Nada Alachkar

Associate Professor

20102019
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Research Output 2010 2019

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Article
2019

ACTH Gel in Resistant Focal Segmental Glomerulosclerosis after Kidney Transplantation

Alhamad, T., Manllo DIeck, J., Younus, U., Matar, D., Alasfar, S., Vujjini, V., Wall, D., Kanawati, B., Reiser, J., Brennan, D. & Alachkar, N., Jan 1 2019, In : Transplantation. 103, 1, p. 202-209 8 p.

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Kidney Transplantation
Adrenocorticotropic Hormone
Sclerosis
Gels

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease

CureGN Consortium, Feb 1 2019, In : American Journal of Kidney Diseases. 73, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Observational Studies
Prospective Studies
Chronic Kidney Failure
IGA Glomerulonephritis
Lipoid Nephrosis

Health-related quality of life in glomerular disease

CureGN Consortium, May 1 2019, In : Kidney International. 95, 5, p. 1209-1224 16 p.

Research output: Contribution to journalArticle

Open Access
Quality of Life
Immunosuppression
Edema
Demography
Lipoid Nephrosis

Intrinsic tumor necrosis factor-α pathway is activated in a subset of patients with focal segmental glomerulosclerosis

Chung, C. F., Kitzler, T., Kachurina, N., Pessina, K., Babayeva, S., Bitzan, M., Kaskel, F., Colmegna, I., Alachkar, N., Goodyer, P., Cybulsky, A. V. & Torban, E., May 1 2019, In : PloS one. 14, 5, e0216426.

Research output: Contribution to journalArticle

Open Access
Focal Segmental Glomerulosclerosis
tumor necrosis factors
nephrotic syndrome
Podocytes
Poisons
2018

Monitoring suPAR levels in post-kidney transplant focal segmental glomerulosclerosis treated with therapeutic plasma exchange and rituximab

Alachkar, N., Li, J., Matar, D., Vujjini, V., Alasfar, S., Tracy, M., Reiser, J. & Wei, C., Dec 17 2018, In : BMC Nephrology. 19, 1, 361.

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Plasma Exchange
Transplants
Kidney
Proteinuria

Rituximab and Therapeutic Plasma Exchange in Recurrent Focal Segmental Glomerulosclerosis Postkidney Transplantation

Alasfar, S., Matar, D., Montgomery, R. A., Desai, N. M., Lonze, B., Vujjini, V., Estrella, M. M., Manllo DIeck, J., Khneizer, G., Sever, S., Reiser, J. & Alachkar, N., Mar 1 2018, In : Transplantation. 102, 3, p. e115-e120

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Plasma Exchange
Transplantation
Recurrence
Therapeutics

The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell–mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials

Haas, M., Loupy, A., Lefaucheur, C., Roufosse, C., Glotz, D., Seron, D., Nankivell, B. J., Halloran, P. F., Colvin, R. B., Akalin, E., Alachkar, N., Bagnasco, S. M., Bouatou, Y., Becker, J. U., Cornell, L. D., van Huyen, J. P. D., Gibson, I. W., Kraus, E., Mannon, R. B., Naesens, M. & 9 others, Nickeleit, V., Nickerson, P., Segev, D., Singh, H. K., Stegall, M., Randhawa, P., Racusen, L. C., Solez, K. & Mengel, M., Feb 1 2018, In : American Journal of Transplantation. 18, 2, p. 293-307 15 p.

Research output: Contribution to journalArticle

Clinical Trials
Kidney
Atrophy
Antibodies
Fibrosis
2017

Nontraditional sites for vascular anastomoses to enable kidney transplantation in patients with major systemic venous thromboses

Lonze, B. E., Dagher, N. N., Alachkar, N., Jackson, A. & Montgomery, R. A., Dec 1 2017, In : Clinical Transplantation. 31, 12, e13127.

Research output: Contribution to journalArticle

Venous Thrombosis
Kidney Transplantation
Blood Vessels
Allografts
Drainage

Outcomes and risk stratification for late antibody-mediated rejection in recipients of ABO-incompatible kidney transplants: A retrospective study

Lonze, B. E., Bae, S., Kraus, E., Holechek, M. J., King, K. E., Alachkar, N., Naqvi, F., Dagher, N. N., Sharif, A., Desai, N. M., Segev, D. & Montgomery, R. A., 2017, (Accepted/In press) In : Transplant International.

Research output: Contribution to journalArticle

Retrospective Studies
Transplants
Kidney
Antibodies
Incidence

The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

Loupy, A., Haas, M., Solez, K., Racusen, L. C., Glotz, D., Seron, D., Nankivell, B. J., Colvin, R. B., Afrouzian, M., Akalin, E., Alachkar, N., Bagnasco, S. M., Becker, J. U., Cornell, L., Drachenberg, C., Dragun, D., de Kort, H., Gibson, I. W., Kraus, E., Lefaucheur, C. & 17 others, Legendre, C., Liapis, H., Muthukumar, T., Nickeleit, V., Orandi, B., Park, W., Rabant, M., Randhawa, P., Reed, E. F., Roufosse, C., Seshan, S. V., Sis, B., Singh, H. K., Schinstock, C., Tambur, A., Zeevi, A. & Mengel, M., Jan 1 2017, In : American Journal of Transplantation. 17, 1, p. 28-41 14 p.

Research output: Contribution to journalArticle

Molecular Pathology
Transplants
Kidney
Antibodies
Composite Tissue Allografts
2016

Ammonia level and mortality in acute liver failure: A single-center experience

Niranjan-Azadi, A., Araz, F., Patle, Y. A., Alachkar, N., Alqahtani, S. A., Cameron, A. M., Stevens, R. D. & Gurakar, A., Aug 2 2016, In : Annals of Transplantation. 21, p. 479-483 5 p.

Research output: Contribution to journalArticle

Acute Liver Failure
Ammonia
Mortality
Renal Dialysis
Acute Kidney Injury

Membranoproliferative glomerulonephritis recurrence after kidney transplantation: Using the new classification

Alasfar, S., Carter-Monroe, N., Rosenberg, A., Montgomery, R. A. & Alachkar, N., Jan 11 2016, In : BMC Nephrology. 17, 1, 7.

Research output: Contribution to journalArticle

Membranoproliferative Glomerulonephritis
Kidney Transplantation
Recurrence
Allografts
Glomerulonephritis

Novel unbiased assay for circulating podocyte-toxic factors associated with recurrent focal segmental glomerulosclerosis

Kachurina, N., Chung, C. F., Benderoff, E., Babayeva, S., Bitzan, M., Goodyer, P., Kitzler, T., Matar, D., Cybulsky, A. V., Alachkar, N. & Torban, E., May 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 10, p. F1148-F1156

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Podocytes
Poisons
Sclerosis
Focal Adhesions

Presentation and outcomes of C4d-negative antibody-mediated rejection after kidney transplantation

Orandi, B. J., Alachkar, N., Kraus, E., Naqvi, F., Lonze, B. E., Lees, L., Van Arendonk, K. J., Wickliffe, C., Bagnasco, S. M., Zachary, A. A., Segev, D. & Montgomery, R. A., Jan 1 2016, In : American Journal of Transplantation. 16, 1, p. 213-220 8 p.

Research output: Contribution to journalArticle

Kidney Transplantation
Antibodies
Transplants
Tissue Donors
Graft Survival

Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection

Alachkar, H., Mutonga, M., Kato, T., Kalluri, S., Kakuta, Y., Uemura, M., Imamura, R., Nonomura, N., Vujjini, V., Alasfar, S., Rabb, H., Nakamura, Y. & Alachkar, N., Nov 21 2016, In : BMC Nephrology. 17, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Graft Rejection
Biomarkers
T-Lymphocytes
Kidney
T-Cell Antigen Receptor

Recurrent IgA Nephropathy After Kidney Transplantation

Nijim, S., Vujjini, V., Alasfar, S., Luo, X., Orandi, B., Delp, C., Desai, N. M., Montgomery, R. A., Lonze, B. E. & Alachkar, N., Oct 1 2016, In : Transplantation Proceedings. 48, 8, p. 2689-2694 6 p.

Research output: Contribution to journalArticle

Kidney Transplantation
Immunoglobulin A
Recurrence
Allografts
Living Donors

Splenic Irradiation for the Treatment of Severe Antibody-Mediated Rejection

Orandi, B. J., Lonze, B. E., Jackson, A., Terezakis, S. A., Kraus, E., Alachkar, N., Bagnasco, S. M., Segev, D., Orens, J. B. & Montgomery, R. A., 2016, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

Splenectomy
Plasmapheresis
Intravenous Immunoglobulins
Transplants
Antibodies
Disseminated Intravascular Coagulation
Fibrin
Acute Kidney Injury
Kidney Transplantation
Thrombosis
2015

Frailty, mycophenolate reduction, and graft loss in kidney transplant recipients

McAdams Demarco, M. A., Law, A., Tan, J., Delp, C., King, E., Orandi, B., Salter, M., Alachkar, N., Desai, N. M., Grams, M., Walston, J. D. & Segev, D., Apr 1 2015, In : Transplantation. 99, 4, p. 805-810 6 p.

Research output: Contribution to journalArticle

Mycophenolic Acid
Transplants
Kidney
Kidney Transplantation
Tissue Donors

Frailty and mortality in kidney transplant recipients

McAdams Demarco, M. A., Law, A., King, E., Orandi, B., Salter, M., Gupta, N., Chow, E., Alachkar, N., Desai, N. M., Varadhan, R., Walston, J. D. & Segev, D., Jan 1 2015, In : American Journal of Transplantation. 15, 1, p. 149-154 6 p.

Research output: Contribution to journalArticle

Transplantation
Kidney
Mortality
Registries
Delayed Graft Function

Management of hepatitis C infection among patients with renal failure

Latt, N. L., Araz, F., Alachkar, N., Durand, C. & Gurakar, A., Mar 1 2015, In : Minerva Gastroenterologica e Dietologica. 61, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

Hepatitis C
Hepacivirus
Renal Insufficiency
Infection
Virus Diseases

Quantifying renal allograft loss following early antibody-mediated rejection

Orandi, B. J., Chow, E. H. K., Hsu, A., Gupta, N., Van Arendonk, K. J., Garonzik, J., Montgomery, J. R., Wickliffe, C., Lonze, B. E., Bagnasco, S. M., Alachkar, N., Kraus, E., Jackson, A., Montgomery, R. A. & Segev, D., Feb 1 2015, In : American Journal of Transplantation. 15, 2, p. 489-498 10 p.

Research output: Contribution to journalArticle

Allografts
Kidney
Antibodies
Tissue Donors
Transplants
2014

Abatacept in B7-1-positive proteinuric kidney disease

Alachkar, N., Carter-Monroe, N. & Reiser, J., 2014, In : New England Journal of Medicine. 370, 13, p. 1263 1 p.

Research output: Contribution to journalArticle

CD80 Antigens
Immunoconjugates
Focal Segmental Glomerulosclerosis
Kidney Diseases
Abatacept

A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation

Delville, M., Sigdel, T. K., Wei, C., Li, J., Hsieh, S. C., Fornoni, A., Burke, G. W., Bruneval, P., Naesens, M., Jackson, A., Alachkar, N., Canaud, G., Legendre, C., Anglicheau, D., Reiser, J. & Sarwal, M. M., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra136.

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Kidney Transplantation
Recurrence
Antibodies
Antigens

Atypical hemolytic uremic syndrome recurrence after kidney transplantation

Matar, D., Naqvi, F., Racusen, L. C., Carter-Monroe, N., Montgomery, R. A. & Alachkar, N., Dec 15 2014, In : Transplantation. 98, 11, p. 1205-1212 8 p.

Research output: Contribution to journalArticle

Kidney Transplantation
Recurrence
Mutation
Alternative Complement Pathway
Atypical Hemolytic Uremic Syndrome
Kidney Diseases
Virus Diseases
Myeloid Cells
Interleukin-12
Dendritic Cells

Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis

Garin, E. H., Reiser, J., Cara-Fuentes, G., Wei, C., Matar, D., Wang, H., Alachkar, N. & Johnson, R. J., 2014, In : Pediatric Nephrology. 30, 3, p. 469-477 9 p.

Research output: Contribution to journalArticle

Lipoid Nephrosis
Focal Segmental Glomerulosclerosis
Immunoglobulin G
Proteinuria
Podocytes
End Stage Liver Disease
Graft Survival
Hepacivirus
Kidney
Liver

Eculizumab and splenectomy as salvage therapy for severe antibody-mediated rejection after HLA-incompatible kidney transplantation

Orandi, B. J., Zachary, A. A., Dagher, N. N., Bagnasco, S. M., Garonzik, J., Van Arendonk, K. J., Gupta, N., Lonze, B. E., Alachkar, N., Kraus, E., Desai, N. M., Locke, J. E., Racusen, L. C., Segev, D. & Montgomery, R. A., 2014, In : Transplantation. 98, 8, p. 857-863 7 p.

Research output: Contribution to journalArticle

Salvage Therapy
Splenectomy
Kidney Transplantation
Antibodies
Transplants

Histologic phenotype on 1-year posttransplantation biopsy and allograft survival in HLA-incompatible kidney transplants

Sharif, A., Kraus, E., Zachary, A. A., Lonze, B. E., Nazarian, S. M., Segev, D., Alachkar, N., Arend, L. J., Bagnasco, S. M., Racusen, L. C. & Montgomery, R. A., Mar 15 2014, In : Transplantation. 97, 5, p. 541-547 7 p.

Research output: Contribution to journalArticle

Allografts
Transplants
Phenotype
Kidney
Biopsy

Late antibody-mediated rejection in renal allografts: Outcome after conventional and novel therapies

Gupta, G., Abu Jawdeh, B. G., Racusen, L. C., Bhasin, B., Arend, L. J., Trollinger, B., Kraus, E., Rabb, H., Zachary, A. A., Montgomery, R. A. & Alachkar, N., Jun 27 2014, In : Transplantation. 97, 12, p. 1240-1246 7 p.

Research output: Contribution to journalArticle

Allografts
Kidney
Antibodies
Creatinine
Therapeutics

Permeability Factors in Focal and Segmental Glomerulosclerosis

Reiser, J., Nast, C. C. & Alachkar, N., 2014, In : Advances in Chronic Kidney Disease. 21, 5, p. 417-421 5 p.

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Permeability
Podocytes
Sclerosis
Genetic Predisposition to Disease

Proteinuria: abate or applaud abatacept in proteinuric kidney disease?

Reiser, J. & Alachkar, N., 2014, In : Nature Reviews Nephrology. 10, 3, p. 128-130 3 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Kidney Diseases
Proteinuria
CD80 Antigens
Focal Segmental Glomerulosclerosis

Sarcoidosis in native and transplanted kidneys: Incidence, pathologic findings, and clinical course

Bagnasco, S. M., Gottipati, S., Kraus, E., Alachkar, N., Montgomery, R. A., Racusen, L. C. & Arend, L. J., Oct 20 2014, In : PLoS One. 9, 10, e110778.

Research output: Contribution to journalArticle

Biopsy
Sarcoidosis
disease course
kidneys
Kidney

Time course of pathologic changes in kidney allografts of positive crossmatch HLA-incompatible transplant recipients

Bagnasco, S. M., Zachary, A. A., Racusen, L. C., Arend, L. J., Carter-Monroe, N., Alachkar, N., Nazarian, S. M., Lonze, B. E., Montgomery, R. A. & Kraus, E., Feb 27 2014, In : Transplantation. 97, 4, p. 440-445 6 p.

Research output: Contribution to journalArticle

Allografts
Transplants
Kidney
Biopsy
Antibodies
2013

Angiotensin antibodies and focal segmental glomerulosclerosis

Alachkar, N., Gupta, G. & Montgomery, R. A., Mar 7 2013, In : New England Journal of Medicine. 368, 10, p. 971-973 3 p.

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Angiotensins
Antibodies

Podocyte effacement closely links to suPAR levels at time of posttransplantation focal segmental glomerulosclerosis occurrence and improves with therapy

Alachkar, N., Wei, C., Arend, L. J., Jackson, A., Racusen, L. C., Fornoni, A., Burke, G., Rabb, H., Kakkad, K., Reiser, J. & Estrella, M. M., Oct 15 2013, In : Transplantation. 96, 7, p. 649-656 8 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Focal Segmental Glomerulosclerosis
Podocytes
Proteinuria
Allografts

Reply to "defining the benefits of desensitization therapy"

Singer, A. L., Alachkar, N., Montgomery, R. A. & Zachary, A. A., May 27 2013, In : Transplantation. 95, 6

Research output: Contribution to journalArticle

Therapeutics
2012
Antibodies, Monoclonal, Humanized
Hemolytic-Uremic Syndrome
Plasma Exchange
Graft Rejection
Kidney Transplantation

Hepatitis C virus and its renal manifestations: A review and update

Latt, N., Alachkar, N. & Gurakar, A., Jul 2012, In : Gastroenterology and Hepatology. 8, 7, p. 434-445 12 p.

Research output: Contribution to journalArticle

Hepacivirus
Kidney
Chronic Hepatitis C
Virus Diseases
Membranoproliferative Glomerulonephritis

Incidence and outcomes of BK virus allograft nephropathy among ABO- and HLA-incompatible kidney transplant recipients

Sharif, A., Alachkar, N., Bagnasco, S. M., Geetha, D., Gupta, G., Womer, K., Arend, L. J., Racusen, L. C., Montgomery, R. & Kraus, E., Aug 2012, In : Clinical Journal of the American Society of Nephrology. 7, 8, p. 1320-1327 8 p.

Research output: Contribution to journalArticle

BK Virus
Allografts
Kidney
Incidence
Biopsy

Incompatible kidney transplantation: A brief overview of the past, present and future

Sharif, A., Alachkar, N. & Kraus, E., Dec 2012, In : QJM. 105, 12, p. 1141-1150 10 p., hcs154.

Research output: Contribution to journalArticle

Kidney Transplantation
Kidney
Blood Group Antigens
HLA Antigens
Transplantation

Infusion of high-dose intravenous immunoglobulin fails to lower the strength of human leukocyte antigen antibodies in highly sensitized patients

Alachkar, N., Lonze, B. E., Zachary, A. A., Holechek, M. J., Schillinger, K., Cameron, A. M., Desai, N. M., Dagher, N. N., Segev, D., Montgomery, R. A. & Singer, A. L., Jul 27 2012, In : Transplantation. 94, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

Intravenous Immunoglobulins
HLA Antigens
Transplantation
Antibodies
Tissue Donors

Rescue kidney paired donation as emergency salvage for failed desensitization

Sharif, A., Zachary, A. A., Hiller, J., Segev, D., Alachkar, N., Kraus, E., Desai, N. M., Dagher, N. N., Singer, A. L. & Montgomery, R. A., Apr 15 2012, In : Transplantation. 93, 7

Research output: Contribution to journalArticle

Murine-Derived Monoclonal Antibodies
Directed Tissue Donation
Immunologic Desensitization
Blood Group Incompatibility
Salvage Therapy

Serum and urinary biomarkers in acute kidney transplant rejection

Alachkar, N., Feb 2012, In : Nephrologie et Therapeutique. 8, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

Graft Rejection
Allografts
Biomarkers
Kidney
Serum
2011

Molecular imaging of the kidneys

Szabo, Z., Alachkar, N., Xia, J., Mathews, W. B. & Rabb, H., Jan 2011, In : Seminars in Nuclear Medicine. 41, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Molecular Imaging
Kidney
Kidney Neoplasms
Radiopharmaceuticals
Renal Circulation

Urinary biomarkers in acute kidney transplant dysfunction

Alachkar, N., Rabb, H. & Jaar, B., May 2011, In : Nephron - Clinical Practice. 118, 2

Research output: Contribution to journalArticle

Allografts
Biomarkers
Transplants
Kidney
Biopsy
2010

Incidental Discovery of a Renal Cell Carcinoma on Native Kidney Biopsy

Sperati, C. J., Alachkar, N., Rodriguez, R., Haas, M. & Choi, M. J., Jul 2010, In : American Journal of Kidney Diseases. 56, 1, p. 175-180 6 p.

Research output: Contribution to journalArticle

Incidental Findings
Kidney Neoplasms
Renal Cell Carcinoma
Kidney
Biopsy

Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function

Alachkar, N., Ugarte, R., Huang, E., Womer, K. L., Montgomery, R., Kraus, E. & Rabb, H., Nov 2010, In : Transplantation Proceedings. 42, 9, p. 3399-3405 7 p.

Research output: Contribution to journalArticle

Interleukin-16
Interleukin-2 Receptor alpha Subunit
Delayed Graft Function
Stem Cell Factor
Biomarkers