Mohammad Hoque

Associate Professor

1994 …2020

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2020

Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma

Schubert, A. D., Channah Broner, E., Agrawal, N., London, N., Pearson, A., Gupta, A., Wali, N., Seiwert, T. Y., Wheelan, S., Lingen, M., Macleod, K., Allen, H., Chatterjee, A., Vassiliki, S., Gaykalova, D., Hoque, M. O., Sidransky, D., Suresh, K. & Izumchenko, E., Feb 28 2020, In : Cancer Letters. 471, p. 49-60 12 p.

Research output: Contribution to journalArticle

2019

Expression of programmed cell death ligand 1 in non–small cell lung cancer: Comparison between cytologic smears, core biopsies, and whole sections using the SP263 assay

Munari, E., Zamboni, G., Sighele, G., Marconi, M., Sommaggio, M., Lunardi, G., Rossi, G., Cavazza, A., Moretta, F., Gilioli, E., Caliò, A., Netto, G. J., Hoque, M., Martignoni, G., Brunelli, M., Vacca, P., Moretta, L. & Bogina, G., Feb 1 2019, In : Cancer cytopathology. 127, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

GSTP1 as a Potential Marker of Early Chemotherapy Response for Noninvasive Detection

Izumchenko, E., Shavit Grievink, L., Rosenbaum, E. & Hoque, M., Jan 1 2019, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Immune profiles in primary squamous cell carcinoma of the head and neck

Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I., Zhavoronkov, A., Sidransky, D., Bedi, A., Hoque, M. O., Koeppen, H., Keck, M. K., Khattri, A., London, N., Kotlov, N., Fatima, A., Vougiouklakis, T., Nakamura, Y., Lingen, M., Agrawal, N. & 5 others, Savage, P. A., Kron, S., Kline, J., Kowanetz, M. & Seiwert, T. Y., Sep 1 2019, In : Oral Oncology. 96, p. 77-88 12 p.

Research output: Contribution to journalArticle

2018

Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma

Ooki, A., Dinalankara, W., Marchionni, L., Tsay, J. C. J., Goparaju, C., Maleki, Z., Rom, W. N., Pass, H. I. & Hoque, M. O., Nov 8 2018, In : Oncogene. 37, 45, p. 5967-5981 15 p.

Research output: Contribution to journalArticle

Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1

Maldonado, L., Brait Rodrigues De Oliveira, M., Izumchenko, E., Begum, S., Chatterjee, A., Sen, T., Loyo, M., Barbosa, A., Poeta, M. L., Makarev, E., Zhavoronkov, A., Fazio, V. M., Angioli, R., Rabitti, C., Ongenaert, M., Van Criekinge, W., Noordhuis, M. G., de Graeff, P., Wisman, G. B. A., van der Zee, A. G. J. & 1 others, Hoque, M., Oct 1 2018, In : Cancer Letters. 433, p. 242-251 10 p.

Research output: Contribution to journalArticle

PD-L1 Assays 22C3 and SP263 are Not Interchangeable in Non-Small Cell Lung Cancer When Considering Clinically Relevant Cutoffs

Munari, E., Rossi, G., Zamboni, G., Lunardi, G., Marconi, M., Sommaggio, M., Netto, G. J., Hoque, M., Brunelli, M., Martignoni, G., Haffner, M. C., Moretta, F., Pegoraro, M. C., Cavazza, A., Samogin, G., Furlan, V., Mariotti, F. R., Vacca, P., Moretta, L. & Bogina, G., Oct 1 2018, In : American Journal of Surgical Pathology. 42, 10, p. 1384-1389 6 p.

Research output: Contribution to journalArticle

PD-L1 expression comparison between primary and relapsed non-small cell lung carcinoma using whole sections and clone SP263

Munari, E., Zamboni, G., Lunardi, G., Marconi, M., Sommaggio, M., Brunelli, M., Martignoni, G., Netto, G. J., Hoque, M. O., Moretta, F., Mingari, M. C., Pegoraro, M. C., Mariotti, F. R., Vacca, P., Moretta, L. & Bogina, G., Jul 1 2018, In : Oncotarget. 9, 54, p. 30465-30471 7 p.

Research output: Contribution to journalArticle

PD-L1 Expression Heterogeneity in Non–Small Cell Lung Cancer: Defining Criteria for Harmonization between Biopsy Specimens and Whole Sections

Munari, E., Zamboni, G., Lunardi, G., Marchionni, L., Marconi, M., Sommaggio, M., Brunelli, M., Martignoni, G., Netto, G. J., Hoque, M., Moretta, F., Mingari, M. C., Pegoraro, M. C., Inno, A., Paiano, S., Terzi, A., Cavazza, A., Rossi, G., Mariotti, F. R., Vacca, P. & 2 others, Moretta, L. & Bogina, G., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells

Ooki, A., Del Carmen Rodriguez Pena, M., Marchionni, L., Dinalankara, W., Begum, A., Hahn, N., VandenBussche, C., Rasheed, Z. A., Mao, S., Netto, G. J., Sidransky, D. & Hoque, M., Jan 1 2018, In : Cancer Research. 78, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

2017

A panel of novel detection and prognostic methylated DNA markers in primary non–small cell lung cancer and serum DNA

Ooki, A., Maleki, Z., Tsay, J. C. J., Goparaju, C., Brait Rodrigues De Oliveira, M., Turaga, N., Nam, H. S., Rom, W. N., Pass, H. I., Sidransky, D., Guerrero-Preston, R. & Hoque, M., Nov 15 2017, In : Clinical Cancer Research. 23, 22, p. 7141-7152 12 p.

Research output: Contribution to journalArticle

Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease

Datta, S., Nam, H. S., Hayashi, M., Maldonado, L., Goldberg, R., Brait Rodrigues De Oliveira, M., Sidransky, D., Illei, P. B., Baras, A., Vij, N. & Hoque, M., Mar 1 2017, In : Respiratory Medicine. 124, p. 72-78 7 p.

Research output: Contribution to journalArticle

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

Makarev, E., Schubert, A. D., Kanherkar, R. R., London, N., Teka, M., Ozerov, I., Lezhnina, K., Bedi, A., Ravi, R., Mehra, R., Hoque, M. O., Sloma, I., Gaykalova, D. A., Csoka, A. B., Sidransky, D., Zhavoronkov, A. & Izumchenko, E., Dec 4 2017, In : Cell Death Discovery. 3, 1, 17022.

Research output: Contribution to journalArticle

Open Access

Intravesical BCG Induces CD4+ T-cell expansion in an immune competent model of bladder cancer

Kates, M., Nirschl, T., Sopko, N. A., Matsui, H., Kochel, C. M., Reis, L. O., Netto, G. J., Hoque, M., Hahn, N., McConkey, D., Baras, A., Drake, C. G. & Bivalacqua, T., Jul 1 2017, In : Cancer immunology research. 5, 7, p. 594-603 10 p.

Research output: Contribution to journalArticle

MicroRNA expression profiling of Xp11 renal cell carcinoma

Marchionni, L., Hayashi, M., Guida, E., Ooki, A., Munari, E., Jabboure, F. J., Dinalankara, W., Raza, A., Netto, G. J., Hoque, M. O. & Argani, P., Sep 2017, In : Human pathology. 67, p. 18-29 12 p.

Research output: Contribution to journalArticle

MicroRNAs, promising biomarkers in the diagnosis of Xp11 translocation RCC-reply

Marchionni, L., Netto, G. J., Hoque, M. & Argani, P., 2017, (Accepted/In press) In : Human Pathology.

Research output: Contribution to journalArticle

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L. H., Hoque, M. O., Rodriguez-Galindo, C., Pass, H., Peled, N. & 4 others, Davies, A., Morris, R., Hidalgo, M. & Sidransky, D., Jan 1 2017, In : Annals of Oncology. 28, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

Promoter methylation of MCAM, ERa and ERβ in serum of early stage prostate cancer patients

Brait, M., Banerjee, M., Maldonado, L., Ooki, A., Loyo, M., Guida, E., Izumchenko, E., Mangold, L., Humphreys, E., Rosenbaum, E., Partin, A., Sidransky, D. & Hoque, M. O., Jan 1 2017, In : Oncotarget. 8, 9, p. 15431-15440 10 p.

Research output: Contribution to journalArticle

2016

Differences in the Molecular Characteristics of Bladder Cancer between Smokers and Nonsmokers

Hoque, M., 2016, (Accepted/In press) In : European Urology Focus.

Research output: Contribution to journalArticle

High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing

Duberow, D. P., Brait Rodrigues De Oliveira, M., Hoque, M., Theodorescu, D., Sidransky, D., Dasgupta, S. & Mathies, R. A., Mar 31 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-10 10 p.

Research output: Contribution to journalArticle

Patient-derived xenografts as tools in pharmaceutical development

Izumchenko, E., Meir, J., Bedi, A., Wysocki, P. T., Hoque, M. O. & Sidransky, D., Jun 1 2016, In : Clinical pharmacology and therapeutics. 99, 6, p. 612-621 10 p.

Research output: Contribution to journalArticle

2015

An integrated genome-wide approach to discover deregulated microRNAs in non-small cell lung cancer: Clinical significance of MIR-23b-3p deregulation

Begum, S., Hayashi, M., Ogawa, T., Jabboure, F. J., Brait, M., Izumchenko, E., Tabak, S., Ahrendt, S. A., Westra, W. H., Koch, W., Sidransky, D. & Hoque, M. O., Aug 28 2015, In : Scientific reports. 5, 13236.

Research output: Contribution to journalArticle

Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: A tissue microarray study of 149 patients treated by transurethral resection

Munari, E., Chaux, A., Maldonado, L., Compérat, E., Varinot, J., Bivalacqua, T. J., Hoque, M. O. & Netto, G. J., Jan 1 2015, In : Histopathology. 66, 2, p. 262-269 8 p.

Research output: Contribution to journalArticle

Epigenetic silencing of S100A2 in bladder and head and neck cancers

Lee, J., Wysocki, P. T., Topaloglu, O., Maldonado, L., Brait, M., Begum, S., Moon, D., Kim, M. S., Califano, J. A., Sidransky, D., Hoque, M. O. & Moon, C., Jan 1 2015, In : Oncoscience. 2, 4, p. 410-418 9 p.

Research output: Contribution to journalArticle

Gemcitabine and cisplatin neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma: Predicting response and assessing outcomes

Gandhi, N. M., Baras, A., Munari, E., Faraj, S., Reis, L. O., Liu, J. J., Kates, M., Hoque, M. O., Berman, D., Hahn, N. M., Eisenberger, M., Netto, G. J., Schoenberg, M. P. & Bivalacqua, T. J., May 1 2015, In : Urologic Oncology: Seminars and Original Investigations. 33, 5, p. 204.e1-204.e7

Research output: Contribution to journalArticle

Identification and validation of Protein biomarkers of response to neoadjuvant platinum chemotherapy in muscle invasive urothelial carcinoma

Baras, A. S., Gandhi, N., Munari, E., Faraj, S., Shultz, L., Marchionni, L., Schoenberg, M., Hahn, N., Hoque, M., Berman, D., Bivalacqua, T. J. & Netto, G., Jul 31 2015, In : PloS one. 10, 7, e0131245.

Research output: Contribution to journalArticle

Involvement of epigenetics and EMT-related miRNA in arsenic-induced neoplastic transformation and their potential clinical use

Michailidi, C., Hayashi, M., Datta, S., Sen, T., Zenner, K., Oladeru, O., Brait, M., Izumchenko, E., Baras, A., VandenBussche, C., Argos, M., Bivalacqua, T. J., Ahsan, H., Hahn, N. M., Netto, G. J., Sidransky, D. & Hoque, M. O., Mar 1 2015, In : Cancer Prevention Research. 8, 3, p. 208-221 14 p.

Research output: Contribution to journalArticle

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA

Izumchenko, E., Chang, X., Brait, M., Fertig, E., Kagohara, L. T., Bedi, A., Marchionni, L., Agrawal, N., Ravi, R., Jones, S., Hoque, M. O., Westra, W. H. & Sidransky, D., Sep 16 2015, In : Nature communications. 6, 8258.

Research output: Contribution to journalArticle

2014

An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine

Maldonado, L., Brait, M., Michailidi, C., Munari, E., Driscoll, T., Schultz, L., Bivalacqua, T., Schoenberg, M., Sidransky, D., Netto, G. J. & Hoque, M. O., 2014, In : Oncotarget. 5, 14, p. 5218-5233 16 p.

Research output: Contribution to journalArticle

Open Access

Clear cell papillary renal cell carcinoma: Micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma

Munari, E., Marchionni, L., Chitre, A., Hayashi, M., Martignoni, G., Brunelli, M., Gobbo, S., Argani, P., Allaf, M., Hoque, M. O. & Netto, G. J., Jun 2014, In : Human pathology. 45, 6, p. 1130-1138 9 p.

Research output: Contribution to journalArticle

Epigenetic inactivation of VGF associated with Urothelial Cell Carcinoma and its potential as a non-invasive biomarker using urine

Hayashi, M., Bernert, H., Kagohara, L. T., Maldonado, L., Brait, M., Schoenberg, M., Bivalacqua, T., Netto, G. J., Koch, W., Sidransky, D. & Hoque, M. O., 2014, In : Oncotarget. 5, 10, p. 3350-3361 12 p.

Research output: Contribution to journalArticle

Open Access

GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer

Maldonado, L., Brait, M., Loyo, M., Sullenberger, L., Wang, K., Peskoe, S. B., Rosenbaum, E., Howard, R., Toubaji, A., Albadine, R., Netto, G. J., Hoque, M. O., Platz, E. A. & Sidransky, D., Nov 1 2014, In : Journal of Urology. 192, 5, p. 1542-1548 7 p.

Research output: Contribution to journalArticle

Involvement of miR-518c-5p to growth and metastasis in oral cancer

Kinouchi, M., Uchida, D., Kuribayashi, N., Tamatani, T., Nagai, H., Miyamoto, Y. & Hoque, M. O., Dec 23 2014, In : PloS one. 9, 12, e115936.

Research output: Contribution to journalArticle

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors

Izumchenko, E., Chang, X., Michailidi, C., Kagohara, L., Ravi, R., Paz, K., Brait, M., Hoque, M., Ling, S., Bedi, A. & Sidransky, D., Jul 15 2014, In : Cancer Research. 74, 14, p. 3995-4005 11 p.

Research output: Contribution to journalArticle

2013

Association of Promoter Methylation of VGF and PGP9.5 with Ovarian Cancer Progression

Brait, M., Maldonado, L., Noordhuis, M., Begum, S., Loyo, M., Poeta, M. L., Barbosa, A., Fazio, V. M., Angioli, R., Rabitti, C., Marchionni, L., de Graeff, P., van der Zee, A. G. J., Wisman, G. B. A., Sidransky, D. & Hoque, M. O., Sep 27 2013, In : PloS one. 8, 9, e70878.

Research output: Contribution to journalArticle

Cigarette smoke induces methylation of the tumor suppressor gene NISCH

Ostrow, K. L., Michalidi, C., Guerrero-Preston, R., Hoque, M. O., Greenberg, A., Rom, W. & Sidransky, D., Apr 2013, In : Epigenetics. 8, 4, p. 383-388 6 p.

Research output: Contribution to journalArticle

Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma

Brait, M., Munari, E., LeBron, C., Noordhuis, M. G., Begum, S., Michailidi, C., Gonzalez-Roibon, N., Maldonado, L., Sen, T., Guerrero-Preston, R., Cope, L., Parrellaw, P., Faziow, V. M., Ha, P. K., Netto, G. J., Sidransky, D. & Hoque, M. O., Apr 1 2013, In : Cell Cycle. 12, 7, p. 1058-1070 13 p.

Research output: Contribution to journalArticle

Hypermethylation of Genes Detected in Urine from Ghanaian Adults with Bladder Pathology Associated with Schistosoma haematobium Infection

Zhong, X., Isharwal, S., Naples, J. M., Shiff, C., Veltri, R. W., Shao, C., Bosompem, K. M., Sidransky, D. & Hoque, M. O., Mar 18 2013, In : PloS one. 8, 3, e59089.

Research output: Contribution to journalArticle

SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.

Dasgupta, S., Jang, J. S., Shao, C., Mukhopadhyay, N. D., Sokhi, U. K., Das, S. K., Brait, M., Talbot, C., Yung, R. C., Begum, S., Westra, W. H., Hoque, M. O., Yang, P., Yi, J. E., Lam, S., Gazdar, A. F., Fisher, P. B., Jen, J. & Sidransky, D., Mar 2013, In : Journal of molecular medicine (Berlin, Germany). 91, 3, p. 381-393 13 p.

Research output: Contribution to journalArticle

2012

AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer

Yu, Y., Yin, D., Hoque, M. O., Cao, B., Jia, Y., Yang, Y. & Guo, M., Apr 1 2012, In : Tumor Biology. 33, 2, p. 307-314 8 p.

Research output: Contribution to journalArticle

A single nucleotide polymorphism in the human PIGK gene associates with low PIGK expression in colorectal cancer patients

Dasgupta, S., Pal, P., Mukhopadhyay, N. D., Fu, Y., Ratovitski, E. A., Moon, C. S., Hoque, M. O., Fisher, P. B. & Trink, B., Oct 1 2012, In : International journal of oncology. 41, 4, p. 1405-1410 6 p.

Research output: Contribution to journalArticle

Correlation between BRAF mutation and promoter methylation of TIMP3, RARβ2 and RASSF1A in thyroid cancer

Brait, M., Loyo, M., Rosenbaum, E., Ostrow, K. L., Markova, A., Papagerakis, S., Zahurak, M., Goodman, S. N., Zeiger, M., Sidransky, D., Umbricht, C. B. & Hoque, M. O., Jan 1 2012, In : Epigenetics. 7, 7, p. 710-719 10 p.

Research output: Contribution to journalArticle

Open Access

DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma

Brait, M., Maldonado, L., Begum, S., Loyo, M., Wehle, D., Tavora, F. F., Looijenga, L. H. J., Kowalski, J., Zhang, Z., Rosenbaum, E., Halachmi, S., Netto, G. J. & Hoque, M. O., Jan 17 2012, In : British journal of cancer. 106, 2, p. 414-423 10 p.

Research output: Contribution to journalArticle

OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB Function

Sen, T., Sen, N., Noordhuis, M. G., Ravi, R., Wu, T. C., Ha, P. K., Sidransky, D. & Hoque, M. O., Nov 12 2012, In : PloS one. 7, 11, e48770.

Research output: Contribution to journalArticle

2011

An epigenetic marker panel for detection of lung cancer using cell-free serum DNA

Begum, S., Brait, M., Dasgupta, S., Ostrow, K. L., Zahurak, M., Carvalho, A. L., Califano, J. A., Goodman, S. N., Westra, W. H., Hoque, M. O. & Sidransky, D., Jul 1 2011, In : Clinical Cancer Research. 17, 13, p. 4494-4503 10 p.

Research output: Contribution to journalArticle

A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma

Loyo, M., Brait, M., Kim, M. S., Ostrow, K. L., Jie, C. C., Chuang, A. Y., Califano, J. A., Liégeois, N. J., Begum, S., Westra, W. H., Hoque, M. O., Tao, Q. & Sidransky, D., Mar 15 2011, In : International Journal of Cancer. 128, 6, p. 1393-1403 11 p.

Research output: Contribution to journalArticle

Detection of promoter hypermethylation in salivary rinses as a biomarker for head and neck squamous cell carcinoma surveillance

Carvalho, A. L., Henrique, R., Jeronimo, C., Nayak, C. S., Reddy, A. N., Hoque, M. O., Chang, S., Brait, M., Jiang, W. W., Kim, M. M., Claybourne, Q., Goldenberg, D., Khan, Z., Khan, T., Westra, W. H., Sidransky, D., Koch, W. & Califano, J. A., Jul 15 2011, In : Clinical Cancer Research. 17, 14, p. 4782-4789 8 p.

Research output: Contribution to journalArticle