Monique Stins

Assistant Professor

1992 …2019
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Research Output 1992 2019

2019

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak

Gramagliaid, I., Velez, J., Chang, Y. S., Caparros-Wanderley, W., Combes, V., Grau, G., Stins, M. & Van Der Heyde, H. C., Mar 1 2019, In : PloS one. 14, 3, e0213428.

Research output: Contribution to journalArticle

Open Access
Cerebral Malaria
citrulline
Citrulline
blood vessels
Blood Vessels
Open Access
Blood-Brain Barrier
Brain
Blood Vessels
Homeostasis
Central Nervous System
2018

Brain vascular heterogeneity: Implications for disease pathogenesis and design of in vitro blood-brain barrier models

Noumbissi, M. E., Galasso, B. & Stins, M., Apr 23 2018, In : Fluids and Barriers of the CNS. 15, 1, 12.

Research output: Contribution to journalReview article

Blood-Brain Barrier
Blood Vessels
Brain
Cerebrovascular Disorders
Endothelial Cells
2017

Soluble lipoprotein receptor-related protein immunoreactive species in cell culture media and serum replacement supplements

Fitzsimmons, C., Johnstone, D., Conant, K., St Hillaire, C., Parsons, C. H., Stins, M., Moir, R. & Milward, E. A., Jan 7 2017, In : Analytical Methods. 9, 1, p. 110-116 7 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Lipoproteins
Cell culture
Culture Media
Ligands
2015

CD68 acts as a major gateway for malaria sporozoite liver infection

Cha, S-J., Park, K., Srinivasan, P., Schindler, C. W., Van Rooijen, N., Stins, M. & Jacobs-Lorena, M., 2015, In : Journal of Experimental Medicine. 212, 9, p. 1391-1403 13 p.

Research output: Contribution to journalArticle

Sporozoites
Kupffer Cells
Malaria
Liver
Infection

Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: Potential implications for malarial pathogenesis

Gillrie, M. R., Avril, M., Brazier, A. J., Davis, S. P., Stins, M., Smith, J. D. & Ho, M., Dec 1 2015, In : Cellular Microbiology. 17, 12, p. 1883-1899 17 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Protein C
Ligation
Endothelial Cells
Parasites

Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

Petersen, J. E. V., Bouwens, E. A. M., Tamayo, I., Turner, L., Wang, C. W., Stins, M., Theander, T. G., Hermida, J., Mosnier, L. O. & Lavstsen, T., 2015, In : Thrombosis and Haemostasis. 114, 5, p. 1038-1048 11 p.

Research output: Contribution to journalArticle

Protein C
Malaria
Parasites
Proteins
Endothelial Cells
2012

A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells

Avril, M., Tripathi, A., Brazier, A. J., Andisi, C., Janes, J. H., Soma, V. L., Sullivan, D. J., Bull, P. C., Stins, M. & Smith, J. D., Jun 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 26

Research output: Contribution to journalArticle

Plasmodium falciparum
Endothelial Cells
Erythrocytes
Cerebral Malaria
Brain

Delivering minocycline into brain endothelial cells with liposome-based technology

Xing, C., Levchenko, T., Guo, S., Stins, M., Torchilin, V. P. & Lo, E. H., Jun 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 6, p. 983-988 6 p.

Research output: Contribution to journalArticle

Minocycline
Liposomes
Endothelial Cells
Technology
Brain
2011

Amplification of p. falciparum cytoadherence through induction of a pro-adhesive state in host endothelium

Wu, Y., Szestak, T., Stins, M. & Craig, A. G., Oct 17 2011, In : PLoS One. 6, 10, e24784.

Research output: Contribution to journalArticle

Endothelial cells
endothelium
cell adhesion
adhesives
Adhesives

How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?

Grab, D. J., Chakravorty, S. J., van der Heyde, H. & Stins, M., Oct 2011, In : Cellular Microbiology. 13, 10, p. 1470-1478 9 p.

Research output: Contribution to journalArticle

Microbial Interactions
Blood-Brain Barrier
Brain
Brain Diseases
Seizures

The relevance of non-human primate and rodent malaria models for humans

Langhorne, J., Buffet, P., Galinski, M., Good, M., Harty, J., Leroy, D., Mota, M. M., Pasini, E., Renia, L., Riley, E., Stins, M. & Duffy, P., 2011, In : Malaria Journal. 10, 23.

Research output: Contribution to journalArticle

Primates
Malaria
Rodentia
Animal Models
Host-Parasite Interactions
2010

Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells

Guo, S., Stins, M., Ning, M. & Lo, E. H., Aug 2010, In : Cerebrovascular Diseases. 30, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Dipyridamole
Matrix Metalloproteinase 9
Endothelial Cells
Inflammation
Vascular Cell Adhesion Molecule-1
2009

Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes

Guo, S., Arai, K., Stins, M., Chuang, D. M. & Lo, E. H., Feb 2009, In : Stroke. 40, 2, p. 652-655 4 p.

Research output: Contribution to journalArticle

Lithium
Astrocytes
Vascular Endothelial Growth Factor A
Up-Regulation
Endothelial Cells

Plasmodium falciparum-infected erythrocytes induce NF-κB regulated inflammatory pathways in human cerebral endothelium

Tripathi, A., Sha, W., Shulaev, V., Stins, M. & Sullivan, D. J., Nov 5 2009, In : Blood. 114, 19, p. 4243-4252 10 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Endothelium
Brain
Erythrocytes
Cerebral Malaria
2008

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons

Guo, S., Kim, W. J., Lok, J., Lee, S. R., Besancon, E., Luo, B. H., Stins, M., Wang, X., Dedhar, S. & Lo, E. H., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7582-7587 6 p.

Research output: Contribution to journalArticle

Endothelium
Brain-Derived Neurotrophic Factor
Endothelial Cells
Neurons
Conditioned Culture Medium

Protecting against cerebrovascular injury: Contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia

Jin, G., Arai, K., Murata, Y., Wang, S., Stins, M., Lo, E. H. & Van Leyen, K., Sep 1 2008, In : Stroke. 39, 9, p. 2538-2543 6 p.

Research output: Contribution to journalArticle

Lipoxygenase Inhibitors
Edema
Ischemia
Wounds and Injuries
Brain
2007

Balamuthia mandrillaris interactions with human brain microvascular endothelial cells in vitro

Matin, A., Siddiqui, R., Jung, S. Y., Kim, K. S., Stins, M. & Khan, N. A., Aug 2007, In : Journal of Medical Microbiology. 56, 8, p. 1110-1115 6 p.

Research output: Contribution to journalArticle

Balamuthia mandrillaris
Endothelial Cells
Galactose
Amoeba
Brain

Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity

Siddiqui, R., Matin, A., Warhurst, D., Stins, M. & Khan, N. A., Dec 2007, In : Antimicrobial Agents and Chemotherapy. 51, 12, p. 4471-4473 3 p.

Research output: Contribution to journalArticle

Balamuthia mandrillaris
Cysts
Endothelial Cells
Ergosterol
Cytochalasin D

Effects of human serum on Balamuthia mandrillaris interactions with human brain microvascular endothelial cells

Matin, A., Jeong, S. R., Stins, M. & Khan, N. A., Jan 2007, In : Journal of Medical Microbiology. 56, 1, p. 30-35 6 p.

Research output: Contribution to journalArticle

Balamuthia mandrillaris
Endothelial Cells
Brain
Serum
Blood-Brain Barrier

Glial activation and matrix metalloproteinase release in cerebral malaria.

Szklarczyk, A., Stins, M., Milward, E. A., Ryu, H., Fitzsimmons, C., Sullivan, D. J. & Conant, K., 2007, In : Journal of NeuroVirology. 13, 1, p. 2-10 9 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Matrix Metalloproteinases
Neuroglia
Blood-Brain Barrier
Astrocytes

Gp120-mediated cytotoxicity of human brain microvascular endothelial cells is dependent on p38 mitogen-activated protein kinase activation

Khan, N. A., Di Cello, F., Stins, M. & Kim, K. S., May 2007, In : Journal of NeuroVirology. 13, 3, p. 242-251 10 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Endothelial Cells
Brain
Blood-Brain Barrier
Interferons

HIV-1 gp120 as well as alcohol affect blood-brain barrier permeability and stress fiber formation: Involvement of reactive oxygen species

Shiu, C., Barbier, E., Cello, F. D., Choi, H. J. & Stins, M., Jan 2007, In : Alcoholism: Clinical and Experimental Research. 31, 1, p. 130-137 8 p.

Research output: Contribution to journalArticle

Stress Fibers
Blood-Brain Barrier
HIV-1
Permeability
Reactive Oxygen Species
Plasmodium falciparum
Blood-Brain Barrier
Endothelial Cells
Erythrocytes
Electric Impedance
2006

Balamuthia mandrillaris exhibits metalloprotease activities

Matin, A., Stins, M., Kim, K. S. & Khan, N. A., Jun 2006, In : FEMS Immunology and Medical Microbiology. 47, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Balamuthia mandrillaris
Metalloproteases
Peptide Hydrolases
Extracellular Matrix
Encephalitis

Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

Chan, C. W., Crafton, E., Fan, H. N., Flook, J., Yoshimura, K., Skarica, M., Brockstedt, D., Dubensky, T. W., Stins, M., Lanier, L. L., Pardoll, A. M. & Housseau, F., Mar 14 2006, In : Nature Medicine. 12, 2, p. 207-213 7 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Innate Immunity
Dendritic Cells
Interferons
Natural Killer Cells

Modulating CCR2 and CCL2 at the blood-brain barrier: Relevance for multiple sclerosis pathogenesis

Mahad, D., Callahan, M. K., Williams, K. A., Ubogu, E. E., Kivisäkk, P., Tucky, B., Kidd, G., Kingsbury, G. A., Chang, A., Fox, R. J., Mack, M., Sniderman, M. B., Ravid, R., Staugaitis, S. M., Stins, M. & Ransohoff, R. M., Jan 2006, In : Brain. 129, 1, p. 212-223 12 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Multiple Sclerosis
Monocytes
T-Lymphocytes
Chemokine Receptors

Newly identified interferon-producing natural killer-dendritic cell hybrid

Chan, C. W., Crafton, E., Fan, H. N., Flook, J., Yoshimura, K., Skarica, M., Stins, M., Brockstedt, D., Dubensky, T. W., Lanier, L. L. & Wasta, V., Apr 2006, In : Cancer Biology and Therapy. 5, 4, p. 342-343 2 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Dendritic Cells
Interferons
Intercellular Adhesion Molecule-1
Plasmodium falciparum
Cell Adhesion Molecules
Endothelium
Erythrocytes

The fibrinolytic system facilitates tumor cell migration across the blood-brain barrier in experimental melanoma brain metastasis

Perides, G., Zhuge, Y., Lin, T., Stins, M., Bronson, R. T. & Wu, J. K., Mar 9 2006, In : BMC Cancer. 6, 56.

Research output: Contribution to journalArticle

Experimental Melanomas
Blood-Brain Barrier
Cell Movement
Neoplasm Metastasis
Brain

Use of in vitro assays to determine effects of human serum on biological characteristics of Acanthamoeba castellanii

Sissons, J., Alsam, S., Stins, M., Rivas, A. O., Morales, J. L., Faull, J. & Khan, N. A., Jul 2006, In : Journal of Clinical Microbiology. 44, 7, p. 2595-2600 6 p.

Research output: Contribution to journalArticle

Acanthamoeba castellanii
Acanthamoeba
Serum
Peptide Hydrolases
Endothelial Cells
2005

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism

Sissons, J., Kim, K. S., Stins, M., Jayasekera, S., Alsam, S. & Khan, N. A., May 2005, In : Infection and Immunity. 73, 5, p. 2704-2708 5 p.

Research output: Contribution to journalArticle

Acanthamoeba castellanii
Phosphatidylinositol 3-Kinase
Acanthamoeba
Cell Death
Endothelial Cells

Borrelia burgdorferi, host-derived proteases, and the blood-brain barrier

Grab, D. J., Perides, G., Dumler, J. S., Kim, K. J., Park, J., Kim, Y. V., Nikolskaia, O., Choi, K. S., Stins, M. & Kim, K. S., Feb 2005, In : Infection and Immunity. 73, 2, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Blood-Brain Barrier
Peptide Hydrolases
Endothelial Cells
Brain

Erratum: Borrelia burgdorferi, host-derived proteases, and the blood-brain barrier (Infection and Immunity (2005) 73, 2 (1014-1022))

Grab, D. J., Perides, G., Dumler, J. S., Kim, K. J., Park, J., Kim, Y. V., Nikolskaia, O., Choi, K. S., Stins, M. & Kim, K. S., Apr 2005, In : Infection and Immunity. 73, 4, p. 2569 1 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Blood-Brain Barrier
Immunity
Peptide Hydrolases
Infection
2004

Acanthamoeba induces cell-cycle arrest in host cells

Sissons, J., Alsam, S., Jayasekera, S., Kim, K. S., Stins, M. & Khan, N. A., Aug 2004, In : Journal of Medical Microbiology. 53, 8, p. 711-717 7 p.

Research output: Contribution to journalArticle

Acanthamoeba
Cell Cycle Checkpoints
Cell Cycle
Phosphorylation
Keratitis

African trypanosome interactions with an in vitro model of the human blood-brain barrier

Grab, D. J., Nikolskaia, O., Kim, Y. V., Lonsdale-Eccles, J. D., Ito, S., Hara, T., Fukuma, T., Nyarko, E., Kim, K. J., Stins, M., Delannoy, M. J., Rodgers, J. & Kim, K. S., Oct 2004, In : Journal of Parasitology. 90, 5, p. 970-979 10 p.

Research output: Contribution to journalArticle

blood-brain barrier
Trypanosomiasis
Blood-Brain Barrier
brain
endothelial cells
CD4 Antigens
Chemokine Receptors
HIV-1
Endothelial Cells
Brain

Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier

Chang, Y. C., Stins, M., McCaffery, M. J., Miller, G. F., Pare, D. R., Dam, T., Paul-Satyasee, M., Kim, K. S. & Kwon-Chung, K. J., Sep 2004, In : Infection and Immunity. 72, 9, p. 4985-4995 11 p.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Blood-Brain Barrier
Central Nervous System
Yeasts
Brain

CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer

Callahan, M. K., Williams, K. A., Kivisäkk, P., Pearce, D., Stins, M. & Ransohoff, R. M., Aug 2004, In : Journal of Neuroimmunology. 153, 1-2, p. 150-157 8 p.

Research output: Contribution to journalArticle

Endothelial Cells
T-Lymphocytes
Brain
Blood-Brain Barrier
CXCR3 Receptors

Erratum: Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier (Infection and Immunity (2004) 72, 9 (4985-4995))

Chang, Y. C., Stins, M., McCaffery, M. J., Miller, G. F., Pare, D. R., Dam, T., Paul-Satyaseela, M., Kim, K. S. & Kwon-Chung, K. J., Nov 2004, In : Infection and Immunity. 72, 11, p. 6753 1 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Immunity
Central Nervous System
Yeasts
Infection
2003

37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake

Chung, J. W., Hong, S. J., Kim, K. J., Goti, D., Stins, M., Shin, S., Dawson, V., Dawson, T. M. & Kim, K. S., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16857-16862 6 p.

Research output: Contribution to journalArticle

Laminin Receptors
Chemical activation
rho GTP-Binding Proteins
Endothelial cells
Eukaryotic Cells

Acanthamoeba interactions with human brain microvascular endothelial cells

Alsam, S., Kim, K. S., Stins, M., Rivas, A. O., Sissons, J. & Khan, N. A., Dec 2003, In : Microbial Pathogenesis. 35, 6, p. 235-241 7 p.

Research output: Contribution to journalArticle

Acanthamoeba
Endothelial Cells
Brain
Encephalitis
Blood-Brain Barrier

Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells

Jong, A. Y., Chen, S. H. M., Stins, M., Kim, K. S., Tuan, T. L. & Huang, S. H., Aug 1 2003, In : Journal of Medical Microbiology. 52, 8, p. 615-622 8 p.

Research output: Contribution to journalArticle

Phosphopyruvate Hydratase
Fibrinolysin
Plasminogen
Candida albicans
Endothelial Cells

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells

Chen, S. H. M., Stins, M., Huang, S. H., Chen, Y. H., Kwon-Chung, K. J., Chang, Y., Kim, K. S., Suzuki, K. & Jong, A. Y., Nov 2003, In : Journal of Medical Microbiology. 52, 11, p. 961-970 10 p.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Cytoskeleton
Endothelial Cells
Brain
Actin Depolymerizing Factors

Induction of Intercellular Adhesion Molecule-1 on Human Brain Endothelial Cells by HIV-1 gp120: Role of CD4 and Chemokine Coreceptors

Stins, M., Pearce, D., Di Cello, F., Erdreich-Epstein, A., Pardo-Villamizar, C. A. & Kim, K. S., Dec 2003, In : Laboratory Investigation. 83, 12, p. 1787-1798 12 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Chemokines
HIV-1
Endothelial Cells
Chemokine Receptors

The K1 capsule modulates trafficking of E. coli-containing vacuoles and enhances intracellular bacterial survival in human brain microvascular endothelial cells

Kim, K. J., Elliott, S. J., Di Cello, F., Stins, M. & Kim, K. S., Apr 1 2003, In : Cellular Microbiology. 5, 4, p. 245-252 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Vacuoles
Escherichia coli
Capsules
Brain
2002

Ceramide signaling in fenretinide-induced endothelial cell apoptosis

Erdreich-Epstein, A., Tran, L. B., Bowman, N. N., Wang, H., Cabot, M. C., Durden, D. L., Vlckova, J., Reynolds, C. P., Stins, M., Groshen, S. & Millard, M., Dec 20 2002, In : Journal of Biological Chemistry. 277, 51, p. 49531-49537 7 p.

Research output: Contribution to journalArticle

Fenretinide
Ceramides
Endothelial cells
Endothelial Cells
Apoptosis
Transcytosis
Endothelial cells
Transforming Growth Factors
Escherichia coli
Brain

αv-integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin

Taga, T., Suzuki, A., Gonzalez-Gomez, I., Gilles, F. H., Stins, M., Shimada, H., Barsky, L., Weinberg, K. I. & Laug, W. E., Apr 10 2002, In : International Journal of Cancer. 98, 5, p. 690-697 8 p.

Research output: Contribution to journalArticle

Vitronectin
Tenascin
Integrins
Brain Neoplasms
Apoptosis
2001

Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells

Stins, M., Badger, J. & Kim, K. S., 2001, In : Microbial Pathogenesis. 30, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

Transcytosis
Endothelial Cells
Brain
Blood-Brain Barrier
Citrobacter