Nadia Hansel

Professor

20042019
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Research Output 2004 2019

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Article
2019

A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography

Oelsner, E. C., Ortega, V. E., Smith, B. M., Nguyen, J. N., Manichaikul, A. W., Hoffman, E. A., Guo, X., Taylor, K. D., Woodruff, P. G., Couper, D. J., Hansel, N., Martinez, F. J., Paine, R., Han, M. K., Cooper, C., Dransfield, M. T., Criner, G., Krishnan, J. A., Bowler, R., Bleecker, E. R. & 5 others, Peters, S., Rich, S. S., Meyers, D. A., Rotter, J. I. & Graham Barr, R., Sep 15 2019, In : American journal of respiratory and critical care medicine. 200, 6, p. 721-731 11 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Chronic Obstructive Pulmonary Disease
Tomography
Lung
Outcome Assessment (Health Care)
Obstructive Lung Diseases
Chronic Obstructive Pulmonary Disease
Nebulizers and Vaporizers
Adrenal Cortex Hormones
Outcome Assessment (Health Care)

Ambient air pollution and variation in multiple domains of asthma morbidity among Peruvian children

and the GASP Study Investigators, Mar 1 2019, In : Annals of the American Thoracic Society. 16, 3, p. 348-355 8 p.

Research output: Contribution to journalArticle

Air Pollution
Asthma
Morbidity
Patient Acceptance of Health Care
Quality of Life

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

Christenson, S. A., Van Den Berge, M., Faiz, A., Inkamp, K., Bhakta, N., Bonser, L. R., Zlock, L. T., Barjaktarevic, I. Z., Barr, R. G., Bleecker, E. R., Boucher, R. C., Bowler, R. P., Comellas, A. P., Curtis, J. L., Han, M. L. K., Hansel, N., Hiemstra, P. S., Kaner, R. J., Krishnanm, J. A., Martinez, F. J. & 7 others, O'Neal, W. K., Paine, R., Timens, W., Wells, J. M., Spira, A., Erle, D. J. & Woodruff, P. G., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI121087.

Research output: Contribution to journalArticle

Interleukin-17
Chronic Obstructive Pulmonary Disease
Steroids
Adrenal Cortex Hormones
Inflammation

Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study

SPIROMICS investigators, Mar 1 2019, In : CHEST. 155, 3, p. 519-527 9 p.

Research output: Contribution to journalArticle

Propensity Score
Chronic Obstructive Pulmonary Disease
Aspirin
Outcome Assessment (Health Care)
Morbidity
Prediabetic State
Asthma
Hemoglobins
Obesity
Confidence Intervals

Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD

Fawzy, A., Anderson, J. A., Cowans, N. J., Crim, C., Wise, R. A., Yates, J. C. & Hansel, N., May 8 2019, In : Respiratory research. 20, 1, 86.

Research output: Contribution to journalArticle

Open Access
Platelet Count
Chronic Obstructive Pulmonary Disease
Morbidity
Mortality
Confidence Intervals
Open Access
asthma
loci
Asthma
Genes
Chromosomes

Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet

Younas, H., Vieira, M., Gu, C., Lee, R., Shin, M-K., Berger, S., Loube, J., Nelson, A., Bevans-Fonti, S., Zhong, Q., D'Alessio, F., McCormack, M., Hansel, N., Mitzner, W. A. & Polotsky, V., Dec 1 2019, In : Scientific Reports. 9, 1, 279.

Research output: Contribution to journalArticle

Caloric Restriction
High Fat Diet
Interleukin-1
Diet
Interleukin 1 Receptor Antagonist Protein

Chronic obstructive pulmonary disease in America's black population

Ejike, C. O., Dransfield, M. T., Hansel, N., Putcha, N., Raju, S., Martinez, C. H. & Han, M. L. K., Aug 15 2019, In : American journal of respiratory and critical care medicine. 200, 4, p. 423-430 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Population

Developing an advanced PM 2.5 exposure model in Lima, Peru

Vu, B. N., Sánchez, O., Bi, J., Xiao, Q., Hansel, N., Checkley, W., Gonzales, G. F., Steenland, K. & Liu, Y., Jan 1 2019, In : Remote Sensing. 11, 6, 641.

Research output: Contribution to journalArticle

Open Access
optical depth
spatial resolution
aerosol
albedo
exposure

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

SpiroMeta consortium, International COPD Genetics Consortium & Understanding Society Scientific group, Mar 1 2019, In : Nature genetics. 51, 3, p. 494-505 12 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Phenotype
Lung
Genetic Loci
Genetic Heterogeneity

Household food insecurity is associated with asthma control in Peruvian children living in a resource-poor setting

Tarazona-Meza, C. E., Nicholson, A., Romero, K. M., Pollard, S., Gálvez-Davila, R. M., Hansel, N. & Checkley, W., Jan 1 2019, (Accepted/In press) In : Journal of Asthma.

Research output: Contribution to journalArticle

Food Supply
Asthma
Peru
Food
Social Class

Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: The SubPopulations and intermediate outcome measures in COPD study (SPIROMICS)

Haghighi, B., Choi, S., Choi, J., Hoffman, E. A., Comellas, A. P., Newell, J. D., Lee, C. H., Barr, R. G., Bleecker, E., Cooper, C. B., Couper, D., Han, M. L., Hansel, N., Kanner, R. E., Kazerooni, E. A., Kleerup, E. A. C., Martinez, F. J., O'Neal, W., Paine, R., Rennard, S. I. & 3 others, Smith, B. M., Woodruff, P. G. & Lin, C. L., Jul 15 2019, In : Respiratory research. 20, 1, 153.

Research output: Contribution to journalArticle

Open Access
Emphysema
Chronic Obstructive Pulmonary Disease
Outcome Assessment (Health Care)
Cluster Analysis
Phenotype
Tobacco Smoke Pollution
Asthma
Caregivers
Social Support
Logistic Models

Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD

Chisholm, J. F., Shenoy, S. K., Shade, J. K., Kim, V., Putcha, N., Carson, K. A., Wise, R. A., Hansel, N., Hanes, J. S., Suk, J. S. & Neptune, E., Aug 1 2019, In : European Respiratory Journal. 54, 2, 1900088.

Research output: Contribution to journalArticle

Open Access
Sputum
Nanoparticles
Chronic Obstructive Pulmonary Disease
Mucus
Lung

Omega-3 and omega-6 intake modifies asthma severity and response to indoor air pollution in children

Brigham, E. P., Woo, H., McCormack, M., Rice, J., Koehler, K., Vulcain, T., Wu, T., Koch, A., Sharma, S., Kolahdooz, F., Bose, S., Hanson, C., Romero, K., Diette, G. & Hansel, N. N., Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1478-1486 9 p.

Research output: Contribution to journalArticle

Indoor Air Pollution
Particulate Matter
Asthma
Fatty Acids
Omega-6 Fatty Acids

Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD

Lemoine, S. C. M., Brigham, E., Woo, H., Hanson, C. K., McCormack, M., Koch, A., Putcha, N. & Hansel, N., May 21 2019, In : BMC pulmonary medicine. 19, 1, 97.

Research output: Contribution to journalArticle

Open Access
alpha-Linolenic Acid
Omega-3 Fatty Acids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Chronic Obstructive Pulmonary Disease

Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS

SPIROMICS investigators, Oct 1 2019, In : The European respiratory journal. 54, 4

Research output: Contribution to journalArticle

Total Lung Capacity
Spirometry
Chronic Obstructive Pulmonary Disease
Outcome Assessment (Health Care)
Lung
Poverty
Chronic Obstructive Pulmonary Disease
Odds Ratio
Heating
Environmental Pollutants

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

Labaki, W. W., Gu, T., Murray, S., Curtis, J. L., Yeomans, L., Bowler, R. P., Barr, R. G., Comellas, A. P., Hansel, N., Cooper, C. B., Barjaktarevic, I., Kanner, R. E., Paine, R., McDonald, M. L. N., Krishnan, J. A., Peters, S. P., Woodruff, P. G., O’Neal, W. K., Diao, W., He, B. & 4 others, Martinez, F. J., Standiford, T. J., Stringer, K. A. & Han, M. L. K., Dec 1 2019, In : Scientific reports. 9, 1, 11367.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Chronic Obstructive Pulmonary Disease
Amino Acids
Serum
Tryptophan

Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

National Heart, Lung and Blood Institute's SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) and Severe Asthma Research Program (SARP), Jul 1 2019, In : Korean journal of radiology. 20, 7, p. 1236-1245 10 p.

Research output: Contribution to journalArticle

Thorax
Tomography
Lung
Lung Diseases
Air

Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS

Garudadri, S., Woodruff, P. G., Han, M. L. K., Curtis, J. L., Barr, R. G., Bleecker, E. R., Bowler, R. P., Comellas, A., Cooper, C. B., Criner, G., Dransfield, M. T., Hansel, N., Paine, R., Krishnan, J. A., Peters, S. P., Hastie, A. T., Martinez, F. J., O'Neal, W. K., Couper, D. J., Alexis, N. E. & 1 others, Christenson, S. A., May 1 2019, In : CHEST. 155, 5, p. 908-917 10 p.

Research output: Contribution to journalArticle

Spirometry
Chronic Obstructive Pulmonary Disease
Outcome Assessment (Health Care)
Inflammation
C-Reactive Protein

The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition

COPDGene Investigators, Oct 2019, In : CHEST. 156, 4, p. 685-695 11 p.

Research output: Contribution to journalArticle

Chronic Bronchitis
Chronic Obstructive Pulmonary Disease
Surveys and Questionnaires
Particulate Matter
Vitamin D
Asthma
Indoor Air Pollution
Morbidity
2018

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

for the, Jan 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 1, p. 429-432 4 p.

Research output: Contribution to journalArticle

Eosinophilia
Chronic Obstructive Pulmonary Disease

Anemia and adverse outcomes in a chronic obstructive pulmonary disease population with a high burden of comorbidities an analysis from SPIROMICS

on behalf of the SPIROMICS Investigators, Jun 1 2018, In : Annals of the American Thoracic Society. 15, 6, p. 710-717 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Comorbidity
Anemia
Outcome Assessment (Health Care)
Population

Association between exhaled carbon monoxide and asthma outcomes in Peruvian children

GASP Study Investigators, Dec 1 2018, In : Respiratory Medicine. 145, p. 212-216 5 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Asthma
Logistic Models
Peru
Linear Models

Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohorts

and for the SPIROMICS and COPDGene Investigators, Jan 26 2018, In : Respiratory Research. 19, 1, 20.

Research output: Contribution to journalArticle

Thrombocytosis
Chronic Obstructive Pulmonary Disease
Morbidity
Confidence Intervals
Odds Ratio

Association of traffic air pollution and rhinitis quality of life in Peruvian children with asthma

Bose, S., Romero, K., Psoter, K., Curriero, F. C., Chen, C., Johnson, C. M., Kaji, D., Breysse, P. N., Williams, DA. L., Ramanathan, M., Checkley, W. & Hansel, N., Mar 1 2018, In : PLoS One. 13, 3, e0193910.

Research output: Contribution to journalArticle

Soot
rhinitis
Air Pollution
asthma
air pollution

Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study

COPDGene Investigators, Feb 1 2018, In : Chest. 153, 2, p. 339-348 10 p.

Research output: Contribution to journalArticle

Asthma
Lung
Chronic Obstructive Pulmonary Disease
Pneumonia
Disease Progression

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

COPDGene and ECLIPSE Investigators, Jun 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2037-2047.e10

Research output: Contribution to journalArticle

Eosinophils
Chronic Obstructive Pulmonary Disease
Biomarkers
Cell Count
Molecular Epidemiology

Centrilobular emphysema and coronary artery calcification: Mediation analysis in the SPIROMICS cohort

Bhatt, S. P., Nath, H. P., Kim, Y. I., Ramachandran, R., Watts, J. R., Terry, N. L. J., Sonavane, S., Deshmane, S. P., Woodruff, P. G., Oelsner, E. C., Bodduluri, S., Han, M. K., Labaki, W. W., Michael Wells, J., Martinez, F. J., Barr, R. G., Dransfield, M. T., Alexis, N. E., Anderson, W. H., Bleecker, E. R. & 35 others, Boucher, R. C., Bowler, R. P., Carretta, E. E., Christenson, S. A., Comellas, A. P., Cooper, C. B., Couper, D. J., Criner, G. J., Crystal, R. G., Curtis, J. L., Doerschuk, C. M., Freeman, C. M., Hansel, N. N., Hastie, A. T., Hoffman, E. A., Kaner, R. J., Kanner, R. E., Kleerup, E. C., Krishnan, J. A., Lavange, L. M., Lazarus, S. C., Meyers, D. A., Moore, W. C., Newell, J. D., Paulin, L., Peters, S., O'Neal, W. K., Ortega, V. E., Paine, R., Putcha, N., Rennard, S. I., Tashkin, D. P., Scholand, M. B., Michael Wells, J. & Wise, R. A., Dec 18 2018, In : Respiratory Research. 19, 1, 257.

Research output: Contribution to journalArticle

Pulmonary Emphysema
Coronary Vessels
Emphysema
Chronic Obstructive Pulmonary Disease
Inflammation

Diet pattern and respiratory morbidity in the atherosclerosis risk in communities study

Brigham, E., Steffen, L. M., London, S. J., Boyce, D., Diette, G. B., Hansel, N., Rice, J. & McCormack, M., Jun 1 2018, In : Annals of the American Thoracic Society. 15, 6, p. 675-682 8 p.

Research output: Contribution to journalArticle

Atherosclerosis
Diet
Morbidity
Forced Expiratory Volume
Chronic Obstructive Pulmonary Disease

Genome-wide association study of lung function and clinical implication in heavy smokers

for the SPIROMICS Research Group, Aug 1 2018, In : BMC Medical Genetics. 19, 1, 134.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Chronic Obstructive Pulmonary Disease
Bronchodilator Agents
Lung
Genotype

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), Nov 20 2018, In : Respiratory Research. 19, 1, 1 p.

Research output: Contribution to journalArticle

Vital Capacity
Forced Expiratory Volume
Lung Diseases
Smoking
Emphysema

High fat diet induces airway hyperresponsiveness in mice

Fricke, K., Vieira, M., Younas, H., Shin, M-K., Bevans-Fonti, S., Berger, S., Lee, R., D'Alessio, F., Zhong, Q., Nelson, A., Loube, J., Sanchez, I., Hansel, N., Mitzner, W. A. & Polotsky, V., Dec 1 2018, In : Scientific Reports. 8, 1, 6404.

Research output: Contribution to journalArticle

High Fat Diet
Interleukin-1
Methacholine Chloride
Lung
Bronchoalveolar Lavage

Human airway branch variation and chronic obstructive pulmonary disease

the MESA Lung and SPIROMICS investigators, Jan 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 5, p. E974-E981

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung
Disease Susceptibility
Emphysema
Genetic Polymorphisms

Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Haghighi, B., Choi, S., Choi, J., Hoffman, E. A., Comellas, A. P., Newell, J. D., Graham Barr, R., Bleecker, E., Cooper, C. B., Couper, D., Han, M. L., Hansel, N., Kanner, R. E., Kazerooni, E. A., Kleerup, E. A. C., Martinez, F. J., O'Neal, W., Rennard, S. I., Woodruff, P. G. & Lin, C. L., Sep 18 2018, In : Respiratory Research. 19, 1, 178.

Research output: Contribution to journalArticle

Hematology
Total Lung Capacity
Chronic Obstructive Pulmonary Disease
Medicine
Outcome Assessment (Health Care)

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression

for the, Jan 1 2018, In : Chest. 153, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

Emphysema
Disease Progression
Chronic Obstructive Pulmonary Disease
alpha 1-Antitrypsin Deficiency
Molecular Epidemiology

Longitudinal phenotypes and mortality in preserved ratio impaired spirometry in the COPDGene study

For the COPDGene Investigators, Dec 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 11, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

Spirometry
Phenotype
Mortality
Lung
Tomography

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS

Putcha, N., Paul, G. G., Azar, A., Wise, R. A., O'Neal, W. K., Dransfield, M. T., Woodruff, P. G., Curtis, J. L., Comellas, A. P., Drummond, M. B., Lambert, A. A., Paulin, L. M., Fawzy, A., Kanner, R. E., Paine, R., Han, M. L. K., Martinez, F. J., Bowler, R. P., Barr, R. G. & Hansel, N., Jan 1 2018, In : PLoS One. 13, 4, e0194924.

Research output: Contribution to journalArticle

Immunoglobulin A
Chronic Obstructive Pulmonary Disease
Serum
cohort studies
dose response

Marijuana use associations with pulmonary symptoms and function in Tobacco smokers enrolled in the Subpopulations and Intermediate Outcome Measures in COPD study (SPIROMICS)

Morris, M. A., Jacobson, S. R., Kinney, G. L., Tashkin, D. P., Woodruff, P. G., Hoffman, E. A., Kanner, R. E., Cooper, C. B., Drummond, M. B., Graham Barr, R., Oelsner, E. C., Make, B. J., Han, M. L. K., Hansel, N., O'Neal, W. K. & Bowler, R. P., Jan 1 2018, In : Chronic Obstructive Pulmonary Diseases. 5, 1, p. 46-56 11 p.

Research output: Contribution to journalArticle

Cannabis
Chronic Obstructive Pulmonary Disease
Tobacco
Outcome Assessment (Health Care)
Lung

Nasal high flow, but not supplemental O2, reduces peripheral vascular sympathetic activity during sleep in COPD patients

Fricke, K., Schneider, H., Biselli, P., Hansel, N., Zhang, Z. G., Sowho, M. O. & Grote, L., Jan 1 2018, In : International journal of chronic obstructive pulmonary disease. 13, p. 3635-3643 9 p.

Research output: Contribution to journalArticle

Nose
Chronic Obstructive Pulmonary Disease
Blood Vessels
Sleep
REM Sleep

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort

Labaki, W. W., Xia, M., Murray, S., Curtis, J. L., Barr, R. G., Bhatt, S. P., Bleecker, E. R., Hansel, N., Cooper, C. B., Dransfield, M. T., Wells, J. M., Hoffman, E. A., Kanner, R. E., Paine, R., Ortega, V. E., Peters, S. P., Krishnan, J. A., Bowler, R. P., Couper, D. J., Woodruff, P. G. & 3 others, Martinez, F. J., Martinez, C. H. & Han, M. L. K., Jul 1 2018, In : Respiratory Medicine. 140, p. 87-93 7 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Chronic Obstructive Pulmonary Disease
Cohort Studies
Cardiovascular Diseases
Smoking

Occupational exposures and computed tomographic imaging characteristics in the SpiromICS cohort

Paulin, L. M., Smith, B. M., Koch, A., Han, M. L., Hoffman, E. A., Martinez, C., Ejike, C., Blanc, P. D., Rous, J., Graham Barr, R., Peters, S. P., Paine, R., Pirozzi, C., Cooper, C. B., Dransfield, M. T., Comellas, A. P., Kanner, R. E., Brad Drummond, M., Putcha, N. & Hansel, N., Dec 1 2018, In : Annals of the American Thoracic Society. 15, 12, p. 1411-1419 9 p.

Research output: Contribution to journalArticle

Occupational Exposure
Dust
Emphysema
Confidence Intervals
Gases
Tobacco Smoke Pollution
Asthma
Obesity
Morbidity
Parabens
Asthma
Population
Hospital Emergency Service
Morbidity

Rare loss of function variants in candidate genes and risk of colorectal cancer

NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group & 15 others, Steering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In : Human Genetics. 137, 10, p. 795-806 12 p.

Research output: Contribution to journalArticle

Polyps
Colorectal Neoplasms
Genes
Penetrance
Genetic Testing
Sleep Apnea Syndromes
Chronic Obstructive Pulmonary Disease
Research
Research Personnel
Pulmonary Medicine