : PloS one. 8, 1, e55013.

Research output: Contribution to journalArticle

Undisclosed antiretroviral drug use in a multinational clinical trial (HIV prevention trials network 052)

Fogel, J. M., Wang, L., Parsons, T. L., Ou, S. S., Piwowar-Manning, E., Chen, Y., Mudhune, V. O., Hosseinipour, M. C., Kumwenda, J., Hakim, J. G., Chariyalertsak, S., Panchia, R., Sanne, I., Kumarasamy, N., Grinsztejn, B., Makhema, J., Pilotto, J., Santos, B. R., Mayer, K. H., McCauley, M. & 5 others, Gamble, T., Bumpus, N. N., Hendrix, C. W., Cohen, M. S. & Eshleman, S. H., Nov 15 2013, In : Journal of Infectious Diseases. 208, 10, p. 1624-1628 5 p.

Research output: Contribution to journalArticle

2012

Antiretroviral prophylaxis for HIV prevention in heterosexual men and women

Baeten, J. M., Donnell, D., Ndase, P., Mugo, N. R., Campbell, J. D., Wangisi, J., Tappero, J. W., Bukusi, E. A., Cohen, C. R., Katabira, E., Ronald, A., Tumwesigye, E., Were, E., Fife, K. H., Kiarie, J., Farquhar, C., John-Stewart, G., Kakia, A., Odoyo, J., Mucunguzi, A. & 25 others, Nakku-Joloba, E., Twesigye, R., Ngure, K., Apaka, C., Tamooh, H., Gabona, F., Mujugira, A., Panteleeff, D., Thomas, K. K., Kidoguchi, L., Krows, M., Revall, J., Morrison, S., Haugen, H., Emmanuel-Ogier, M., Ondrejcek, L., Coombs, R. W., Frenkel, L., Hendrix, C., Bumpus, N. N., Bangsberg, D., Haberer, J. E., Stevens, W. S., Lingappa, J. R. & Celum, C., Aug 2 2012, In : New England Journal of Medicine. 367, 5, p. 399-410 12 p.

Research output: Contribution to journalArticle

Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz

Tovar-y-Romo, L. B., Bumpus, N. N., Pomerantz, D., Avery, L. B., Sacktor, N., McArthur, J. C. & Haughey, N. J., Dec 2012, In : Journal of Pharmacology and Experimental Therapeutics. 343, 3, p. 696-703 8 p.

Research output: Contribution to journalArticle

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate

Anton, P. A., Cranston, R. D., Kashuba, A., Hendrix, C. W., Bumpus, N. N., Richardson-Harman, N., Elliott, J., Janocko, L., Khanukhova, E., Dennis, R., Cumberland, W. G., Ju, C., Carballo-Diéguez, A., Mauck, C. & McGowan, I., Nov 1 2012, In : AIDS research and human retroviruses. 28, 11, p. 1412-1421 10 p.

Research output: Contribution to journalArticle

2011
2010
2008

Investigation of the mechanisms underlying the differential effects of the K262R Mutation of P450 2B6 on catalytic activity

Bumpus, N. N. & Hollenberg, P. F., Oct 2008, In : Molecular Pharmacology. 74, 4, p. 990-999 10 p.

Research output: Contribution to journalArticle

2006

Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms

Bumpus, N. N., Kent, U. M. & Hollenberg, P. F., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 1, p. 345-351 7 p.

Research output: Contribution to journalArticle

2005

The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation

Bumpus, N. N., Sridar, C., Kent, U. M. & Hollenberg, P. F., Jun 2005, In : Drug Metabolism and Disposition. 33, 6, p. 795-802 8 p.

Research output: Contribution to journalArticle

2004

Metabolism of N,N′,N″-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms

Harleton, E., Webster, M., Bumpus, N. N., Kent, U. M., Rae, J. M. & Hollenberg, P. F., Sep 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 3, p. 1011-1019 9 p.

Research output: Contribution to journalArticle